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The map label for this gene is ethA [H]

Identifier: 189353603

GI number: 189353603

Start: 1858777

End: 1860291

Strand: Reverse

Name: ethA [H]

Synonym: BMULJ_04847

Alternate gene names: 189353603

Gene position: 1860291-1858777 (Counterclockwise)

Preceding gene: 189353606

Following gene: 189353602

Centisome position: 75.22

GC content: 64.29

Gene sequence:

>1515_bases
ATGAAGACCGACTTCGACGTCCTGATCATTGGAGCCGGCATTTCCGGAATCGGGATGGCATGCCATCTGGCGAGGGAATG
CCCGGACAAGCGCGTTGGCATTCTCGAGCGCCGCCGCGCGATCGGCGGGACGTGGGATTTGTTCCGTTATCCCGGTATTC
GGTCCGATTCGGACATGTTCAGTTTCGGCTACCAATTCCGGCCGTGGCATGAATACAAGGTTCTCGCCGACGGCCCGTCG
ATCCGGCAATACGTTGCCGATACCGCGCGCGAGCATGGTGTCGATCGGCTCATCCGGTTCGGCGTCCGGATAGACGGCGC
ATCGTGGTCGACCGAGCGGTGTCGCTGGACGGTCAGTGCGCGTCAGGAAGACACGGGCGAAGCGCTGACTTTCACGTGCG
CGTACCTGATTCCCTGTACCGGCTATTACAACCACGATCAGGGCTACTTGCCGGACTTCCCCGGACAAGAGCGATTCAAG
GGGCTGCGCATTCACCCGCAGCACTGGCCCGAGGAACTCGACTATCGCGGCAAGCGCGTCGTCGTGATCGGCAGCGGGGC
AACGGCCGTGACGCTCGTGCCCGCCATGGCCGGCCGTGCGGCCCACGTCACGATGCTGCAGCGCTCGCCGAGCTACATCT
TTTCGGTTCCGGCCTACGACAAGATCTCTGCGGCGCTCGATCGCGTGCTGCCGACGCGGTGGGTATACGGGCTGGCGCGC
TGGCGCAATATCCGCCTGCAGCGTCTGATCTACAAGGCGGCCAAGCGATGGCCGCGCCCGGTCCGCTCCTGGCTGCTGTC
GCACGTCGAGAAGCGGGTCGGCGGCGGCGTCGACATGCGTCACTTCACGCCGAAGTACAACCCGTGGGACGAACGGCTAT
GTGCCGTTCCGGACGGCGACCTGTTCAAGGTGCTGCGCGAGGGTAAAGCGTCTGTCGTGACCGACCATATCGAGACGTTC
ACCGAAAGCGGCATCCTGCTGAAATCGGGCAAGACGCTCGAGGCGGACATCATCGTCACCGCGACCGGTCTGCAACTTCA
GTCGCTTGGCGGCATGAGCCTGCATGTCGACGGGCGACAGGTCGAGGTCGGCAAGACGATGACGTACAAGGGCGTGCTGA
TGCAGGACGTGCCGAATTTCGCCTACCTGTTCGGCTATACCAACGCGCCGTGGACGCTCAAGATCGACATGGCGGCAAAC
TATGTGTGTCGTCTGTTGAAGCATATGGATGCCGAAGGGTTTCAGACGGTGACCGCTCATGCGCCCGGCGGCGAGATGCT
CGACGAATCGATCCTCGGTTCGCTGCAGTCGGGCTACGTGCAGCGCGGCCAGGACGTGCTGCCGCGCCAGGGGCGCGCGT
TGCCGTGGCGCGTCCTGCACAGCTTCGAGGCCGATCGCGACATGCTGCTGAAGGACGGCATCGTCGATTCCGCACTGGTA
TTCCGCCGTGCGGCGTCCGGTGCCGATGCGGCCGCTGTCGCCGGTCTGGCCGGCGGGCAGCCCGCATCCGCGTGA

Upstream 100 bases:

>100_bases
ATGTCTCAAAATGTAAAACAATAGTCTCGTGACGTCAAATAGCGCGCGTGCGCGATTGCTAGAGTGCGGGTGTCGATCAC
CAACAACGAGGAGACATCCG

Downstream 100 bases:

>100_bases
CGGGAGTCGATCATGCTCAGCTTCGATTCCAGGTTTCCGAGCGAGGGCGAGGATTGCGCCGGGACGCTCATGCTGCCGGA
CGGCAACGGCAGACCGCCCG

Product: predicted flavoprotein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKTDFDVLIIGAGISGIGMACHLARECPDKRVGILERRRAIGGTWDLFRYPGIRSDSDMFSFGYQFRPWHEYKVLADGPS
IRQYVADTAREHGVDRLIRFGVRIDGASWSTERCRWTVSARQEDTGEALTFTCAYLIPCTGYYNHDQGYLPDFPGQERFK
GLRIHPQHWPEELDYRGKRVVVIGSGATAVTLVPAMAGRAAHVTMLQRSPSYIFSVPAYDKISAALDRVLPTRWVYGLAR
WRNIRLQRLIYKAAKRWPRPVRSWLLSHVEKRVGGGVDMRHFTPKYNPWDERLCAVPDGDLFKVLREGKASVVTDHIETF
TESGILLKSGKTLEADIIVTATGLQLQSLGGMSLHVDGRQVEVGKTMTYKGVLMQDVPNFAYLFGYTNAPWTLKIDMAAN
YVCRLLKHMDAEGFQTVTAHAPGGEMLDESILGSLQSGYVQRGQDVLPRQGRALPWRVLHSFEADRDMLLKDGIVDSALV
FRRAASGADAAAVAGLAGGQPASA

Sequences:

>Translated_504_residues
MKTDFDVLIIGAGISGIGMACHLARECPDKRVGILERRRAIGGTWDLFRYPGIRSDSDMFSFGYQFRPWHEYKVLADGPS
IRQYVADTAREHGVDRLIRFGVRIDGASWSTERCRWTVSARQEDTGEALTFTCAYLIPCTGYYNHDQGYLPDFPGQERFK
GLRIHPQHWPEELDYRGKRVVVIGSGATAVTLVPAMAGRAAHVTMLQRSPSYIFSVPAYDKISAALDRVLPTRWVYGLAR
WRNIRLQRLIYKAAKRWPRPVRSWLLSHVEKRVGGGVDMRHFTPKYNPWDERLCAVPDGDLFKVLREGKASVVTDHIETF
TESGILLKSGKTLEADIIVTATGLQLQSLGGMSLHVDGRQVEVGKTMTYKGVLMQDVPNFAYLFGYTNAPWTLKIDMAAN
YVCRLLKHMDAEGFQTVTAHAPGGEMLDESILGSLQSGYVQRGQDVLPRQGRALPWRVLHSFEADRDMLLKDGIVDSALV
FRRAASGADAAAVAGLAGGQPASA
>Mature_504_residues
MKTDFDVLIIGAGISGIGMACHLARECPDKRVGILERRRAIGGTWDLFRYPGIRSDSDMFSFGYQFRPWHEYKVLADGPS
IRQYVADTAREHGVDRLIRFGVRIDGASWSTERCRWTVSARQEDTGEALTFTCAYLIPCTGYYNHDQGYLPDFPGQERFK
GLRIHPQHWPEELDYRGKRVVVIGSGATAVTLVPAMAGRAAHVTMLQRSPSYIFSVPAYDKISAALDRVLPTRWVYGLAR
WRNIRLQRLIYKAAKRWPRPVRSWLLSHVEKRVGGGVDMRHFTPKYNPWDERLCAVPDGDLFKVLREGKASVVTDHIETF
TESGILLKSGKTLEADIIVTATGLQLQSLGGMSLHVDGRQVEVGKTMTYKGVLMQDVPNFAYLFGYTNAPWTLKIDMAAN
YVCRLLKHMDAEGFQTVTAHAPGGEMLDESILGSLQSGYVQRGQDVLPRQGRALPWRVLHSFEADRDMLLKDGIVDSALV
FRRAASGADAAAVAGLAGGQPASA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17555726, Length=390, Percent_Identity=23.8461538461538, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56180; Mature: 56180

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDFDVLIIGAGISGIGMACHLARECPDKRVGILERRRAIGGTWDLFRYPGIRSDSDMF
CCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHH
SFGYQFRPWHEYKVLADGPSIRQYVADTAREHGVDRLIRFGVRIDGASWSTERCRWTVSA
HCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCEEEEEEC
RQEDTGEALTFTCAYLIPCTGYYNHDQGYLPDFPGQERFKGLRIHPQHWPEELDYRGKRV
CCCCCCCEEEEEEEEEEECCCCEECCCCCCCCCCCHHHCCCCCCCCCCCCHHHCCCCCEE
VVIGSGATAVTLVPAMAGRAAHVTMLQRSPSYIFSVPAYDKISAALDRVLPTRWVYGLAR
EEEECCCCEEEEHHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
WRNIRLQRLIYKAAKRWPRPVRSWLLSHVEKRVGGGVDMRHFTPKYNPWDERLCAVPDGD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCEEECCCCH
LFKVLREGKASVVTDHIETFTESGILLKSGKTLEADIIVTATGLQLQSLGGMSLHVDGRQ
HHHHHHCCCHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECCCEEECCCCEEEEECCCE
VEVGKTMTYKGVLMQDVPNFAYLFGYTNAPWTLKIDMAANYVCRLLKHMDAEGFQTVTAH
EECCCEEEECCCHHHCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEE
APGGEMLDESILGSLQSGYVQRGQDVLPRQGRALPWRVLHSFEADRDMLLKDGIVDSALV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCHHHHHH
FRRAASGADAAAVAGLAGGQPASA
HHHHCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKTDFDVLIIGAGISGIGMACHLARECPDKRVGILERRRAIGGTWDLFRYPGIRSDSDMF
CCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHH
SFGYQFRPWHEYKVLADGPSIRQYVADTAREHGVDRLIRFGVRIDGASWSTERCRWTVSA
HCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCEEEEEEC
RQEDTGEALTFTCAYLIPCTGYYNHDQGYLPDFPGQERFKGLRIHPQHWPEELDYRGKRV
CCCCCCCEEEEEEEEEEECCCCEECCCCCCCCCCCHHHCCCCCCCCCCCCHHHCCCCCEE
VVIGSGATAVTLVPAMAGRAAHVTMLQRSPSYIFSVPAYDKISAALDRVLPTRWVYGLAR
EEEECCCCEEEEHHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
WRNIRLQRLIYKAAKRWPRPVRSWLLSHVEKRVGGGVDMRHFTPKYNPWDERLCAVPDGD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCEEECCCCH
LFKVLREGKASVVTDHIETFTESGILLKSGKTLEADIIVTATGLQLQSLGGMSLHVDGRQ
HHHHHHCCCHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECCCEEECCCCEEEEECCCE
VEVGKTMTYKGVLMQDVPNFAYLFGYTNAPWTLKIDMAANYVCRLLKHMDAEGFQTVTAH
EECCCEEEECCCHHHCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEE
APGGEMLDESILGSLQSGYVQRGQDVLPRQGRALPWRVLHSFEADRDMLLKDGIVDSALV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCHHHHHH
FRRAASGADAAAVAGLAGGQPASA
HHHHCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]