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The map label for this gene is betC [H]

Identifier: 189353702

GI number: 189353702

Start: 1965263

End: 1966798

Strand: Reverse

Name: betC [H]

Synonym: BMULJ_04947

Alternate gene names: 189353702

Gene position: 1966798-1965263 (Counterclockwise)

Preceding gene: 189353704

Following gene: 189353701

Centisome position: 79.53

GC content: 68.49

Gene sequence:

>1536_bases
ATGACGAACCCGACTCCCAACATCCTGATCCTGATGGCCGACCAGCTGACGCCGTTCGCGCTGCCGGCATACGGTAACCG
CGTGGCGCGCACGCCGACGCTCGACCGGCTCGCCGCGCAAGGCGTGGTGTTCGACGCCGCTTACTGCGCGAGCCCGCTCT
GCGCGCCGTCGCGCTTCTCGCTGCTGACCGGCAAGCTGCCGTCCGGGATCGGCGCCTACGATAACGCCGCCGAATTGCCG
GCGCAAACGCTGACGTTCGCGCACTATCTGCGCGCGGCCGGCTATCGGACGATGCTGTCCGGCAAGATGCACTTCTGCGG
GCCCGATCAGCTGCACGGCTTCGAGGAGCGGCTGACGACCGACATCTATCCGGCCGATTTCGGCTGGGTGCCCGACTGGG
ATCGCCCGACCGAGCGGCCGAGCTGGTATCACAACATGAGCTCGGTGCTCGACGCGGGCCCGTGCGTGCGCACGAACCAG
CTCGACTTCGACGACGAAGTGACGTTCGCCGCAAAGCAGAAGCTCTACGACGTCGCGCGCGAGCGCGCCGCGGGCCGCGA
CGAACGGCCGTTCTGCATGGTCGTGTCGCTGACGCACCCGCACGACCCGTATGCGATCACGCGCGAATACTGGGATCTGT
ACAGCGACGACGAGATCGACATGCCGGCCGTGCAGCTCGGCGCATCGGACAGCGATCCGCATTCGCAGCGGCTGCGCTTC
GTCTGCGAGAACGACCGCACGCCGCCGAGCGACGCGCAGATCCGCGCGGCGCGGCGTGCCTACTACGGCGCGACGTCGTA
CGTCGACGCGCAGTTCGGCAGCGTGCTCGCGGCGCTCGAACAGTGCGGATTCGCCGACGATACGATCGTGATCGTCACGT
CCGATCACGGCGACATGCTCGGCGAGCGCGGGCTCTGGTACAAGATGACGTTCTTCGAAGGCGGCTGCCGCGTGCCGCTG
ATCGTCCATGCACCGCAGCGCTTCGACGCCGCGCGCGTGCGCGGTCCCGTGTCGCATCTCGATCTACTGCCGACGCTCGT
CGAACTCGCGAGCGCGACGCCGGAAGGCGGCTGGCCCGACGCGGTGGACGGCGCCAGTCTCGTCCCGCATCTGCGCGGCA
CGGCCGCACACGATGTCGCGCTCGGCGAATATCTGGCCGAAGGCGCGATCGCGCCGATCGTGATGATCCGGCGTGGCGAC
TGGAAGTACGTGCATTGCCCGGCCGATCCGGAGCAGCTGTACAACCTGTCCGACGATCCGCGCGAACTGACGAATCTCGC
GGGCGCGCCGGAGGCGGCCGACGTGCTGGCCGCCTTCCGCGCGGAAGCGGCACGGCGCTGGAACCTGCCCGAACTCGACC
GGCAGGTGCGCGCGAGCCAGCGTCGGCGCCGCTTTCATTACGCGGCGACGACGCAAGGGCGGATCCAGCCGTGGGACTGG
CAGCCTTTCACCGATGCGAGCCAGCGCTATATGCGCAATCACATCGAACTCGACACGCTCGAAGCGATGGCGCGCTTTCC
GCGCGTCGGGCACTGA

Upstream 100 bases:

>100_bases
GCGCGCGGCACTTTCTGCAGGCTGCGTCCGCGATGCCGGATGCGCCGCTGCCTGCGCGTCGATCCGCTCCATTCGAACAG
CGATTTCCTCACGAACGCCG

Downstream 100 bases:

>100_bases
ACGTATCGCATCGCGATCACTGACAAACGACGGAGGAAGCGGACGATGAAACGGCAACGGCAATGCAATGCAGCAATCCG
GATCGGTGCGGCGCTCGCCG

Product: choline-sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTNPTPNILILMADQLTPFALPAYGNRVARTPTLDRLAAQGVVFDAAYCASPLCAPSRFSLLTGKLPSGIGAYDNAAELP
AQTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTTDIYPADFGWVPDWDRPTERPSWYHNMSSVLDAGPCVRTNQ
LDFDDEVTFAAKQKLYDVARERAAGRDERPFCMVVSLTHPHDPYAITREYWDLYSDDEIDMPAVQLGASDSDPHSQRLRF
VCENDRTPPSDAQIRAARRAYYGATSYVDAQFGSVLAALEQCGFADDTIVIVTSDHGDMLGERGLWYKMTFFEGGCRVPL
IVHAPQRFDAARVRGPVSHLDLLPTLVELASATPEGGWPDAVDGASLVPHLRGTAAHDVALGEYLAEGAIAPIVMIRRGD
WKYVHCPADPEQLYNLSDDPRELTNLAGAPEAADVLAAFRAEAARRWNLPELDRQVRASQRRRRFHYAATTQGRIQPWDW
QPFTDASQRYMRNHIELDTLEAMARFPRVGH

Sequences:

>Translated_511_residues
MTNPTPNILILMADQLTPFALPAYGNRVARTPTLDRLAAQGVVFDAAYCASPLCAPSRFSLLTGKLPSGIGAYDNAAELP
AQTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTTDIYPADFGWVPDWDRPTERPSWYHNMSSVLDAGPCVRTNQ
LDFDDEVTFAAKQKLYDVARERAAGRDERPFCMVVSLTHPHDPYAITREYWDLYSDDEIDMPAVQLGASDSDPHSQRLRF
VCENDRTPPSDAQIRAARRAYYGATSYVDAQFGSVLAALEQCGFADDTIVIVTSDHGDMLGERGLWYKMTFFEGGCRVPL
IVHAPQRFDAARVRGPVSHLDLLPTLVELASATPEGGWPDAVDGASLVPHLRGTAAHDVALGEYLAEGAIAPIVMIRRGD
WKYVHCPADPEQLYNLSDDPRELTNLAGAPEAADVLAAFRAEAARRWNLPELDRQVRASQRRRRFHYAATTQGRIQPWDW
QPFTDASQRYMRNHIELDTLEAMARFPRVGH
>Mature_510_residues
TNPTPNILILMADQLTPFALPAYGNRVARTPTLDRLAAQGVVFDAAYCASPLCAPSRFSLLTGKLPSGIGAYDNAAELPA
QTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTTDIYPADFGWVPDWDRPTERPSWYHNMSSVLDAGPCVRTNQL
DFDDEVTFAAKQKLYDVARERAAGRDERPFCMVVSLTHPHDPYAITREYWDLYSDDEIDMPAVQLGASDSDPHSQRLRFV
CENDRTPPSDAQIRAARRAYYGATSYVDAQFGSVLAALEQCGFADDTIVIVTSDHGDMLGERGLWYKMTFFEGGCRVPLI
VHAPQRFDAARVRGPVSHLDLLPTLVELASATPEGGWPDAVDGASLVPHLRGTAAHDVALGEYLAEGAIAPIVMIRRGDW
KYVHCPADPEQLYNLSDDPRELTNLAGAPEAADVLAAFRAEAARRWNLPELDRQVRASQRRRRFHYAATTQGRIQPWDWQ
PFTDASQRYMRNHIELDTLEAMARFPRVGH

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4557659, Length=406, Percent_Identity=30.7881773399015, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI39930577, Length=448, Percent_Identity=26.3392857142857, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI5360208, Length=323, Percent_Identity=29.7213622291022, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI71852584, Length=422, Percent_Identity=30.0947867298578, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI31742482, Length=431, Percent_Identity=27.8422273781903, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI58743319, Length=431, Percent_Identity=28.3062645011601, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4504061, Length=475, Percent_Identity=24.2105263157895, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI262118210, Length=325, Percent_Identity=30.1538461538462, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI53831991, Length=131, Percent_Identity=38.1679389312977, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4503899, Length=128, Percent_Identity=37.5, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI157266309, Length=111, Percent_Identity=40.5405405405405, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI45430057, Length=497, Percent_Identity=26.1569416498994, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI71852586, Length=110, Percent_Identity=41.8181818181818, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4506919, Length=509, Percent_Identity=24.5579567779961, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI146229331, Length=111, Percent_Identity=41.4414414414414, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI146229329, Length=111, Percent_Identity=41.4414414414414, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI6005990, Length=111, Percent_Identity=41.4414414414414, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI146229324, Length=111, Percent_Identity=41.4414414414414, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1790112, Length=441, Percent_Identity=29.4784580498866, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17559078, Length=109, Percent_Identity=38.5321100917431, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24656835, Length=425, Percent_Identity=30.3529411764706, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI281366397, Length=424, Percent_Identity=25.4716981132075, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366395, Length=424, Percent_Identity=25.4716981132075, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666163, Length=424, Percent_Identity=25.4716981132075, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 57012; Mature: 56880

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPTPNILILMADQLTPFALPAYGNRVARTPTLDRLAAQGVVFDAAYCASPLCAPSRFS
CCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHCCCEEEHHHHCCCCCCCCCHH
LLTGKLPSGIGAYDNAAELPAQTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTT
HHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHCCHHHHHHC
DIYPADFGWVPDWDRPTERPSWYHNMSSVLDAGPCVRTNQLDFDDEVTFAAKQKLYDVAR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ERAAGRDERPFCMVVSLTHPHDPYAITREYWDLYSDDEIDMPAVQLGASDSDPHSQRLRF
HHHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHEECCCCCCCHHHHHHH
VCENDRTPPSDAQIRAARRAYYGATSYVDAQFGSVLAALEQCGFADDTIVIVTSDHGDML
HCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHH
GERGLWYKMTFFEGGCRVPLIVHAPQRFDAARVRGPVSHLDLLPTLVELASATPEGGWPD
CCCCCEEEEEEECCCCCEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
AVDGASLVPHLRGTAAHDVALGEYLAEGAIAPIVMIRRGDWKYVHCPADPEQLYNLSDDP
CCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCHHHHCCCCCCH
RELTNLAGAPEAADVLAAFRAEAARRWNLPELDRQVRASQRRRRFHYAATTQGRIQPWDW
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
QPFTDASQRYMRNHIELDTLEAMARFPRVGH
CCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TNPTPNILILMADQLTPFALPAYGNRVARTPTLDRLAAQGVVFDAAYCASPLCAPSRFS
CCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHCCCEEEHHHHCCCCCCCCCHH
LLTGKLPSGIGAYDNAAELPAQTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTT
HHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHCCHHHHHHC
DIYPADFGWVPDWDRPTERPSWYHNMSSVLDAGPCVRTNQLDFDDEVTFAAKQKLYDVAR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ERAAGRDERPFCMVVSLTHPHDPYAITREYWDLYSDDEIDMPAVQLGASDSDPHSQRLRF
HHHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHEECCCCCCCHHHHHHH
VCENDRTPPSDAQIRAARRAYYGATSYVDAQFGSVLAALEQCGFADDTIVIVTSDHGDML
HCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHH
GERGLWYKMTFFEGGCRVPLIVHAPQRFDAARVRGPVSHLDLLPTLVELASATPEGGWPD
CCCCCEEEEEEECCCCCEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
AVDGASLVPHLRGTAAHDVALGEYLAEGAIAPIVMIRRGDWKYVHCPADPEQLYNLSDDP
CCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCHHHHCCCCCCH
RELTNLAGAPEAADVLAAFRAEAARRWNLPELDRQVRASQRRRRFHYAATTQGRIQPWDW
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
QPFTDASQRYMRNHIELDTLEAMARFPRVGH
CCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]