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The map label for this gene is glyA [H]

Identifier: 189353726

GI number: 189353726

Start: 1993938

End: 1995212

Strand: Reverse

Name: glyA [H]

Synonym: BMULJ_04971

Alternate gene names: 189353726

Gene position: 1995212-1993938 (Counterclockwise)

Preceding gene: 189353728

Following gene: 189353725

Centisome position: 80.67

GC content: 67.61

Gene sequence:

>1275_bases
ATGTCGAACACCCAGTCTTTCTTTTCGCAGCCCCTTGCAGAGCGCGACGCGCCGGTGCGCAGCGCCATCCTGAAGGAACT
CGAGCGTCAGCAGTCGCAGGTCGAACTGATCGCGTCGGAAAACATCGTGTCGCGCGCCGTGCTCGAGGCGCAAGGCTCGG
TGCTCACGAACAAGTACGCGGAAGGCTATCCGGGCAAGCGCTATTACGGCGGCTGCGAGTTCGCGGATGAAGTCGAGGCG
CTCGCGATCGACCGCGTGAAGAAGATCTTCAATGCCGGCTATGCGAACGTGCAGCCGCACTCGGGCGCGCAGGCGAACGG
CTCGGTGATGCTCGCGCTCGCCAAGCCGGGCGACACGGTGCTCGGGATGTCGCTCGACGCGGGCGGCCACCTGACGCACG
GCGCGAAGCCGGCGCTGTCGGGCAAGTGGTTCAACGCGGTCCAGTACGGCGTGAACCGCGACACGATGCGCATCGACTAC
GACCAGGTCGAGGAACTCGCCCAGCAGCACAAGCCGAGCCTCATCATCGCGGGCTTCTCCGCGTACCCGCGCGCGCTCGA
CTTCGCGCGCTTCCGTGCGATCGCCGACAGCGTCGGCGCGAAGCTGATGGTCGACATGGCGCACATCGCGGGCGTGATCG
CCGCCGGCCGCCATGCGAACCCGGTCGAACACGCGCACGTCGTCACGTCGACCACGCACAAGACGCTGCGCGGCCCGCGC
GGCGGCTTCGTGCTGACCAACGACGAAGAGATCGCGAAGAAGATCAACTCGGCCGTGTTCCCCGGCCTGCAGGGCGGCCC
GCTGATGCACGTGATCGCCGGCAAGGCGGTCGCGTTCGGCGAAGTGCTGCAGCCCGACTTCAAGACGTACATCGACAACG
TCCTCGCCAACGCGCAGGCGCTCGGCGAAGTGCTGAAGGCGGGCGGCGTCGATCTCGTCACGGGCGGCACCGACAACCAT
CTGCTGCTCGTCGACCTGCGCCCGAAGGGGCTGAAGGGCGCGCAGGTCGAGCAGGCGCTCGAACGTGCCGGCATCACCTG
CAACAAGAACGGCATTCCGTTCGACACCGAGAAGCCGACGATCACGTCGGGCATCCGTCTCGGCACGCCGGCCGGCACGA
CGCGCGGCTTCGGCGTCGCGGAGTTCCGCGAGATCGGCCGCCTGATCCTCGAGGTGTTCGACGCACTGCGCGCGAACCCG
GAGGGCGACGCCGCGACCGAGCAGCGCGTGCGCCGCGAAATCTTCGCGCTCTGCGAGCGCTTCCCGATTTACTGA

Upstream 100 bases:

>100_bases
TAGAGCCGTCGGCAACCTTGTCTGCAACACGCTTCAAAGCCAGGCAGGGCGGGCCCTTGAGCATCGGTTGCAGCCCCTTA
TTCTTCGTCACGGACGCACT

Downstream 100 bases:

>100_bases
CCCACACCGGACGAGACTGGAGCGAGAGACGGATATGAGCACGCTGCATGACGACAGCATCATCATCGACGGCCTGAACA
TTTCGAAGTTCGAGAAGCCG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSNTQSFFSQPLAERDAPVRSAILKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCEFADEVEA
LAIDRVKKIFNAGYANVQPHSGAQANGSVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRDTMRIDY
DQVEELAQQHKPSLIIAGFSAYPRALDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEVLQPDFKTYIDNVLANAQALGEVLKAGGVDLVTGGTDNH
LLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDTEKPTITSGIRLGTPAGTTRGFGVAEFREIGRLILEVFDALRANP
EGDAATEQRVRREIFALCERFPIY

Sequences:

>Translated_424_residues
MSNTQSFFSQPLAERDAPVRSAILKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCEFADEVEA
LAIDRVKKIFNAGYANVQPHSGAQANGSVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRDTMRIDY
DQVEELAQQHKPSLIIAGFSAYPRALDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEVLQPDFKTYIDNVLANAQALGEVLKAGGVDLVTGGTDNH
LLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDTEKPTITSGIRLGTPAGTTRGFGVAEFREIGRLILEVFDALRANP
EGDAATEQRVRREIFALCERFPIY
>Mature_423_residues
SNTQSFFSQPLAERDAPVRSAILKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCEFADEVEAL
AIDRVKKIFNAGYANVQPHSGAQANGSVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRDTMRIDYD
QVEELAQQHKPSLIIAGFSAYPRALDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPRG
GFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEVLQPDFKTYIDNVLANAQALGEVLKAGGVDLVTGGTDNHL
LLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDTEKPTITSGIRLGTPAGTTRGFGVAEFREIGRLILEVFDALRANPE
GDAATEQRVRREIFALCERFPIY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI22547186, Length=414, Percent_Identity=48.792270531401, Blast_Score=341, Evalue=9e-94,
Organism=Homo sapiens, GI19923315, Length=405, Percent_Identity=46.4197530864198, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI261862352, Length=405, Percent_Identity=46.4197530864198, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI261862350, Length=405, Percent_Identity=46.4197530864198, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI261862348, Length=405, Percent_Identity=46.4197530864198, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI261862346, Length=405, Percent_Identity=45.1851851851852, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI22547189, Length=400, Percent_Identity=46, Blast_Score=305, Evalue=5e-83,
Organism=Escherichia coli, GI1788902, Length=415, Percent_Identity=56.8674698795181, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI25144729, Length=414, Percent_Identity=46.8599033816425, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25144732, Length=414, Percent_Identity=46.8599033816425, Blast_Score=345, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=42.5790754257908, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6323087, Length=408, Percent_Identity=44.1176470588235, Blast_Score=318, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24640005, Length=403, Percent_Identity=47.8908188585608, Blast_Score=358, Evalue=5e-99,
Organism=Drosophila melanogaster, GI221329721, Length=407, Percent_Identity=47.6658476658477, Blast_Score=357, Evalue=8e-99,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45541; Mature: 45410

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTQSFFSQPLAERDAPVRSAILKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYA
CCCCHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EGYPGKRYYGGCEFADEVEALAIDRVKKIFNAGYANVQPHSGAQANGSVMLALAKPGDTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEE
LGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRDTMRIDYDQVEELAQQHKPSLIIAGFS
EEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEECHHHHHHHHHHCCCCEEEECCC
AYPRALDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHHHHCCCC
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEVLQPDFKTYIDNVLANAQA
CCEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHH
LGEVLKAGGVDLVTGGTDNHLLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDTEKPT
HHHHHHCCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
ITSGIRLGTPAGTTRGFGVAEFREIGRLILEVFDALRANPEGDAATEQRVRREIFALCER
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FPIY
CCCC
>Mature Secondary Structure 
SNTQSFFSQPLAERDAPVRSAILKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYA
CCCHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EGYPGKRYYGGCEFADEVEALAIDRVKKIFNAGYANVQPHSGAQANGSVMLALAKPGDTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEE
LGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRDTMRIDYDQVEELAQQHKPSLIIAGFS
EEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEECHHHHHHHHHHCCCCEEEECCC
AYPRALDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHHHHCCCC
GGFVLTNDEEIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEVLQPDFKTYIDNVLANAQA
CCEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHH
LGEVLKAGGVDLVTGGTDNHLLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDTEKPT
HHHHHHCCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
ITSGIRLGTPAGTTRGFGVAEFREIGRLILEVFDALRANPEGDAATEQRVRREIFALCER
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FPIY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA