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The map label for this gene is iorB [H]

Identifier: 189353515

GI number: 189353515

Start: 1736816

End: 1739032

Strand: Direct

Name: iorB [H]

Synonym: BMULJ_04759

Alternate gene names: 189353515

Gene position: 1736816-1739032 (Clockwise)

Preceding gene: 189353514

Following gene: 189353516

Centisome position: 70.23

GC content: 70.46

Gene sequence:

>2217_bases
ATGACGATCGAACTCGATACGCGCGATTCGGTGCGTCCGTCGCGCCGCACGTTCCTGAAGGCCGCGGGCGCCGCGGCCGC
GGTCAGCCTGACGATCGGCTTCGAATGGGCCGGCCTCGGCCGGCGCGCGCTCGCCGCGACGACCGCGCCCGAGGCCGGCG
CATTCGCGCCGAACGCGTTCCTGCGCGTCACGCCCGACGGCGCGGTGACGGTGATCGCGAAGCACGTCGAACTCGGCCAG
GGCGCCTATACGGGCATCGCGACGATCGTCGCCGAGGAGCTCGACGCCGACTGGTCGCGCGTGCGCGTCGAAAGCGCGCC
GGCCGACGCGAAGCGCTACGCGAACCTCGCATTCGGCACGATGCAGGGCACGGGCGGCAGCTCGGCGATGTCGAACTCGT
GGCAGCAGCTGCGCGAAGCCGGCGGCAAGGCGCGCGCGATGCTCGTGTCGGCGGCCGCCGCGCGCTGGAACGTGCCGGCA
AGCGAATTGACGACCGCGAACGGCGTCGTCACGCACGCGAAAAGCGGCAAGACGGCCGCCTACGGCACGCTCGTCGCCGA
CGCATCGAAGCTGCCGGTACCGGACAAGGTCGTGCTGAAGCAGCCGGCCGACTTCAAGCTGATCGGCCATCGCATTCCGC
GCGTCGACGCATCGGCGAAATCGAACGGCACCGCGCATTTCACGCTCGACACGACGTTCCCCGGCATGCGCGTCGCGCTG
CTGCAGCGCCCGCCGCGCTTCGGCGCGACCGTGAAGTCGTTCGACGCGACGGCCGCGAAGGCCGTGCCGGGCGTGGTGTC
GGTCGTGCAGGTGCCGGCCGGTATCGCGGTCGTCGCAACGGGCTTCTGGGCCGCGAAACAGGGCCGCGACGCGCTGAAGG
TCGAATGGGACGAAACGCACGCCGAAAAGCGCGGCTCGGACGAGATCATGCGCGAATACCGGCAGCTGGCCGCCAAGCCC
GGCGCATCGGCGCGCAAGGACGGCGATGCCGACGCGGCGATCGCGGGCGCCGCGCGCAAGATCAGCGCGAGCTACGAGTT
CCCGTATCTCGCGCATGCGCCGATGGAGCCGCTCGACGCGGTCGTCAAGCTGACCAAGGACAGCTGCGAGATCTGGGCCG
GCGACCAGTTCCAGACGGTCGACCAGGGCAACGCGGCCAAGGTCGCGGGCCTCAAGCCCGAGCAGGTGCAGATCCATACG
CTCTACGCGGGCGGCAGCTTCGGCCGGCGTGCGAATGCGTGGTCGGACTACGTCGTCGAGGCCGTGTCGATCGCGAAGGC
GCTCGGCGCGGACGGCAAGCCGGTCAAGCTGCAGTGGACGCGCGAGGACGACATCCAGGGCGGCTTCTATCGCCCGATGT
ACTTCCACAAGCTCGATGCGGGGCTGACCGCCGACGGCCGGCTGGTGGGCTGGCGTCACCGGATCGTCGGCCAGTCGATC
CTCGCCGGCACGCCGTTCGAGGCCTTCATGGTCAAGAACGGCATCGACGCGACGTCGGTCGAGGGGGCGGCGAACCTGCC
GTACGCGGTGCCGAACGTGTCGGTCGAACTGACGACCACCAAGGTCGGCCTGCCCGTGCTCTGGTGGCGCGTGGTCGGCA
GCTCGCACACGGCCTACGCGGTCGAGGCGTTCATCGACGAAGCCGCGCACGCGGCCGGCAAGGATCCGTACCTGTTCCGC
CGCGACCTGCTCGCCAAGGAGCCGCGCATGCGGGCGGTGCTGGGGCTGGCCGCGCAGAAGGCCGGCTGGGATCCGGCGAA
GCCGCTGCCGAAAGGTCGCGGACGCGGGATCGCGGTGGCCGAGGCGTTCAAGAGCTATGTCGCGCAGGTCGCCGAGGTGT
CGGTCGATGCGGACGGCAAGGTGAAGGTCGAGCGCGTGGTCTGCGCCGTCGATTGCGGGATCGCGATCAATCCCGACATC
GTCGCCGCGCAGATGGAAGGCGGTATCGGCTTCGGGCTCGGCGCGGCGATGCACAGCGCCATCACGCTGAAGGACGGGCG
CGTCGAGCAGCGCAACTTCGACGGCTATCAGGTGCTGCGGATGGCCGAGATGCCGAAGGTCGAGGTGCATATCGTGCCGT
CCGCCGAAGCGCCGACCGGCGTCGGCGAGCCGGGCGTCGCGCCGATCGGGCCGGCGGTCGCGAACGCGATCTTCGCGGCC
ACCGGCAAGCGGCACTACGTGCTGCCGTTCGATTCGGGCACGAACGCGAGCGCTTGA

Upstream 100 bases:

>100_bases
ACATCGATGCGGCGATGAACGGCAACCTGTGCCGCTGTGCGACCTACGCGCGGATCCGCGCGGCGATCCACGACGCGGCC
GCGACGCTGGGAGCGTGACC

Downstream 100 bases:

>100_bases
TGGCTTGATGGCTTGATCGCCTGCGCCGGTCGGCCGCGCACACTGTGCGGCGGCCGGCGCGGCGGCTGGCCTCGTCGCAT
TCGCTGGCTTCGCTACCTTT

Product: isoquinoline 1-oxidoreductase, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MTIELDTRDSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATTAPEAGAFAPNAFLRVTPDGAVTVIAKHVELGQ
GAYTGIATIVAEELDADWSRVRVESAPADAKRYANLAFGTMQGTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWNVPA
SELTTANGVVTHAKSGKTAAYGTLVADASKLPVPDKVVLKQPADFKLIGHRIPRVDASAKSNGTAHFTLDTTFPGMRVAL
LQRPPRFGATVKSFDATAAKAVPGVVSVVQVPAGIAVVATGFWAAKQGRDALKVEWDETHAEKRGSDEIMREYRQLAAKP
GASARKDGDADAAIAGAARKISASYEFPYLAHAPMEPLDAVVKLTKDSCEIWAGDQFQTVDQGNAAKVAGLKPEQVQIHT
LYAGGSFGRRANAWSDYVVEAVSIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGRLVGWRHRIVGQSI
LAGTPFEAFMVKNGIDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYAVEAFIDEAAHAAGKDPYLFR
RDLLAKEPRMRAVLGLAAQKAGWDPAKPLPKGRGRGIAVAEAFKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDI
VAAQMEGGIGFGLGAAMHSAITLKDGRVEQRNFDGYQVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPIGPAVANAIFAA
TGKRHYVLPFDSGTNASA

Sequences:

>Translated_738_residues
MTIELDTRDSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATTAPEAGAFAPNAFLRVTPDGAVTVIAKHVELGQ
GAYTGIATIVAEELDADWSRVRVESAPADAKRYANLAFGTMQGTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWNVPA
SELTTANGVVTHAKSGKTAAYGTLVADASKLPVPDKVVLKQPADFKLIGHRIPRVDASAKSNGTAHFTLDTTFPGMRVAL
LQRPPRFGATVKSFDATAAKAVPGVVSVVQVPAGIAVVATGFWAAKQGRDALKVEWDETHAEKRGSDEIMREYRQLAAKP
GASARKDGDADAAIAGAARKISASYEFPYLAHAPMEPLDAVVKLTKDSCEIWAGDQFQTVDQGNAAKVAGLKPEQVQIHT
LYAGGSFGRRANAWSDYVVEAVSIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGRLVGWRHRIVGQSI
LAGTPFEAFMVKNGIDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYAVEAFIDEAAHAAGKDPYLFR
RDLLAKEPRMRAVLGLAAQKAGWDPAKPLPKGRGRGIAVAEAFKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDI
VAAQMEGGIGFGLGAAMHSAITLKDGRVEQRNFDGYQVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPIGPAVANAIFAA
TGKRHYVLPFDSGTNASA
>Mature_737_residues
TIELDTRDSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATTAPEAGAFAPNAFLRVTPDGAVTVIAKHVELGQG
AYTGIATIVAEELDADWSRVRVESAPADAKRYANLAFGTMQGTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWNVPAS
ELTTANGVVTHAKSGKTAAYGTLVADASKLPVPDKVVLKQPADFKLIGHRIPRVDASAKSNGTAHFTLDTTFPGMRVALL
QRPPRFGATVKSFDATAAKAVPGVVSVVQVPAGIAVVATGFWAAKQGRDALKVEWDETHAEKRGSDEIMREYRQLAAKPG
ASARKDGDADAAIAGAARKISASYEFPYLAHAPMEPLDAVVKLTKDSCEIWAGDQFQTVDQGNAAKVAGLKPEQVQIHTL
YAGGSFGRRANAWSDYVVEAVSIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGRLVGWRHRIVGQSIL
AGTPFEAFMVKNGIDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYAVEAFIDEAAHAAGKDPYLFRR
DLLAKEPRMRAVLGLAAQKAGWDPAKPLPKGRGRGIAVAEAFKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIV
AAQMEGGIGFGLGAAMHSAITLKDGRVEQRNFDGYQVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPIGPAVANAIFAAT
GKRHYVLPFDSGTNASA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786478, Length=503, Percent_Identity=23.8568588469185, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 77762; Mature: 77631

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIELDTRDSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATTAPEAGAFAPNAF
CEEEECCCCCCCHHHHHHHHHCCCEEEEEEEEEEEECCCCCHHEEECCCCCCCCCCCCCE
LRVTPDGAVTVIAKHVELGQGAYTGIATIVAEELDADWSRVRVESAPADAKRYANLAFGT
EEECCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHEEEEE
MQGTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWNVPASELTTANGVVTHAKSGKTAA
ECCCCCCHHHHHHHHHHHHCCCHHEEHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCEE
YGTLVADASKLPVPDKVVLKQPADFKLIGHRIPRVDASAKSNGTAHFTLDTTFPGMRVAL
EEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LQRPPRFGATVKSFDATAAKAVPGVVSVVQVPAGIAVVATGFWAAKQGRDALKVEWDETH
ECCCCCCCCCHHHCCCHHHHHCCHHHHHHHCCCCEEEEEECHHHHCCCCCCEEEEECHHH
AEKRGSDEIMREYRQLAAKPGASARKDGDADAAIAGAARKISASYEFPYLAHAPMEPLDA
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHH
VVKLTKDSCEIWAGDQFQTVDQGNAAKVAGLKPEQVQIHTLYAGGSFGRRANAWSDYVVE
HHHHCCCCCEEECCCCEEECCCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHH
AVSIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGRLVGWRHRIVGQSI
HHHHHHHHCCCCCEEEEEECCCCCCCCCEECCEEEEECCCCCCCCCCEEEEHHHHHCCHH
LAGTPFEAFMVKNGIDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYA
HCCCCHHHHHEECCCCCCCCCCCCCCCEECCCCEEEEEEEECCCCEEEEEECCCCCCHHH
VEAFIDEAAHAAGKDPYLFRRDLLAKEPRMRAVLGLAAQKAGWDPAKPLPKGRGRGIAVA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
EAFKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIVAAQMEGGIGFGLGAAMHSA
HHHHHHHHHHHHEECCCCCCEEEEEEEEEEECCEEECCCEEEEEECCCCCCCHHHHHHHE
ITLKDGRVEQRNFDGYQVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPIGPAVANAIFAA
EEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHC
TGKRHYVLPFDSGTNASA
CCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
TIELDTRDSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATTAPEAGAFAPNAF
EEEECCCCCCCHHHHHHHHHCCCEEEEEEEEEEEECCCCCHHEEECCCCCCCCCCCCCE
LRVTPDGAVTVIAKHVELGQGAYTGIATIVAEELDADWSRVRVESAPADAKRYANLAFGT
EEECCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHEEEEE
MQGTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWNVPASELTTANGVVTHAKSGKTAA
ECCCCCCHHHHHHHHHHHHCCCHHEEHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCEE
YGTLVADASKLPVPDKVVLKQPADFKLIGHRIPRVDASAKSNGTAHFTLDTTFPGMRVAL
EEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LQRPPRFGATVKSFDATAAKAVPGVVSVVQVPAGIAVVATGFWAAKQGRDALKVEWDETH
ECCCCCCCCCHHHCCCHHHHHCCHHHHHHHCCCCEEEEEECHHHHCCCCCCEEEEECHHH
AEKRGSDEIMREYRQLAAKPGASARKDGDADAAIAGAARKISASYEFPYLAHAPMEPLDA
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHH
VVKLTKDSCEIWAGDQFQTVDQGNAAKVAGLKPEQVQIHTLYAGGSFGRRANAWSDYVVE
HHHHCCCCCEEECCCCEEECCCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHH
AVSIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGRLVGWRHRIVGQSI
HHHHHHHHCCCCCEEEEEECCCCCCCCCEECCEEEEECCCCCCCCCCEEEEHHHHHCCHH
LAGTPFEAFMVKNGIDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYA
HCCCCHHHHHEECCCCCCCCCCCCCCCEECCCCEEEEEEEECCCCEEEEEECCCCCCHHH
VEAFIDEAAHAAGKDPYLFRRDLLAKEPRMRAVLGLAAQKAGWDPAKPLPKGRGRGIAVA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
EAFKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIVAAQMEGGIGFGLGAAMHSA
HHHHHHHHHHHHEECCCCCCEEEEEEEEEEECCEEECCCEEEEEECCCCCCCHHHHHHHE
ITLKDGRVEQRNFDGYQVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPIGPAVANAIFAA
EEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHC
TGKRHYVLPFDSGTNASA
CCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]