| Definition | Wolbachia endosymbiont of Culex quinquefasciatus Pel, complete genome. |
|---|---|
| Accession | NC_010981 |
| Length | 1,482,455 |
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The map label for this gene is virB4 [H]
Identifier: 190571043
GI number: 190571043
Start: 694193
End: 696547
Strand: Direct
Name: virB4 [H]
Synonym: WPa_0636
Alternate gene names: 190571043
Gene position: 694193-696547 (Clockwise)
Preceding gene: 190571042
Following gene: 190571044
Centisome position: 46.83
GC content: 31.63
Gene sequence:
>2355_bases ATGCAACCAAAAGTACCAGCCACTAGATCTAATTCTGAAAAAAAGAACAATTTAGCGTTACTAGAAAGTATTAATTTAGA TTTTATCCCTTATGCTTGCCACTACGATGAAGAAACTATACTAACAAAACAGGGGGAATTATTAAAAATAATCAAATTAG AAGACTATTCTTCAGTTGATAACTATGGTGATCTTAGAACTGAAATTAGAAAAAGTATATCAAAAAATATCAAGAGTTTA TATTTTACCGTTTGGATTCACACTGTCCGTAAGCGCAATAAACTGAGCTTACAGTGGAATAAAACTTCAGACTTTTCCGA TCAGCTACACTCAACGTGGTTTAATAAACTAGTTGATAGTAAACTACAGTATATAAATGAGTTATACATTGTGGTGTTAC TTAGTGATTTTGGCAAACATATTAATAATGCATTTTTTTTTGGCAGGATAAAGAATAGGCACAAGTTATTTTTACAAAAA AATCATCAAGAATTACAAAAAATAACTGACCTGATTCAAAAAGATTTAGAACCTTTTGGAGCTAAAAAACTGGGCCTTAG GTCTAGTGAAGGCAAAATATATTCTCAAATGATGGAATTTCTCCATTACATTATTACATTAACGCACAAAGATTATCCAA TATGTGAAAGGGATCTATCGCAGCATGTTAAAAATTTAAAAGTAGCTTTTGGTTTCAATAAATTTCAAACATCGTTTGAA GGTCAACAGAAGTTTGGTTCTATTTTTTGCATAAAGGAATATCGAGAAATCCCCTTAGAAAATATAGATAGGTGTTTGCA ACTTGACTCTGAGCTTATCATCACAGAAATAATAATATTTACTAGTAATAATAAAGCAGTAAAAGAATTCAAAAAACAAA TTAATATACTGCAAATCAGTGAGGACAATACCTTACTTCAAAACTCAGGAATAAATGAAATAATAGAGCTTGAAAAAATT TCTGCTATGGATTTTTGTCAACAGAAAATTATTGTTACAATCTTTGCAGATGATAAGAATAGGTTAGCTAAAAATATCAG TGATTTATCCTCTGTAATGTCGTTAATCGGGTTGATGATGTTTAGGACTGATCTGCACATGGAAAATCATTTTTGGGCAC AGCTTCCTGGAAACTTTGCTTTTGTTACACAACCAAAAAATATATTAGAAAAATATGCTTGCAGCTTTGCTATGTTGCAT GATTTTACATCAGGTACGTTAAAAGGAGGAAGATGGAAAGAAGCAGTAACAGTTTTTTTTTCAAAAAAAGGCAGTCCTTA CTTTTTTAACTTTCATGGAAAGAAAAATAATGGTCATACCACAATACTTGGAGCTCCAAATTCAGGTAGAACCTCACTGA TCAATTTCTTACTTTCGGAATCAAGAAAATTTAACCCTAGGATTGTTATATTGGATAATACTGGAAAATCAATAATATTT ACTAAAGCAGTAAGCGGCCAATATTACATAATTGATCCAAAATATAAAGATAAAAGTCTAAAATTTAACCCACTGAACAT TGAAGATAGTGCTTCTAATCGCAATATGCTTGTTGAATTGATCAAAAGGATGGTTGCAGATGCAAGTTTGGTAGACGTAG AAGAAAAGACAAAAAAAATTGTAGATTCTATATTTGCTATACCAAGAGAATCGCGATCTATTTCTCAAATTTCTGAAGTG CTTTTACTTCTTGGAGGCAAAATAAGTAAATGGTGTGGTGAAGGTGAATTTGCTTACTTATTCCAAGATGGTGATGAGTC