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The map label for this gene is map [H]

Identifier: 190571320

GI number: 190571320

Start: 994361

End: 995143

Strand: Direct

Name: map [H]

Synonym: WPa_0925

Alternate gene names: 190571320

Gene position: 994361-995143 (Clockwise)

Preceding gene: 190571319

Following gene: 190571322

Centisome position: 67.08

GC content: 35.89

Gene sequence:

>783_bases
ATGAACATAACTATACATTCACAAGAAGATTTTGACTTTATGCGTAAAGCTGGCAGGCTTGCAGCTGAAACCCTTGATTT
TATTGCACCACACGTCAAAGTAGGCGTAACAACTAATGAATTAAATGATCTATGTCATGATTTTATAATCAATGCAGGTG
CAATTCCAGCACCACTGAATTATAAGGGATATCCGAAATCAATTTGTACTTCGAAAAATGCTGTTGTATGTCATGGTATT
CCTGATGATAAACCTCTTAAAGATGGAGATATTTTAAATATTGACGTTACAGTGATTTTAAATGGCTGGTATGGTGACAC
AAGTCGCATGTTTTGGGCTGGTAAACCCTCAATAAAAGCAAAGCGTTTGTGTAATGCTACTTATAATGCGCTAATGGAAG
CAATAAAACAAGTCAGGCCAGGCAATAAGTTAAATAAAATAGGACTTACTATAGAAAAATATATTGAAGATTTTGGATAT
TCTATCGTACGCAATTATTGTGGACATGGCATAGGAAAGGTTTTTCATGCTCCACCAAATGTTGTACATTTTTATGATGA
AGGTGAGGATCTTATCTTAAAAGAAGGCATGTTTTTTACGGTAGAACCAATGATCAATGCTGGAAAACATGAAACTCTGC
TCAGCAAGCTAGATGGCTGGACAGTGACAACACGTGATCTTTCACTTTCTGCACAGTTTGAGCATACGCTTGGAGTCACA
AAAGATGGAGTTGAAATATTTACACTATCACCTAAAAATTGGCATTTTCCACCTTATGATTAG

Upstream 100 bases:

>100_bases
TTAATATACAAATGGCTTGATCTAAGAGCTTATTTTTATAGTATTATTACACTGATGTATCCGTAAGAGAAGCAGAAAAT
TACAATAAAACGTAAGAAAC

Downstream 100 bases:

>100_bases
ATTTTTTAAACACTTGGTTTTTGAAAAAATCTAACTCTTAACTTGTGATATAGCAACTAACCCAATTAATGCACAGAAAA
TCATGTAAAAACTTGCTAAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MNITIHSQEDFDFMRKAGRLAAETLDFIAPHVKVGVTTNELNDLCHDFIINAGAIPAPLNYKGYPKSICTSKNAVVCHGI
PDDKPLKDGDILNIDVTVILNGWYGDTSRMFWAGKPSIKAKRLCNATYNALMEAIKQVRPGNKLNKIGLTIEKYIEDFGY
SIVRNYCGHGIGKVFHAPPNVVHFYDEGEDLILKEGMFFTVEPMINAGKHETLLSKLDGWTVTTRDLSLSAQFEHTLGVT
KDGVEIFTLSPKNWHFPPYD

Sequences:

>Translated_260_residues
MNITIHSQEDFDFMRKAGRLAAETLDFIAPHVKVGVTTNELNDLCHDFIINAGAIPAPLNYKGYPKSICTSKNAVVCHGI
PDDKPLKDGDILNIDVTVILNGWYGDTSRMFWAGKPSIKAKRLCNATYNALMEAIKQVRPGNKLNKIGLTIEKYIEDFGY
SIVRNYCGHGIGKVFHAPPNVVHFYDEGEDLILKEGMFFTVEPMINAGKHETLLSKLDGWTVTTRDLSLSAQFEHTLGVT
KDGVEIFTLSPKNWHFPPYD
>Mature_260_residues
MNITIHSQEDFDFMRKAGRLAAETLDFIAPHVKVGVTTNELNDLCHDFIINAGAIPAPLNYKGYPKSICTSKNAVVCHGI
PDDKPLKDGDILNIDVTVILNGWYGDTSRMFWAGKPSIKAKRLCNATYNALMEAIKQVRPGNKLNKIGLTIEKYIEDFGY
SIVRNYCGHGIGKVFHAPPNVVHFYDEGEDLILKEGMFFTVEPMINAGKHETLLSKLDGWTVTTRDLSLSAQFEHTLGVT
KDGVEIFTLSPKNWHFPPYD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=46.9879518072289, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=41.6, Blast_Score=197, Evalue=7e-51,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=56.5737051792829, Blast_Score=289, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=42.1052631578947, Blast_Score=197, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6323273, Length=252, Percent_Identity=44.047619047619, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI21355531, Length=253, Percent_Identity=48.2213438735178, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=43.9024390243902, Blast_Score=213, Evalue=8e-56,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29060; Mature: 29060

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITIHSQEDFDFMRKAGRLAAETLDFIAPHVKVGVTTNELNDLCHDFIINAGAIPAPLN
CEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCC
YKGYPKSICTSKNAVVCHGIPDDKPLKDGDILNIDVTVILNGWYGDTSRMFWAGKPSIKA
CCCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCEEECCCCCCHH
KRLCNATYNALMEAIKQVRPGNKLNKIGLTIEKYIEDFGYSIVRNYCGHGIGKVFHAPPN
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
VVHFYDEGEDLILKEGMFFTVEPMINAGKHETLLSKLDGWTVTTRDLSLSAQFEHTLGVT
EEEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHHCCCCEEEEECEEEEEEEHHHCCCC
KDGVEIFTLSPKNWHFPPYD
CCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNITIHSQEDFDFMRKAGRLAAETLDFIAPHVKVGVTTNELNDLCHDFIINAGAIPAPLN
CEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCC
YKGYPKSICTSKNAVVCHGIPDDKPLKDGDILNIDVTVILNGWYGDTSRMFWAGKPSIKA
CCCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCEEECCCCCCHH
KRLCNATYNALMEAIKQVRPGNKLNKIGLTIEKYIEDFGYSIVRNYCGHGIGKVFHAPPN
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
VVHFYDEGEDLILKEGMFFTVEPMINAGKHETLLSKLDGWTVTTRDLSLSAQFEHTLGVT
EEEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHHCCCCEEEEECEEEEEEEHHHCCCC
KDGVEIFTLSPKNWHFPPYD
CCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]