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The map label for this gene is gmd [H]

Identifier: 189424552

GI number: 189424552

Start: 1559004

End: 1560086

Strand: Reverse

Name: gmd [H]

Synonym: Glov_1491

Alternate gene names: 189424552

Gene position: 1560086-1559004 (Counterclockwise)

Preceding gene: 189424553

Following gene: 189424551

Centisome position: 39.82

GC content: 57.53

Gene sequence:

>1083_bases
ATGAAAAAGGCATTAATCACCGGCATCACCGGGCAGGATGGGGCCTATCTGGCCGAACTGCTGCTTGAGAAGGGGTATGA
GGTCCACGGCATCAAGCGGCGTGCCTCCCTGTTCAACACCGACCGGATTGACCACCTCTACCAGGACCCCCATGAAAAGG
GGCGCCGGTTGGTCCTGCACTACGGTGACATGACCGACTCCACCAACCTGATCCGGATCATTCAGGCCGTGCAACCGGAC
GAGATCTACAACCTGGCAGCCCAGTCCCATGTTGCCGTCTCCTTTGAGACCCCTGAATACACCGCCAATGCCGACGCCAT
CGGTCCCTTGCGGATTCTGGAGGCGATCCGGATCTTGGGGCTTGAGAAAAAGACCCGCTTCTACCAGGCCTCCACCTCCG
AACTCTACGGCCTGGTCCAGGAAATCCCCCAGAAGGAAACCACCCCCTTCTACCCCCGGTCCCCCTATGCCGTAGCCAAA
CTCTACGCCTACTGGATCACCGTCAACTACCGCGAAGCCTACGGCATCTACGGCTGCAACGGCATCCTCTTCAACCACGA
ATCACCGTTACGGGGAGAAACCTTTGTCACCCGCAAGATCACCCGTGCCCTGGCCCGGATCAAACTGGGGCTTCAGGACT
GCCTCTACCTGGGCAACCTTGACTCCCTGCGGGACTGGGGCCATGCCAAAGACTATGTCGAAATGCAATGGCTGCTGATG
CAACAGGAGCACCCTGAAGACTGGGTCATTGCCACCGGTATCCAGCACAGCGTCAGAGAGTTCGTCAATACCGCCGCTGA
AGAACTTGGGATGAAAATCAGCTGGCAGGGCAGCGGCGTCGATGAAACCGGTACCGACCAGAGCGGTAGAGTGATTGTCA
GGGTTGATCCCCGTTACTTCCGTCCCACTGAAGTCGAAACCCTGCTGGGAGATCCGGGCAAGGCCCGTGAGAAACTGGGC
TGGACGCCGAAGATCAGCTTTAAGGAACTGGTTGCCGAAATGGTTCGTGAAGATCTGAAGGCGGCTGAACGGGATGAACT
GGTCAAAAAGCACGGCTACCGGGCGTTTGACTATAATGAATAA

Upstream 100 bases:

>100_bases
ATTGAGCGCCAATACGAAACGCCTGAGGGTCGTCGTATGAACGAGTATTGGATACAGCTTACTGATGGTCTTTAGCCTGT
ATTTTGAAAATGGAGCTGCT

Downstream 100 bases:

>100_bases
GACTACAAAAATATTCATCGCCGGTTCCAAAGGGCTGGTAGGCTCTGCTCTTGTACGGTGCCTGCAAGCGGCCAGCTACT
TGAACCTGCTTACCCCTGAA

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKKALITGITGQDGAYLAELLLEKGYEVHGIKRRASLFNTDRIDHLYQDPHEKGRRLVLHYGDMTDSTNLIRIIQAVQPD
EIYNLAAQSHVAVSFETPEYTANADAIGPLRILEAIRILGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAK
LYAYWITVNYREAYGIYGCNGILFNHESPLRGETFVTRKITRALARIKLGLQDCLYLGNLDSLRDWGHAKDYVEMQWLLM
QQEHPEDWVIATGIQHSVREFVNTAAEELGMKISWQGSGVDETGTDQSGRVIVRVDPRYFRPTEVETLLGDPGKAREKLG
WTPKISFKELVAEMVREDLKAAERDELVKKHGYRAFDYNE

Sequences:

>Translated_360_residues
MKKALITGITGQDGAYLAELLLEKGYEVHGIKRRASLFNTDRIDHLYQDPHEKGRRLVLHYGDMTDSTNLIRIIQAVQPD
EIYNLAAQSHVAVSFETPEYTANADAIGPLRILEAIRILGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAK
LYAYWITVNYREAYGIYGCNGILFNHESPLRGETFVTRKITRALARIKLGLQDCLYLGNLDSLRDWGHAKDYVEMQWLLM
QQEHPEDWVIATGIQHSVREFVNTAAEELGMKISWQGSGVDETGTDQSGRVIVRVDPRYFRPTEVETLLGDPGKAREKLG
WTPKISFKELVAEMVREDLKAAERDELVKKHGYRAFDYNE
>Mature_360_residues
MKKALITGITGQDGAYLAELLLEKGYEVHGIKRRASLFNTDRIDHLYQDPHEKGRRLVLHYGDMTDSTNLIRIIQAVQPD
EIYNLAAQSHVAVSFETPEYTANADAIGPLRILEAIRILGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAK
LYAYWITVNYREAYGIYGCNGILFNHESPLRGETFVTRKITRALARIKLGLQDCLYLGNLDSLRDWGHAKDYVEMQWLLM
QQEHPEDWVIATGIQHSVREFVNTAAEELGMKISWQGSGVDETGTDQSGRVIVRVDPRYFRPTEVETLLGDPGKAREKLG
WTPKISFKELVAEMVREDLKAAERDELVKKHGYRAFDYNE

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=340, Percent_Identity=62.6470588235294, Blast_Score=447, Evalue=1e-126,
Organism=Escherichia coli, GI1788366, Length=363, Percent_Identity=72.4517906336088, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI48994969, Length=245, Percent_Identity=27.3469387755102, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788353, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17507723, Length=348, Percent_Identity=65.5172413793103, Blast_Score=480, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI133901790, Length=340, Percent_Identity=63.5294117647059, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17539424, Length=340, Percent_Identity=63.5294117647059, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI133901788, Length=340, Percent_Identity=63.5294117647059, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17539422, Length=340, Percent_Identity=63.5294117647059, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI133901786, Length=340, Percent_Identity=63.5294117647059, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24158427, Length=348, Percent_Identity=63.2183908045977, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 41163; Mature: 41163

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKALITGITGQDGAYLAELLLEKGYEVHGIKRRASLFNTDRIDHLYQDPHEKGRRLVLH
CCCCEEECCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCHHHHHHHHCCHHHHCCEEEEE
YGDMTDSTNLIRIIQAVQPDEIYNLAAQSHVAVSFETPEYTANADAIGPLRILEAIRILG
ECCCCCCHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHC
LEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGIYGCN
CCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEEEEEEEEEHHHCCEEECC
GILFNHESPLRGETFVTRKITRALARIKLGLQDCLYLGNLDSLRDWGHAKDYVEMQWLLM
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
QQEHPEDWVIATGIQHSVREFVNTAAEELGMKISWQGSGVDETGTDQSGRVIVRVDPRYF
HCCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEEECCCCC
RPTEVETLLGDPGKAREKLGWTPKISFKELVAEMVREDLKAAERDELVKKHGYRAFDYNE
CCCCHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKKALITGITGQDGAYLAELLLEKGYEVHGIKRRASLFNTDRIDHLYQDPHEKGRRLVLH
CCCCEEECCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCHHHHHHHHCCHHHHCCEEEEE
YGDMTDSTNLIRIIQAVQPDEIYNLAAQSHVAVSFETPEYTANADAIGPLRILEAIRILG
ECCCCCCHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHC
LEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGIYGCN
CCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEEEEEEEEEHHHCCEEECC
GILFNHESPLRGETFVTRKITRALARIKLGLQDCLYLGNLDSLRDWGHAKDYVEMQWLLM
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
QQEHPEDWVIATGIQHSVREFVNTAAEELGMKISWQGSGVDETGTDQSGRVIVRVDPRYF
HCCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEEECCCCC
RPTEVETLLGDPGKAREKLGWTPKISFKELVAEMVREDLKAAERDELVKKHGYRAFDYNE
CCCCHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]