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The map label for this gene is lrhA [H]

Identifier: 189354046

GI number: 189354046

Start: 2373244

End: 2374104

Strand: Direct

Name: lrhA [H]

Synonym: BMULJ_05299

Alternate gene names: 189354046

Gene position: 2373244-2374104 (Clockwise)

Preceding gene: 189354043

Following gene: 189354049

Centisome position: 95.96

GC content: 68.87

Gene sequence:

>861_bases
ATGAATAGACCTTTGTTCGACCTCGACCTGCTTCGCGCGCTCGTGATGGTCGCCGATTGCGGCAGCTTTACGGCGGCGTC
CGCGCGGCTGCACTCGACGCAGTCGACGGTGAGCCAGAAGGTGCGGCGGCTCGAGGAGATCGCGGGGCATCGTCTGCTCG
ATCGCGGCACGCGCGACGTGCGGCCGACCGATGCGGGCGTGACCGTGCTGAGCTATGCGCGGCGCATGCTCGCGCTGAAC
GACGAGATGCTCGAAGTACTGGCCGGCGCGACGGTGGCGCTCACCATCCGGCTCGGCGTGCCGGACGATTTCGCGGCGGG
CCGCACGACGCACGCGCTCGCCGCGTTCAAGCGCGCCCATCCGCAAGTGAAACTCGAAGTGACGTGCGGGCTGAGCCGCG
ACGTCAGCGCCGCGTACGATCGCGGCGAACTCGATCTCGTGCTGATCAAGCAGCGGCGCGACAGCCGCGAAGCGGTCGCG
CGCTGGCCGGAGAAACTGCGCTGGATCGACAGCGCGAAGCATCCGTCGATCGATCTCGACCCGCTGCCGATCGTCGCGTT
TCCGCCGCGCGGGCTCTATCGCGACGACATGATCCAGGCGATCGAGGCACGCGGCCGCCGCTGGCGCATCGCGTTCACGA
CGTCGAGCCTGAGCGGCATTCAGGCGGCCGTCGCCGACGGGCTCGGGATCAGCGTGCTGCCCGCGCGCGCCGTGACGGCC
GAGCACGTCGTGCTGACCGCGACGCAAGGCTTCGCGCCGATCGAGAACATGGACGTCGCGATCCTGCATCGGCCGACCGC
CGATCCGATGGTGCGCGAGCTGACGAAGACGCTCGCGGACATGCTCGAACACGAGCAGTAA

Upstream 100 bases:

>100_bases
CCCGATCCGGCGAAACCGCGATTGCCCGGCGTGGCGCCGCATGTTAAAAGTCGTCCCCCGCATTCGGAAACGCAATGCTC
GCCCCACCAGAAGTGCAGAA

Downstream 100 bases:

>100_bases
GCCGCGCGCCGCAACGCGGTATGCGGGACGGTGTGCGGCCACACACGTGCCGCCGCGCACCGCCGTGCGCAGGTCAGACC
AGCGCGCCGTTTCGCGCGAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNRPLFDLDLLRALVMVADCGSFTAASARLHSTQSTVSQKVRRLEEIAGHRLLDRGTRDVRPTDAGVTVLSYARRMLALN
DEMLEVLAGATVALTIRLGVPDDFAAGRTTHALAAFKRAHPQVKLEVTCGLSRDVSAAYDRGELDLVLIKQRRDSREAVA
RWPEKLRWIDSAKHPSIDLDPLPIVAFPPRGLYRDDMIQAIEARGRRWRIAFTTSSLSGIQAAVADGLGISVLPARAVTA
EHVVLTATQGFAPIENMDVAILHRPTADPMVRELTKTLADMLEHEQ

Sequences:

>Translated_286_residues
MNRPLFDLDLLRALVMVADCGSFTAASARLHSTQSTVSQKVRRLEEIAGHRLLDRGTRDVRPTDAGVTVLSYARRMLALN
DEMLEVLAGATVALTIRLGVPDDFAAGRTTHALAAFKRAHPQVKLEVTCGLSRDVSAAYDRGELDLVLIKQRRDSREAVA
RWPEKLRWIDSAKHPSIDLDPLPIVAFPPRGLYRDDMIQAIEARGRRWRIAFTTSSLSGIQAAVADGLGISVLPARAVTA
EHVVLTATQGFAPIENMDVAILHRPTADPMVRELTKTLADMLEHEQ
>Mature_286_residues
MNRPLFDLDLLRALVMVADCGSFTAASARLHSTQSTVSQKVRRLEEIAGHRLLDRGTRDVRPTDAGVTVLSYARRMLALN
DEMLEVLAGATVALTIRLGVPDDFAAGRTTHALAAFKRAHPQVKLEVTCGLSRDVSAAYDRGELDLVLIKQRRDSREAVA
RWPEKLRWIDSAKHPSIDLDPLPIVAFPPRGLYRDDMIQAIEARGRRWRIAFTTSSLSGIQAAVADGLGISVLPARAVTA
EHVVLTATQGFAPIENMDVAILHRPTADPMVRELTKTLADMLEHEQ

Specific function: Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=284, Percent_Identity=28.169014084507, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787806, Length=234, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790262, Length=144, Percent_Identity=30.5555555555556, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787589, Length=136, Percent_Identity=39.7058823529412, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787879, Length=255, Percent_Identity=30.1960784313725, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=25.8196721311475, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31482; Mature: 31482

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRPLFDLDLLRALVMVADCGSFTAASARLHSTQSTVSQKVRRLEEIAGHRLLDRGTRDV
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPTDAGVTVLSYARRMLALNDEMLEVLAGATVALTIRLGVPDDFAAGRTTHALAAFKRAH
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCC
PQVKLEVTCGLSRDVSAAYDRGELDLVLIKQRRDSREAVARWPEKLRWIDSAKHPSIDLD
CCEEEEEEECCCCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PLPIVAFPPRGLYRDDMIQAIEARGRRWRIAFTTSSLSGIQAAVADGLGISVLPARAVTA
CCCEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCEEECCHHHCC
EHVVLTATQGFAPIENMDVAILHRPTADPMVRELTKTLADMLEHEQ
CEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRPLFDLDLLRALVMVADCGSFTAASARLHSTQSTVSQKVRRLEEIAGHRLLDRGTRDV
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPTDAGVTVLSYARRMLALNDEMLEVLAGATVALTIRLGVPDDFAAGRTTHALAAFKRAH
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCC
PQVKLEVTCGLSRDVSAAYDRGELDLVLIKQRRDSREAVARWPEKLRWIDSAKHPSIDLD
CCEEEEEEECCCCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PLPIVAFPPRGLYRDDMIQAIEARGRRWRIAFTTSSLSGIQAAVADGLGISVLPARAVTA
CCCEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCEEECCHHHCC
EHVVLTATQGFAPIENMDVAILHRPTADPMVRELTKTLADMLEHEQ
CEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]