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The map label for this gene is dxr

Identifier: 190570579

GI number: 190570579

Start: 116933

End: 118108

Strand: Reverse

Name: dxr

Synonym: WPa_0113

Alternate gene names: 190570579

Gene position: 118108-116933 (Counterclockwise)

Preceding gene: 190570580

Following gene: 190570563

Centisome position: 7.97

GC content: 35.46

Gene sequence:

>1176_bases
GTGAAAAAAGTTTCAGTTTTAGGATCAACAGGAAGCATTGGAAAAAAGACTGTAGATTTGCTCTTAAAGAGAAAGGAAGA
ATATCAGGTGGAAGCACTAAGTGCCAATTCTAACTTTGCTCTGCTAGCACAACAGGCAAATCTACTTAATGCAAAATATG
CTGCCATTTCTGATGAAAGGTTCTACAAAGATTTAAAAGAAGATCTACTTGGTACAAACGTCAAAGTAGAAGTTGGTGCT
CCAGGTCTAGCAAATGTTGCTTCTCTACCCGTTGATCTCTCAGTTATTGCAATAGTTGGCATCGCAGGCCTTGAGCCAGT
TATAAAGGTTATAGAAAGCGGTACTAAAGTTATTGCTCTAGCAAACAAAGAGAGTATTGTTTGCGGTGGTAAGTTACTAC
TTAAAAAAGCTAAAGAAAGGAGCGTACAAATAATTCCCATCGACTCTGAACACAACGCAATTTTTCAAGTTTTGCAAAAT
GATGATAAATGTGTAGAAAAGATTATACTCACTGCCTCTGGTGGACCATTTTTAAATTATAGCCTTGAACAATTAAGAAA
TATCACAGTAAATCAGGCACTAAGTCACCCTACTTGGAAAATGGGAAAGAAAATATCAGTTGATAGTGCAACAATGATGA
ATAAAGCACTAGAAATAATAGAAGCACATCATTTGTTTAAAATTAGCCCAAATAGAATTGAAGCAGTAGTGCATCCTGAA
TCGATAGTACATGGAGTTGTAGTTTACCAGGATGGGTTTAGCTTTGCTGTGCTTGCAGAAACTGATATGGAAATTCCCAT
TGCATATGCTTTGTCTTGGCCAGAAAGATCAACTTTGAACTACAAGTTAGACTTAACAAAACAAAAAAAATTGACCTTTC
AAGAACCAGACCACAAATGTTTTTCTTCACTAAAGCTAAGCATGGAAGTGTTAAATTCTTCTTCTCCACATACAAATAGT
ATTGTTTTGAACGCTGCAAATGAGATAGCTGTTAACGAATTTTTGAAGTCACGAATCGGCTTTTTAGAAGTAGTAGAGGT
AGTAAAATCAACAATAGAAAACTTTGACAAGTACTCTGATATTAACTCACTATCCGACATAATAAGTGTCGATTTTGAAA
GCCGTATTCTTGCCAATGAAATCATAAAAAGTAAAGGTATCTGTTCAGTAGAGTGA

Upstream 100 bases:

>100_bases
TGATCATCATGGCCAATCTTTTTCACCTGGTCCTTCACCATCTGTTGGTGATGATCATGAGCTTGGTTACTAAATAACTA
AGAAGATTTTATTGTAATTA

Downstream 100 bases:

>100_bases
TAAAATAAGGTAGACGAGAAAAGACAACTAAATGGTCAAGTAGCCCCATTTCATACTCCTGTCATCCTAGTAGCTGACAC
TGGGATCCAGAAAAATTTAC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKKVSVLGSTGSIGKKTVDLLLKRKEEYQVEALSANSNFALLAQQANLLNAKYAAISDERFYKDLKEDLLGTNVKVEVGA
PGLANVASLPVDLSVIAIVGIAGLEPVIKVIESGTKVIALANKESIVCGGKLLLKKAKERSVQIIPIDSEHNAIFQVLQN
DDKCVEKIILTASGGPFLNYSLEQLRNITVNQALSHPTWKMGKKISVDSATMMNKALEIIEAHHLFKISPNRIEAVVHPE
SIVHGVVVYQDGFSFAVLAETDMEIPIAYALSWPERSTLNYKLDLTKQKKLTFQEPDHKCFSSLKLSMEVLNSSSPHTNS
IVLNAANEIAVNEFLKSRIGFLEVVEVVKSTIENFDKYSDINSLSDIISVDFESRILANEIIKSKGICSVE

Sequences:

>Translated_391_residues
MKKVSVLGSTGSIGKKTVDLLLKRKEEYQVEALSANSNFALLAQQANLLNAKYAAISDERFYKDLKEDLLGTNVKVEVGA
PGLANVASLPVDLSVIAIVGIAGLEPVIKVIESGTKVIALANKESIVCGGKLLLKKAKERSVQIIPIDSEHNAIFQVLQN
DDKCVEKIILTASGGPFLNYSLEQLRNITVNQALSHPTWKMGKKISVDSATMMNKALEIIEAHHLFKISPNRIEAVVHPE
SIVHGVVVYQDGFSFAVLAETDMEIPIAYALSWPERSTLNYKLDLTKQKKLTFQEPDHKCFSSLKLSMEVLNSSSPHTNS
IVLNAANEIAVNEFLKSRIGFLEVVEVVKSTIENFDKYSDINSLSDIISVDFESRILANEIIKSKGICSVE
>Mature_391_residues
MKKVSVLGSTGSIGKKTVDLLLKRKEEYQVEALSANSNFALLAQQANLLNAKYAAISDERFYKDLKEDLLGTNVKVEVGA
PGLANVASLPVDLSVIAIVGIAGLEPVIKVIESGTKVIALANKESIVCGGKLLLKKAKERSVQIIPIDSEHNAIFQVLQN
DDKCVEKIILTASGGPFLNYSLEQLRNITVNQALSHPTWKMGKKISVDSATMMNKALEIIEAHHLFKISPNRIEAVVHPE
SIVHGVVVYQDGFSFAVLAETDMEIPIAYALSWPERSTLNYKLDLTKQKKLTFQEPDHKCFSSLKLSMEVLNSSSPHTNS
IVLNAANEIAVNEFLKSRIGFLEVVEVVKSTIENFDKYSDINSLSDIISVDFESRILANEIIKSKGICSVE

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=41.2658227848101, Blast_Score=273, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_WOLPP (B3CN89)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001974937.1
- EnsemblBacteria:   EBWOLT00000000748
- GeneID:   6384470
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0113
- GeneTree:   EBGT00050000030923
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42908; Mature: 42908

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVSVLGSTGSIGKKTVDLLLKRKEEYQVEALSANSNFALLAQQANLLNAKYAAISDER
CCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHCCCHHHEECHHH
FYKDLKEDLLGTNVKVEVGAPGLANVASLPVDLSVIAIVGIAGLEPVIKVIESGTKVIAL
HHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEE
ANKESIVCGGKLLLKKAKERSVQIIPIDSEHNAIFQVLQNDDKCVEKIILTASGGPFLNY
ECCCCEEECHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHHHEEEEECCCCCCCC
SLEQLRNITVNQALSHPTWKMGKKISVDSATMMNKALEIIEAHHLFKISPNRIEAVVHPE
CHHHHHCCHHHHHHCCCCHHCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCEEEEECHH
SIVHGVVVYQDGFSFAVLAETDMEIPIAYALSWPERSTLNYKLDLTKQKKLTFQEPDHKC
HHHEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCHHH
FSSLKLSMEVLNSSSPHTNSIVLNAANEIAVNEFLKSRIGFLEVVEVVKSTIENFDKYSD
HHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
INSLSDIISVDFESRILANEIIKSKGICSVE
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKVSVLGSTGSIGKKTVDLLLKRKEEYQVEALSANSNFALLAQQANLLNAKYAAISDER
CCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHCCCHHHEECHHH
FYKDLKEDLLGTNVKVEVGAPGLANVASLPVDLSVIAIVGIAGLEPVIKVIESGTKVIAL
HHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEE
ANKESIVCGGKLLLKKAKERSVQIIPIDSEHNAIFQVLQNDDKCVEKIILTASGGPFLNY
ECCCCEEECHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHHHEEEEECCCCCCCC
SLEQLRNITVNQALSHPTWKMGKKISVDSATMMNKALEIIEAHHLFKISPNRIEAVVHPE
CHHHHHCCHHHHHHCCCCHHCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCEEEEECHH
SIVHGVVVYQDGFSFAVLAETDMEIPIAYALSWPERSTLNYKLDLTKQKKLTFQEPDHKC
HHHEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCHHH
FSSLKLSMEVLNSSSPHTNSIVLNAANEIAVNEFLKSRIGFLEVVEVVKSTIENFDKYSD
HHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
INSLSDIISVDFESRILANEIIKSKGICSVE
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA