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The map label for this gene is hsrA [H]

Identifier: 189353541

GI number: 189353541

Start: 1779109

End: 1780524

Strand: Direct

Name: hsrA [H]

Synonym: BMULJ_04785

Alternate gene names: 189353541

Gene position: 1779109-1780524 (Clockwise)

Preceding gene: 189353539

Following gene: 189353542

Centisome position: 71.94

GC content: 68.22

Gene sequence:

>1416_bases
ATGACGCCTTTACCGCGCGCCCAGCCCATGTCGCCCGTCTTCCTAGCACCGCTCATCGTTGCCTGTGCGTTGTTCATGGA
AAGCGTCGACGCGAACATCATCGTCACCGCGCTGCCCGCGATGGCGAGGGACTTCGGGCACAATCCCGTCACGCTGAACA
TCGCGATCACGGCCTACGTGGTCGGCCTCGGCGTGTTCATCCCGATCTGCGGCTGGCTCGCCGACCGCTTCAGCGCACGC
GCGGTGTTCCGCACCGCGATCGGCATCTTCGTCGCCGGCTCGCTACTCTGCGCCGCATCCAATTCCCTCGGCCTGCTCAC
GTTCGCGCGCTTCGTGCAGGGCGTCGGCGGCGCGATGATGGTGCCGGTCGGCCGGATCATCATCTTCCGCGCGGTGCCGC
GCTCCGATCTTGTGCGCGCGATGAACTACCTCGCGATTCCCGCGCTGTTCGGGCCGACCGTCGGGCCGCTCGTCGGCGGC
TTCATCACGACGTATCTGCACTGGCGGATGATCTTCTTCATCAACGTGCCGATCGGTCTGTACGGGATCTACCTCGCGAC
GCGGCACATCGCGAACACGCACGAGCCCGATCCGGGCCCGCTCGACTGGTTCGGCTTCCTGCTCTCGGCAAGCGGCGCCG
CGCTGCTGCTAATGGGGCTCACGCTGATCGACGGCGCGCTCACGACCCGCACGAACGCGCTCGCGATGTGCGCGACCGGT
GCGGTGCTGCTCGCGCTCTACGTGCCGTACGCGCGACGCAAGGAACGGCCGGTGCTCGATCTGAGCTTCCTGAAGATTCC
GACGTACCACGCGAGCGTCGTCGGCGGATCGCTGTTCCGGATCGGGCTCGGCGCGGTGCCGTTCCTGCTGCCGCTCGCGC
TGCAGGAAGGGCTCGGCATGAGCGCGTTCCATTCTGGGCTGATCACCTGCGCGTCGGCGCTCGGCGGCGCCGTGAGCCGC
TCGACCGCCACGCATACGCTGCGCCGCTTCGGCTTTCGCACCGTGCTGATCTACAACGCCGCGTTCGCGGGCCTCGCGAT
CGCCGCGTACGGCGTGTTCCATCCGGGCATGCCGACCTGGGCGATCTGGGTCATCGTGCTCGTCGGCGGGATTTTCCCGG
CGCTGCAGTTCACGAGCCTGAACTCGATGATCTACGCGGACATCTCGCCGCGCGACGCGGGCCGCGCCACGAGCCTCGGC
AGCGTCGTGCAGCAGATGTCGCTCGGGCTCGGCGTGACGGTCGCCGGTCTCGTGCTGCACCTGTCGCACTGGCTGCAGGG
CCATCAGGCGATGGTGTGGTCGGATTTCTGGCCCGCGTTCGTCGTGGTCGGGCTGTGCTCGTTCGCGTCGATTCCGATCA
CGCGCCGGCTGCCGCCCGGTGCCGGCGACGAAGTCGCGCGCGGCAAGCGGCAGTAG

Upstream 100 bases:

>100_bases
CGCGCAGTCGTCCTTTTTCCGCGCGCGGCGCAGGAACGACTATTGCAACATGCGGAACAAGCGTTGTCGTACGTGACGCG
GCGACAACAATATGGGCATA

Downstream 100 bases:

>100_bases
ACGGCCGCGCGGGCGAACGCCGAACGCCGAACGCTCGAACGCGCTCGCTGCAGAAACGGAATCGGAAAAAAATCAGCGGA
CATCCACATGGGGCCGGTGC

Product: permease of the major facilitator superfamily

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTPLPRAQPMSPVFLAPLIVACALFMESVDANIIVTALPAMARDFGHNPVTLNIAITAYVVGLGVFIPICGWLADRFSAR
AVFRTAIGIFVAGSLLCAASNSLGLLTFARFVQGVGGAMMVPVGRIIIFRAVPRSDLVRAMNYLAIPALFGPTVGPLVGG
FITTYLHWRMIFFINVPIGLYGIYLATRHIANTHEPDPGPLDWFGFLLSASGAALLLMGLTLIDGALTTRTNALAMCATG
AVLLALYVPYARRKERPVLDLSFLKIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSGLITCASALGGAVSR
STATHTLRRFGFRTVLIYNAAFAGLAIAAYGVFHPGMPTWAIWVIVLVGGIFPALQFTSLNSMIYADISPRDAGRATSLG
SVVQQMSLGLGVTVAGLVLHLSHWLQGHQAMVWSDFWPAFVVVGLCSFASIPITRRLPPGAGDEVARGKRQ

Sequences:

>Translated_471_residues
MTPLPRAQPMSPVFLAPLIVACALFMESVDANIIVTALPAMARDFGHNPVTLNIAITAYVVGLGVFIPICGWLADRFSAR
AVFRTAIGIFVAGSLLCAASNSLGLLTFARFVQGVGGAMMVPVGRIIIFRAVPRSDLVRAMNYLAIPALFGPTVGPLVGG
FITTYLHWRMIFFINVPIGLYGIYLATRHIANTHEPDPGPLDWFGFLLSASGAALLLMGLTLIDGALTTRTNALAMCATG
AVLLALYVPYARRKERPVLDLSFLKIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSGLITCASALGGAVSR
STATHTLRRFGFRTVLIYNAAFAGLAIAAYGVFHPGMPTWAIWVIVLVGGIFPALQFTSLNSMIYADISPRDAGRATSLG
SVVQQMSLGLGVTVAGLVLHLSHWLQGHQAMVWSDFWPAFVVVGLCSFASIPITRRLPPGAGDEVARGKRQ
>Mature_470_residues
TPLPRAQPMSPVFLAPLIVACALFMESVDANIIVTALPAMARDFGHNPVTLNIAITAYVVGLGVFIPICGWLADRFSARA
VFRTAIGIFVAGSLLCAASNSLGLLTFARFVQGVGGAMMVPVGRIIIFRAVPRSDLVRAMNYLAIPALFGPTVGPLVGGF
ITTYLHWRMIFFINVPIGLYGIYLATRHIANTHEPDPGPLDWFGFLLSASGAALLLMGLTLIDGALTTRTNALAMCATGA
VLLALYVPYARRKERPVLDLSFLKIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSGLITCASALGGAVSRS
TATHTLRRFGFRTVLIYNAAFAGLAIAAYGVFHPGMPTWAIWVIVLVGGIFPALQFTSLNSMIYADISPRDAGRATSLGS
VVQQMSLGLGVTVAGLVLHLSHWLQGHQAMVWSDFWPAFVVVGLCSFASIPITRRLPPGAGDEVARGKRQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=455, Percent_Identity=36.7032967032967, Blast_Score=304, Evalue=7e-84,
Organism=Escherichia coli, GI1788392, Length=464, Percent_Identity=34.9137931034483, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1789042, Length=430, Percent_Identity=24.4186046511628, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI87081983, Length=414, Percent_Identity=25.6038647342995, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788710, Length=296, Percent_Identity=25.3378378378378, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325455, Length=278, Percent_Identity=26.978417266187, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322958, Length=231, Percent_Identity=29.4372294372294, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50062; Mature: 49931

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLPRAQPMSPVFLAPLIVACALFMESVDANIIVTALPAMARDFGHNPVTLNIAITAYV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCEEEEEHHHHHH
VGLGVFIPICGWLADRFSARAVFRTAIGIFVAGSLLCAASNSLGLLTFARFVQGVGGAMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEH
VPVGRIIIFRAVPRSDLVRAMNYLAIPALFGPTVGPLVGGFITTYLHWRMIFFINVPIGL
HHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCHHH
YGIYLATRHIANTHEPDPGPLDWFGFLLSASGAALLLMGLTLIDGALTTRTNALAMCATG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHH
AVLLALYVPYARRKERPVLDLSFLKIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGM
HHHHHHHCCHHHCCCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCH
SAFHSGLITCASALGGAVSRSTATHTLRRFGFRTVLIYNAAFAGLAIAAYGVFHPGMPTW
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCHHH
AIWVIVLVGGIFPALQFTSLNSMIYADISPRDAGRATSLGSVVQQMSLGLGVTVAGLVLH
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
LSHWLQGHQAMVWSDFWPAFVVVGLCSFASIPITRRLPPGAGDEVARGKRQ
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure 
TPLPRAQPMSPVFLAPLIVACALFMESVDANIIVTALPAMARDFGHNPVTLNIAITAYV
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCEEEEEHHHHHH
VGLGVFIPICGWLADRFSARAVFRTAIGIFVAGSLLCAASNSLGLLTFARFVQGVGGAMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEH
VPVGRIIIFRAVPRSDLVRAMNYLAIPALFGPTVGPLVGGFITTYLHWRMIFFINVPIGL
HHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCHHH
YGIYLATRHIANTHEPDPGPLDWFGFLLSASGAALLLMGLTLIDGALTTRTNALAMCATG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHH
AVLLALYVPYARRKERPVLDLSFLKIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGM
HHHHHHHCCHHHCCCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCH
SAFHSGLITCASALGGAVSRSTATHTLRRFGFRTVLIYNAAFAGLAIAAYGVFHPGMPTW
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCHHH
AIWVIVLVGGIFPALQFTSLNSMIYADISPRDAGRATSLGSVVQQMSLGLGVTVAGLVLH
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
LSHWLQGHQAMVWSDFWPAFVVVGLCSFASIPITRRLPPGAGDEVARGKRQ
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]