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The map label for this gene is nhaA [H]

Identifier: 189423909

GI number: 189423909

Start: 865490

End: 866662

Strand: Reverse

Name: nhaA [H]

Synonym: Glov_0842

Alternate gene names: 189423909

Gene position: 866662-865490 (Counterclockwise)

Preceding gene: 189423910

Following gene: 189423908

Centisome position: 22.12

GC content: 52.0

Gene sequence:

>1173_bases
TTGAAAATTATCAAGGATTTTTACGAGCGGGAATCGTCGGTCGGCGTTGTCCTCATTACGGTGACGTGCCTCGCGTTATT
GCTGAAAAACTCTCCCTTTGCGGAGGCATATAACCTCTTTTTGCACACCCCGGTGGAAATCAGGTTCGGGGCACTCGATA
TCGCCAAGCCGCTGCTGCTCTGGATCAACGACGGCCTCATGGCCGTATTTTTTCTACTGGTAGGGCTTGAAGTAAAACGG
GAAATCCTTTACGGCAGTCTCTCTTCATGGTCCCAGGCTGCGTTGCCGGTCATTGCAGCTCTGGGCGGTATGACCGTACC
CGCTCTCATCTACATCGGCTTTAATCGCGAGCAGCCGCTTGCCCTCCAAGGATGGGCAATCCCTACGGCTACAGATATCG
CCTTTGCCTTGGGGATATTATCCCTGCTTGGCAAAAGAGTGCCGACGTCACTGAAGATTTTTCTCCTGGCCCTCGCTATC
ATAGATGACCTGGGCGCCATCGTGATAATCGCACTGTTTTTTACCGCTGAACTTTCGCACGTTTCCATGGCGATTGCCTC
TGTAACACTGGTCCTGCTTTTTATCGTCAATCGAATCGGCGTCACACGCCAGGCCGCCTATATCCTGTTGGGATCAGTAC
TCTGGGTCAGCGTGCTCAAATCAGGAGTCCACGCCACCTTGGCTGGGGTTGCCCTCGCCTTCATGATACCGATGGAAGCG
AAAGAAAGTAATGGAACCAGAGTAGCACTTGCCGAACGACTTGAGCATGACCTGCATCCCTGGGTATCTTTTTTGATCCT
GCCGCTCTTCGCCTTTGTCAATGCGGGCATTGACCTGAGAGGGTTATCGCTCAGGGAAATTTTCGGTCCGGTGCCCATGG
GTATCATGTGTGGCTTGTTCTTCGGTAAACAGATCGGGGTGTTTCTGTTCAGCTGGGTAGCGATCCGGCTGAAATTTGCC
GTATTGCCGCACGGCGTCACGTGGTCACAGTTCTATGGTGTTGCGATCATGACGGGTATCGGGTTTACCATGAGTCTGTT
CATCGATTCACTGGCATTTGTTGATGACAAAGTCTACCAGTATGCCGACAAGCTGGCTGTTCTGCTGGGATCGCTCCTTT
CGGGGGTTGCCGGCTATCTGGTATTGAGATTTAAAACCGCAACTCAAAAGTAA

Upstream 100 bases:

>100_bases
ACGAGGAACTTTTCGAAAAATCGTATGGGTATATCCGGCAGTATTACTGAGCCGAGAATAATGAATTTCTGCGGCCACTG
CCGTTTCATGGAGCTATGTA

Downstream 100 bases:

>100_bases
CAACTCGGATTGACCCTTATTACAGATTCCCGCGTGAATTGATTCAAACAAAGCAACACGCCCGATCAGGGTTGTTTTGA
ATTACGGCTCAAGGCCTTTC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKIIKDFYERESSVGVVLITVTCLALLLKNSPFAEAYNLFLHTPVEIRFGALDIAKPLLLWINDGLMAVFFLLVGLEVKR
EILYGSLSSWSQAALPVIAALGGMTVPALIYIGFNREQPLALQGWAIPTATDIAFALGILSLLGKRVPTSLKIFLLALAI
IDDLGAIVIIALFFTAELSHVSMAIASVTLVLLFIVNRIGVTRQAAYILLGSVLWVSVLKSGVHATLAGVALAFMIPMEA
KESNGTRVALAERLEHDLHPWVSFLILPLFAFVNAGIDLRGLSLREIFGPVPMGIMCGLFFGKQIGVFLFSWVAIRLKFA
VLPHGVTWSQFYGVAIMTGIGFTMSLFIDSLAFVDDKVYQYADKLAVLLGSLLSGVAGYLVLRFKTATQK

Sequences:

>Translated_390_residues
MKIIKDFYERESSVGVVLITVTCLALLLKNSPFAEAYNLFLHTPVEIRFGALDIAKPLLLWINDGLMAVFFLLVGLEVKR
EILYGSLSSWSQAALPVIAALGGMTVPALIYIGFNREQPLALQGWAIPTATDIAFALGILSLLGKRVPTSLKIFLLALAI
IDDLGAIVIIALFFTAELSHVSMAIASVTLVLLFIVNRIGVTRQAAYILLGSVLWVSVLKSGVHATLAGVALAFMIPMEA
KESNGTRVALAERLEHDLHPWVSFLILPLFAFVNAGIDLRGLSLREIFGPVPMGIMCGLFFGKQIGVFLFSWVAIRLKFA
VLPHGVTWSQFYGVAIMTGIGFTMSLFIDSLAFVDDKVYQYADKLAVLLGSLLSGVAGYLVLRFKTATQK
>Mature_390_residues
MKIIKDFYERESSVGVVLITVTCLALLLKNSPFAEAYNLFLHTPVEIRFGALDIAKPLLLWINDGLMAVFFLLVGLEVKR
EILYGSLSSWSQAALPVIAALGGMTVPALIYIGFNREQPLALQGWAIPTATDIAFALGILSLLGKRVPTSLKIFLLALAI
IDDLGAIVIIALFFTAELSHVSMAIASVTLVLLFIVNRIGVTRQAAYILLGSVLWVSVLKSGVHATLAGVALAFMIPMEA
KESNGTRVALAERLEHDLHPWVSFLILPLFAFVNAGIDLRGLSLREIFGPVPMGIMCGLFFGKQIGVFLFSWVAIRLKFA
VLPHGVTWSQFYGVAIMTGIGFTMSLFIDSLAFVDDKVYQYADKLAVLLGSLLSGVAGYLVLRFKTATQK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=388, Percent_Identity=55.9278350515464, Blast_Score=389, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 42409; Mature: 42409

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIKDFYERESSVGVVLITVTCLALLLKNSPFAEAYNLFLHTPVEIRFGALDIAKPLLL
CCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHEECCCEEEECHHHHHHHHHH
WINDGLMAVFFLLVGLEVKREILYGSLSSWSQAALPVIAALGGMTVPALIYIGFNREQPL
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEECCCCCCC
ALQGWAIPTATDIAFALGILSLLGKRVPTSLKIFLLALAIIDDLGAIVIIALFFTAELSH
EEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSMAIASVTLVLLFIVNRIGVTRQAAYILLGSVLWVSVLKSGVHATLAGVALAFMIPMEA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KESNGTRVALAERLEHDLHPWVSFLILPLFAFVNAGIDLRGLSLREIFGPVPMGIMCGLF
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHH
FGKQIGVFLFSWVAIRLKFAVLPHGVTWSQFYGVAIMTGIGFTMSLFIDSLAFVDDKVYQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADKLAVLLGSLLSGVAGYLVLRFKTATQK
HHHHHHHHHHHHHHHHHHHHHHEEECCCCC
>Mature Secondary Structure
MKIIKDFYERESSVGVVLITVTCLALLLKNSPFAEAYNLFLHTPVEIRFGALDIAKPLLL
CCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHEECCCEEEECHHHHHHHHHH
WINDGLMAVFFLLVGLEVKREILYGSLSSWSQAALPVIAALGGMTVPALIYIGFNREQPL
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEECCCCCCC
ALQGWAIPTATDIAFALGILSLLGKRVPTSLKIFLLALAIIDDLGAIVIIALFFTAELSH
EEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSMAIASVTLVLLFIVNRIGVTRQAAYILLGSVLWVSVLKSGVHATLAGVALAFMIPMEA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KESNGTRVALAERLEHDLHPWVSFLILPLFAFVNAGIDLRGLSLREIFGPVPMGIMCGLF
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHH
FGKQIGVFLFSWVAIRLKFAVLPHGVTWSQFYGVAIMTGIGFTMSLFIDSLAFVDDKVYQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADKLAVLLGSLLSGVAGYLVLRFKTATQK
HHHHHHHHHHHHHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA