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The map label for this gene is add

Identifier: 189424067

GI number: 189424067

Start: 1039405

End: 1040454

Strand: Reverse

Name: add

Synonym: Glov_1001

Alternate gene names: 189424067

Gene position: 1040454-1039405 (Counterclockwise)

Preceding gene: 189424068

Following gene: 189424062

Centisome position: 26.56

GC content: 58.86

Gene sequence:

>1050_bases
ATGAACCTCACCAACATTCCACGCCAGGCCCTGCCTGAGCTGCTCTGCCGGATGCCAAAGGCTGAACTGCATATCCATAT
TGAAGGATCGCTGGAGCCGGAACTTATCTTTGCCCTGGCAGAGCGGAACCGGCTGCAACTAGCCTACCCCACCATTGAGT
CGCTGCGGGCAGCCTATGCCTTTACCAACCTGCAGAGTTTTCTGGATATCTACTATGCCGGGGCCAGTGTGCTGCAGACC
GAACAGGATTTCTTTGACATGGCCTGGGCCTACCTGCTGCGGGCCAAGGCAGATAACGTTGTCCATGCCGAGATCTTTTT
TGATCCCCAGACCCATACGGCCCGGGGGATTCCGTTTGCAACCATCATCAACGGGCTGGACCGGGCGATCCAGCAGGGCC
GGAACGAGCTGGGGATCAGCGCGGCCCTGATACTCTGCTTTCTGCGCCACCTGACTGAAGCAGATGCCTTTACGGTGCTG
GAAGAGGCGCTGCCGTTCCGGGACAAATTCATCGGGGTCGGGCTTGATAGCGGAGAAAAAGGCAATCCGCCGGAGAAGTT
CAGCAGGGTCTTTGCCCGCTGCCGGGAACTGGGGCTGCGGCTGGTGGCCCATGCCGGTGAAGAGGGCACTGCTGAGTATA
TCTGGCATGCCCTTGATCTGCTGCAGGCAGAACGGATCGACCACGGTGTACACTGCCTGGATGACCCGCAGCTGGTGACC
CGGCTGGTGCAGCAGCAGGTTCCGCTGACGGTCTGCCCGCTCTCCAACGTGAAGCTGCGGGTGTTCCCCGACCTTGCGGC
CCACAACATTGCCAGGCTGCTGGCCTGCGGCATCAGGGCCACCATCAACTCTGATGATCCGGCCTATTTTGGTGGCTACC
TGAACCAGAACTATCTGGAGACCTTTGCAGCGCTGCCGGAACTTGGGGCAGCGGAAGCATACCAACTGGCCCGCAACAGC
TTTGAGGCAAGCTTTGTGGATGCAGAGGTTAAGGCTGGCTGGATCAGGGAGCTTGATCAGTTCTTCCAGCAGCAGTGTGA
TAAGATCTAA

Upstream 100 bases:

>100_bases
GGTTTAATCACTGCCTGCTGGAGTTCCTGCGCAAGGTTGCTCCCACAGCGCTGAATGACGGTACGATTGGATGCCACTGC
TGACCGGAAAGGAGAACACC

Downstream 100 bases:

>100_bases
ACCGGTTACAACGGAACCTGCTACCCGGTCTGCTGCAGTCCGGGTAGCAGCAGCATCATCTCACCTCGCCATCAGCTCCC
GGTAATCAGCCGGTGTCACC

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNLTNIPRQALPELLCRMPKAELHIHIEGSLEPELIFALAERNRLQLAYPTIESLRAAYAFTNLQSFLDIYYAGASVLQT
EQDFFDMAWAYLLRAKADNVVHAEIFFDPQTHTARGIPFATIINGLDRAIQQGRNELGISAALILCFLRHLTEADAFTVL
EEALPFRDKFIGVGLDSGEKGNPPEKFSRVFARCRELGLRLVAHAGEEGTAEYIWHALDLLQAERIDHGVHCLDDPQLVT
RLVQQQVPLTVCPLSNVKLRVFPDLAAHNIARLLACGIRATINSDDPAYFGGYLNQNYLETFAALPELGAAEAYQLARNS
FEASFVDAEVKAGWIRELDQFFQQQCDKI

Sequences:

