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The map label for this gene is pcaR [H]

Identifier: 189353914

GI number: 189353914

Start: 2228059

End: 2228844

Strand: Direct

Name: pcaR [H]

Synonym: BMULJ_05166

Alternate gene names: 189353914

Gene position: 2228059-2228844 (Clockwise)

Preceding gene: 189353911

Following gene: 189353917

Centisome position: 90.09

GC content: 66.41

Gene sequence:

>786_bases
ATGACCACCGAAGACATTCAGAAACCCGGCGATTCCTACGTCCAGTCGTTTGCGCGCGGCCTCGCGGTGATCCGCGCGTT
CGATGCGCAGCGTCCCGAGCAGACGCTGACCGAAGTCGCGTCGGCCACCGGCCTCACGCGCGCGGGCGCGCGCCGCATCC
TGCTCACGCTGCAGACGCTCGGCTACGTCGAGGCCGACGGCCGGCTGTTCCGGCTCACGCCGAAGATTCTCGAACTCGGC
TTCGCCTATCTGACGTCGATGCCGTTCTGGAATCTCGCGGAGCCTGTGATGGAACAATTGTCCGCGCGCATCCACGAAAG
CTGTTCGGCCGCCGTGCTCGATCGCACCGAGATCGTCTACGTGCTGCGCGTGCCGACGCACAAGATCATGACGATCAATC
TGTCGATCGGCAGCCGGCTGCCCGCGTACTGCACGTCGATGGGCCGCGTGCTGCTGTCCGCACTCGACGACGCGGCGCTC
GACGAGACGCTTGCGCAGAGCGGAATCCGCGCGCACACGCCGCGCACGATCACCGATCCGGCGGAACTGAAGGCGACGAT
CGCGCAAGTGCGCCAGCAGGGCTGGGCCGTCGTCGATCAGGAACTCGAAGTGGGGCTGATGTCGATCTCCGCGCCGATCC
GCAACCGGCGCGGGCAGATCATCGCCGCGATGAACATCAGCGGCAATGCGCAGCGGCATACCGCCAAGCAGATGGTCAAG
GAGTTTCTCGGGCCGCTGCAGGAAGCCGCACAGACCGTGTCGGAGCTCGTCGCGCGGCGCGGTTGA

Upstream 100 bases:

>100_bases
AGGGAGTGCGGGGACGACCTGTCAAGCGCGCGGTCGGCCGTGCGGTTGGCGCGTCGCGCCCGGTACGCTATCTTCTCGGC
TGCACCTATTCCGACTGCTC

Downstream 100 bases:

>100_bases
GCGCGCGCCGCGCGTGCGCGCGGCGTCAGTCCATCGATTCGTGCGCGGTCTCGCGCAGCATCGCGACCGCGATCAGCGAC
AGCACGACGCACGCTGCGAC

Product: IclR family pca regulon regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTTEDIQKPGDSYVQSFARGLAVIRAFDAQRPEQTLTEVASATGLTRAGARRILLTLQTLGYVEADGRLFRLTPKILELG
FAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVYVLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSALDDAAL
DETLAQSGIRAHTPRTITDPAELKATIAQVRQQGWAVVDQELEVGLMSISAPIRNRRGQIIAAMNISGNAQRHTAKQMVK
EFLGPLQEAAQTVSELVARRG

Sequences:

>Translated_261_residues
MTTEDIQKPGDSYVQSFARGLAVIRAFDAQRPEQTLTEVASATGLTRAGARRILLTLQTLGYVEADGRLFRLTPKILELG
FAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVYVLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSALDDAAL
DETLAQSGIRAHTPRTITDPAELKATIAQVRQQGWAVVDQELEVGLMSISAPIRNRRGQIIAAMNISGNAQRHTAKQMVK
EFLGPLQEAAQTVSELVARRG
>Mature_260_residues
TTEDIQKPGDSYVQSFARGLAVIRAFDAQRPEQTLTEVASATGLTRAGARRILLTLQTLGYVEADGRLFRLTPKILELGF
AYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVYVLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSALDDAALD
ETLAQSGIRAHTPRTITDPAELKATIAQVRQQGWAVVDQELEVGLMSISAPIRNRRGQIIAAMNISGNAQRHTAKQMVKE
FLGPLQEAAQTVSELVARRG

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=256, Percent_Identity=30.859375, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI87082359, Length=250, Percent_Identity=28.8, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786468, Length=218, Percent_Identity=30.7339449541284, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786715, Length=229, Percent_Identity=25.764192139738, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789999, Length=258, Percent_Identity=27.5193798449612, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788581, Length=193, Percent_Identity=25.9067357512953, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790752, Length=193, Percent_Identity=22.7979274611399, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI145693096, Length=229, Percent_Identity=27.0742358078603, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28599; Mature: 28468

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEDIQKPGDSYVQSFARGLAVIRAFDAQRPEQTLTEVASATGLTRAGARRILLTLQTL
CCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GYVEADGRLFRLTPKILELGFAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVY
CEEECCCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSALDDAALDETLAQSGIRAHTPRTITDP
EEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
AELKATIAQVRQQGWAVVDQELEVGLMSISAPIRNRRGQIIAAMNISGNAQRHTAKQMVK
HHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCHHHCCCCCEEEEEECCCCCHHHHHHHHHH
EFLGPLQEAAQTVSELVARRG
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTEDIQKPGDSYVQSFARGLAVIRAFDAQRPEQTLTEVASATGLTRAGARRILLTLQTL
CCHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GYVEADGRLFRLTPKILELGFAYLTSMPFWNLAEPVMEQLSARIHESCSAAVLDRTEIVY
CEEECCCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VLRVPTHKIMTINLSIGSRLPAYCTSMGRVLLSALDDAALDETLAQSGIRAHTPRTITDP
EEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
AELKATIAQVRQQGWAVVDQELEVGLMSISAPIRNRRGQIIAAMNISGNAQRHTAKQMVK
HHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCHHHCCCCCEEEEEECCCCCHHHHHHHHHH
EFLGPLQEAAQTVSELVARRG
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]