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The map label for this gene is folK [H]

Identifier: 189423446

GI number: 189423446

Start: 350395

End: 350889

Strand: Reverse

Name: folK [H]

Synonym: Glov_0375

Alternate gene names: 189423446

Gene position: 350889-350395 (Counterclockwise)

Preceding gene: 189423447

Following gene: 189423445

Centisome position: 8.96

GC content: 61.01

Gene sequence:

>495_bases
GTGGAAACCGATGCTTACATCGCCCTCGGCTCTAATCTGGGGGATCGGGAACTGAACCTGTTGCGGGCCGTGGCAGAACT
GGGCAAGATAGCCGGCTGCCGCGTGACGGCCCTGTCCAGGTTTTATGAGACGTCACCGGTGGGTATGCCGTCCGGCACTC
CCTCCTTTTACAACGGGGTTGCACGGCTGGCCACCACCCTGCCGCCCCATGAGCTGCTGCATGAGCTGCAACGGATAGAA
CGGGAGATCTTTGGTCGGACTCCTGCCGCCAGGCCGCAATCGCGACGGCTTGATCTGGATCTGCTCCTGTACGGCAGCAC
ACAACTTGCAACACCTGACCTGACCCTGCCCCATCCCCGGATGACGGCACGCCGTTTTGTACTGCTGCCGTTGGCTGATA
TCGCCCCTGAATTATGCGAGCCGGCCAGCAAACGTACCATAGCAGAGCTGCTGACCTGCCTTGAAACCGACGAGCAGGTC
AGCCCCCTGGAGTAA

Upstream 100 bases:

>100_bases
TCGGGGGTCTCATCGCCCTCGTTGCCGCCCCTCCTGGTGACGGGGGCTTTTTTTGTCCTGCGGTTGACGCCCCCCCACAA
GTATGGTTTAATCCCGCCTT

Downstream 100 bases:

>100_bases
TGACGCCATGTTTCGCCTAGTAATCTGGTTGCTGCTGGCCTATATCGGATTCCGGGTCTTCAAGGCACTTGTTGCCCCCA
GGCAATCTTCCGCGCCAAAG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
METDAYIALGSNLGDRELNLLRAVAELGKIAGCRVTALSRFYETSPVGMPSGTPSFYNGVARLATTLPPHELLHELQRIE
REIFGRTPAARPQSRRLDLDLLLYGSTQLATPDLTLPHPRMTARRFVLLPLADIAPELCEPASKRTIAELLTCLETDEQV
SPLE

Sequences:

>Translated_164_residues
METDAYIALGSNLGDRELNLLRAVAELGKIAGCRVTALSRFYETSPVGMPSGTPSFYNGVARLATTLPPHELLHELQRIE
REIFGRTPAARPQSRRLDLDLLLYGSTQLATPDLTLPHPRMTARRFVLLPLADIAPELCEPASKRTIAELLTCLETDEQV
SPLE
>Mature_164_residues
METDAYIALGSNLGDRELNLLRAVAELGKIAGCRVTALSRFYETSPVGMPSGTPSFYNGVARLATTLPPHELLHELQRIE
REIFGRTPAARPQSRRLDLDLLLYGSTQLATPDLTLPHPRMTARRFVLLPLADIAPELCEPASKRTIAELLTCLETDEQV
SPLE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=42.4460431654676, Blast_Score=98, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324073, Length=156, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18093; Mature: 18093

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METDAYIALGSNLGDRELNLLRAVAELGKIAGCRVTALSRFYETSPVGMPSGTPSFYNGV
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ARLATTLPPHELLHELQRIEREIFGRTPAARPQSRRLDLDLLLYGSTQLATPDLTLPHPR
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
MTARRFVLLPLADIAPELCEPASKRTIAELLTCLETDEQVSPLE
HHHHHHHEEEHHHHCHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
METDAYIALGSNLGDRELNLLRAVAELGKIAGCRVTALSRFYETSPVGMPSGTPSFYNGV
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ARLATTLPPHELLHELQRIEREIFGRTPAARPQSRRLDLDLLLYGSTQLATPDLTLPHPR
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
MTARRFVLLPLADIAPELCEPASKRTIAELLTCLETDEQVSPLE
HHHHHHHEEEHHHHCHHHCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]