>Translated_349_residues
MNLTNIPRQALPELLCRMPKAELHIHIEGSLEPELIFALAERNRLQLAYPTIESLRAAYAFTNLQSFLDIYYAGASVLQT
EQDFFDMAWAYLLRAKADNVVHAEIFFDPQTHTARGIPFATIINGLDRAIQQGRNELGISAALILCFLRHLTEADAFTVL
EEALPFRDKFIGVGLDSGEKGNPPEKFSRVFARCRELGLRLVAHAGEEGTAEYIWHALDLLQAERIDHGVHCLDDPQLVT
RLVQQQVPLTVCPLSNVKLRVFPDLAAHNIARLLACGIRATINSDDPAYFGGYLNQNYLETFAALPELGAAEAYQLARNS
FEASFVDAEVKAGWIRELDQFFQQQCDKI
>Mature_349_residues
MNLTNIPRQALPELLCRMPKAELHIHIEGSLEPELIFALAERNRLQLAYPTIESLRAAYAFTNLQSFLDIYYAGASVLQT
EQDFFDMAWAYLLRAKADNVVHAEIFFDPQTHTARGIPFATIINGLDRAIQQGRNELGISAALILCFLRHLTEADAFTVL
EEALPFRDKFIGVGLDSGEKGNPPEKFSRVFARCRELGLRLVAHAGEEGTAEYIWHALDLLQAERIDHGVHCLDDPQLVT
RLVQQQVPLTVCPLSNVKLRVFPDLAAHNIARLLACGIRATINSDDPAYFGGYLNQNYLETFAALPELGAAEAYQLARNS
FEASFVDAEVKAGWIRELDQFFQQQCDKI

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=304, Percent_Identity=25.6578947368421, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1787910, Length=321, Percent_Identity=30.8411214953271, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17538512, Length=355, Percent_Identity=22.8169014084507, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32565969, Length=340, Percent_Identity=22.9411764705882, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324188, Length=336, Percent_Identity=43.1547619047619, Blast_Score=282, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_GEOLS (B3E600)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001951244.1
- ProteinModelPortal:   B3E600
- SMR:   B3E600
- GeneID:   6367699
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_1001
- HOGENOM:   HBG630382
- OMA:   YFGGYLN
- ProtClustDB:   CLSK2324783
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 39130; Mature: 39130

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 207-207 BINDING 26-26 BINDING 28-28 BINDING 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTNIPRQALPELLCRMPKAELHIHIEGSLEPELIFALAERNRLQLAYPTIESLRAAYA
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCEEEECCCHHHHHHHHH
FTNLQSFLDIYYAGASVLQTEQDFFDMAWAYLLRAKADNVVHAEIFFDPQTHTARGIPFA
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHH
TIINGLDRAIQQGRNELGISAALILCFLRHLTEADAFTVLEEALPFRDKFIGVGLDSGEK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCCCCCC
GNPPEKFSRVFARCRELGLRLVAHAGEEGTAEYIWHALDLLQAERIDHGVHCLDDPQLVT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RLVQQQVPLTVCPLSNVKLRVFPDLAAHNIARLLACGIRATINSDDPAYFGGYLNQNYLE
HHHHHCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHH
TFAALPELGAAEAYQLARNSFEASFVDAEVKAGWIRELDQFFQQQCDKI
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLTNIPRQALPELLCRMPKAELHIHIEGSLEPELIFALAERNRLQLAYPTIESLRAAYA
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCEEEECCCHHHHHHHHH
FTNLQSFLDIYYAGASVLQTEQDFFDMAWAYLLRAKADNVVHAEIFFDPQTHTARGIPFA
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHH
TIINGLDRAIQQGRNELGISAALILCFLRHLTEADAFTVLEEALPFRDKFIGVGLDSGEK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCCCCCC
GNPPEKFSRVFARCRELGLRLVAHAGEEGTAEYIWHALDLLQAERIDHGVHCLDDPQLVT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RLVQQQVPLTVCPLSNVKLRVFPDLAAHNIARLLACGIRATINSDDPAYFGGYLNQNYLE
HHHHHCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHH
TFAALPELGAAEAYQLARNSFEASFVDAEVKAGWIRELDQFFQQQCDKI
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA