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The map label for this gene is hemA [H]

Identifier: 190571180

GI number: 190571180

Start: 851689

End: 852885

Strand: Direct

Name: hemA [H]

Synonym: WPa_0778

Alternate gene names: 190571180

Gene position: 851689-852885 (Clockwise)

Preceding gene: 190571179

Following gene: 190571184

Centisome position: 57.45

GC content: 37.18

Gene sequence:

>1197_bases
TTGGTAGACTACGAAAAAATATTCTTAAATAAAATCAAAGATATAAAAGAAGAAGGGCGCTATCGTGAATTTACGCATTT
TGCGTCATTACCTGGCAAACTTCCCTATATTATGGATTATGAAAGAAATAGAGAGGTTATTGTCTGGTGCAGTAATAATT
ATCTGGGAATGTCACAAAACGATAGTGTCATTGCTGCTATTCAAAATTCATCTGTTGGTGCTGGAGGAACAAGAAATATA
TCAGGTACAACAAAGGAAGTTGTTGAGCTCGAGAAATCTTTGGCTGACTTGCATCAAAAAGAAGCTGCTTTAACTTTTGC
TTGTGGCTATCTTGCCAACCAAACTACACTTAGTACTTTATCGTCTGTTATTCCGGGCGTGGTAATTTTTTCAGATGAGA
AAAACCATTCTTCAATGATAGAAGGTATAAAATCAGGAAAAAGACCGAAGCACATATTTAGGCATAATGATGTTGATCAC
TTAGAGCAGTTGCTAAAGTCTATAGATATAAAAACGCCGAAAATAATAGCACTTGAATCTGTATACTCAATGGATGGTGA
TGTAGCACCGCTTGAAGCGATATGTGATCTAGCAGATCAGTATAATGCAATTACCTATTTGGATGAGGTACACGCAGTTG
GCATGTATGGACCGCGCGGTGGCGGAATTGCAGAAAGAGAAGGTTTGATGGATAGAATAACTGTTATTCAGGGTACATTA
TCAAAGGCTTTTGGAGTGATGGGTGGATATATAGCGTCTTCAAAGAGCTTGGTGGATGTAATAAGAAGTTCAGCCCCAGG
ATTTATTTTTACTACTGCTATGTCGCCCGTTTTAGCAGCAGCAGCAAAGGCAAGCGTTGAGCATCTAAAATCAAGCAACA
TTGAAAGAGAAAAGCAGAAGCAGGTGGTTGAGAAAGTAAAAGACTCACTGAGAAATGCAGGAGTGAATTTTATGCAAACA
GAAACTCATATAATTCCAATCATAATTGGCGATCCTGAGTTGTCCAAAAAAGCATCAAAATTGTTATTTGATGAGTATGG
AATATATGTACAACATATAAATTACCCAACAGTTTCAAAGGGGACTGAGCGCTTCCGTATTACTCCTACGCCTTACCATA
CAAATGAAATGATAGAGCATTTAACAAAATCTCTTGTAAAAGTTTTTGAGAAATTATCTGTTTGTGTCTGTTGTTGA

Upstream 100 bases:

>100_bases
AAGGTTATGCAGACAGAAGAATGTCAGTCTAAGTAATAAATATAGTAGTCTATCATTTAATAATTTATTATAATTATATT
GATTGTTAATAGATAAAAAC

Downstream 100 bases:

>100_bases
GTTTAAAGTTGCCAAGAATAAGGTATCTATTTAAAAGCATGGTTAATGTACAAAATCAGTGCTTTATTTCTTGTCATGAA
AGTAGCTAACACTGGGATCC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MVDYEKIFLNKIKDIKEEGRYREFTHFASLPGKLPYIMDYERNREVIVWCSNNYLGMSQNDSVIAAIQNSSVGAGGTRNI
SGTTKEVVELEKSLADLHQKEAALTFACGYLANQTTLSTLSSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFRHNDVDH
LEQLLKSIDIKTPKIIALESVYSMDGDVAPLEAICDLADQYNAITYLDEVHAVGMYGPRGGGIAEREGLMDRITVIQGTL
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQKQVVEKVKDSLRNAGVNFMQT
ETHIIPIIIGDPELSKKASKLLFDEYGIYVQHINYPTVSKGTERFRITPTPYHTNEMIEHLTKSLVKVFEKLSVCVCC

Sequences:

>Translated_398_residues
MVDYEKIFLNKIKDIKEEGRYREFTHFASLPGKLPYIMDYERNREVIVWCSNNYLGMSQNDSVIAAIQNSSVGAGGTRNI
SGTTKEVVELEKSLADLHQKEAALTFACGYLANQTTLSTLSSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFRHNDVDH
LEQLLKSIDIKTPKIIALESVYSMDGDVAPLEAICDLADQYNAITYLDEVHAVGMYGPRGGGIAEREGLMDRITVIQGTL
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQKQVVEKVKDSLRNAGVNFMQT
ETHIIPIIIGDPELSKKASKLLFDEYGIYVQHINYPTVSKGTERFRITPTPYHTNEMIEHLTKSLVKVFEKLSVCVCC
>Mature_398_residues
MVDYEKIFLNKIKDIKEEGRYREFTHFASLPGKLPYIMDYERNREVIVWCSNNYLGMSQNDSVIAAIQNSSVGAGGTRNI
SGTTKEVVELEKSLADLHQKEAALTFACGYLANQTTLSTLSSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFRHNDVDH
LEQLLKSIDIKTPKIIALESVYSMDGDVAPLEAICDLADQYNAITYLDEVHAVGMYGPRGGGIAEREGLMDRITVIQGTL
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQKQVVEKVKDSLRNAGVNFMQT
ETHIIPIIIGDPELSKKASKLLFDEYGIYVQHINYPTVSKGTERFRITPTPYHTNEMIEHLTKSLVKVFEKLSVCVCC

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977440, Length=411, Percent_Identity=44.7688564476886, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI83977442, Length=411, Percent_Identity=44.7688564476886, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI83977444, Length=411, Percent_Identity=44.7688564476886, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI4502025, Length=401, Percent_Identity=46.1346633416459, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI40316939, Length=401, Percent_Identity=46.1346633416459, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI7657118, Length=393, Percent_Identity=30.7888040712468, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=33.5243553008596, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=29.041095890411, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=27.6881720430108, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=27.6679841897233, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=30.3258145363409, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=29.512893982808, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=32, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=29.1891891891892, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=358, Percent_Identity=27.3743016759777, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=358, Percent_Identity=27.3743016759777, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=251, Percent_Identity=28.2868525896414, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=251, Percent_Identity=28.2868525896414, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=418, Percent_Identity=43.5406698564593, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=27.0491803278689, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=289, Percent_Identity=25.2595155709343, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137420, Length=397, Percent_Identity=47.8589420654912, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24662918, Length=357, Percent_Identity=31.0924369747899, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17136286, Length=377, Percent_Identity=25.4641909814324, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24653280, Length=289, Percent_Identity=25.2595155709343, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653276, Length=289, Percent_Identity=25.2595155709343, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653278, Length=289, Percent_Identity=25.2595155709343, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44060; Mature: 44060

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDYEKIFLNKIKDIKEEGRYREFTHFASLPGKLPYIMDYERNREVIVWCSNNYLGMSQN
CCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCEECCCCC
DSVIAAIQNSSVGAGGTRNISGTTKEVVELEKSLADLHQKEAALTFACGYLANQTTLSTL
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFRHNDVDHLEQLLKSIDIKTPKIIALES
HHHHCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCEEEEHH
VYSMDGDVAPLEAICDLADQYNAITYLDEVHAVGMYGPRGGGIAEREGLMDRITVIQGTL
HHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQK
HHHHHHHHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QVVEKVKDSLRNAGVNFMQTETHIIPIIIGDPELSKKASKLLFDEYGIYVQHINYPTVSK
HHHHHHHHHHHHCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCC
GTERFRITPTPYHTNEMIEHLTKSLVKVFEKLSVCVCC
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDYEKIFLNKIKDIKEEGRYREFTHFASLPGKLPYIMDYERNREVIVWCSNNYLGMSQN
CCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCEECCCCC
DSVIAAIQNSSVGAGGTRNISGTTKEVVELEKSLADLHQKEAALTFACGYLANQTTLSTL
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFRHNDVDHLEQLLKSIDIKTPKIIALES
HHHHCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCEEEEHH
VYSMDGDVAPLEAICDLADQYNAITYLDEVHAVGMYGPRGGGIAEREGLMDRITVIQGTL
HHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQK
HHHHHHHHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QVVEKVKDSLRNAGVNFMQTETHIIPIIIGDPELSKKASKLLFDEYGIYVQHINYPTVSK
HHHHHHHHHHHHCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCC
GTERFRITPTPYHTNEMIEHLTKSLVKVFEKLSVCVCC
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]