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The map label for this gene is nth [C]

Identifier: 189423447

GI number: 189423447

Start: 351090

End: 351767

Strand: Reverse

Name: nth [C]

Synonym: Glov_0376

Alternate gene names: 189423447

Gene position: 351767-351090 (Counterclockwise)

Preceding gene: 189423448

Following gene: 189423446

Centisome position: 8.98

GC content: 56.49

Gene sequence:

>678_bases
TTGGCAGATAAGCGGCTTGACAGGATTTTCACTACCCTGCTGGAACGGTATGGCCCCCGGCATTGGTGGCCCGGTGAAAC
CCCCTTTGAGGTCTGCGTCGGTGCTATCCTGACCCAGAATACCAACTGGGGCAATGTGGAAAAGGCGATTGCGAACCTGA
AGGCGGCTGACAGACTGTCCGTTACAGGCATCGCAGACCTGTTGCCGGCTGCACTGGCAGCACTGATCAGACCGGCAGGT
TACTTTAACGTCAAGGCAGTAAGGCTACAGGCATTTACCACCTTTTTGCAGCAACAGTACCAGGGCAGCCTTGACCGGCT
TTTTGCCGCCCCCTGGCAGCAGACCAGAACAGAGCTGCTTGCGGTCAAGGGGATCGGGCCTGAAACCGCCGACTCGATCC
TGCTCTATGCCGGTCACAAACCAAGCTTTGTGGTGGATGCCTATACCAGACGCATCTTCAGCCGGCTGGGGCTGGTCGAT
GAGCGGATCAGCTATGACGGGTTACGACGCCACTTCATGGATCGCCTGACCTTGGACACAGCCCTGTTTAACGAGTACCA
TGCGCTGCTCGTCGAGCTGGGGAAGCAGGCCTGCCGTCCAAGGCCGCAATGTAGCAGCTGTTGTCTGGCAGCCCAGTGTT
CCTATAACGCAACAAAAAACCAATCAAAATGCTCTTAA

Upstream 100 bases:

>100_bases
TGGTTCATGGCGCGCATCACCGATGTCAGCGACCTGTATAAAGGCTATGTCACGGTTTCCGGCGGTTATAAGGTCAATCC
TCAAAACCTGCGGGTGCTGG

Downstream 100 bases:

>100_bases
AAAGTAATTTTCTTTCATACATAATTAGTTACAAAACTTTTATTGCGCCGGCTGCCCGGCTTGAGTACACTATTAGTAGA
GAATATGTTTGCGAGCCCCC

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MADKRLDRIFTTLLERYGPRHWWPGETPFEVCVGAILTQNTNWGNVEKAIANLKAADRLSVTGIADLLPAALAALIRPAG
YFNVKAVRLQAFTTFLQQQYQGSLDRLFAAPWQQTRTELLAVKGIGPETADSILLYAGHKPSFVVDAYTRRIFSRLGLVD
ERISYDGLRRHFMDRLTLDTALFNEYHALLVELGKQACRPRPQCSSCCLAAQCSYNATKNQSKCS

Sequences:

>Translated_225_residues
MADKRLDRIFTTLLERYGPRHWWPGETPFEVCVGAILTQNTNWGNVEKAIANLKAADRLSVTGIADLLPAALAALIRPAG
YFNVKAVRLQAFTTFLQQQYQGSLDRLFAAPWQQTRTELLAVKGIGPETADSILLYAGHKPSFVVDAYTRRIFSRLGLVD
ERISYDGLRRHFMDRLTLDTALFNEYHALLVELGKQACRPRPQCSSCCLAAQCSYNATKNQSKCS
>Mature_224_residues
ADKRLDRIFTTLLERYGPRHWWPGETPFEVCVGAILTQNTNWGNVEKAIANLKAADRLSVTGIADLLPAALAALIRPAGY
FNVKAVRLQAFTTFLQQQYQGSLDRLFAAPWQQTRTELLAVKGIGPETADSILLYAGHKPSFVVDAYTRRIFSRLGLVDE
RISYDGLRRHFMDRLTLDTALFNEYHALLVELGKQACRPRPQCSSCCLAAQCSYNATKNQSKCS

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG2231

COG function: function code L; Uncharacterized protein related to Endonuclease III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=187, Percent_Identity=28.3422459893048, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 4.2.99.18

Molecular weight: Translated: 25229; Mature: 25098

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKRLDRIFTTLLERYGPRHWWPGETPFEVCVGAILTQNTNWGNVEKAIANLKAADRLS
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VTGIADLLPAALAALIRPAGYFNVKAVRLQAFTTFLQQQYQGSLDRLFAAPWQQTRTELL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHH
AVKGIGPETADSILLYAGHKPSFVVDAYTRRIFSRLGLVDERISYDGLRRHFMDRLTLDT
HHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
ALFNEYHALLVELGKQACRPRPQCSSCCLAAQCSYNATKNQSKCS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ADKRLDRIFTTLLERYGPRHWWPGETPFEVCVGAILTQNTNWGNVEKAIANLKAADRLS
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VTGIADLLPAALAALIRPAGYFNVKAVRLQAFTTFLQQQYQGSLDRLFAAPWQQTRTELL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHH
AVKGIGPETADSILLYAGHKPSFVVDAYTRRIFSRLGLVDERISYDGLRRHFMDRLTLDT
HHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
ALFNEYHALLVELGKQACRPRPQCSSCCLAAQCSYNATKNQSKCS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]