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The map label for this gene is hemE

Identifier: 190571243

GI number: 190571243

Start: 919573

End: 920589

Strand: Reverse

Name: hemE

Synonym: WPa_0843

Alternate gene names: 190571243

Gene position: 920589-919573 (Counterclockwise)

Preceding gene: 190571246

Following gene: 190571242

Centisome position: 62.1

GC content: 36.09

Gene sequence:

>1017_bases
TTGGAAAGCAACAAACCAGCGATAGTAAGAATTATTAAGCAGAATAAGCCAAATGAAAAAGTACCTATTTGGTTAATGCG
CCAGGCTGGTAGATCTCTTCCTGAGTATCGCAAAGCCGTAGAAAAAACGAGTAATTTCATGGAGATATGCTATAGCATAG
ATTTAGTGGTAGAGCTGACGCTACAGCCAATAAAAAGATTTGATATGGACGCAGCCATAATTTTTTCAGACATTTTAATA
ATAGCTGACGTTTTAGGTTGTGATGTGAATTTTGTTCGCGGTGTGGGTCCAATAATAAAACCTGTGAAAAGCTCTGAGGA
GTTAAAAAATTCACAAGAATTTGAAACTAAAACCTTTCCAATCTTAAATGCCATCAGGAAAGTAAGAAGCCAATTATCAG
AGGAAAAGTCCCTTATAGGCTTTGCTGGAGGGCCGTGGACGGTAGCTTCCTACATCATAGAGGGTGGTAGTAGTAAAACT
TTTTCTAAAGTATTACATTTCTGTTCCCTAGAACTAGAAGAAGTAATTAAAAAAATAACAGAAGCGACAATTATTTATCT
AATCAAACAGATAGAGTTTGGAGCAGATGTTATTCAGTTATTCGACAGCAATGCTGGTATATTGCAGGGAGAACTGTTTG
AAAGGTATGTAATCAAGCCAACAAAGGAAATTGTTTCAGCAATAAAGAATAAGTTTCCTGATTTTCCTATAATAGGTTTT
CCACGCTCTGCTGGAAATCTTTATAAGGATTACTATGAGAAAACAGGTGTATCTGCAGTAAGTATAGATTATAATGTTCC
AATAGAATGGGCGAAAGCAAATCTAAAAATTCCTCTGCAAGGGAACCTTAATCCTAGTCTTTTGGCCTACAATAAGGCAG
AAGCAATTGAAGAAGCAAAGCGTATAATAGATTGTTTTAGAGGGTTACCTTTTATATTTAATCTTGGACATGGAGTGCTT
CCTGATACTCCGGTTGAAAATATTGCTGCATTAGTGGACCTAGTAAGAAACTACTAA

Upstream 100 bases:

>100_bases
AGTAACAATAATTTTTACTGAATTTTAAGTTAATAACAATTTATTGATAGAACTATTATTACTACTATACTTTAGTATAG
AAAAAAGTAGATAAAATAGA

Downstream 100 bases:

>100_bases
AACTCTTGTATGAAAAGCCTTTATGAGGGTGGAATGAAAACCTTACTTGACAAATCTTTACACTTTCCTTATTATGGCAA
TAAGAGTATTTATCCTTGTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MESNKPAIVRIIKQNKPNEKVPIWLMRQAGRSLPEYRKAVEKTSNFMEICYSIDLVVELTLQPIKRFDMDAAIIFSDILI
IADVLGCDVNFVRGVGPIIKPVKSSEELKNSQEFETKTFPILNAIRKVRSQLSEEKSLIGFAGGPWTVASYIIEGGSSKT
FSKVLHFCSLELEEVIKKITEATIIYLIKQIEFGADVIQLFDSNAGILQGELFERYVIKPTKEIVSAIKNKFPDFPIIGF
PRSAGNLYKDYYEKTGVSAVSIDYNVPIEWAKANLKIPLQGNLNPSLLAYNKAEAIEEAKRIIDCFRGLPFIFNLGHGVL
PDTPVENIAALVDLVRNY

Sequences:

