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The map label for this gene is phoR [H]

Identifier: 189353749

GI number: 189353749

Start: 2025924

End: 2028281

Strand: Reverse

Name: phoR [H]

Synonym: BMULJ_04996

Alternate gene names: 189353749

Gene position: 2028281-2025924 (Counterclockwise)

Preceding gene: 189353750

Following gene: 189353747

Centisome position: 82.01

GC content: 70.1

Gene sequence:

>2358_bases
ATGATGCGCGTCGACGCCGCGCACGGGCCTTCGGGTTTCGTGCGCGAATGCATCGCGATCGCCGCGTTCGTGCTGCTGCT
CTGCGTGTCGTTGACCGCGACGGGCGTGCTGCGCCGCGCGGACCTGTTCTTCTTCGACATCGTGCAGCCCTTGCTGCAGC
GACCGTCGCCGCACAAGATCGTGCTGATTGCGATCGACGCTGCGAGCGCGAAGGCGCTCGGCGGATGGCCGGTCAAGCGC
GCCGATTACGCGGCGCTGATCGACCGGCTGACCGAAGCCGGTGTCGCGGCCGTCGGGCTCGACGTCGCGGTCACGCATCC
CGGCAGAATCCTGCCGGCCGGCGACGCGTGGCTTGCCCGCGCGGCCGAGCGCAACGGTCGCGTGGTGCTGCCGGTGGTCG
CGGTCGACGAAGACGGGGAGGCGAGCGCGGTGCCGCCGCTCGCGCCGATCGCGGCGGCCGCATTCGCGGTCGCACACGTG
AACGCCGTGCCGGACGCGGATCGCGTATCGCGCAGCTTTTATCTGCGCGAGGGGCCGCCGCATACCGACTACGAGCATAT
GAGCGTCGCGCTGTTGCGTGCGAGCGGCGTGCCGTTCGCGCGCTGCGGCGAGCGGCCCGAGCACGACATGCTGCGCTGGA
GCGGTGCGTGCCGCCGCTATGTGCCGTTTGCTTCGCGTCCGTCGTATCGGACGATCGCCTTTCTCGATGCCCTCGAAGGA
CGCGTCGCGCCCGGCTTGCTGAAGGACGCGATCGTGCTGATCGGGCCGACCACGAGCACGGCCGACACGCACTTCATCAC
GCCGGGCAGCGAACCGCAGTCGCGCGCCGGTGTCGAGTTCGTTGCGCAGTCGACGTACGCGCTCGCGAGCGGGTCGCTCG
TGCGCCGCGCGTCGTGGGGCGGCCAGTTGCTGTTCAGTCTGTCGGTGCTGCCGTGGCTGTGCGCGGCGCTCGGCATGCTC
GGTCCGCGTGCCGCGCTGCTCGCGTCGATCGGCACGGCGGTCTTTGCGGGCGGCATGTCGCTGCTGATGCTGAAAACGGT
CCATCTGTTCTTCTTTCCGGCGCCGGCGGTGGCCGCCTGCTTGTGCGCGTACGCGTTCAGCGCGTGGCGCCGGCAGGAAG
CGCTACTGCAGTATCTGACGCGCGAAGCCGAGCGTGCGATGGCCGATCCCGGCCTGCCCGGCGACGCGCCGATTTGCCCG
AACGCGACCGACCCGTTCCGCCGGCGCGTACTCGTGATGAGCGCGATGATCGACCGGCTGCGGCGTTCGGCGCGTCTGAT
TTCCGAATGGATGAACAGCCTGCCCGAAGCGACGCTCGTCGCATCCGCGTCGGGTGCGGTCATGCTCGCGAACCGCAGGG
CGCTCGCGCTCTACGACACAGGCGCTGAGCGGCGCAGTTTGACGCGGCCGGCCGCGGGCCGCCATGCGGCGCAGATGCTG
CGCGAGATGACGGCGTCGGACGACGCAGCGCAGTATGCGCACCGCGCGCTGCAGACGCTCGCGCAACGCAGCGGCGCCGC
GACCGCAAGCGCGCCCGCCGCGCCGATGGACGGCCTCGAGATCGTCGATGCGCGACAGCGCTCGCTGCTGGTCAAATGCG
CGATCGTGCCGGCACACGAAGCGGGTGACGCGATGGTGATCTTCCACGTCGCGGACGTCACGCCGATGCGGGCGGCCGAG
CGCCAGCGCGATGCGGCGCTGCGCTTTCTGTCGCACGACATGCGTTCGCCGCAAGCGGCGATCCTCGCGCTGATCGAGCA
GCGTCGTCAGACGCCGGCCGACTTGTCCGAAGCGCAGTTCGCCGATCTCGTCGGTCACTATGCGCGCTGGACGCTCACGC
TCGCCGACCAGTTCCTGCTGCTGGCGCGCGCGCAGGCACGCGCATCGAAAGCGACGGAAGTCGACCTCGTGCCGCTGCTC
GGCGACGCGGTCGACGACCTGTGGGCGCATGCGAGCGCGAAGCGCGTCGGGATCCGGCTGTTCGCCGAACCGGGCATGCT
CGTGGTTGCCGATGCGTTGCTGCTGCGCCGCGCGTTCGCGAATCTGATCGACAACGCGGTGCGGTTCAGCCCCGAAGGGG
CGACCGTCACCGTCTCGGCCGACGAGCGCGACGGACGCTGGTGCGTGAGCGTCGCCGATACGGGCATCGGCATACCGGCC
CATCAGCTGCCGAATCTGTTCACCGAGTTCTTCCGTGTCGACGCGCGCGGCGCGACCGCCGGGCATGGCCTCGGGCTCGC
GTTCGTCAAGCAGGTGGTCGATGCGCTCGGCGGCTCAATCCACGTCGAAAGTGCGGTCGGGCGCGGTTCCGTATTTACGG
TGCTGCTGCCTCGCAACGTCGCGCAACGCGACAGTTGA

Upstream 100 bases:

>100_bases
ATCGAGCCTGCAGCCGGCGCTCGCGCGGCCGCTGACCCCGGCGGGATTCGAGTGTGAATGAGTCCGCCCCCTTCGTGCGA
GTGCGTGCCGTGGGCGACGT

Downstream 100 bases:

>100_bases
ACGCCGGCGCAAGCGCGCCGAAATCACGCATCCGGAATTTTCTTCCGATTCCCCTGTCCACTCGAAAGCGAGTGCATACG
TATCGCGTCGCGCAGCGATA

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MMRVDAAHGPSGFVRECIAIAAFVLLLCVSLTATGVLRRADLFFFDIVQPLLQRPSPHKIVLIAIDAASAKALGGWPVKR
ADYAALIDRLTEAGVAAVGLDVAVTHPGRILPAGDAWLARAAERNGRVVLPVVAVDEDGEASAVPPLAPIAAAAFAVAHV
NAVPDADRVSRSFYLREGPPHTDYEHMSVALLRASGVPFARCGERPEHDMLRWSGACRRYVPFASRPSYRTIAFLDALEG
RVAPGLLKDAIVLIGPTTSTADTHFITPGSEPQSRAGVEFVAQSTYALASGSLVRRASWGGQLLFSLSVLPWLCAALGML
GPRAALLASIGTAVFAGGMSLLMLKTVHLFFFPAPAVAACLCAYAFSAWRRQEALLQYLTREAERAMADPGLPGDAPICP
NATDPFRRRVLVMSAMIDRLRRSARLISEWMNSLPEATLVASASGAVMLANRRALALYDTGAERRSLTRPAAGRHAAQML
REMTASDDAAQYAHRALQTLAQRSGAATASAPAAPMDGLEIVDARQRSLLVKCAIVPAHEAGDAMVIFHVADVTPMRAAE
RQRDAALRFLSHDMRSPQAAILALIEQRRQTPADLSEAQFADLVGHYARWTLTLADQFLLLARAQARASKATEVDLVPLL
GDAVDDLWAHASAKRVGIRLFAEPGMLVVADALLLRRAFANLIDNAVRFSPEGATVTVSADERDGRWCVSVADTGIGIPA
HQLPNLFTEFFRVDARGATAGHGLGLAFVKQVVDALGGSIHVESAVGRGSVFTVLLPRNVAQRDS

Sequences:

>Translated_785_residues
MMRVDAAHGPSGFVRECIAIAAFVLLLCVSLTATGVLRRADLFFFDIVQPLLQRPSPHKIVLIAIDAASAKALGGWPVKR
ADYAALIDRLTEAGVAAVGLDVAVTHPGRILPAGDAWLARAAERNGRVVLPVVAVDEDGEASAVPPLAPIAAAAFAVAHV
NAVPDADRVSRSFYLREGPPHTDYEHMSVALLRASGVPFARCGERPEHDMLRWSGACRRYVPFASRPSYRTIAFLDALEG
RVAPGLLKDAIVLIGPTTSTADTHFITPGSEPQSRAGVEFVAQSTYALASGSLVRRASWGGQLLFSLSVLPWLCAALGML
GPRAALLASIGTAVFAGGMSLLMLKTVHLFFFPAPAVAACLCAYAFSAWRRQEALLQYLTREAERAMADPGLPGDAPICP
NATDPFRRRVLVMSAMIDRLRRSARLISEWMNSLPEATLVASASGAVMLANRRALALYDTGAERRSLTRPAAGRHAAQML
REMTASDDAAQYAHRALQTLAQRSGAATASAPAAPMDGLEIVDARQRSLLVKCAIVPAHEAGDAMVIFHVADVTPMRAAE
RQRDAALRFLSHDMRSPQAAILALIEQRRQTPADLSEAQFADLVGHYARWTLTLADQFLLLARAQARASKATEVDLVPLL
GDAVDDLWAHASAKRVGIRLFAEPGMLVVADALLLRRAFANLIDNAVRFSPEGATVTVSADERDGRWCVSVADTGIGIPA
HQLPNLFTEFFRVDARGATAGHGLGLAFVKQVVDALGGSIHVESAVGRGSVFTVLLPRNVAQRDS
>Mature_785_residues
MMRVDAAHGPSGFVRECIAIAAFVLLLCVSLTATGVLRRADLFFFDIVQPLLQRPSPHKIVLIAIDAASAKALGGWPVKR
ADYAALIDRLTEAGVAAVGLDVAVTHPGRILPAGDAWLARAAERNGRVVLPVVAVDEDGEASAVPPLAPIAAAAFAVAHV
NAVPDADRVSRSFYLREGPPHTDYEHMSVALLRASGVPFARCGERPEHDMLRWSGACRRYVPFASRPSYRTIAFLDALEG
RVAPGLLKDAIVLIGPTTSTADTHFITPGSEPQSRAGVEFVAQSTYALASGSLVRRASWGGQLLFSLSVLPWLCAALGML
GPRAALLASIGTAVFAGGMSLLMLKTVHLFFFPAPAVAACLCAYAFSAWRRQEALLQYLTREAERAMADPGLPGDAPICP
NATDPFRRRVLVMSAMIDRLRRSARLISEWMNSLPEATLVASASGAVMLANRRALALYDTGAERRSLTRPAAGRHAAQML
REMTASDDAAQYAHRALQTLAQRSGAATASAPAAPMDGLEIVDARQRSLLVKCAIVPAHEAGDAMVIFHVADVTPMRAAE
RQRDAALRFLSHDMRSPQAAILALIEQRRQTPADLSEAQFADLVGHYARWTLTLADQFLLLARAQARASKATEVDLVPLL
GDAVDDLWAHASAKRVGIRLFAEPGMLVVADALLLRRAFANLIDNAVRFSPEGATVTVSADERDGRWCVSVADTGIGIPA
HQLPNLFTEFFRVDARGATAGHGLGLAFVKQVVDALGGSIHVESAVGRGSVFTVLLPRNVAQRDS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=30.4166666666667, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=30.4147465437788, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=29.7413793103448, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=214, Percent_Identity=29.9065420560748, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=30.188679245283, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=28.0334728033473, Blast_Score=83, Evalue=9e-17,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=31.1965811965812, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=211, Percent_Identity=27.4881516587678, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=26.5486725663717, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=26.6129032258064, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1788713, Length=275, Percent_Identity=24.3636363636364, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=27.1255060728745, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=214, Percent_Identity=26.6355140186916, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=264, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83868; Mature: 83868

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRVDAAHGPSGFVRECIAIAAFVLLLCVSLTATGVLRRADLFFFDIVQPLLQRPSPHKI
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VLIAIDAASAKALGGWPVKRADYAALIDRLTEAGVAAVGLDVAVTHPGRILPAGDAWLAR
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCEEEEECCCCEEECCHHHHHH
AAERNGRVVLPVVAVDEDGEASAVPPLAPIAAAAFAVAHVNAVPDADRVSRSFYLREGPP
HHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCC
HTDYEHMSVALLRASGVPFARCGERPEHDMLRWSGACRRYVPFASRPSYRTIAFLDALEG
CCCHHHHHEEEEHHCCCCHHHCCCCCCHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHCC
RVAPGLLKDAIVLIGPTTSTADTHFITPGSEPQSRAGVEFVAQSTYALASGSLVRRASWG
CCCCCHHHCCEEEEECCCCCCCCEEECCCCCCCHHCCHHHHHHHHHHHHCCCHHHHCCCC
GQLLFSLSVLPWLCAALGMLGPRAALLASIGTAVFAGGMSLLMLKTVHLFFFPAPAVAAC
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LCAYAFSAWRRQEALLQYLTREAERAMADPGLPGDAPICPNATDPFRRRVLVMSAMIDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRSARLISEWMNSLPEATLVASASGAVMLANRRALALYDTGAERRSLTRPAAGRHAAQML
HHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCEEEEEECCCHHHHCCCCCCHHHHHHHH
REMTASDDAAQYAHRALQTLAQRSGAATASAPAAPMDGLEIVDARQRSLLVKCAIVPAHE
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEEEECCC
AGDAMVIFHVADVTPMRAAERQRDAALRFLSHDMRSPQAAILALIEQRRQTPADLSEAQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHH
ADLVGHYARWTLTLADQFLLLARAQARASKATEVDLVPLLGDAVDDLWAHASAKRVGIRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCHHHEEEEE
FAEPGMLVVADALLLRRAFANLIDNAVRFSPEGATVTVSADERDGRWCVSVADTGIGIPA
ECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCEEEEEECCCCCCCH
HQLPNLFTEFFRVDARGATAGHGLGLAFVKQVVDALGGSIHVESAVGRGSVFTVLLPRNV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCC
AQRDS
CCCCC
>Mature Secondary Structure
MMRVDAAHGPSGFVRECIAIAAFVLLLCVSLTATGVLRRADLFFFDIVQPLLQRPSPHKI
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VLIAIDAASAKALGGWPVKRADYAALIDRLTEAGVAAVGLDVAVTHPGRILPAGDAWLAR
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCEEEEECCCCEEECCHHHHHH
AAERNGRVVLPVVAVDEDGEASAVPPLAPIAAAAFAVAHVNAVPDADRVSRSFYLREGPP
HHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCC
HTDYEHMSVALLRASGVPFARCGERPEHDMLRWSGACRRYVPFASRPSYRTIAFLDALEG
CCCHHHHHEEEEHHCCCCHHHCCCCCCHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHCC
RVAPGLLKDAIVLIGPTTSTADTHFITPGSEPQSRAGVEFVAQSTYALASGSLVRRASWG
CCCCCHHHCCEEEEECCCCCCCCEEECCCCCCCHHCCHHHHHHHHHHHHCCCHHHHCCCC
GQLLFSLSVLPWLCAALGMLGPRAALLASIGTAVFAGGMSLLMLKTVHLFFFPAPAVAAC
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LCAYAFSAWRRQEALLQYLTREAERAMADPGLPGDAPICPNATDPFRRRVLVMSAMIDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRSARLISEWMNSLPEATLVASASGAVMLANRRALALYDTGAERRSLTRPAAGRHAAQML
HHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCEEEEEECCCHHHHCCCCCCHHHHHHHH
REMTASDDAAQYAHRALQTLAQRSGAATASAPAAPMDGLEIVDARQRSLLVKCAIVPAHE
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEEEECCC
AGDAMVIFHVADVTPMRAAERQRDAALRFLSHDMRSPQAAILALIEQRRQTPADLSEAQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHH
ADLVGHYARWTLTLADQFLLLARAQARASKATEVDLVPLLGDAVDDLWAHASAKRVGIRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCHHHEEEEE
FAEPGMLVVADALLLRRAFANLIDNAVRFSPEGATVTVSADERDGRWCVSVADTGIGIPA
ECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCEEEEEECCCCCCCH
HQLPNLFTEFFRVDARGATAGHGLGLAFVKQVVDALGGSIHVESAVGRGSVFTVLLPRNV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCC
AQRDS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]