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The map label for this gene is lysR [H]

Identifier: 189353548

GI number: 189353548

Start: 1785479

End: 1786426

Strand: Reverse

Name: lysR [H]

Synonym: BMULJ_04792

Alternate gene names: 189353548

Gene position: 1786426-1785479 (Counterclockwise)

Preceding gene: 189353550

Following gene: 189353547

Centisome position: 72.23

GC content: 69.83

Gene sequence:

>948_bases
GTGGCTTCGCTCACGCATCGTCATATCGAGGTGTTTCGCGCGCTGATGCTGAGCGGCAGCACGACGCGCGCGGCCGAGAT
GCTCTATACGTCGCAGCCGACGATCAGCCGCGAGCTCGCGCGGATGGAGCAGATCGTCGGCTTCGCGCTGTTCGAGCGCG
CGCACGGGCGGCTGCGGCCGACGATGGCCGCGCTGACGCTGTTCGACGACGTGCGGCTCGCGTATGTGGGGCTCGAGCGC
GTCGCGGCGACGGCCGCGCGGCTGCGCGAGTTTCGCGACGGCCAGCTGTCGGTGATCGCGCTGCCCGCGTTCGCGCATGC
GATCCTGCCGGGCGCTTGCCGGCGCTTTCGCGATGCGCATGCGGGCGTCAGCGTATCGGTCGCGACGCAGGAGTCGCCGG
TGCTCGAGGAGTGGTTGACGGCGCAGCGTTACGACATCGGACTGACCGAACACGATGTCGCGCCGCCCGGCACGTTGCTG
ACGCCGCTCCTGGAGGTGGACGAGGTCTGCGTGCTGCCGGACGGCCATCCGCTGCTCGCGCGCGAGGCGATCGATCTTGC
CGATCTCGCCGATCGCCCGTTCGTCAGCCTGTCGCTGAACGATCCGTACCGCGTCATGATCGACGACGCGTTCGCGCAAC
TCGGCGTCGCGCCGCGCTCGGTCGTCGAGACGCCGTCCGCGGTGTCGGTCTGCGCGTTCGTGCGGCAAGGGCTCGGCGCG
GCGATCGTCAATCCGCTGACCGCGCTCGATTTCGTCGGCCGCGACCTGCACGTGCGGCCGCTCACGCGTTCGTTTCCGTA
TCGCGTCAGCGTGATCGTTCCTGAACACCGGCCGAAAAGCCTGCTTGTCGATGCGTTCGCCGACGCGCTGCGCGGCGAAG
CGACGGCGATTCGCGAGCGGCTTGCCGCGCATCTCGGCACGCGTGCCGTGCACGCGCCGCGTGCGTAA

Upstream 100 bases:

>100_bases
CGGATGGATCGGTCGATTGAACGGACAGTCGCGATGATGCGCGCAATCTGCTATGCAGTAAAATGCCGATTTATCGACAT
TCAATTCATTCGGGATATAG

Downstream 100 bases:

>100_bases
GCGTTGCCGATGCGGCCGTCGCGCGACGCTCGTATGATCGCGGATATGCCGTCCCTGCCGACTCTGTCGTTACTTCAACG
GAATCCGTCATGACCGATGC

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MASLTHRHIEVFRALMLSGSTTRAAEMLYTSQPTISRELARMEQIVGFALFERAHGRLRPTMAALTLFDDVRLAYVGLER
VAATAARLREFRDGQLSVIALPAFAHAILPGACRRFRDAHAGVSVSVATQESPVLEEWLTAQRYDIGLTEHDVAPPGTLL
TPLLEVDEVCVLPDGHPLLAREAIDLADLADRPFVSLSLNDPYRVMIDDAFAQLGVAPRSVVETPSAVSVCAFVRQGLGA
AIVNPLTALDFVGRDLHVRPLTRSFPYRVSVIVPEHRPKSLLVDAFADALRGEATAIRERLAAHLGTRAVHAPRA

Sequences:

>Translated_315_residues
MASLTHRHIEVFRALMLSGSTTRAAEMLYTSQPTISRELARMEQIVGFALFERAHGRLRPTMAALTLFDDVRLAYVGLER
VAATAARLREFRDGQLSVIALPAFAHAILPGACRRFRDAHAGVSVSVATQESPVLEEWLTAQRYDIGLTEHDVAPPGTLL
TPLLEVDEVCVLPDGHPLLAREAIDLADLADRPFVSLSLNDPYRVMIDDAFAQLGVAPRSVVETPSAVSVCAFVRQGLGA
AIVNPLTALDFVGRDLHVRPLTRSFPYRVSVIVPEHRPKSLLVDAFADALRGEATAIRERLAAHLGTRAVHAPRA
>Mature_314_residues
ASLTHRHIEVFRALMLSGSTTRAAEMLYTSQPTISRELARMEQIVGFALFERAHGRLRPTMAALTLFDDVRLAYVGLERV
AATAARLREFRDGQLSVIALPAFAHAILPGACRRFRDAHAGVSVSVATQESPVLEEWLTAQRYDIGLTEHDVAPPGTLLT
PLLEVDEVCVLPDGHPLLAREAIDLADLADRPFVSLSLNDPYRVMIDDAFAQLGVAPRSVVETPSAVSVCAFVRQGLGAA
IVNPLTALDFVGRDLHVRPLTRSFPYRVSVIVPEHRPKSLLVDAFADALRGEATAIRERLAAHLGTRAVHAPRA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=292, Percent_Identity=49.3150684931507, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=27.2340425531915, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788887, Length=304, Percent_Identity=26.6447368421053, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787530, Length=247, Percent_Identity=25.9109311740891, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693105, Length=233, Percent_Identity=20.6008583690987, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788481, Length=243, Percent_Identity=27.1604938271605, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34356; Mature: 34225

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLTHRHIEVFRALMLSGSTTRAAEMLYTSQPTISRELARMEQIVGFALFERAHGRLRP
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TMAALTLFDDVRLAYVGLERVAATAARLREFRDGQLSVIALPAFAHAILPGACRRFRDAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
AGVSVSVATQESPVLEEWLTAQRYDIGLTEHDVAPPGTLLTPLLEVDEVCVLPDGHPLLA
CCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCHHH
REAIDLADLADRPFVSLSLNDPYRVMIDDAFAQLGVAPRSVVETPSAVSVCAFVRQGLGA
HHHHHHHHHCCCCEEEEECCCCEEEEEEHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCH
AIVNPLTALDFVGRDLHVRPLTRSFPYRVSVIVPEHRPKSLLVDAFADALRGEATAIRER
HHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
LAAHLGTRAVHAPRA
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
ASLTHRHIEVFRALMLSGSTTRAAEMLYTSQPTISRELARMEQIVGFALFERAHGRLRP
CCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TMAALTLFDDVRLAYVGLERVAATAARLREFRDGQLSVIALPAFAHAILPGACRRFRDAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
AGVSVSVATQESPVLEEWLTAQRYDIGLTEHDVAPPGTLLTPLLEVDEVCVLPDGHPLLA
CCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCHHH
REAIDLADLADRPFVSLSLNDPYRVMIDDAFAQLGVAPRSVVETPSAVSVCAFVRQGLGA
HHHHHHHHHCCCCEEEEECCCCEEEEEEHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCH
AIVNPLTALDFVGRDLHVRPLTRSFPYRVSVIVPEHRPKSLLVDAFADALRGEATAIRER
HHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
LAAHLGTRAVHAPRA
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]