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The map label for this gene is udg [H]

Identifier: 189424207

GI number: 189424207

Start: 1191445

End: 1192800

Strand: Reverse

Name: udg [H]

Synonym: Glov_1142

Alternate gene names: 189424207

Gene position: 1192800-1191445 (Counterclockwise)

Preceding gene: 189424208

Following gene: 189424206

Centisome position: 30.45

GC content: 56.86

Gene sequence:

>1356_bases
ATGAAAATTTCCGTATTTGGTGCCGGTTATGTCGGCCTGGTTGCTGCGGCCTGCTTTGCTGAGAGCGGCAACAGCGTTAT
CGCCGTTGATGTTGATCAGAAGAAGATTGAAGGTTTGAAAAACGGCATCATTCCGATTTATGAACCCGGCCTGAAGGAGT
TGATCCTGCGTAACCAGGCTGAAGGCCGTCTTTCCTTTACCACCGACATGGTTGAAGCGGTCGAACAGTCCCTGATCCAG
TTCATTGCCGTTGGCACGCCGCCGGGAGAAGATGGTTCCGCCGATCTGCAGTACGTGCTTTCCGTTGGCCGCACCATTGG
CCGTCATATGAACGGCTTCAAGATCATTGTTGACAAATCCACCGTGCCGGTCGGCACGGCTGACAAGGTCAGGCTGGCGG
TACAGGAAGAGCTTGAAAAGCGGGCCTCACATCTGGAGTTTGATGTTGTCTCCAACCCGGAATTTCTCAAGGAAGGCGCC
GCCATTGACGACTTCATGCAGCCTGACCGGGTCGTGATCGGCACCGACAACGTCCGCACCGCCGAGATCATGAAAGAACT
GTACGACCCGTTCATGCGCAAACAGAACCGGCTGATCATCATGGATATCCGCAGCGCCGAGATGACCAAGTATGCTGCCA
ACGCCATGCTGGCCACCCGGATTTCCTTCATGAACCAGATCGCCAACCTCTGCGAACGGATGGGGGCCGATGTAGCGGCT
GTCAGGGAAGGGATCGGTTCAGACTCCCGCATCGGCTACGACTTCCTCTTCCCCGGTCCCGGTTACGGCGGTTCCTGCTT
TCCCAAGGACGTCAAGGCCCTGATCCGCACGGCCGAAGAATGCAACTACGATTTCCTGCTGCTCAAGGCAGTGGAAGAAG
CCAATGAGCGCCAGAAAGAGGTTCTGGCTGACAAACTGATCAAGGCCCTGGGTTCCGGCGACAAGGAAGGACCGTTGGCC
GGTCGTACCATCGCCTGCTGGGGGCTTTCCTTCAAACCCCGTACCGATGATATGCGCGAAGCGCCATCACTGACCATCAT
CGAACGTCTGCTGGCTGCCGGGGCCGTTGTGCGGGCCCACGACCCGGAAGCGCTGACAGAGGCAAAGAAGCTGTTCGGCG
ACCGGATCGAGTACAGCAGCAACCAGTACGACATCCTGAACAATGCCGACGCCCTGACGGTTATCACCGACTGGCACGAA
TACCGCAATCCCGACTTTGAGCGGATCAAGGGTCTGCTGAAACAACCCCTGATTGTTGATGGCCGCAACCTCTACAAACT
GGACCGGATGCAGGAGATGGAGATCCGCTACATCCCGCTCGGCAGGGCCGGTAACGGCATCTCTGAAACAAACTAA

Upstream 100 bases:

>100_bases
GGTGGCGGCGGCGACCGGCCTGCCGCGGCGTGAACTGTATGCGCAGGCATTGCTGCTGAGAACCAATCTGTAAGATATAC
CCCTGCAAGGAGCTGCTTTG

Downstream 100 bases:

>100_bases
ACAGGGATGAAAGGGATTTAAGGGATAGTTCAATGATATTGTCTGAACTGACTGAAGCTATTCTGGCGGCCTGTTTTGAA
GTAAGCAATGAACTAGGAGT

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKISVFGAGYVGLVAAACFAESGNSVIAVDVDQKKIEGLKNGIIPIYEPGLKELILRNQAEGRLSFTTDMVEAVEQSLIQ
FIAVGTPPGEDGSADLQYVLSVGRTIGRHMNGFKIIVDKSTVPVGTADKVRLAVQEELEKRASHLEFDVVSNPEFLKEGA
AIDDFMQPDRVVIGTDNVRTAEIMKELYDPFMRKQNRLIIMDIRSAEMTKYAANAMLATRISFMNQIANLCERMGADVAA
VREGIGSDSRIGYDFLFPGPGYGGSCFPKDVKALIRTAEECNYDFLLLKAVEEANERQKEVLADKLIKALGSGDKEGPLA
GRTIACWGLSFKPRTDDMREAPSLTIIERLLAAGAVVRAHDPEALTEAKKLFGDRIEYSSNQYDILNNADALTVITDWHE
YRNPDFERIKGLLKQPLIVDGRNLYKLDRMQEMEIRYIPLGRAGNGISETN

Sequences:

>Translated_451_residues
MKISVFGAGYVGLVAAACFAESGNSVIAVDVDQKKIEGLKNGIIPIYEPGLKELILRNQAEGRLSFTTDMVEAVEQSLIQ
FIAVGTPPGEDGSADLQYVLSVGRTIGRHMNGFKIIVDKSTVPVGTADKVRLAVQEELEKRASHLEFDVVSNPEFLKEGA
AIDDFMQPDRVVIGTDNVRTAEIMKELYDPFMRKQNRLIIMDIRSAEMTKYAANAMLATRISFMNQIANLCERMGADVAA
VREGIGSDSRIGYDFLFPGPGYGGSCFPKDVKALIRTAEECNYDFLLLKAVEEANERQKEVLADKLIKALGSGDKEGPLA
GRTIACWGLSFKPRTDDMREAPSLTIIERLLAAGAVVRAHDPEALTEAKKLFGDRIEYSSNQYDILNNADALTVITDWHE
YRNPDFERIKGLLKQPLIVDGRNLYKLDRMQEMEIRYIPLGRAGNGISETN
>Mature_451_residues
MKISVFGAGYVGLVAAACFAESGNSVIAVDVDQKKIEGLKNGIIPIYEPGLKELILRNQAEGRLSFTTDMVEAVEQSLIQ
FIAVGTPPGEDGSADLQYVLSVGRTIGRHMNGFKIIVDKSTVPVGTADKVRLAVQEELEKRASHLEFDVVSNPEFLKEGA
AIDDFMQPDRVVIGTDNVRTAEIMKELYDPFMRKQNRLIIMDIRSAEMTKYAANAMLATRISFMNQIANLCERMGADVAA
VREGIGSDSRIGYDFLFPGPGYGGSCFPKDVKALIRTAEECNYDFLLLKAVEEANERQKEVLADKLIKALGSGDKEGPLA
GRTIACWGLSFKPRTDDMREAPSLTIIERLLAAGAVVRAHDPEALTEAKKLFGDRIEYSSNQYDILNNADALTVITDWHE
YRNPDFERIKGLLKQPLIVDGRNLYKLDRMQEMEIRYIPLGRAGNGISETN

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=449, Percent_Identity=34.5211581291759, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI296040438, Length=355, Percent_Identity=34.6478873239437, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI296040443, Length=304, Percent_Identity=34.5394736842105, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI48994968, Length=446, Percent_Identity=29.1479820627803, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788340, Length=379, Percent_Identity=26.6490765171504, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17560350, Length=470, Percent_Identity=34.0425531914894, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17136908, Length=469, Percent_Identity=33.9019189765458, Blast_Score=252, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49852; Mature: 49852

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISVFGAGYVGLVAAACFAESGNSVIAVDVDQKKIEGLKNGIIPIYEPGLKELILRNQA
CEEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHCCC
EGRLSFTTDMVEAVEQSLIQFIAVGTPPGEDGSADLQYVLSVGRTIGRHMNGFKIIVDKS
CCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
TVPVGTADKVRLAVQEELEKRASHLEFDVVSNPEFLKEGAAIDDFMQPDRVVIGTDNVRT
CCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AEIMKELYDPFMRKQNRLIIMDIRSAEMTKYAANAMLATRISFMNQIANLCERMGADVAA
HHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VREGIGSDSRIGYDFLFPGPGYGGSCFPKDVKALIRTAEECNYDFLLLKAVEEANERQKE
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
VLADKLIKALGSGDKEGPLAGRTIACWGLSFKPRTDDMREAPSLTIIERLLAAGAVVRAH
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHCCCEEECC
DPEALTEAKKLFGDRIEYSSNQYDILNNADALTVITDWHEYRNPDFERIKGLLKQPLIVD
CCHHHHHHHHHHCCHHCCCCCCEEECCCCCEEEEEECHHHHCCCCHHHHHHHHHCCEEEC
GRNLYKLDRMQEMEIRYIPLGRAGNGISETN
CCCHHHHHHHHCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKISVFGAGYVGLVAAACFAESGNSVIAVDVDQKKIEGLKNGIIPIYEPGLKELILRNQA
CEEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHCCC
EGRLSFTTDMVEAVEQSLIQFIAVGTPPGEDGSADLQYVLSVGRTIGRHMNGFKIIVDKS
CCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
TVPVGTADKVRLAVQEELEKRASHLEFDVVSNPEFLKEGAAIDDFMQPDRVVIGTDNVRT
CCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCHHHHCCCCEEEEECCCCCH
AEIMKELYDPFMRKQNRLIIMDIRSAEMTKYAANAMLATRISFMNQIANLCERMGADVAA
HHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VREGIGSDSRIGYDFLFPGPGYGGSCFPKDVKALIRTAEECNYDFLLLKAVEEANERQKE
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
VLADKLIKALGSGDKEGPLAGRTIACWGLSFKPRTDDMREAPSLTIIERLLAAGAVVRAH
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHCCCEEECC
DPEALTEAKKLFGDRIEYSSNQYDILNNADALTVITDWHEYRNPDFERIKGLLKQPLIVD
CCHHHHHHHHHHCCHHCCCCCCEEECCCCCEEEEEECHHHHCCCCHHHHHHHHHCCEEEC
GRNLYKLDRMQEMEIRYIPLGRAGNGISETN
CCCHHHHHHHHCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]