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The map label for this gene is serA [H]

Identifier: 189353756

GI number: 189353756

Start: 2036152

End: 2037081

Strand: Reverse

Name: serA [H]

Synonym: BMULJ_05003

Alternate gene names: 189353756

Gene position: 2037081-2036152 (Counterclockwise)

Preceding gene: 189353762

Following gene: 189353755

Centisome position: 82.37

GC content: 71.4

Gene sequence:

>930_bases
ATGAAACCGGAACTGCTGGTCCTCATTGCGCTGCGCGACGACGCGCAGCGCCGCATTGCCGCGTCGTTCGAGGTGCGCTA
CGCACCGACCGCCGAGCTGCGCGCACGCACGATCGCCGAGCACGGCGGCACGATCCGCGCGGTGCTGACCAACGGCAGCA
CGGGGCTCGCCGCGCACGAGATCGATGCACTGCCGCAGGTCAGGCTCGTCGGCGCGCTCGGCGCCGGCTACGAGCAGATC
GACGTCGCGCATGCGAAGGCGCGCGGGATCGCGGTCGTCACCGGCGCCGGCACCAACGACGACTGCGTCGCCGATCATGC
GTTCGCACTGCTGCTCGCTGCGGTACGCGGCATCGTGCGGCTCGATGCGGCGACGCGCGCGGGCGTCTGGCGCGACGCGC
TGCCGATGCCGCCGAACGTGTCGGGCAAGCGGCTCGGCATCGTCGGGCTGGGCCGGATCGGCGAGAAATGCGCACGGCGC
GCGGCGGGCTTCGACATCGAGATCGGCTATCACAACCGCGCGGCGAAGCAGGTTCCGTACCGCTACTTCGAACGGCTCGA
CGCGCTCGCGCAGTGGGCCGATTTTCTGATCGTCGCGACGCCGGGCGGCGCGGGCACGCGCCATCTGATCGACCGCACGG
TGCTCGATGCGCTCGGCCCGCACGGGTTTCTCGTCAACGTTTCGCGCGGCAGCGTCGTCGATACCGCTGCTTTGGCAGAC
GCGCTGCGCGAACGGCGCCTCGCGGGCGCGGCGCTCGACGTGTACGAAGGCGAACCCGAACCGCCGCGCGCGCTGACCGC
GCTCGACAACGTCGTGCTGACGCCGCACCTCGGCGGCTGGTCGCCCGAGGCGCTCGATCGTTCGGTGCAGCAGTTTCTCG
ACAACGCCGCGCGGCATTTCGCGGGCGAGCCGCTGCTCACGCCGCTGTGA

Upstream 100 bases:

>100_bases
CGCGCGGCCGCGTGGCCCCTGCGCGCGTGGGGACAACCGGCGGCCGGTGCGCGGCCTTGCTACACTGCAAGCCGTTCCCG
CCCTGCGGACATCTGCTGCC

Downstream 100 bases:

>100_bases
GTGCGGCCGCCGCCGCGCACATCACGCATTTTTTTCGTCTACGAAGGAATCCCGATGTCGACGTACATCGCTGAAGTGGA
ATGGCAGGCCGCCCCCGACG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKPELLVLIALRDDAQRRIAASFEVRYAPTAELRARTIAEHGGTIRAVLTNGSTGLAAHEIDALPQVRLVGALGAGYEQI
DVAHAKARGIAVVTGAGTNDDCVADHAFALLLAAVRGIVRLDAATRAGVWRDALPMPPNVSGKRLGIVGLGRIGEKCARR
AAGFDIEIGYHNRAAKQVPYRYFERLDALAQWADFLIVATPGGAGTRHLIDRTVLDALGPHGFLVNVSRGSVVDTAALAD
ALRERRLAGAALDVYEGEPEPPRALTALDNVVLTPHLGGWSPEALDRSVQQFLDNAARHFAGEPLLTPL

Sequences:

>Translated_309_residues
MKPELLVLIALRDDAQRRIAASFEVRYAPTAELRARTIAEHGGTIRAVLTNGSTGLAAHEIDALPQVRLVGALGAGYEQI
DVAHAKARGIAVVTGAGTNDDCVADHAFALLLAAVRGIVRLDAATRAGVWRDALPMPPNVSGKRLGIVGLGRIGEKCARR
AAGFDIEIGYHNRAAKQVPYRYFERLDALAQWADFLIVATPGGAGTRHLIDRTVLDALGPHGFLVNVSRGSVVDTAALAD
ALRERRLAGAALDVYEGEPEPPRALTALDNVVLTPHLGGWSPEALDRSVQQFLDNAARHFAGEPLLTPL
>Mature_309_residues
MKPELLVLIALRDDAQRRIAASFEVRYAPTAELRARTIAEHGGTIRAVLTNGSTGLAAHEIDALPQVRLVGALGAGYEQI
DVAHAKARGIAVVTGAGTNDDCVADHAFALLLAAVRGIVRLDAATRAGVWRDALPMPPNVSGKRLGIVGLGRIGEKCARR
AAGFDIEIGYHNRAAKQVPYRYFERLDALAQWADFLIVATPGGAGTRHLIDRTVLDALGPHGFLVNVSRGSVVDTAALAD
ALRERRLAGAALDVYEGEPEPPRALTALDNVVLTPHLGGWSPEALDRSVQQFLDNAARHFAGEPLLTPL

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=32.156862745098, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=28.0442804428044, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=28.0442804428044, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI145580578, Length=278, Percent_Identity=27.6978417266187, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557499, Length=278, Percent_Identity=27.6978417266187, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=27.843137254902, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI145580575, Length=252, Percent_Identity=28.968253968254, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082289, Length=295, Percent_Identity=31.1864406779661, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789279, Length=242, Percent_Identity=31.8181818181818, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787645, Length=255, Percent_Identity=26.2745098039216, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788660, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=264, Percent_Identity=31.4393939393939, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=269, Percent_Identity=27.5092936802974, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=277, Percent_Identity=26.7148014440433, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=32.9268292682927, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=230, Percent_Identity=28.695652173913, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=172, Percent_Identity=33.7209302325581, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574286, Length=273, Percent_Identity=32.2344322344322, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585514, Length=275, Percent_Identity=29.4545454545455, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574282, Length=275, Percent_Identity=29.4545454545455, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552429, Length=275, Percent_Identity=29.4545454545455, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574284, Length=275, Percent_Identity=29.4545454545455, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45551003, Length=275, Percent_Identity=29.4545454545455, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571528, Length=225, Percent_Identity=33.7777777777778, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921140, Length=239, Percent_Identity=31.3807531380753, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646446, Length=273, Percent_Identity=30.03663003663, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646448, Length=273, Percent_Identity=30.03663003663, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646452, Length=273, Percent_Identity=30.03663003663, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646450, Length=273, Percent_Identity=30.03663003663, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI62472511, Length=247, Percent_Identity=31.1740890688259, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=27.6264591439689, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32878; Mature: 32878

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPELLVLIALRDDAQRRIAASFEVRYAPTAELRARTIAEHGGTIRAVLTNGSTGLAAHE
CCCCEEEEEEECCCHHHHHHHHEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHH
IDALPQVRLVGALGAGYEQIDVAHAKARGIAVVTGAGTNDDCVADHAFALLLAAVRGIVR
HHCCCCEEEEHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LDAATRAGVWRDALPMPPNVSGKRLGIVGLGRIGEKCARRAAGFDIEIGYHNRAAKQVPY
HCCHHHCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCCHHHHCCH
RYFERLDALAQWADFLIVATPGGAGTRHLIDRTVLDALGPHGFLVNVSRGSVVDTAALAD
HHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
ALRERRLAGAALDVYEGEPEPPRALTALDNVVLTPHLGGWSPEALDRSVQQFLDNAARHF
HHHHHHHHCCEEEECCCCCCCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AGEPLLTPL
CCCCCCCCC
>Mature Secondary Structure
MKPELLVLIALRDDAQRRIAASFEVRYAPTAELRARTIAEHGGTIRAVLTNGSTGLAAHE
CCCCEEEEEEECCCHHHHHHHHEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHH
IDALPQVRLVGALGAGYEQIDVAHAKARGIAVVTGAGTNDDCVADHAFALLLAAVRGIVR
HHCCCCEEEEHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LDAATRAGVWRDALPMPPNVSGKRLGIVGLGRIGEKCARRAAGFDIEIGYHNRAAKQVPY
HCCHHHCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCCHHHHCCH
RYFERLDALAQWADFLIVATPGGAGTRHLIDRTVLDALGPHGFLVNVSRGSVVDTAALAD
HHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
ALRERRLAGAALDVYEGEPEPPRALTALDNVVLTPHLGGWSPEALDRSVQQFLDNAARHF
HHHHHHHHCCEEEECCCCCCCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AGEPLLTPL
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA