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The map label for this gene is hslU [H]

Identifier: 190571157

GI number: 190571157

Start: 820970

End: 822421

Strand: Direct

Name: hslU [H]

Synonym: WPa_0755

Alternate gene names: 190571157

Gene position: 820970-822421 (Clockwise)

Preceding gene: 190571156

Following gene: 190571160

Centisome position: 55.38

GC content: 35.06

Gene sequence:

>1452_bases
ATGTCAAGAACTTTGTGTGATAATTTTTCTAGTCAATCTGTAGTAGGTCAATTTGATAATAATGATGACTATAATGAGAA
AAATAGCCTCTATGAAAATGAAGGTACAGGAAGTAGCAGCATTCAAAGCTCACAAGCTTTATTAGATGATCTACCACCAC
AGAAGATAGTTAAAGAATTAGACAGATTTATAATCGGGCAGAATGATGCAAAGCGCGCTGTTGCTATTGCACTCAGAAAT
CGTTGGCGTCGAAATAAAGTCCCACTTCCACTACGTGAAGAGATTATACCTAAGAATATACTCATGATAGGCCATACGGG
AGTTGGTAAAACTGAAATAGCTCGCCGTTTAGCAAAGCTTGCTGGTGCACCTTTTATAAAAGTTGAAGCAACGAAATTTA
CTGAAATAGGATATGTTGGACGTGATGTTGACTCGATAATACGTGATTTAGTTGACGCAGCAATAGTTTTAGTTAAGGAA
AAAGCACGTAAAGCCTTAACTAAAAAAGCTTTAGGTTTGGCTGAAAAGATAATAGTCAACTCCATGGTTGGTGAAGATGC
AACCGAGGAAAGCAAAAAAGTTTTCAGAGAAAGACTGAGAAATAAGGAATTTGAAGATGGAGAAGTTTCTATTAACGTCA
GGGAGAGCAAGGGTATGCTACCCACTTTTGATATACCTGGTATGCCAGGTGGGCAAATTGGCGTGATGAACGTAACAGAA
ATAGTGGGTAAGATGTTTAATGGGAACAAAAAAACAAAAACTATTACAGTTAAAGTGAAAGAAGCACGTGAAATATTGAT
TAATGAAGAAAGCGAAAGGTTAATGGATGAAGACAAGATAATCAAAGAAGCGATTGATCTTGTTAGCAATGAAGGCATAG
TGTTTTTAGATGAAATAGATAAAATTGCAGCACGTACAGAAATAAAAGGTGAAGTCAACAGAGAAGGAGTGCAGCGCGAT
CTGTTACCATTACTTGAGGGAACAACTGTTTCAACTAAGTATGGCCCCGTAAAAACAGACTATATATTATTTATTGCATC
TGGTGCTTTTCATTTATCTAAGCCATCTGATCTTTTACCAGAATTACAGGGTAGATTGCCAATTAGAGTGGAACTTAAGG
CGCTTACTCAAGAGGATCTAATAAAAATATTAAAGGAACCAGAATCTAGTTTGTTAAAACAGTATATAGCGTTAATGAAA
ACGGAAAATGTAACACTTGAGTTTACTGATGATGGTATAGAGACTATAGCTGAAATAGCATTTACAGTTAATAGAGAAGT
GGAAAATATAGGTGCAAGAAGACTTCATACTGTCATGGAGAAGCTTTTGGATGAAATAAGTTTTATCGCTTCTGAAAAAA
ATAGTGAAAAATTTGTTATAGATAGCAAATATGTAAGAGATAAACTAGAGTCAATTTCAAAACAGCTTGATTTATCTAAA
TTTATACTTTAG

Upstream 100 bases:

>100_bases
ATATCAATAGAGGAGATTGCAAAAAAGGCTATGAAGATAGCTGCCGATATATGTGTTTATACAAACCATAATCTAATTAT
CGAAAAAATAGAGGAGTAAT

Downstream 100 bases:

>100_bases
AGGAAGCCTGCTTTAAGTAATATAGAGCATTCAAGAGGTTTTATTTTTTCTTACTTCGTAATTCTTTAAGCTATTTTTCA
ATAGTAGAATTCAAGCTTAA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSRTLCDNFSSQSVVGQFDNNDDYNEKNSLYENEGTGSSSIQSSQALLDDLPPQKIVKELDRFIIGQNDAKRAVAIALRN
RWRRNKVPLPLREEIIPKNILMIGHTGVGKTEIARRLAKLAGAPFIKVEATKFTEIGYVGRDVDSIIRDLVDAAIVLVKE
KARKALTKKALGLAEKIIVNSMVGEDATEESKKVFRERLRNKEFEDGEVSINVRESKGMLPTFDIPGMPGGQIGVMNVTE
IVGKMFNGNKKTKTITVKVKEAREILINEESERLMDEDKIIKEAIDLVSNEGIVFLDEIDKIAARTEIKGEVNREGVQRD
LLPLLEGTTVSTKYGPVKTDYILFIASGAFHLSKPSDLLPELQGRLPIRVELKALTQEDLIKILKEPESSLLKQYIALMK
TENVTLEFTDDGIETIAEIAFTVNREVENIGARRLHTVMEKLLDEISFIASEKNSEKFVIDSKYVRDKLESISKQLDLSK
FIL

Sequences:

>Translated_483_residues
MSRTLCDNFSSQSVVGQFDNNDDYNEKNSLYENEGTGSSSIQSSQALLDDLPPQKIVKELDRFIIGQNDAKRAVAIALRN
RWRRNKVPLPLREEIIPKNILMIGHTGVGKTEIARRLAKLAGAPFIKVEATKFTEIGYVGRDVDSIIRDLVDAAIVLVKE
KARKALTKKALGLAEKIIVNSMVGEDATEESKKVFRERLRNKEFEDGEVSINVRESKGMLPTFDIPGMPGGQIGVMNVTE
IVGKMFNGNKKTKTITVKVKEAREILINEESERLMDEDKIIKEAIDLVSNEGIVFLDEIDKIAARTEIKGEVNREGVQRD
LLPLLEGTTVSTKYGPVKTDYILFIASGAFHLSKPSDLLPELQGRLPIRVELKALTQEDLIKILKEPESSLLKQYIALMK
TENVTLEFTDDGIETIAEIAFTVNREVENIGARRLHTVMEKLLDEISFIASEKNSEKFVIDSKYVRDKLESISKQLDLSK
FIL
>Mature_482_residues
SRTLCDNFSSQSVVGQFDNNDDYNEKNSLYENEGTGSSSIQSSQALLDDLPPQKIVKELDRFIIGQNDAKRAVAIALRNR
WRRNKVPLPLREEIIPKNILMIGHTGVGKTEIARRLAKLAGAPFIKVEATKFTEIGYVGRDVDSIIRDLVDAAIVLVKEK
ARKALTKKALGLAEKIIVNSMVGEDATEESKKVFRERLRNKEFEDGEVSINVRESKGMLPTFDIPGMPGGQIGVMNVTEI
VGKMFNGNKKTKTITVKVKEAREILINEESERLMDEDKIIKEAIDLVSNEGIVFLDEIDKIAARTEIKGEVNREGVQRDL
LPLLEGTTVSTKYGPVKTDYILFIASGAFHLSKPSDLLPELQGRLPIRVELKALTQEDLIKILKEPESSLLKQYIALMKT
ENVTLEFTDDGIETIAEIAFTVNREVENIGARRLHTVMEKLLDEISFIASEKNSEKFVIDSKYVRDKLESISKQLDLSKF
IL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=91, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790366, Length=450, Percent_Identity=52.6666666666667, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1786642, Length=233, Percent_Identity=34.3347639484979, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319704, Length=142, Percent_Identity=34.5070422535211, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648289, Length=245, Percent_Identity=29.7959183673469, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648291, Length=245, Percent_Identity=29.7959183673469, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 54177; Mature: 54046

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTLCDNFSSQSVVGQFDNNDDYNEKNSLYENEGTGSSSIQSSQALLDDLPPQKIVKEL
CCCCCCCCCCCCCEEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHH
DRFIIGQNDAKRAVAIALRNRWRRNKVPLPLREEIIPKNILMIGHTGVGKTEIARRLAKL
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
AGAPFIKVEATKFTEIGYVGRDVDSIIRDLVDAAIVLVKEKARKALTKKALGLAEKIIVN
HCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVGEDATEESKKVFRERLRNKEFEDGEVSINVRESKGMLPTFDIPGMPGGQIGVMNVTE
HHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEHHH
IVGKMFNGNKKTKTITVKVKEAREILINEESERLMDEDKIIKEAIDLVSNEGIVFLDEID
HHHHHHCCCCCEEEEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
KIAARTEIKGEVNREGVQRDLLPLLEGTTVSTKYGPVKTDYILFIASGAFHLSKPSDLLP
HHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCCHHHHH
ELQGRLPIRVELKALTQEDLIKILKEPESSLLKQYIALMKTENVTLEFTDDGIETIAEIA
HHHCCCCEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
FTVNREVENIGARRLHTVMEKLLDEISFIASEKNSEKFVIDSKYVRDKLESISKQLDLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHH
FIL
HCC
>Mature Secondary Structure 
SRTLCDNFSSQSVVGQFDNNDDYNEKNSLYENEGTGSSSIQSSQALLDDLPPQKIVKEL
CCCCCCCCCCCCEEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHH
DRFIIGQNDAKRAVAIALRNRWRRNKVPLPLREEIIPKNILMIGHTGVGKTEIARRLAKL
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
AGAPFIKVEATKFTEIGYVGRDVDSIIRDLVDAAIVLVKEKARKALTKKALGLAEKIIVN
HCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVGEDATEESKKVFRERLRNKEFEDGEVSINVRESKGMLPTFDIPGMPGGQIGVMNVTE
HHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEHHH
IVGKMFNGNKKTKTITVKVKEAREILINEESERLMDEDKIIKEAIDLVSNEGIVFLDEID
HHHHHHCCCCCEEEEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
KIAARTEIKGEVNREGVQRDLLPLLEGTTVSTKYGPVKTDYILFIASGAFHLSKPSDLLP
HHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCCHHHHH
ELQGRLPIRVELKALTQEDLIKILKEPESSLLKQYIALMKTENVTLEFTDDGIETIAEIA
HHHCCCCEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
FTVNREVENIGARRLHTVMEKLLDEISFIASEKNSEKFVIDSKYVRDKLESISKQLDLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHH
FIL
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA