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The map label for this gene is hisE

Identifier: 189424083

GI number: 189424083

Start: 1057428

End: 1057754

Strand: Reverse

Name: hisE

Synonym: Glov_1017

Alternate gene names: 189424083

Gene position: 1057754-1057428 (Counterclockwise)

Preceding gene: 189424084

Following gene: 189424082

Centisome position: 27.0

GC content: 55.96

Gene sequence:

>327_bases
ATGAACAGCAACCAGCATATTCTGGATGAGTTGTATCAGGTGATTCTCTCCCGCAAGGGGGCCTCGCCGGACAGTTCCTA
TACCGCCTCCCTGCTGCACAAAGGGGTGGACAAGATCCTCAAGAAGGTCGGAGAAGAAGCTACTGAAGTGGTGATTGCCG
GTAAAGGTGGGACAGACACCGAGCTGATCTACGAAACCGCCGACCTGCTCTATCACGGCCTGGTGCTGCTGGCAGCCCGT
GATATTCCGGCCGATGCCGTCTGGTCTGAACTGCAACGTCGCTTTGGTACCTCGGGCATAGTTGAAAAAGCCGCCCGGAA
GGAATAG

Upstream 100 bases:

>100_bases
GCCTGCCTGGCAGCCTCAATCTTCCACTTCCGGCAGCATACGGTACAGGAAGCCAAGCAGTATCTCCAAGGACGGGGCGT
CCCGATCAGGATGGTTTAAG

Downstream 100 bases:

>100_bases
CAAAACCTGAGTCCCATGCAAAATGTCATGGGGAAGGCCGGATACAAGGTGTAGGTTGCGCAGCGGCGGAGATATAACAC
CCGGTTAGACAGAGAAGCGA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MNSNQHILDELYQVILSRKGASPDSSYTASLLHKGVDKILKKVGEEATEVVIAGKGGTDTELIYETADLLYHGLVLLAAR
DIPADAVWSELQRRFGTSGIVEKAARKE

Sequences:

>Translated_108_residues
MNSNQHILDELYQVILSRKGASPDSSYTASLLHKGVDKILKKVGEEATEVVIAGKGGTDTELIYETADLLYHGLVLLAAR
DIPADAVWSELQRRFGTSGIVEKAARKE
>Mature_108_residues
MNSNQHILDELYQVILSRKGASPDSSYTASLLHKGVDKILKKVGEEATEVVIAGKGGTDTELIYETADLLYHGLVLLAAR
DIPADAVWSELQRRFGTSGIVEKAARKE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=39.7727272727273, Blast_Score=62, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_GEOLS (B3E616)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001951260.1
- ProteinModelPortal:   B3E616
- SMR:   B3E616
- GeneID:   6369139
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_1017
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11783; Mature: 11783

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNQHILDELYQVILSRKGASPDSSYTASLLHKGVDKILKKVGEEATEVVIAGKGGTDT
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHEEEECCCCCCH
ELIYETADLLYHGLVLLAARDIPADAVWSELQRRFGTSGIVEKAARKE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MNSNQHILDELYQVILSRKGASPDSSYTASLLHKGVDKILKKVGEEATEVVIAGKGGTDT
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHEEEECCCCCCH
ELIYETADLLYHGLVLLAARDIPADAVWSELQRRFGTSGIVEKAARKE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA