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The map label for this gene is ltaA [H]

Identifier: 189353962

GI number: 189353962

Start: 2277815

End: 2278828

Strand: Reverse

Name: ltaA [H]

Synonym: BMULJ_05215

Alternate gene names: 189353962

Gene position: 2278828-2277815 (Counterclockwise)

Preceding gene: 189353963

Following gene: 189353959

Centisome position: 92.14

GC content: 69.43

Gene sequence:

>1014_bases
ATGATCGATTTGCGCAGCGATACCGTGACACGTCCGAGCCAGGCGATGCTGGCCGCGATGACTGCCGCCGAAGTCGGCGA
CGACGTTTGGGGCGACGACCCGACCGTGCTGCGCCTGCAGGCCGCCACGGCCGAGCGGGCCGGCAAGGAAGCGGGGCTGT
TCTTCCCGAGCGGCACGCAGAGCAATCTGGCCGCGCTGATGGCGCATTGCGAACGCGGCGACGAATACATCGTCGGGCAG
CTCGCCCACACGTACAAATACGAAGGCGGCGGCGCGGCGGTGCTCGGCAGCATCCAGCCGCAACCGATCGAGAACGCGCC
CGACGGCACGCTGCCGCTCGCGAAGATCGCGGCCGCGATCAAGCCGCTCGACAACCACTTCGCGCGCACGCGCCTGCTCG
CGCTCGAGAACACGATCGGCGGTCAGGTGCTGCCGGAAGGCTACGTGCAGGAAGCCGTCGCGTTCGCGCGCAGCCGCGGC
TTGTCGGCGCACCTCGACGGCGCGCGCGTCTGCAATGCGGCCGTCGCGTCGGGCCGCTCGATCGCCGAGCTCTGCGCGCC
GTTCGATACCGTGTCGATCTGCTTCTCGAAGGGGCTCGGCGCACCGGTCGGCTCGGTGCTGGTCGGCAGCCGTGCGCTGA
TCGAGCGCGCGCAGCGCTGGCGCAAGGTGCTCGGCGGCGGGATGCGGCAGTCGGGCATTCTCGCGGCGGCGTGCCTGTAT
GCGCTCGACCACAACGTCGAACGCCTGGCCGACGATCATGCGAACGCCGCACATCTCGCCGAAGGGCTCGCGCGCATCGA
ACCGGTCAAAGTGCTCTCGCAGGCGACGAACATGGTGTTCGCGCAGTTCCCCGAAGCCGATTGCGCACCGCTCGAGGCCT
GGCTGAAGGCGCGCGGGATCTTGACGCAGATGCTCTACGCGTCGCGCTTCGTCACGCACTGCGACGTCTCGCGCGCGGAC
ATCGACACCTTCATCGACGCCGTCGGCGCGTACTTCGCCCAGCGTCGCGCGTGA

Upstream 100 bases:

>100_bases
GCGCGTTCCGCGCGCGCGTCGCGAATTGCGTACACTCTGAGTTTCGTTTCGGCAGGGCCGGGCGCTACGGATCCGGTCCG
CGTTCACTCAGGGCACGAAG

Downstream 100 bases:

>100_bases
AACGGAATGCGCCGGCCGGCGGAGCGCGCCGGCGCGACAGGGCGCGAAGCAGGGAACGAGGGTGACGGGGCGATGCGGTG
CCCCGTCTTTCGATTGAGGG

Product: threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MIDLRSDTVTRPSQAMLAAMTAAEVGDDVWGDDPTVLRLQAATAERAGKEAGLFFPSGTQSNLAALMAHCERGDEYIVGQ
LAHTYKYEGGGAAVLGSIQPQPIENAPDGTLPLAKIAAAIKPLDNHFARTRLLALENTIGGQVLPEGYVQEAVAFARSRG
LSAHLDGARVCNAAVASGRSIAELCAPFDTVSICFSKGLGAPVGSVLVGSRALIERAQRWRKVLGGGMRQSGILAAACLY
ALDHNVERLADDHANAAHLAEGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKARGILTQMLYASRFVTHCDVSRAD
IDTFIDAVGAYFAQRRA

Sequences:

>Translated_337_residues
MIDLRSDTVTRPSQAMLAAMTAAEVGDDVWGDDPTVLRLQAATAERAGKEAGLFFPSGTQSNLAALMAHCERGDEYIVGQ
LAHTYKYEGGGAAVLGSIQPQPIENAPDGTLPLAKIAAAIKPLDNHFARTRLLALENTIGGQVLPEGYVQEAVAFARSRG
LSAHLDGARVCNAAVASGRSIAELCAPFDTVSICFSKGLGAPVGSVLVGSRALIERAQRWRKVLGGGMRQSGILAAACLY
ALDHNVERLADDHANAAHLAEGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKARGILTQMLYASRFVTHCDVSRAD
IDTFIDAVGAYFAQRRA
>Mature_337_residues
MIDLRSDTVTRPSQAMLAAMTAAEVGDDVWGDDPTVLRLQAATAERAGKEAGLFFPSGTQSNLAALMAHCERGDEYIVGQ
LAHTYKYEGGGAAVLGSIQPQPIENAPDGTLPLAKIAAAIKPLDNHFARTRLLALENTIGGQVLPEGYVQEAVAFARSRG
LSAHLDGARVCNAAVASGRSIAELCAPFDTVSICFSKGLGAPVGSVLVGSRALIERAQRWRKVLGGGMRQSGILAAACLY
ALDHNVERLADDHANAAHLAEGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKARGILTQMLYASRFVTHCDVSRAD
IDTFIDAVGAYFAQRRA

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=321, Percent_Identity=61.0591900311526, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=42.7745664739884, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=42.7745664739884, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=42.7745664739884, Blast_Score=237, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6320789, Length=335, Percent_Identity=36.7164179104478, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21355439, Length=300, Percent_Identity=46.6666666666667, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 35740; Mature: 35740

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLRSDTVTRPSQAMLAAMTAAEVGDDVWGDDPTVLRLQAATAERAGKEAGLFFPSGTQ
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCCCH
SNLAALMAHCERGDEYIVGQLAHTYKYEGGGAAVLGSIQPQPIENAPDGTLPLAKIAAAI
HHHHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHH
KPLDNHFARTRLLALENTIGGQVLPEGYVQEAVAFARSRGLSAHLDGARVCNAAVASGRS
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCH
IAELCAPFDTVSICFSKGLGAPVGSVLVGSRALIERAQRWRKVLGGGMRQSGILAAACLY
HHHHHCCHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ALDHNVERLADDHANAAHLAEGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKARGI
HHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LTQMLYASRFVTHCDVSRADIDTFIDAVGAYFAQRRA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDLRSDTVTRPSQAMLAAMTAAEVGDDVWGDDPTVLRLQAATAERAGKEAGLFFPSGTQ
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCCCH
SNLAALMAHCERGDEYIVGQLAHTYKYEGGGAAVLGSIQPQPIENAPDGTLPLAKIAAAI
HHHHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHH
KPLDNHFARTRLLALENTIGGQVLPEGYVQEAVAFARSRGLSAHLDGARVCNAAVASGRS
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCH
IAELCAPFDTVSICFSKGLGAPVGSVLVGSRALIERAQRWRKVLGGGMRQSGILAAACLY
HHHHHCCHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ALDHNVERLADDHANAAHLAEGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKARGI
HHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LTQMLYASRFVTHCDVSRADIDTFIDAVGAYFAQRRA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]