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The map label for this gene is acs [H]

Identifier: 189353616

GI number: 189353616

Start: 1873917

End: 1875623

Strand: Reverse

Name: acs [H]

Synonym: BMULJ_04860

Alternate gene names: 189353616

Gene position: 1875623-1873917 (Counterclockwise)

Preceding gene: 189353617

Following gene: 189353615

Centisome position: 75.84

GC content: 68.01

Gene sequence:

>1707_bases
ATGACGGTACAGGCATTCCTGGACGCACGCGATTTTCTGCTGCGCCACCGCACCGACTACGAAACCGCCTATCGCGATTT
CGCATGGCCGGTGCTCGACACGTTCAACTGGGCGCTCGACTACTTCGATCCGATGGCGCGCGGCAACGACCGGCCCGCGC
TCTGGATCGTCGACGGCGCGACCGGCACCGGCGAGCCGTATTCGTTCGCGCAGATGTCCGAACGCTCGTCGCGGATCGCG
AACTGGCTGCGCGGCATCGGCGTCGGGCGCGGCGACCGGATCCTGCTGATGCTGCCGAACCGCGTCGAGCTCTGGGACGC
GATGCTCGCCGCGATGAAGCTCGGCGCGATCGTGCTGCCCGCGACGACGCAGCTGTCGGCCGACGACGTGCGCGACCGCG
TGCAGATCGGCGGCGCGAAATACGCGATCGTCGACGAGAACGAAACCGCGAAGTTCGAGCAGCCGGGGCTCGGCCTCGCG
CAGAGGATCGTCGCGGGCGCGCCGCGCGACGGCTGGCTCGCGATGAACGACGGCTACGCGGCGAGCGGCGCCTTCGAGCC
CGACGCCGTCACGCATGCGAACGATCCGATGCTGCTGTATTTCACGTCGGGCACGACGTCGAAGCCGAAGCTCGTCGAGC
ATACGCACCGTACCTATCCGGTCGGTCATCTGTCGACGATGTACTGGATCGGGCTGCAGCCGGGCGACATCCACTGGAAC
ATCAGCTCGCCGGGTTGGGCCAAGCACGCGTGGAGCTGCTTCTACGCGCCGTGGAACGCGCAGGCCTGCGTGTTCGCGTT
CAACTATGCGCGCTTCGAGGCGAAGGCCGTGCTCGACGCGCTCGTCAAATACCGCGTGACGACGCTGTGTGCGCCGCCGA
CGGTATGGCGGATGCTCGTGCAGCAGCCGCTCGCGTCGTTCGACGTGGCGCTGCGCGAGATCGTCGGCGCGGGCGAGCCG
CTGAATCCGGAAATCATCGAGCGCGTGAAGAAGGCGTGGGGCATCACGATCCGCGACGGCTACGGCCAGACCGAGACGAC
CTGCCTGATCGGCAACTCGCCGGGCCAGCCGGTCGTCGCCGGATCGATGGGCCGGCCGCTGCCCGGCTATCGGATCGCGC
TGCTCGATCCCGACGGCGCACCGGTGAGCGAGGGCGAGGTCGCGCTGCCGCTCGACGCGGACGGCGCGCGCCCGGTCGGC
CTGATGACCGGCTATGCGAACAACCGCGACGCGACCGCGCACGCGATGCGCGACGGTCACTACCGGACATCGGACATCGC
GATGCGTCGCGACGACGGCTACTACGTCTATATCGGCCGCGCGGACGACGTGTTCAAGTCGTCCGACTACCGGCTGAGCC
CGTTCGAGCTCGAAAGCGTGCTGATCGAGCATCCGGCGATCGCCGAAGCGGCCGTCGTGCCGAGCCCCGATCCGGTGCGG
CTGTCGGTGCCGAAGACGTACATCACGCTGCGGCAGGGCTACGAGGAAAGCGCGGCGCTCGCGCTCGAGATCTTCCGGTT
CTCGCGCGACAAGCTCGCGCCGTACAAGCGCATCCGCCGGCTGCAGTTCGCCGAGCTGCCGAAGACGATCTCCGGGAAGA
TTCGCCGCGTCGAGCTGCGCCGCCGCGAAATCGAGCGCGGCGACGACGCGACCGCACGCATGCCCGGCGAATACTGGGAA
GACGATTTTTCCGCCGAACTGAAATGA

Upstream 100 bases:

>100_bases
CCGTGCGCCGTCCGACAAGCAACCGTCCGGTGCGCGGCCGTGCGCCGGACGGTTGCGCGATGCATGGAGACATGCCCGGC
ATGGGACAGGAGACGACACG

Downstream 100 bases:

>100_bases
CCGTGCCGCGCGCTGTGCGCCGTGTGCGTGCAGCGCGGCCGGCCTGAACCTGCCGTCCGCGCACGTCGCGCGGCGGCGCG
CTGAAGGAGAGAGGATCGAT

Product: acetyl-CoA synthetase

Products: Acetyl-CoA; AMP; Diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MTVQAFLDARDFLLRHRTDYETAYRDFAWPVLDTFNWALDYFDPMARGNDRPALWIVDGATGTGEPYSFAQMSERSSRIA
NWLRGIGVGRGDRILLMLPNRVELWDAMLAAMKLGAIVLPATTQLSADDVRDRVQIGGAKYAIVDENETAKFEQPGLGLA
QRIVAGAPRDGWLAMNDGYAASGAFEPDAVTHANDPMLLYFTSGTTSKPKLVEHTHRTYPVGHLSTMYWIGLQPGDIHWN
ISSPGWAKHAWSCFYAPWNAQACVFAFNYARFEAKAVLDALVKYRVTTLCAPPTVWRMLVQQPLASFDVALREIVGAGEP
LNPEIIERVKKAWGITIRDGYGQTETTCLIGNSPGQPVVAGSMGRPLPGYRIALLDPDGAPVSEGEVALPLDADGARPVG
LMTGYANNRDATAHAMRDGHYRTSDIAMRRDDGYYVYIGRADDVFKSSDYRLSPFELESVLIEHPAIAEAAVVPSPDPVR
LSVPKTYITLRQGYEESAALALEIFRFSRDKLAPYKRIRRLQFAELPKTISGKIRRVELRRREIERGDDATARMPGEYWE
DDFSAELK

Sequences:

>Translated_568_residues
MTVQAFLDARDFLLRHRTDYETAYRDFAWPVLDTFNWALDYFDPMARGNDRPALWIVDGATGTGEPYSFAQMSERSSRIA
NWLRGIGVGRGDRILLMLPNRVELWDAMLAAMKLGAIVLPATTQLSADDVRDRVQIGGAKYAIVDENETAKFEQPGLGLA
QRIVAGAPRDGWLAMNDGYAASGAFEPDAVTHANDPMLLYFTSGTTSKPKLVEHTHRTYPVGHLSTMYWIGLQPGDIHWN
ISSPGWAKHAWSCFYAPWNAQACVFAFNYARFEAKAVLDALVKYRVTTLCAPPTVWRMLVQQPLASFDVALREIVGAGEP
LNPEIIERVKKAWGITIRDGYGQTETTCLIGNSPGQPVVAGSMGRPLPGYRIALLDPDGAPVSEGEVALPLDADGARPVG
LMTGYANNRDATAHAMRDGHYRTSDIAMRRDDGYYVYIGRADDVFKSSDYRLSPFELESVLIEHPAIAEAAVVPSPDPVR
LSVPKTYITLRQGYEESAALALEIFRFSRDKLAPYKRIRRLQFAELPKTISGKIRRVELRRREIERGDDATARMPGEYWE
DDFSAELK
>Mature_567_residues
TVQAFLDARDFLLRHRTDYETAYRDFAWPVLDTFNWALDYFDPMARGNDRPALWIVDGATGTGEPYSFAQMSERSSRIAN
WLRGIGVGRGDRILLMLPNRVELWDAMLAAMKLGAIVLPATTQLSADDVRDRVQIGGAKYAIVDENETAKFEQPGLGLAQ
RIVAGAPRDGWLAMNDGYAASGAFEPDAVTHANDPMLLYFTSGTTSKPKLVEHTHRTYPVGHLSTMYWIGLQPGDIHWNI
SSPGWAKHAWSCFYAPWNAQACVFAFNYARFEAKAVLDALVKYRVTTLCAPPTVWRMLVQQPLASFDVALREIVGAGEPL
NPEIIERVKKAWGITIRDGYGQTETTCLIGNSPGQPVVAGSMGRPLPGYRIALLDPDGAPVSEGEVALPLDADGARPVGL
MTGYANNRDATAHAMRDGHYRTSDIAMRRDDGYYVYIGRADDVFKSSDYRLSPFELESVLIEHPAIAEAAVVPSPDPVRL
SVPKTYITLRQGYEESAALALEIFRFSRDKLAPYKRIRRLQFAELPKTISGKIRRVELRRREIERGDDATARMPGEYWED
DFSAELK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=555, Percent_Identity=36.2162162162162, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=37.3358348968105, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI122937307, Length=534, Percent_Identity=37.8277153558052, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI58082049, Length=540, Percent_Identity=34.2592592592593, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI157311624, Length=540, Percent_Identity=33.8888888888889, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI157311622, Length=540, Percent_Identity=33.8888888888889, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI115511026, Length=537, Percent_Identity=32.4022346368715, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI42544134, Length=381, Percent_Identity=33.0708661417323, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI195947378, Length=446, Percent_Identity=29.1479820627803, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI8923896, Length=572, Percent_Identity=28.3216783216783, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI253970489, Length=384, Percent_Identity=32.8125, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI13375727, Length=563, Percent_Identity=26.8206039076377, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI28416953, Length=595, Percent_Identity=26.0504201680672, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI156151445, Length=531, Percent_Identity=25.6120527306968, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI187761345, Length=541, Percent_Identity=22.550831792976, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI187761343, Length=541, Percent_Identity=22.550831792976, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790505, Length=566, Percent_Identity=29.6819787985866, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI221142682, Length=501, Percent_Identity=25.1497005988024, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1788107, Length=553, Percent_Identity=25.3164556962025, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786529, Length=535, Percent_Identity=26.5420560747664, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI145693145, Length=543, Percent_Identity=24.8618784530387, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1786801, Length=423, Percent_Identity=25.2955082742317, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788595, Length=482, Percent_Identity=23.2365145228216, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786810, Length=546, Percent_Identity=22.7106227106227, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71982997, Length=552, Percent_Identity=29.7101449275362, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71983001, Length=552, Percent_Identity=29.7101449275362, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17531443, Length=505, Percent_Identity=24.7524752475248, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71996755, Length=483, Percent_Identity=25.2587991718427, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559526, Length=375, Percent_Identity=27.2, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17557194, Length=531, Percent_Identity=23.5404896421846, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17560308, Length=527, Percent_Identity=24.6679316888046, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=534, Percent_Identity=23.0337078651685, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71994703, Length=534, Percent_Identity=23.0337078651685, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71994690, Length=534, Percent_Identity=23.0337078651685, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=535, Percent_Identity=24.4859813084112, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=504, Percent_Identity=22.4206349206349, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=515, Percent_Identity=21.747572815534, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=366, Percent_Identity=22.9508196721311, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=593, Percent_Identity=28.3305227655987, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6319264, Length=596, Percent_Identity=27.0134228187919, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319699, Length=353, Percent_Identity=26.3456090651558, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667955, Length=536, Percent_Identity=30.410447761194, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI62472339, Length=536, Percent_Identity=30.410447761194, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24667959, Length=373, Percent_Identity=33.5120643431635, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21355181, Length=514, Percent_Identity=26.0700389105058, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21355225, Length=533, Percent_Identity=27.5797373358349, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859661, Length=508, Percent_Identity=25, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24581924, Length=536, Percent_Identity=23.8805970149254, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356947, Length=487, Percent_Identity=22.9979466119097, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648260, Length=511, Percent_Identity=22.3091976516634, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1 [C]

Molecular weight: Translated: 63303; Mature: 63171

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQAFLDARDFLLRHRTDYETAYRDFAWPVLDTFNWALDYFDPMARGNDRPALWIVDGA
CEEHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCHHHCCCCCCEEEEEECC
TGTGEPYSFAQMSERSSRIANWLRGIGVGRGDRILLMLPNRVELWDAMLAAMKLGAIVLP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEEEC
ATTQLSADDVRDRVQIGGAKYAIVDENETAKFEQPGLGLAQRIVAGAPRDGWLAMNDGYA
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCC
ASGAFEPDAVTHANDPMLLYFTSGTTSKPKLVEHTHRTYPVGHLSTMYWIGLQPGDIHWN
CCCCCCCCCEECCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCEEEE
ISSPGWAKHAWSCFYAPWNAQACVFAFNYARFEAKAVLDALVKYRVTTLCAPPTVWRMLV
CCCCCCCCCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QQPLASFDVALREIVGAGEPLNPEIIERVKKAWGITIRDGYGQTETTCLIGNSPGQPVVA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCEEEECCCCCCCEEEEEECCCCCCEEE
GSMGRPLPGYRIALLDPDGAPVSEGEVALPLDADGARPVGLMTGYANNRDATAHAMRDGH
CCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHCCC
YRTSDIAMRRDDGYYVYIGRADDVFKSSDYRLSPFELESVLIEHPAIAEAAVVPSPDPVR
EECCCEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCEE
LSVPKTYITLRQGYEESAALALEIFRFSRDKLAPYKRIRRLQFAELPKTISGKIRRVELR
EECCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCEEHHHH
RREIERGDDATARMPGEYWEDDFSAELK
HHHHHCCCCCCCCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
TVQAFLDARDFLLRHRTDYETAYRDFAWPVLDTFNWALDYFDPMARGNDRPALWIVDGA
EEHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCHHHCCCCCCEEEEEECC
TGTGEPYSFAQMSERSSRIANWLRGIGVGRGDRILLMLPNRVELWDAMLAAMKLGAIVLP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEEEC
ATTQLSADDVRDRVQIGGAKYAIVDENETAKFEQPGLGLAQRIVAGAPRDGWLAMNDGYA
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCC
ASGAFEPDAVTHANDPMLLYFTSGTTSKPKLVEHTHRTYPVGHLSTMYWIGLQPGDIHWN
CCCCCCCCCEECCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCEEEE
ISSPGWAKHAWSCFYAPWNAQACVFAFNYARFEAKAVLDALVKYRVTTLCAPPTVWRMLV
CCCCCCCCCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QQPLASFDVALREIVGAGEPLNPEIIERVKKAWGITIRDGYGQTETTCLIGNSPGQPVVA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCEEEECCCCCCCEEEEEECCCCCCEEE
GSMGRPLPGYRIALLDPDGAPVSEGEVALPLDADGARPVGLMTGYANNRDATAHAMRDGH
CCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHCCC
YRTSDIAMRRDDGYYVYIGRADDVFKSSDYRLSPFELESVLIEHPAIAEAAVVPSPDPVR
EECCCEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCEE
LSVPKTYITLRQGYEESAALALEIFRFSRDKLAPYKRIRRLQFAELPKTISGKIRRVELR
EECCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCEEHHHH
RREIERGDDATARMPGEYWEDDFSAELK
HHHHHCCCCCCCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetate; ATP; Coenzyme A [C]

Specific reaction: Acetate + ATP + Coenzyme A --> Acetyl-CoA + AMP + Diphosphate [C]

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]