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The map label for this gene is phoP [H]

Identifier: 189353750

GI number: 189353750

Start: 2028321

End: 2029100

Strand: Reverse

Name: phoP [H]

Synonym: BMULJ_04997

Alternate gene names: 189353750

Gene position: 2029100-2028321 (Counterclockwise)

Preceding gene: 189353751

Following gene: 189353749

Centisome position: 82.04

GC content: 64.62

Gene sequence:

>780_bases
ATGCGTGTGCTGATAGTCGAAGATGATCCCGTCCATGCGCAGGCCGCGGCGCGCATCGTTGCGTCGCTCGGCCACGACGT
GGTTGAAGCGGGCGACGGCGAGCACGCGCAGCAGCGGCTGCGCGCCGAGCCGTTCGATCTCGTGATTCTGGACTGGCTGC
TGCCGAGGATGAGCGGCTTCGAAGTGCTGTACTGGATTCGCCGCACGCTCGGCACGACGCCTGCCGTGCTGTTCGTGACG
AGCAAGTCACTCGACGACGACATCGTGCTCGCGATGGACGCGGGCGCCGACGACTACATCGTGAAGCCGTTTCGTGTCGC
CGAATTCGCGAGCCGCGTCAGTGCATTGCTGATGCGGTCGATGCGCGACGCGACTCCGGCCGGCGCAATCCGTGCCGGCG
ACTACGTGCTCGATCCGCGCGAGCGCACGATCCAGTTGCGCGGCGCGCCGATCAAGCTCACGCCGAAGGAATTCGATCTC
GTCGAATTCTTCTTCAGCAACATCGGCAAGCTGCTGTCGCGCAAGGTCGTCTGTATCAGCACGTGGGGACGCGAACTCGA
TCCCGACTCGCGCACGCTCGATACGCACATCTACCGGATCCGGCAAAAGCTCGAACTCGGCCCTGAAAACGGCTTGCGGC
TCAGTTCCGTCTATACGCATGGATATCGGCTCGAGGTCGTATCGTCGGGCCCCGTACACGACAGTGCGGCCGCGCATCGA
TCGAGCCTGCAGCCGGCGCTCGCGCGGCCGCTGACCCCGGCGGGATTCGAGTGTGAATGA

Upstream 100 bases:

>100_bases
GCGCGTGCGCGGCGTGTGCGCTCGTGTGTGAACGCGCGATGGTGCGCATGGACGATGCGGGCCGCGGCGTCCACGTGTTG
ATGACAAGGATGACCCACTG

Downstream 100 bases:

>100_bases
GTCCGCCCCCTTCGTGCGAGTGCGTGCCGTGGGCGACGTATGATGCGCGTCGACGCCGCGCACGGGCCTTCGGGTTTCGT
GCGCGAATGCATCGCGATCG

Product: signal transduction response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MRVLIVEDDPVHAQAAARIVASLGHDVVEAGDGEHAQQRLRAEPFDLVILDWLLPRMSGFEVLYWIRRTLGTTPAVLFVT
SKSLDDDIVLAMDAGADDYIVKPFRVAEFASRVSALLMRSMRDATPAGAIRAGDYVLDPRERTIQLRGAPIKLTPKEFDL
VEFFFSNIGKLLSRKVVCISTWGRELDPDSRTLDTHIYRIRQKLELGPENGLRLSSVYTHGYRLEVVSSGPVHDSAAAHR
SSLQPALARPLTPAGFECE

Sequences:

>Translated_259_residues
MRVLIVEDDPVHAQAAARIVASLGHDVVEAGDGEHAQQRLRAEPFDLVILDWLLPRMSGFEVLYWIRRTLGTTPAVLFVT
SKSLDDDIVLAMDAGADDYIVKPFRVAEFASRVSALLMRSMRDATPAGAIRAGDYVLDPRERTIQLRGAPIKLTPKEFDL
VEFFFSNIGKLLSRKVVCISTWGRELDPDSRTLDTHIYRIRQKLELGPENGLRLSSVYTHGYRLEVVSSGPVHDSAAAHR
SSLQPALARPLTPAGFECE
>Mature_259_residues
MRVLIVEDDPVHAQAAARIVASLGHDVVEAGDGEHAQQRLRAEPFDLVILDWLLPRMSGFEVLYWIRRTLGTTPAVLFVT
SKSLDDDIVLAMDAGADDYIVKPFRVAEFASRVSALLMRSMRDATPAGAIRAGDYVLDPRERTIQLRGAPIKLTPKEFDL
VEFFFSNIGKLLSRKVVCISTWGRELDPDSRTLDTHIYRIRQKLELGPENGLRLSSVYTHGYRLEVVSSGPVHDSAAAHR
SSLQPALARPLTPAGFECE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=207, Percent_Identity=34.7826086956522, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=30.8035714285714, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=34.061135371179, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=31.4159292035398, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=35.0877192982456, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=30.3571428571429, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1787229, Length=208, Percent_Identity=31.7307692307692, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082012, Length=207, Percent_Identity=29.4685990338164, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=31.8777292576419, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=27.8761061946903, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI2367329, Length=209, Percent_Identity=29.1866028708134, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=27.8761061946903, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.936170212766, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=33.6065573770492, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28776; Mature: 28776

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVEDDPVHAQAAARIVASLGHDVVEAGDGEHAQQRLRAEPFDLVILDWLLPRMSGF
CEEEEECCCCCHHHHHHHHHHHHCHHHHHCCCCHHHHHHHCCCCCCEEHHHHHHHCCCCH
EVLYWIRRTLGTTPAVLFVTSKSLDDDIVLAMDAGADDYIVKPFRVAEFASRVSALLMRS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHH
MRDATPAGAIRAGDYVLDPRERTIQLRGAPIKLTPKEFDLVEFFFSNIGKLLSRKVVCIS
HHCCCCCCCEECCCEEECCHHHEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCEEEEE
TWGRELDPDSRTLDTHIYRIRQKLELGPENGLRLSSVYTHGYRLEVVSSGPVHDSAAAHR
ECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCCCCCHHHHHH
SSLQPALARPLTPAGFECE
HCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRVLIVEDDPVHAQAAARIVASLGHDVVEAGDGEHAQQRLRAEPFDLVILDWLLPRMSGF
CEEEEECCCCCHHHHHHHHHHHHCHHHHHCCCCHHHHHHHCCCCCCEEHHHHHHHCCCCH
EVLYWIRRTLGTTPAVLFVTSKSLDDDIVLAMDAGADDYIVKPFRVAEFASRVSALLMRS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHH
MRDATPAGAIRAGDYVLDPRERTIQLRGAPIKLTPKEFDLVEFFFSNIGKLLSRKVVCIS
HHCCCCCCCEECCCEEECCHHHEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCEEEEE
TWGRELDPDSRTLDTHIYRIRQKLELGPENGLRLSSVYTHGYRLEVVSSGPVHDSAAAHR
ECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCCCCCHHHHHH
SSLQPALARPLTPAGFECE
HCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]