>Translated_338_residues
MESNKPAIVRIIKQNKPNEKVPIWLMRQAGRSLPEYRKAVEKTSNFMEICYSIDLVVELTLQPIKRFDMDAAIIFSDILI
IADVLGCDVNFVRGVGPIIKPVKSSEELKNSQEFETKTFPILNAIRKVRSQLSEEKSLIGFAGGPWTVASYIIEGGSSKT
FSKVLHFCSLELEEVIKKITEATIIYLIKQIEFGADVIQLFDSNAGILQGELFERYVIKPTKEIVSAIKNKFPDFPIIGF
PRSAGNLYKDYYEKTGVSAVSIDYNVPIEWAKANLKIPLQGNLNPSLLAYNKAEAIEEAKRIIDCFRGLPFIFNLGHGVL
PDTPVENIAALVDLVRNY
>Mature_338_residues
MESNKPAIVRIIKQNKPNEKVPIWLMRQAGRSLPEYRKAVEKTSNFMEICYSIDLVVELTLQPIKRFDMDAAIIFSDILI
IADVLGCDVNFVRGVGPIIKPVKSSEELKNSQEFETKTFPILNAIRKVRSQLSEEKSLIGFAGGPWTVASYIIEGGSSKT
FSKVLHFCSLELEEVIKKITEATIIYLIKQIEFGADVIQLFDSNAGILQGELFERYVIKPTKEIVSAIKNKFPDFPIIGF
PRSAGNLYKDYYEKTGVSAVSIDYNVPIEWAKANLKIPLQGNLNPSLLAYNKAEAIEEAKRIIDCFRGLPFIFNLGHGVL
PDTPVENIAALVDLVRNY

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=335, Percent_Identity=33.7313432835821, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI2367337, Length=334, Percent_Identity=34.7305389221557, Blast_Score=216, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320252, Length=335, Percent_Identity=32.8358208955224, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI19921920, Length=333, Percent_Identity=35.7357357357357, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI221330099, Length=333, Percent_Identity=35.7357357357357, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_WOLPP (B3CM33)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975601.1
- EnsemblBacteria:   EBWOLT00000001053
- GeneID:   6385569
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0843
- GeneTree:   EBGT00050000031134
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   CLSK2462802
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37936; Mature: 37936

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 151-151 BINDING 203-203 BINDING 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNKPAIVRIIKQNKPNEKVPIWLMRQAGRSLPEYRKAVEKTSNFMEICYSIDLVVELT
CCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQPIKRFDMDAAIIFSDILIIADVLGCDVNFVRGVGPIIKPVKSSEELKNSQEFETKTFP
HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHCCCCHHHHCCCHHHHHHHHH
ILNAIRKVRSQLSEEKSLIGFAGGPWTVASYIIEGGSSKTFSKVLHFCSLELEEVIKKIT
HHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EATIIYLIKQIEFGADVIQLFDSNAGILQGELFERYVIKPTKEIVSAIKNKFPDFPIIGF
HHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEC
PRSAGNLYKDYYEKTGVSAVSIDYNVPIEWAKANLKIPLQGNLNPSLLAYNKAEAIEEAK
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEEECCCCCCCEEECCHHHHHHHHH
RIIDCFRGLPFIFNLGHGVLPDTPVENIAALVDLVRNY
HHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MESNKPAIVRIIKQNKPNEKVPIWLMRQAGRSLPEYRKAVEKTSNFMEICYSIDLVVELT
CCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQPIKRFDMDAAIIFSDILIIADVLGCDVNFVRGVGPIIKPVKSSEELKNSQEFETKTFP
HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHCCCCHHHHCCCHHHHHHHHH
ILNAIRKVRSQLSEEKSLIGFAGGPWTVASYIIEGGSSKTFSKVLHFCSLELEEVIKKIT
HHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EATIIYLIKQIEFGADVIQLFDSNAGILQGELFERYVIKPTKEIVSAIKNKFPDFPIIGF
HHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEC
PRSAGNLYKDYYEKTGVSAVSIDYNVPIEWAKANLKIPLQGNLNPSLLAYNKAEAIEEAK
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEEECCCCCCCEEECCHHHHHHHHH
RIIDCFRGLPFIFNLGHGVLPDTPVENIAALVDLVRNY
HHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA