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The map label for this gene is penA [H]

Identifier: 189423745

GI number: 189423745

Start: 684623

End: 686611

Strand: Reverse

Name: penA [H]

Synonym: Glov_0676

Alternate gene names: 189423745

Gene position: 686611-684623 (Counterclockwise)

Preceding gene: 189423746

Following gene: 189423744

Centisome position: 17.53

GC content: 58.37

Gene sequence:

>1989_bases
ATGAAAAACGACAGGGAAAAGTGGGCACGGGTCAGGATTATCATGGTCTCCTGCCTGTTTGCCTGCGGCTTCCTGGCAGT
CACTGCACGCAGTTTTTATCTGCAGGTGGTTCAACATGACCAGCTGGTCAAACTGGCAGAACGGCAGCACAACCGCACTA
TTCCGATCACACCGGCACGGGGCGGGATCTTTGACCGGACCGGCGCAGCTCTGGCCGTCTCACTGGAAATGGACTCACTC
TACGCTGAGCCCAAACGGATCACTGACCCGGCAGGAATGGCAGCAGCACTTGCCCCGCTCATCCAGATCCCCCAGCACGA
ACTGCAGCGCAAGCTGGATTCGGAGAAGAGTTTTGCCTGGCTTGCCCGCCAGTTGCCGCCGGAAACAGCGTCAAAAATCA
AGCAGCTCAAACTGCCCGGCATCGGCTTTGTTAAAGAAAACAAGCGATTTTATCCCAACTTTGAGATGGCATCCCATGTC
CTGGGATTTACCGGCATGGACCCAGGCGGCCTGGAAGGGCTTGAGCGCCGCTACGACACCACAATCCTGGGCAAAACCGG
CTATCTGCTGACCGAGCGGGATGCCCTGGGACGGGATGTTGCCATCAGAAATGCCGTGGTCCAGGATGCGGCCCCGGGGA
AAAATCTGTATCTGACGCTGGATAAAAACATCCAGTATTTTACCGAAAAAGAGCTTGCCAAGGCAGTGGAAGGCAGCAGG
GCAAAAAGCGGCATGGCCCTGGTCATGGACCCCTGGACCGGCAAGGTGCTGGCCATGGCCAATTATCCGACCTTCAACCC
GAACTCATTCAGGCAGTATCCCTCGCTTAACCTGCGCAACCGCTGTGTGAGTGACAGTTTTGAGCCTGGCTCCACCTTCA
AGGTTTTTCTGCTGTCTGCAGCATTGGAAGAAAAGTTGGTCAGGCCCCAGGATGGCATCAACTGCGAGAATGGCAGGTAC
TCCTTCGGCGGCCGGATCATCAGGGATGACCACCCGCACGGGCGGGTCTCCGTTGCGGAGGTCCTGAAATATTCCAGCAA
CATCGGATCAGCCAAGATCGGCCTGAAGCTGGGGGATGACCGCCTGCACCGCTACCTGAAGGCGTTCGGATTTGGCGACA
AGAGCGGCATTGACCTGCCCGGAGAGGCTTCCGGCGGCCTGCGCCCGGTCAGTCGCTGGTACGGCACCGATATAGCGACC
ATCTCCTTTGGTCAGGGGGTTTCAGCCACAGCCCTGCAGCTGGTGGCTGCCACCTCTGCAGTGGCAAACGGCGGCCTGTT
AATGAAACCGTATCTTGTGGAGCGGGTTACTGACAATGCCGGACTGGAACTGCAGCGTTTTGAACCTCAAACGGTCCGGC
GGGTGATCTCAACCCAGACCGCCGCGACCATGACCCAGATGATGGAAGGGGTCACCCAGAAAGGCGGCACTGCCACGAAT
GCCGCCATAGACGGCTTCAGGGTGGCAGGCAAGACCGGCACCGCACAGAAGGTTGATCCGGTCAGCCGAGGTTATTCCGC
CACCAAGCGGACCGCCTCGTTTGTTGGTTTTGTCCCGGCTGAAAAACCGCTTCTGACTATTCTGGTGGTCATTGATGAAC
CTGCAACCAGTCCCTACGGCGGGGTAGTTGCTGCCCCGGCATTCCGTGAAATCGCTTTCAATACACTGTGTTACCTCAAG
GCAGCCGGTGTGGGCAAGGCCTGTGAACTGCCCAAGTCGCAGACCGTGCAGGCGGCACCGGCAACGGCGGCACAATCACC
GGCTGCAACGGATGCTGAAGAGGGCGGCAGTATCGAGGTCGCCGGCGCAGGAACACCCATGCCTGACTTCAGGGGTATGA
GCATGCGCCGTGTCCTCCAGATTATGGAAAAACGGCAGCTTAATCTACAGCTGCGCGGCAGCGGGCGTGTCATTGAGCAG
CATCCACAGCCTGGGCAGGTTATCCATGGCTCGGACGAAATTTGGGTTCGCCTGGCACCCGCAGCATAA

Upstream 100 bases:

>100_bases
GAGGTAATTGCAAAGCGGGACTTAGGCATGACCGTTCCCCAGGATCAGCAGGTGATACTGGTCAAATGACACCTGTAACA
GCAAACGCAGGGAGCAGCGT

Downstream 100 bases:

>100_bases
GGAACCATGATGCTACTTGAACAACTGCTGCATGAGGTACCACTACAGGCCACCCACGGCAACCTGGATGTTACGGTTTC
CGCGCTTACCTGTGACTCAC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MKNDREKWARVRIIMVSCLFACGFLAVTARSFYLQVVQHDQLVKLAERQHNRTIPITPARGGIFDRTGAALAVSLEMDSL
YAEPKRITDPAGMAAALAPLIQIPQHELQRKLDSEKSFAWLARQLPPETASKIKQLKLPGIGFVKENKRFYPNFEMASHV
LGFTGMDPGGLEGLERRYDTTILGKTGYLLTERDALGRDVAIRNAVVQDAAPGKNLYLTLDKNIQYFTEKELAKAVEGSR
AKSGMALVMDPWTGKVLAMANYPTFNPNSFRQYPSLNLRNRCVSDSFEPGSTFKVFLLSAALEEKLVRPQDGINCENGRY
SFGGRIIRDDHPHGRVSVAEVLKYSSNIGSAKIGLKLGDDRLHRYLKAFGFGDKSGIDLPGEASGGLRPVSRWYGTDIAT
ISFGQGVSATALQLVAATSAVANGGLLMKPYLVERVTDNAGLELQRFEPQTVRRVISTQTAATMTQMMEGVTQKGGTATN
AAIDGFRVAGKTGTAQKVDPVSRGYSATKRTASFVGFVPAEKPLLTILVVIDEPATSPYGGVVAAPAFREIAFNTLCYLK
AAGVGKACELPKSQTVQAAPATAAQSPAATDAEEGGSIEVAGAGTPMPDFRGMSMRRVLQIMEKRQLNLQLRGSGRVIEQ
HPQPGQVIHGSDEIWVRLAPAA

Sequences:

>Translated_662_residues
MKNDREKWARVRIIMVSCLFACGFLAVTARSFYLQVVQHDQLVKLAERQHNRTIPITPARGGIFDRTGAALAVSLEMDSL
YAEPKRITDPAGMAAALAPLIQIPQHELQRKLDSEKSFAWLARQLPPETASKIKQLKLPGIGFVKENKRFYPNFEMASHV
LGFTGMDPGGLEGLERRYDTTILGKTGYLLTERDALGRDVAIRNAVVQDAAPGKNLYLTLDKNIQYFTEKELAKAVEGSR
AKSGMALVMDPWTGKVLAMANYPTFNPNSFRQYPSLNLRNRCVSDSFEPGSTFKVFLLSAALEEKLVRPQDGINCENGRY
SFGGRIIRDDHPHGRVSVAEVLKYSSNIGSAKIGLKLGDDRLHRYLKAFGFGDKSGIDLPGEASGGLRPVSRWYGTDIAT
ISFGQGVSATALQLVAATSAVANGGLLMKPYLVERVTDNAGLELQRFEPQTVRRVISTQTAATMTQMMEGVTQKGGTATN
AAIDGFRVAGKTGTAQKVDPVSRGYSATKRTASFVGFVPAEKPLLTILVVIDEPATSPYGGVVAAPAFREIAFNTLCYLK
AAGVGKACELPKSQTVQAAPATAAQSPAATDAEEGGSIEVAGAGTPMPDFRGMSMRRVLQIMEKRQLNLQLRGSGRVIEQ
HPQPGQVIHGSDEIWVRLAPAA
>Mature_662_residues
MKNDREKWARVRIIMVSCLFACGFLAVTARSFYLQVVQHDQLVKLAERQHNRTIPITPARGGIFDRTGAALAVSLEMDSL
YAEPKRITDPAGMAAALAPLIQIPQHELQRKLDSEKSFAWLARQLPPETASKIKQLKLPGIGFVKENKRFYPNFEMASHV
LGFTGMDPGGLEGLERRYDTTILGKTGYLLTERDALGRDVAIRNAVVQDAAPGKNLYLTLDKNIQYFTEKELAKAVEGSR
AKSGMALVMDPWTGKVLAMANYPTFNPNSFRQYPSLNLRNRCVSDSFEPGSTFKVFLLSAALEEKLVRPQDGINCENGRY
SFGGRIIRDDHPHGRVSVAEVLKYSSNIGSAKIGLKLGDDRLHRYLKAFGFGDKSGIDLPGEASGGLRPVSRWYGTDIAT
ISFGQGVSATALQLVAATSAVANGGLLMKPYLVERVTDNAGLELQRFEPQTVRRVISTQTAATMTQMMEGVTQKGGTATN
AAIDGFRVAGKTGTAQKVDPVSRGYSATKRTASFVGFVPAEKPLLTILVVIDEPATSPYGGVVAAPAFREIAFNTLCYLK
AAGVGKACELPKSQTVQAAPATAAQSPAATDAEEGGSIEVAGAGTPMPDFRGMSMRRVLQIMEKRQLNLQLRGSGRVIEQ
HPQPGQVIHGSDEIWVRLAPAA

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=547, Percent_Identity=35.6489945155393, Blast_Score=314, Evalue=1e-86,
Organism=Escherichia coli, GI1786854, Length=599, Percent_Identity=24.7078464106845, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71746; Mature: 71746

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDREKWARVRIIMVSCLFACGFLAVTARSFYLQVVQHDQLVKLAERQHNRTIPITPAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
GGIFDRTGAALAVSLEMDSLYAEPKRITDPAGMAAALAPLIQIPQHELQRKLDSEKSFAW
CCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
LARQLPPETASKIKQLKLPGIGFVKENKRFYPNFEMASHVLGFTGMDPGGLEGLERRYDT
HHHHCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCC
TILGKTGYLLTERDALGRDVAIRNAVVQDAAPGKNLYLTLDKNIQYFTEKELAKAVEGSR
EEECCCCCEEECCHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC
AKSGMALVMDPWTGKVLAMANYPTFNPNSFRQYPSLNLRNRCVSDSFEPGSTFKVFLLSA
CCCCCEEEECCCCCCEEEEECCCCCCCCCHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHH
ALEEKLVRPQDGINCENGRYSFGGRIIRDDHPHGRVSVAEVLKYSSNIGSAKIGLKLGDD
HHHHHHCCCCCCCCCCCCCEECCCEEEECCCCCCCEEHHHHHHHHCCCCCEEEEEEECHH
RLHRYLKAFGFGDKSGIDLPGEASGGLRPVSRWYGTDIATISFGQGVSATALQLVAATSA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
VANGGLLMKPYLVERVTDNAGLELQRFEPQTVRRVISTQTAATMTQMMEGVTQKGGTATN
HHCCCEEECCHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AAIDGFRVAGKTGTAQKVDPVSRGYSATKRTASFVGFVPAEKPLLTILVVIDEPATSPYG
HHCCCEEEECCCCCCCCCCHHHCCCHHHHHHHHHEEECCCCCCEEEEEEEEECCCCCCCC
GVVAAPAFREIAFNTLCYLKAAGVGKACELPKSQTVQAAPATAAQSPAATDAEEGGSIEV
CEEECCHHHHHHHHHHHHEEECCCCCHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEE
AGAGTPMPDFRGMSMRRVLQIMEKRQLNLQLRGSGRVIEQHPQPGQVIHGSDEIWVRLAP
EECCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCEEECCCCEEEEECC
AA
CC
>Mature Secondary Structure
MKNDREKWARVRIIMVSCLFACGFLAVTARSFYLQVVQHDQLVKLAERQHNRTIPITPAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
GGIFDRTGAALAVSLEMDSLYAEPKRITDPAGMAAALAPLIQIPQHELQRKLDSEKSFAW
CCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
LARQLPPETASKIKQLKLPGIGFVKENKRFYPNFEMASHVLGFTGMDPGGLEGLERRYDT
HHHHCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCC
TILGKTGYLLTERDALGRDVAIRNAVVQDAAPGKNLYLTLDKNIQYFTEKELAKAVEGSR
EEECCCCCEEECCHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC
AKSGMALVMDPWTGKVLAMANYPTFNPNSFRQYPSLNLRNRCVSDSFEPGSTFKVFLLSA
CCCCCEEEECCCCCCEEEEECCCCCCCCCHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHH
ALEEKLVRPQDGINCENGRYSFGGRIIRDDHPHGRVSVAEVLKYSSNIGSAKIGLKLGDD
HHHHHHCCCCCCCCCCCCCEECCCEEEECCCCCCCEEHHHHHHHHCCCCCEEEEEEECHH
RLHRYLKAFGFGDKSGIDLPGEASGGLRPVSRWYGTDIATISFGQGVSATALQLVAATSA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
VANGGLLMKPYLVERVTDNAGLELQRFEPQTVRRVISTQTAATMTQMMEGVTQKGGTATN
HHCCCEEECCHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AAIDGFRVAGKTGTAQKVDPVSRGYSATKRTASFVGFVPAEKPLLTILVVIDEPATSPYG
HHCCCEEEECCCCCCCCCCHHHCCCHHHHHHHHHEEECCCCCCEEEEEEEEECCCCCCCC
GVVAAPAFREIAFNTLCYLKAAGVGKACELPKSQTVQAAPATAAQSPAATDAEEGGSIEV
CEEECCHHHHHHHHHHHHEEECCCCCHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEE
AGAGTPMPDFRGMSMRRVLQIMEKRQLNLQLRGSGRVIEQHPQPGQVIHGSDEIWVRLAP
EECCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCEEECCCCEEEEECC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]