AGACATTGACTGGGGAACAAAAACTATATCCCTCAATACTGCAAATCTCACTAAGCAAAAAGAATGTATGTCCGTGATAC TTTACTATTTCTTATACTCTTTCGAAGCAAAATGTGATGGCTCACCTGCAATACTTGTTTTGGATGAAGCATGGGAGATA AGTAATATTTTTCCTACAGAGGGAGAGTTTGACGACTGGATGCAAAGAATGACAAAGTTAAATGTTGTAGTAATTCTAAG TACTGAAAACTTAAACCTAGCATTTGCTAGCAAGTTTACTCAATATTTAGATAAGCATGTCGATACGAGAATCCTGATGC CGAACATAAATGCAAACAGGTTATACATGAAAGCATTTTCTCTGTCGAAAGAGGAACTGAATGTTATTTTGCAAACACCA ACACAGGAAGGTTTATTTTTGATAAAGCAATACAAAGGTTTAGTAACTTTAAATCTAGATTTGAAGAATATGAAAGAAAT ACATGTACTTTCAGCTAATAAAGAGACTATAAAGTATATGTATGAAGCAATAAAGGAAAAAGGCGAAAAAGTGAGTAAGT GGTTACCGGCGTTCTATGAAAAATGTAAAGCTTAA
Upstream 100 bases:
>100_bases AAAGGACATACAGTTACAATCCAATAACAAAAAAGAAGATAAGGATTAAGTAAGATAGATGATTCTTTATTATCTTTTTA TTGAATACGCATGATATTGT
Downstream 100 bases:
>100_bases TTTTTTATTGATATTCTCCTTGATATTTTGTCTTTCTTATCAAGGATATGCTGATTGTCCGCCTCTTGTAGAGAGTAATA CTACACTTGAAGCTGGAGGC
Product: type IV secretion system protein VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 784; Mature: 784
Protein sequence:
>784_residues MQPKVPATRSNSEKKNNLALLESINLDFIPYACHYDEETILTKQGELLKIIKLEDYSSVDNYGDLRTEIRKSISKNIKSL YFTVWIHTVRKRNKLSLQWNKTSDFSDQLHSTWFNKLVDSKLQYINELYIVVLLSDFGKHINNAFFFGRIKNRHKLFLQK NHQELQKITDLIQKDLEPFGAKKLGLRSSEGKIYSQMMEFLHYIITLTHKDYPICERDLSQHVKNLKVAFGFNKFQTSFE GQQKFGSIFCIKEYREIPLENIDRCLQLDSELIITEIIIFTSNNKAVKEFKKQINILQISEDNTLLQNSGINEIIELEKI SAMDFCQQKIIVTIFADDKNRLAKNISDLSSVMSLIGLMMFRTDLHMENHFWAQLPGNFAFVTQPKNILEKYACSFAMLH DFTSGTLKGGRWKEAVTVFFSKKGSPYFFNFHGKKNNGHTTILGAPNSGRTSLINFLLSESRKFNPRIVILDNTGKSIIF TKAVSGQYYIIDPKYKDKSLKFNPLNIEDSASNRNMLVELIKRMVADASLVDVEEKTKKIVDSIFAIPRESRSISQISEV LLLLGGKISKWCGEGEFAYLFQDGDESDIDWGTKTISLNTANLTKQKECMSVILYYFLYSFEAKCDGSPAILVLDEAWEI SNIFPTEGEFDDWMQRMTKLNVVVILSTENLNLAFASKFTQYLDKHVDTRILMPNINANRLYMKAFSLSKEELNVILQTP TQEGLFLIKQYKGLVTLNLDLKNMKEIHVLSANKETIKYMYEAIKEKGEKVSKWLPAFYEKCKA
Sequences:
>Translated_784_residues MQPKVPATRSNSEKKNNLALLESINLDFIPYACHYDEETILTKQGELLKIIKLEDYSSVDNYGDLRTEIRKSISKNIKSL YFTVWIHTVRKRNKLSLQWNKTSDFSDQLHSTWFNKLVDSKLQYINELYIVVLLSDFGKHINNAFFFGRIKNRHKLFLQK NHQELQKITDLIQKDLEPFGAKKLGLRSSEGKIYSQMMEFLHYIITLTHKDYPICERDLSQHVKNLKVAFGFNKFQTSFE GQQKFGSIFCIKEYREIPLENIDRCLQLDSELIITEIIIFTSNNKAVKEFKKQINILQISEDNTLLQNSGINEIIELEKI SAMDFCQQKIIVTIFADDKNRLAKNISDLSSVMSLIGLMMFRTDLHMENHFWAQLPGNFAFVTQPKNILEKYACSFAMLH DFTSGTLKGGRWKEAVTVFFSKKGSPYFFNFHGKKNNGHTTILGAPNSGRTSLINFLLSESRKFNPRIVILDNTGKSIIF TKAVSGQYYIIDPKYKDKSLKFNPLNIEDSASNRNMLVELIKRMVADASLVDVEEKTKKIVDSIFAIPRESRSISQISEV LLLLGGKISKWCGEGEFAYLFQDGDESDIDWGTKTISLNTANLTKQKECMSVILYYFLYSFEAKCDGSPAILVLDEAWEI SNIFPTEGEFDDWMQRMTKLNVVVILSTENLNLAFASKFTQYLDKHVDTRILMPNINANRLYMKAFSLSKEELNVILQTP TQEGLFLIKQYKGLVTLNLDLKNMKEIHVLSANKETIKYMYEAIKEKGEKVSKWLPAFYEKCKA >Mature_784_residues MQPKVPATRSNSEKKNNLALLESINLDFIPYACHYDEETILTKQGELLKIIKLEDYSSVDNYGDLRTEIRKSISKNIKSL YFTVWIHTVRKRNKLSLQWNKTSDFSDQLHSTWFNKLVDSKLQYINELYIVVLLSDFGKHINNAFFFGRIKNRHKLFLQK NHQELQKITDLIQKDLEPFGAKKLGLRSSEGKIYSQMMEFLHYIITLTHKDYPICERDLSQHVKNLKVAFGFNKFQTSFE GQQKFGSIFCIKEYREIPLENIDRCLQLDSELIITEIIIFTSNNKAVKEFKKQINILQISEDNTLLQNSGINEIIELEKI SAMDFCQQKIIVTIFADDKNRLAKNISDLSSVMSLIGLMMFRTDLHMENHFWAQLPGNFAFVTQPKNILEKYACSFAMLH DFTSGTLKGGRWKEAVTVFFSKKGSPYFFNFHGKKNNGHTTILGAPNSGRTSLINFLLSESRKFNPRIVILDNTGKSIIF TKAVSGQYYIIDPKYKDKSLKFNPLNIEDSASNRNMLVELIKRMVADASLVDVEEKTKKIVDSIFAIPRESRSISQISEV LLLLGGKISKWCGEGEFAYLFQDGDESDIDWGTKTISLNTANLTKQKECMSVILYYFLYSFEAKCDGSPAILVLDEAWEI SNIFPTEGEFDDWMQRMTKLNVVVILSTENLNLAFASKFTQYLDKHVDTRILMPNINANRLYMKAFSLSKEELNVILQTP TQEGLFLIKQYKGLVTLNLDLKNMKEIHVLSANKETIKYMYEAIKEKGEKVSKWLPAFYEKCKA
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 90484; Mature: 90484
Theoretical pI: Translated: 8.87; Mature: 8.87
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQPKVPATRSNSEKKNNLALLESINLDFIPYACHYDEETILTKQGELLKIIKLEDYSSVD CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEECCCCEEEEEEECCCCCCC NYGDLRTEIRKSISKNIKSLYFTVWIHTVRKRNKLSLQWNKTSDFSDQLHSTWFNKLVDS CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH KLQYINELYIVVLLSDFGKHINNAFFFGRIKNRHKLFLQKNHQELQKITDLIQKDLEPFG HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHEEECCCHHHHHHHHHHHHHHCCCCC AKKLGLRSSEGKIYSQMMEFLHYIITLTHKDYPICERDLSQHVKNLKVAFGFNKFQTSFE CHHCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHEEEEECCHHHHHCCC GQQKFGSIFCIKEYREIPLENIDRCLQLDSELIITEIIIFTSNNKAVKEFKKQINILQIS CHHHHCCEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHCCCEEEEC EDNTLLQNSGINEIIELEKISAMDFCQQKIIVTIFADDKNRLAKNISDLSSVMSLIGLMM CCCCEECCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH FRTDLHMENHFWAQLPGNFAFVTQPKNILEKYACSFAMLHDFTSGTLKGGRWKEAVTVFF HHHHHCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEE SKKGSPYFFNFHGKKNNGHTTILGAPNSGRTSLINFLLSESRKFNPRIVILDNTGKSIIF ECCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEE TKAVSGQYYIIDPKYKDKSLKFNPLNIEDSASNRNMLVELIKRMVADASLVDVEEKTKKI EEECCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHH VDSIFAIPRESRSISQISEVLLLLGGKISKWCGEGEFAYLFQDGDESDIDWGTKTISLNT HHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEC ANLTKQKECMSVILYYFLYSFEAKCDGSPAILVLDEAWEISNIFPTEGEFDDWMQRMTKL CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC NVVVILSTENLNLAFASKFTQYLDKHVDTRILMPNINANRLYMKAFSLSKEELNVILQTP CEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEHHCCHHHCEEEEECC TQEGLFLIKQYKGLVTLNLDLKNMKEIHVLSANKETIKYMYEAIKEKGEKVSKWLPAFYE CCCCCEEEEECCCEEEEEECHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH KCKA HHCC >Mature Secondary Structure MQPKVPATRSNSEKKNNLALLESINLDFIPYACHYDEETILTKQGELLKIIKLEDYSSVD CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEECCCCEEEEEEECCCCCCC NYGDLRTEIRKSISKNIKSLYFTVWIHTVRKRNKLSLQWNKTSDFSDQLHSTWFNKLVDS CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH KLQYINELYIVVLLSDFGKHINNAFFFGRIKNRHKLFLQKNHQELQKITDLIQKDLEPFG HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHEEECCCHHHHHHHHHHHHHHCCCCC AKKLGLRSSEGKIYSQMMEFLHYIITLTHKDYPICERDLSQHVKNLKVAFGFNKFQTSFE CHHCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHEEEEECCHHHHHCCC GQQKFGSIFCIKEYREIPLENIDRCLQLDSELIITEIIIFTSNNKAVKEFKKQINILQIS CHHHHCCEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHCCCEEEEC EDNTLLQNSGINEIIELEKISAMDFCQQKIIVTIFADDKNRLAKNISDLSSVMSLIGLMM CCCCEECCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH FRTDLHMENHFWAQLPGNFAFVTQPKNILEKYACSFAMLHDFTSGTLKGGRWKEAVTVFF HHHHHCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEE SKKGSPYFFNFHGKKNNGHTTILGAPNSGRTSLINFLLSESRKFNPRIVILDNTGKSIIF ECCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEE TKAVSGQYYIIDPKYKDKSLKFNPLNIEDSASNRNMLVELIKRMVADASLVDVEEKTKKI EEECCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHH VDSIFAIPRESRSISQISEVLLLLGGKISKWCGEGEFAYLFQDGDESDIDWGTKTISLNT HHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEC ANLTKQKECMSVILYYFLYSFEAKCDGSPAILVLDEAWEISNIFPTEGEFDDWMQRMTKL CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC NVVVILSTENLNLAFASKFTQYLDKHVDTRILMPNINANRLYMKAFSLSKEELNVILQTP CEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEHHCCHHHCEEEEECC TQEGLFLIKQYKGLVTLNLDLKNMKEIHVLSANKETIKYMYEAIKEKGEKVSKWLPAFYE CCCCCEEEEECCCEEEEEECHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH KCKA HHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]