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The map label for this gene is pcp [H]

Identifier: 189353828

GI number: 189353828

Start: 2130477

End: 2132066

Strand: Reverse

Name: pcp [H]

Synonym: BMULJ_05075

Alternate gene names: 189353828

Gene position: 2132066-2130477 (Counterclockwise)

Preceding gene: 189353830

Following gene: 189353827

Centisome position: 86.21

GC content: 71.95

Gene sequence:

>1590_bases
ATGGCAAGGCATCTTCACGCCGACCGCGAACCCCGAATCGTCGCCGACTCCAAGTGTCTCGGCCCGTGCGATCCGGCAGA
ACGCATCCACGTCACGATCATGTTGCGGCGGCAGGAAGAAGGGCAACTCGACACGCTGCTCCAGCGGCTCGCCAGCGGCG
ATCCGCAAGCCAAACCGCTGTCGCGCGATGCATTCGCCCAGCGCTTCTCGGCAAGCCCCGACGACATCCGCAAGACCGAG
GACTTCGCGCGCCGTCATCAGCTGACGGTCGATCGCGTCGATCCGGCCGAAAGCGTCGTCGTGCTGTCGGGCACCATCAA
GCAATTCGAAACCGCGTTCGGCGTGACGCTCGAGCGTTTCGAGCATCACGCGATCGGGCAGTATCGCGGCCGCTCGGGGC
CGATCGCATTGCCGGACGAGCTCGGCGATGCGGTCACGGCCGTGCTCGGCCTCGACAGCCGCCCGCAGGCGCGCCCGCAC
TTCCGGCTGCGCCCGCCGTTCAAGCCCGCGCGCGGCGCGGCGAGCGTCACGTTCACGCCGCCGCAGCTCGCGTCGCTGTA
CGGGTTTCCGGCCGGCGACGGCGCCGGCCAGTGCATCGCGATCGTCGAGCTCGGCGGCGGCTACCGCGCAGCGGACATCG
CGCGGTACTTCAGCGGGCTCGGCATCAAGACGCCGCCGAGGCTCGTCGACGTGAACGTCGGCACCGGCCGCAACACGCCG
ACCGGCGACCCGAACGGCCCGGACGGCGAAGTCGCGCTCGACATCGAGATCGCCGGCGCGATCGCGCCCGCCGCGACAAT
CGCCGTCTACTTCGCGCCGAACAGCGATGCGGGCTTCATCCAGGCCGTCAACGCGGCCGTCAACGACACGAAGAACAAGC
CGTCGGTGATCTCGATCAGCTGGGGCGGCCCGGAGGCGATCTGGCAGGCGCAGTCTGCGCAGGCGTTCAACCGCGTGCTG
CAGGCGGCGGCCGCGCAGGGCATCACCGTTTGCGCGGCGTCCGGCGACAGCGGCTCGGGCGACGGACTGCAGGACGGCAC
CGATCACGTCGACTTCCCCGCGTCGAGCCCGTACGTGCTCGGCTGCGGCGGCACGCAGCTCGACGCGCTGCCGGGGCAGG
GCATCCGCAGCGAAGTCGCGTGGAACGACGAGGCGTCGGGCGGCGGCGCGGGCGGCGGCGGTGTCAGCACGCTGTTCGAT
CTGCCGGCCTGGCAGCACGGGCTTTCGCTGACGCGCGCGGACGGCAGCCGCGCGCCGCTCGCGAAGCGCGGCGTGCCCGA
CGTCGCGGGCGATGCTTCGCCGCAGACGGGCTACGAGGTCTCGGTCGCCGGCACGCCGGCCGTGATGGGCGGCACGAGCG
CGGTCGCGCCGCTGTGGGCCGCGCTGATCGCGCGGATCAACGCGGCGGCCGGCACGTCGGCCGGCTGGATCAACCCGACG
CTGTACCGGCATCCGGACGCGCTGCGCGACATCACGAAAGGATCGAACGGCACGTTTGCGGCGGCCGCCGGCTGGGACGC
CTGCACGGGGCTTGGCAGCCCCGACGGCGCGAAGCTCGCCGCGATCCTCGCGCGCAAGCCGTCGAGCTGA

Upstream 100 bases:

>100_bases
CGCGACCGCGAACCCGACTGACCATACGGAACCGTCTTCCGTCGGCCATGTCCGATTTCCTGGCTGTTCCGTGCAACGCG
GTACAAAGGAGGGTCTGAAC

Downstream 100 bases:

>100_bases
CGCGCGCGACACACGGCTTTTCGTTCGACGCGGGGTTTCCCGCGTCTTTTCTTACTTCCAGGAGCAGCACGATGGGCATC
GATTCCGCATCCTCCGGCGG

Product: kumamolisin

Products: NA

Alternate protein names: Pepstatin-insensitive carboxyl proteinase; Pseudomonapepsin [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MARHLHADREPRIVADSKCLGPCDPAERIHVTIMLRRQEEGQLDTLLQRLASGDPQAKPLSRDAFAQRFSASPDDIRKTE
DFARRHQLTVDRVDPAESVVVLSGTIKQFETAFGVTLERFEHHAIGQYRGRSGPIALPDELGDAVTAVLGLDSRPQARPH
FRLRPPFKPARGAASVTFTPPQLASLYGFPAGDGAGQCIAIVELGGGYRAADIARYFSGLGIKTPPRLVDVNVGTGRNTP
TGDPNGPDGEVALDIEIAGAIAPAATIAVYFAPNSDAGFIQAVNAAVNDTKNKPSVISISWGGPEAIWQAQSAQAFNRVL
QAAAAQGITVCAASGDSGSGDGLQDGTDHVDFPASSPYVLGCGGTQLDALPGQGIRSEVAWNDEASGGGAGGGGVSTLFD
LPAWQHGLSLTRADGSRAPLAKRGVPDVAGDASPQTGYEVSVAGTPAVMGGTSAVAPLWAALIARINAAAGTSAGWINPT
LYRHPDALRDITKGSNGTFAAAAGWDACTGLGSPDGAKLAAILARKPSS

Sequences:

>Translated_529_residues
MARHLHADREPRIVADSKCLGPCDPAERIHVTIMLRRQEEGQLDTLLQRLASGDPQAKPLSRDAFAQRFSASPDDIRKTE
DFARRHQLTVDRVDPAESVVVLSGTIKQFETAFGVTLERFEHHAIGQYRGRSGPIALPDELGDAVTAVLGLDSRPQARPH
FRLRPPFKPARGAASVTFTPPQLASLYGFPAGDGAGQCIAIVELGGGYRAADIARYFSGLGIKTPPRLVDVNVGTGRNTP
TGDPNGPDGEVALDIEIAGAIAPAATIAVYFAPNSDAGFIQAVNAAVNDTKNKPSVISISWGGPEAIWQAQSAQAFNRVL
QAAAAQGITVCAASGDSGSGDGLQDGTDHVDFPASSPYVLGCGGTQLDALPGQGIRSEVAWNDEASGGGAGGGGVSTLFD
LPAWQHGLSLTRADGSRAPLAKRGVPDVAGDASPQTGYEVSVAGTPAVMGGTSAVAPLWAALIARINAAAGTSAGWINPT
LYRHPDALRDITKGSNGTFAAAAGWDACTGLGSPDGAKLAAILARKPSS
>Mature_528_residues
ARHLHADREPRIVADSKCLGPCDPAERIHVTIMLRRQEEGQLDTLLQRLASGDPQAKPLSRDAFAQRFSASPDDIRKTED
FARRHQLTVDRVDPAESVVVLSGTIKQFETAFGVTLERFEHHAIGQYRGRSGPIALPDELGDAVTAVLGLDSRPQARPHF
RLRPPFKPARGAASVTFTPPQLASLYGFPAGDGAGQCIAIVELGGGYRAADIARYFSGLGIKTPPRLVDVNVGTGRNTPT
GDPNGPDGEVALDIEIAGAIAPAATIAVYFAPNSDAGFIQAVNAAVNDTKNKPSVISISWGGPEAIWQAQSAQAFNRVLQ
AAAAQGITVCAASGDSGSGDGLQDGTDHVDFPASSPYVLGCGGTQLDALPGQGIRSEVAWNDEASGGGAGGGGVSTLFDL
PAWQHGLSLTRADGSRAPLAKRGVPDVAGDASPQTGYEVSVAGTPAVMGGTSAVAPLWAALIARINAAAGTSAGWINPTL
YRHPDALRDITKGSNGTFAAAAGWDACTGLGSPDGAKLAAILARKPSS

Specific function: Unknown

COG id: COG4934

COG function: function code O; Predicted protease

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S53 family [H]

Homologues:

Organism=Homo sapiens, GI5729770, Length=552, Percent_Identity=26.8115942028986, Blast_Score=94, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015366
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8; PF09286 Pro-kuma_activ [H]

EC number: =3.4.21.100 [H]

Molecular weight: Translated: 54650; Mature: 54518

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHLHADREPRIVADSKCLGPCDPAERIHVTIMLRRQEEGQLDTLLQRLASGDPQAKPL
CCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCC
SRDAFAQRFSASPDDIRKTEDFARRHQLTVDRVDPAESVVVLSGTIKQFETAFGVTLERF
CHHHHHHHHCCCHHHHHHHHHHHHHHCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
EHHAIGQYRGRSGPIALPDELGDAVTAVLGLDSRPQARPHFRLRPPFKPARGAASVTFTP
HHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEEEECC
PQLASLYGFPAGDGAGQCIAIVELGGGYRAADIARYFSGLGIKTPPRLVDVNVGTGRNTP
HHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCC
TGDPNGPDGEVALDIEIAGAIAPAATIAVYFAPNSDAGFIQAVNAAVNDTKNKPSVISIS
CCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEE
WGGPEAIWQAQSAQAFNRVLQAAAAQGITVCAASGDSGSGDGLQDGTDHVDFPASSPYVL
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEE
GCGGTQLDALPGQGIRSEVAWNDEASGGGAGGGGVSTLFDLPAWQHGLSLTRADGSRAPL
ECCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHCCEEEECCCCCCCH
AKRGVPDVAGDASPQTGYEVSVAGTPAVMGGTSAVAPLWAALIARINAAAGTSAGWINPT
HHCCCCCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LYRHPDALRDITKGSNGTFAAAAGWDACTGLGSPDGAKLAAILARKPSS
HHCCCHHHHHHHCCCCCCEEEECCCHHHCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
ARHLHADREPRIVADSKCLGPCDPAERIHVTIMLRRQEEGQLDTLLQRLASGDPQAKPL
CCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCC
SRDAFAQRFSASPDDIRKTEDFARRHQLTVDRVDPAESVVVLSGTIKQFETAFGVTLERF
CHHHHHHHHCCCHHHHHHHHHHHHHHCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
EHHAIGQYRGRSGPIALPDELGDAVTAVLGLDSRPQARPHFRLRPPFKPARGAASVTFTP
HHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEEEECC
PQLASLYGFPAGDGAGQCIAIVELGGGYRAADIARYFSGLGIKTPPRLVDVNVGTGRNTP
HHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCC
TGDPNGPDGEVALDIEIAGAIAPAATIAVYFAPNSDAGFIQAVNAAVNDTKNKPSVISIS
CCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEE
WGGPEAIWQAQSAQAFNRVLQAAAAQGITVCAASGDSGSGDGLQDGTDHVDFPASSPYVL
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEE
GCGGTQLDALPGQGIRSEVAWNDEASGGGAGGGGVSTLFDLPAWQHGLSLTRADGSRAPL
ECCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHCCEEEECCCCCCCH
AKRGVPDVAGDASPQTGYEVSVAGTPAVMGGTSAVAPLWAALIARINAAAGTSAGWINPT
HHCCCCCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LYRHPDALRDITKGSNGTFAAAAGWDACTGLGSPDGAKLAAILARKPSS
HHCCCHHHHHHHCCCCCCEEEECCCHHHCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929375; 8576087; 10488127; 11747435; 11323721 [H]