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The map label for this gene is iscS [H]

Identifier: 189423903

GI number: 189423903

Start: 855943

End: 857076

Strand: Reverse

Name: iscS [H]

Synonym: Glov_0835

Alternate gene names: 189423903

Gene position: 857076-855943 (Counterclockwise)

Preceding gene: 189423905

Following gene: 189423902

Centisome position: 21.88

GC content: 55.47

Gene sequence:

>1134_bases
ATGGCTATTTATCTGGACTGCAACGCGACAACGCCGGTGGAACCGTCAGTAGCATCGGTGGTGATGCGACTCCTGGAAAA
GGATTTTGGCAATGCTGCGAGTCCTATCCATGATTACGGTGTGTTTGCGCTTGCCGCAGTGGAACATGCCCGGGGGCAGG
TAGCCGAAGTGGTGAAGGCACGCCGCGATGAAGTGATTTTTACCAGCGGCGCGACGGAGAGTAACAACCTGGCAATACTT
GGGCTTGCAGGGGAAGGTGTCCGGAGTGGCCGCCGTCATCTGATTACCACTGCCATAGAGCACAAGGCGGTGCTTGAACC
GTTTGACGAGATGACGCGTCTGGGCTTCGAGGTGCAGATTCTGCCGGTCAGGGGGGATGGCCGTTTTGATCCACAGCGAT
TGGCGGATGTACTTCGTCCCGACACGCTTCTGGTTTCCACCATGCAGGTCAACAACGAGACCGGGATACTGCAACCGCTG
ACAGATGTGACAGATATTTTGTCCAACCATAATGCATGGTGGCATGTCGATGCCGCCCAGGGTTTCGGCAAGGAGTTGGA
GCAGCTCCGGAACCCGCGCATCGATCTCATCTCCATAAGCGGCCATAAGATATACGGTCCCAAAGGTATAGGTGCCCTCA
TTGCCCGCAAGCATGATCGTGAATTCCCGCCACTCCGTCCACTCATGTTCGGCGGTGGGCAGGAGCAGGGACTGCGCCCT
GGCACTCTACCGGTCCCACTCATTGCCGGTCTTGGGGAGGCAGCAAAACTTGCCGTACGAAACAACTGTGAACGGGGGGA
GAAATGCCGGGCATTTCGCGAACAGGCTCTGGCAGTGTTTTCGGAGCTTGGCGCACAGATGAACGGCGCAGAAGAGTACA
CGCTGCCGCATGTACTCAATGTGTCGCTGCCAGGAATCAATTCGGATCTGGCAATCAAGGCTCTTAAGAATGTCATTGCC
GTATCCAGCACCTCGGCATGCACCTCACACACTCACACGCCAAGCCATGTACTGGTAGCAATGGGGTTATCGCCTGAAAA
AGTGGAACAATCAATCCGCTTGTCGTGGTGTCACATGACCCCGGATGTTGACTGGTCTGAAGTTGAAAATATTCTCCGTG
TACTGCGCGGATAA

Upstream 100 bases:

>100_bases
TACTATTCGATATTTATATCGTATCAATAAAAACAATATATTTTTCTTATATACATGCACTGCGTATACTTGGCAATAAA
TTCCGGTGAGAGAGAAATAT

Downstream 100 bases:

>100_bases
GAAAGGTGGTTCACATGAGCGACATATTTAGAGAGCTGGAAGAGGTTACCGTTGAACAGTATGACCACCATGATCTGCCG
AAATGGCTCGCCGACCCCGT

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAIYLDCNATTPVEPSVASVVMRLLEKDFGNAASPIHDYGVFALAAVEHARGQVAEVVKARRDEVIFTSGATESNNLAIL
GLAGEGVRSGRRHLITTAIEHKAVLEPFDEMTRLGFEVQILPVRGDGRFDPQRLADVLRPDTLLVSTMQVNNETGILQPL
TDVTDILSNHNAWWHVDAAQGFGKELEQLRNPRIDLISISGHKIYGPKGIGALIARKHDREFPPLRPLMFGGGQEQGLRP
GTLPVPLIAGLGEAAKLAVRNNCERGEKCRAFREQALAVFSELGAQMNGAEEYTLPHVLNVSLPGINSDLAIKALKNVIA
VSSTSACTSHTHTPSHVLVAMGLSPEKVEQSIRLSWCHMTPDVDWSEVENILRVLRG

Sequences:

>Translated_377_residues
MAIYLDCNATTPVEPSVASVVMRLLEKDFGNAASPIHDYGVFALAAVEHARGQVAEVVKARRDEVIFTSGATESNNLAIL
GLAGEGVRSGRRHLITTAIEHKAVLEPFDEMTRLGFEVQILPVRGDGRFDPQRLADVLRPDTLLVSTMQVNNETGILQPL
TDVTDILSNHNAWWHVDAAQGFGKELEQLRNPRIDLISISGHKIYGPKGIGALIARKHDREFPPLRPLMFGGGQEQGLRP
GTLPVPLIAGLGEAAKLAVRNNCERGEKCRAFREQALAVFSELGAQMNGAEEYTLPHVLNVSLPGINSDLAIKALKNVIA
VSSTSACTSHTHTPSHVLVAMGLSPEKVEQSIRLSWCHMTPDVDWSEVENILRVLRG
>Mature_376_residues
AIYLDCNATTPVEPSVASVVMRLLEKDFGNAASPIHDYGVFALAAVEHARGQVAEVVKARRDEVIFTSGATESNNLAILG
LAGEGVRSGRRHLITTAIEHKAVLEPFDEMTRLGFEVQILPVRGDGRFDPQRLADVLRPDTLLVSTMQVNNETGILQPLT
DVTDILSNHNAWWHVDAAQGFGKELEQLRNPRIDLISISGHKIYGPKGIGALIARKHDREFPPLRPLMFGGGQEQGLRPG
TLPVPLIAGLGEAAKLAVRNNCERGEKCRAFREQALAVFSELGAQMNGAEEYTLPHVLNVSLPGINSDLAIKALKNVIAV
SSTSACTSHTHTPSHVLVAMGLSPEKVEQSIRLSWCHMTPDVDWSEVENILRVLRG

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=40.9326424870466, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI156713448, Length=392, Percent_Identity=32.9081632653061, Blast_Score=181, Evalue=7e-46,
Organism=Escherichia coli, GI48994898, Length=379, Percent_Identity=42.4802110817942, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1787970, Length=233, Percent_Identity=27.8969957081545, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789175, Length=235, Percent_Identity=28.5106382978723, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25143064, Length=362, Percent_Identity=41.1602209944751, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17533177, Length=333, Percent_Identity=31.8318318318318, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319831, Length=353, Percent_Identity=42.7762039660057, Blast_Score=266, Evalue=4e-72,
Organism=Drosophila melanogaster, GI20129463, Length=381, Percent_Identity=41.2073490813648, Blast_Score=251, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41024; Mature: 40892

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYLDCNATTPVEPSVASVVMRLLEKDFGNAASPIHDYGVFALAAVEHARGQVAEVVKA
CEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRDEVIFTSGATESNNLAILGLAGEGVRSGRRHLITTAIEHKAVLEPFDEMTRLGFEVQI
CCCCEEEECCCCCCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEE
LPVRGDGRFDPQRLADVLRPDTLLVSTMQVNNETGILQPLTDVTDILSNHNAWWHVDAAQ
EEECCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHH
GFGKELEQLRNPRIDLISISGHKIYGPKGIGALIARKHDREFPPLRPLMFGGGQEQGLRP
HHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCCC
GTLPVPLIAGLGEAAKLAVRNNCERGEKCRAFREQALAVFSELGAQMNGAEEYTLPHVLN
CCCCHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
VSLPGINSDLAIKALKNVIAVSSTSACTSHTHTPSHVLVAMGLSPEKVEQSIRLSWCHMT
EECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHEEEEEECC
PDVDWSEVENILRVLRG
CCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AIYLDCNATTPVEPSVASVVMRLLEKDFGNAASPIHDYGVFALAAVEHARGQVAEVVKA
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRDEVIFTSGATESNNLAILGLAGEGVRSGRRHLITTAIEHKAVLEPFDEMTRLGFEVQI
CCCCEEEECCCCCCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEE
LPVRGDGRFDPQRLADVLRPDTLLVSTMQVNNETGILQPLTDVTDILSNHNAWWHVDAAQ
EEECCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHH
GFGKELEQLRNPRIDLISISGHKIYGPKGIGALIARKHDREFPPLRPLMFGGGQEQGLRP
HHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCCC
GTLPVPLIAGLGEAAKLAVRNNCERGEKCRAFREQALAVFSELGAQMNGAEEYTLPHVLN
CCCCHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
VSLPGINSDLAIKALKNVIAVSSTSACTSHTHTPSHVLVAMGLSPEKVEQSIRLSWCHMT
EECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHEEEEEECC
PDVDWSEVENILRVLRG
CCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA