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The map label for this gene is hemH

Identifier: 190571153

GI number: 190571153

Start: 817308

End: 818261

Strand: Direct

Name: hemH

Synonym: WPa_0751

Alternate gene names: 190571153

Gene position: 817308-818261 (Clockwise)

Preceding gene: 190571152

Following gene: 190571154

Centisome position: 55.13

GC content: 35.43

Gene sequence:

>954_bases
GTGAAGAAGGCAGTAATCTTATTTAACCTAGGCGGACCTGATTCACTAAGTGCGGTCCGTCCTTTCTTATTTAATCTTTT
TTACGATAAAAGAATAATAAATCTACCAAATCCTTTTCGCTTCCTTTTAGCAAAGTTTATCTCCAAAAGGCGAGAAAGTA
CTGCACAAGAAATATACGAGCACATTGGAGGTAAATCGCCAATCTTGGAGAATACGAAAGCACAAGCTGATGCTTTAGAA
CTAAAATTAAATGAAAATGGAAACCATGTATATAAGATATTCATCTGCATGCGTTATTGGCATCCATTTGCTGATGAAGT
TGTTAAAAGCGTAAAGCAATTCGATCCTGACGAAATCATTCTGTTACCACTATATCCGCAATATTCAACCACCACAACTC
TATCATCCATCGAGAATTGGCAAAAAAATGCCAAACTGGAATGTAACACAAAAACAATTCACCATTATTATGACAATGAA
GACTTTATTGAAGCTCATGTTAATCTGACGTCTAAATATTATAAATTAGCTAGCAAAATCGGTAAGCCAAGAGTCCTATT
CTCGGCTCATAGCTTACCTCTTAGTATCATTAAAAAAGGCGACCCTTACGCTTCACAGATAGAAAAAACAGTAAAATTAA
TAGTAAAAAAATTGAATATTGAAGATCTTGATTGGGGAATATGTTATCAGAGTAAGGTTGGCCCTGTAAAATGGTTGGAG
CCTAGCACTGAAAGTGAGCTATCACGCGCGAAAGACGATAATATACCTGTAGTTTTATCACCTATATCTTTTGTTTCTGA
GCATTCTGAAACACTGGTTGAACTTGATATAGAGTATAAAGCAATTATCAAAGACGGATATTACTTTCGCGTACCAACTC
TCAGTACTGATCTCTTATTTATCAAGTGCTTGGCCGATTTATGTTTAGATCACTCTCAAAGTACTGATTTATAG

Upstream 100 bases:

>100_bases
CTCATCTATTGTATGCCAGTGTAAGAAATTTAGTGCCTGTAACTAAACTTGATGAGTGTGTAGCTGATTTTATAGGCAAA
CCTGAAGAAAGGTGCTGTCA

Downstream 100 bases:

>100_bases
CACTTTTCTTTTTAGATTTTTATAGTATAATATTAAAAAGTTATTATTTTATTATCTACTTATGCCAAAAGGTAAGCCAA
ATACATTTATAGAAAGTATA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKKAVILFNLGGPDSLSAVRPFLFNLFYDKRIINLPNPFRFLLAKFISKRRESTAQEIYEHIGGKSPILENTKAQADALE
LKLNENGNHVYKIFICMRYWHPFADEVVKSVKQFDPDEIILLPLYPQYSTTTTLSSIENWQKNAKLECNTKTIHHYYDNE
DFIEAHVNLTSKYYKLASKIGKPRVLFSAHSLPLSIIKKGDPYASQIEKTVKLIVKKLNIEDLDWGICYQSKVGPVKWLE
PSTESELSRAKDDNIPVVLSPISFVSEHSETLVELDIEYKAIIKDGYYFRVPTLSTDLLFIKCLADLCLDHSQSTDL

Sequences:

>Translated_317_residues
MKKAVILFNLGGPDSLSAVRPFLFNLFYDKRIINLPNPFRFLLAKFISKRRESTAQEIYEHIGGKSPILENTKAQADALE
LKLNENGNHVYKIFICMRYWHPFADEVVKSVKQFDPDEIILLPLYPQYSTTTTLSSIENWQKNAKLECNTKTIHHYYDNE
DFIEAHVNLTSKYYKLASKIGKPRVLFSAHSLPLSIIKKGDPYASQIEKTVKLIVKKLNIEDLDWGICYQSKVGPVKWLE
PSTESELSRAKDDNIPVVLSPISFVSEHSETLVELDIEYKAIIKDGYYFRVPTLSTDLLFIKCLADLCLDHSQSTDL
>Mature_317_residues
MKKAVILFNLGGPDSLSAVRPFLFNLFYDKRIINLPNPFRFLLAKFISKRRESTAQEIYEHIGGKSPILENTKAQADALE
LKLNENGNHVYKIFICMRYWHPFADEVVKSVKQFDPDEIILLPLYPQYSTTTTLSSIENWQKNAKLECNTKTIHHYYDNE
DFIEAHVNLTSKYYKLASKIGKPRVLFSAHSLPLSIIKKGDPYASQIEKTVKLIVKKLNIEDLDWGICYQSKVGPVKWLE
PSTESELSRAKDDNIPVVLSPISFVSEHSETLVELDIEYKAIIKDGYYFRVPTLSTDLLFIKCLADLCLDHSQSTDL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=334, Percent_Identity=34.1317365269461, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=34.1317365269461, Blast_Score=158, Evalue=6e-39,
Organism=Escherichia coli, GI1786681, Length=323, Percent_Identity=25.3869969040248, Blast_Score=81, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324750, Length=333, Percent_Identity=31.8318318318318, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17864156, Length=331, Percent_Identity=30.8157099697885, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24651774, Length=259, Percent_Identity=29.3436293436293, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45552018, Length=135, Percent_Identity=37.7777777777778, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_WOLPP (B3CLU1)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975511.1
- EnsemblBacteria:   EBWOLT00000001133
- GeneID:   6384964
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0751
- GeneTree:   EBGT00050000031382
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36383; Mature: 36383

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAVILFNLGGPDSLSAVRPFLFNLFYDKRIINLPNPFRFLLAKFISKRRESTAQEIYE
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
HIGGKSPILENTKAQADALELKLNENGNHVYKIFICMRYWHPFADEVVKSVKQFDPDEII
HCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHCCCHHHHHHHHHHHCCCCCEE
LLPLYPQYSTTTTLSSIENWQKNAKLECNTKTIHHYYDNEDFIEAHVNLTSKYYKLASKI
EEECCCCCCCHHHHHHHHHHHHCCCEEECCEEEEEECCCCCEEEHHHHHHHHHHHHHHHC
GKPRVLFSAHSLPLSIIKKGDPYASQIEKTVKLIVKKLNIEDLDWGICYQSKVGPVKWLE
CCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEECC
PSTESELSRAKDDNIPVVLSPISFVSEHSETLVELDIEYKAIIKDGYYFRVPTLSTDLLF
CCCHHHHHHCCCCCCCEEECCHHHHHHCCCEEEEEECEEEEEEECCCEEECCCCCHHHHH
IKCLADLCLDHSQSTDL
HHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKKAVILFNLGGPDSLSAVRPFLFNLFYDKRIINLPNPFRFLLAKFISKRRESTAQEIYE
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
HIGGKSPILENTKAQADALELKLNENGNHVYKIFICMRYWHPFADEVVKSVKQFDPDEII
HCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHCCCHHHHHHHHHHHCCCCCEE
LLPLYPQYSTTTTLSSIENWQKNAKLECNTKTIHHYYDNEDFIEAHVNLTSKYYKLASKI
EEECCCCCCCHHHHHHHHHHHHCCCEEECCEEEEEECCCCCEEEHHHHHHHHHHHHHHHC
GKPRVLFSAHSLPLSIIKKGDPYASQIEKTVKLIVKKLNIEDLDWGICYQSKVGPVKWLE
CCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEECC
PSTESELSRAKDDNIPVVLSPISFVSEHSETLVELDIEYKAIIKDGYYFRVPTLSTDLLF
CCCHHHHHHCCCCCCCEEECCHHHHHHCCCEEEEEECEEEEEEECCCEEECCCCCHHHHH
IKCLADLCLDHSQSTDL
HHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA