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The map label for this gene is ivd [H]

Identifier: 189353803

GI number: 189353803

Start: 2095937

End: 2097118

Strand: Reverse

Name: ivd [H]

Synonym: BMULJ_05050

Alternate gene names: 189353803

Gene position: 2097118-2095937 (Counterclockwise)

Preceding gene: 189353805

Following gene: 189353802

Centisome position: 84.8

GC content: 65.57

Gene sequence:

>1182_bases
ATGAGCAACCTGCCCGGCGTGCAATTCATGCTCGGTGAAGACATCGAGATGCTGCGCGATGCCGTCGCGACATTCGCGGC
GAAGGAAATCGCGCCGCGTGCGGCCGAGGTCGACCGTACCGACCAGTTTCCGATGGATCTCTGGAAGAAGTTCGGCGATC
TCGGCGTGCTCGGGATGACGGTGGCCGAGGAGTACGGCGGCGCGAACATGGGCTACACCGCGCACATGGTCGCAATGGAG
GAGATCTCGCGCGCGTCCGCGTCGATCGGCCTGTCGTACGGGGCGCACTCGAACCTGTGCGTGAACCAGATCCACCGCAA
CGGCACCGCCGCGCAGAAGCAGAAGTACCTGCCGAAGCTCGTGTCGGGCGAACACATCGGCGCGCTCGCGATGAGCGAGC
CGAATGCCGGCTCCGACGTCGTCAGCATGAAGCTGCGCGCGGACAAGCGCGGCGACCGCTACGTGCTGAACGGCACGAAG
ATGTGGATCACGAACGGCCCCGATTGCGACACGCTCGTCGTCTATGCGAAGACGGACGTCGACGCCGGCCCGCGCGGCAT
CACGGCCTTCATCGTCGAGAAGGGGATGAAGGGCTTCTCGGTCGCGCAGAAGCTCGACAAGCTCGGCATGCGCGGCTCGC
ATACCGGCGAGCTCGTGTTCCAGGACGTCGAGGTGCCGGAAGAGAACATCCTCGGCCAGCTCAACGGCGGCGTGAAGGTG
CTGATGAGCGGCCTCGACTACGAGCGCGCGGTGCTGTCGGGCGGCCCGACGGGCATCATGGCCGCGTGCCTGGATGCGGT
CGTTCCGTATATCCACGATCGCAAGCAGTTCGGCCAGTCGATCGGCGAGTTCCAGCTGATCCAGGGCAAGGTCGCCGACA
TGTACACGACGTTCCAGGCATGCCGCGCCTATCTCTACGCGGTGGGCCGCCATCTCGACTCGGCGGGCAGCGACCATATC
CGCCAGGTGCGCAAGGACTGCGCGGGCGTGATCCTCTATACGGCCGAGAAGGCGACGTGGATGGCCGGCGAGGCGATCCA
GATCCTCGGCGGCAACGGCTATATCAACGAATACCCGGTCGGCCGCCTGTGGCGCGACGCGAAGCTGTACGAGATCGGCG
CCGGCACGAGCGAGATCCGCCGGATGCTGATCGGCCGCGAGCTGTTCGCGGAAACGATGTAA

Upstream 100 bases:

>100_bases
AAAATTTCCGCAGTAATGGTCAATGAATCGGCGTATCGCCCGATTTGAGCAAAACTCAGAAATCGGCGCATGCGACGCAC
TTTCTGGAGACGGAGGAGAC

Downstream 100 bases:

>100_bases
CGCCCACGTCACGCGAACGGAGCTCCGTCGATGCCGATCATCGAATCCAAACTGAACCCGCGTTCGGAAGAATTCCGTGC
GAATGCCGCGGCGCTCGAGG

Product: isovaleryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSNLPGVQFMLGEDIEMLRDAVATFAAKEIAPRAAEVDRTDQFPMDLWKKFGDLGVLGMTVAEEYGGANMGYTAHMVAME
EISRASASIGLSYGAHSNLCVNQIHRNGTAAQKQKYLPKLVSGEHIGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGTK
MWITNGPDCDTLVVYAKTDVDAGPRGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPEENILGQLNGGVKV
LMSGLDYERAVLSGGPTGIMAACLDAVVPYIHDRKQFGQSIGEFQLIQGKVADMYTTFQACRAYLYAVGRHLDSAGSDHI
RQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM

Sequences:

>Translated_393_residues
MSNLPGVQFMLGEDIEMLRDAVATFAAKEIAPRAAEVDRTDQFPMDLWKKFGDLGVLGMTVAEEYGGANMGYTAHMVAME
EISRASASIGLSYGAHSNLCVNQIHRNGTAAQKQKYLPKLVSGEHIGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGTK
MWITNGPDCDTLVVYAKTDVDAGPRGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPEENILGQLNGGVKV
LMSGLDYERAVLSGGPTGIMAACLDAVVPYIHDRKQFGQSIGEFQLIQGKVADMYTTFQACRAYLYAVGRHLDSAGSDHI
RQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM
>Mature_392_residues
SNLPGVQFMLGEDIEMLRDAVATFAAKEIAPRAAEVDRTDQFPMDLWKKFGDLGVLGMTVAEEYGGANMGYTAHMVAMEE
ISRASASIGLSYGAHSNLCVNQIHRNGTAAQKQKYLPKLVSGEHIGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGTKM
WITNGPDCDTLVVYAKTDVDAGPRGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPEENILGQLNGGVKVL
MSGLDYERAVLSGGPTGIMAACLDAVVPYIHDRKQFGQSIGEFQLIQGKVADMYTTFQACRAYLYAVGRHLDSAGSDHIR
QVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=62.0779220779221, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI226958414, Length=348, Percent_Identity=64.9425287356322, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=40.1055408970976, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=34.9333333333333, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI21361497, Length=379, Percent_Identity=37.2031662269129, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=34.7150259067358, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=34.7150259067358, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=31.1855670103093, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557235, Length=344, Percent_Identity=34.8837209302326, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI76496475, Length=344, Percent_Identity=34.8837209302326, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=30.1837270341207, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=33.7662337662338, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=34.8189415041783, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=25.6944444444444, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=25.6944444444444, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=21.0526315789474, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.720207253886, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87081958, Length=391, Percent_Identity=28.6445012787724, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI87081702, Length=269, Percent_Identity=26.0223048327138, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=26.3565891472868, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=61.2987012987013, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=34.625322997416, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=33.6787564766839, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=32.8912466843501, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=33.0769230769231, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=32.2916666666667, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=388, Percent_Identity=30.6701030927835, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=38.3211678832117, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=32.5779036827195, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17534353, Length=382, Percent_Identity=31.413612565445, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=282, Percent_Identity=34.3971631205674, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.5766423357664, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=29.6, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=381, Percent_Identity=27.2965879265092, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=27.4590163934426, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355753, Length=387, Percent_Identity=63.5658914728682, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=38.5826771653543, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=37.007874015748, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=34.1085271317829, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24666513, Length=385, Percent_Identity=33.5064935064935, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI281363737, Length=351, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=32.1428571428571, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24652780, Length=269, Percent_Identity=24.1635687732342, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 42739; Mature: 42607

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLPGVQFMLGEDIEMLRDAVATFAAKEIAPRAAEVDRTDQFPMDLWKKFGDLGVLGMT
CCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHCCCCCHHHH
VAEEYGGANMGYTAHMVAMEEISRASASIGLSYGAHSNLCVNQIHRNGTAAQKQKYLPKL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEHIGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGTKMWITNGPDCDTLVVYAKTDV
HCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCEEEEEEECCC
DAGPRGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPEENILGQLNGGVKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHCCCCHHH
LMSGLDYERAVLSGGPTGIMAACLDAVVPYIHDRKQFGQSIGEFQLIQGKVADMYTTFQA
HHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHH
CRAYLYAVGRHLDSAGSDHIRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYPV
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCEEECCCEEEEECCCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM
CHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNLPGVQFMLGEDIEMLRDAVATFAAKEIAPRAAEVDRTDQFPMDLWKKFGDLGVLGMT
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHCCCCCHHHH
VAEEYGGANMGYTAHMVAMEEISRASASIGLSYGAHSNLCVNQIHRNGTAAQKQKYLPKL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEHIGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGTKMWITNGPDCDTLVVYAKTDV
HCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCEEEEEEECCC
DAGPRGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPEENILGQLNGGVKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHCCCCHHH
LMSGLDYERAVLSGGPTGIMAACLDAVVPYIHDRKQFGQSIGEFQLIQGKVADMYTTFQA
HHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHH
CRAYLYAVGRHLDSAGSDHIRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYPV
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCEEECCCEEEEECCCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM
CHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]