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The map label for this gene is iorA [H]

Identifier: 189353514

GI number: 189353514

Start: 1736352

End: 1736813

Strand: Direct

Name: iorA [H]

Synonym: BMULJ_04758

Alternate gene names: 189353514

Gene position: 1736352-1736813 (Clockwise)

Preceding gene: 189353512

Following gene: 189353515

Centisome position: 70.21

GC content: 68.83

Gene sequence:

>462_bases
ATGGCCACTACGTTTGTCCTGAACGGCAAGAGCGTGACGCTCGATGCCGATCCGTCGATGCCCGTCCTCTGGGCGATCCG
CGAGCACGCGGGGCTGACCGGCACGAAATTCGGCTGCGGGATGGCGCAGTGCGGCGCGTGCACGATCCACCTCGAAGGCC
AGCCCGTGCGCTCGTGCGTGCTGCCGCTCGCCGGCATCGCCGACAAGCACGTGACGACGATCGAAGGCCTGCAGAGCAAG
CCCGCGCAGGCCGTGCAGGCCGCCTGGGTGAAGCTGCAGGTGCCGCAATGCGGCTACTGTCAGTCCGGGCAGATCATGTC
CGCCACCGCGCTGCTCGAGCAGAACCCGAAACCGACCGACGCCGACATCGATGCGGCGATGAACGGCAACCTGTGCCGCT
GTGCGACCTACGCGCGGATCCGCGCGGCGATCCACGACGCGGCCGCGACGCTGGGAGCGTGA

Upstream 100 bases:

>100_bases
CAAGAAATTTGCAGGATTGGGTAGACGAAAACGGCGGCAGCTCGCGCACACTGCCGGCTATCCCGGCCCGGCGCCGGGTT
TTCCCCACGGAGACACCCCC

Downstream 100 bases:

>100_bases
CCATGACGATCGAACTCGATACGCGCGATTCGGTGCGTCCGTCGCGCCGCACGTTCCTGAAGGCCGCGGGCGCCGCGGCC
GCGGTCAGCCTGACGATCGG

Product: isoquinoline 1-oxidoreductase, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MATTFVLNGKSVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTIHLEGQPVRSCVLPLAGIADKHVTTIEGLQSK
PAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTDADIDAAMNGNLCRCATYARIRAAIHDAAATLGA

Sequences:

>Translated_153_residues
MATTFVLNGKSVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTIHLEGQPVRSCVLPLAGIADKHVTTIEGLQSK
PAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTDADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
>Mature_152_residues
ATTFVLNGKSVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTIHLEGQPVRSCVLPLAGIADKHVTTIEGLQSKP
AQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTDADIDAAMNGNLCRCATYARIRAAIHDAAATLGA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=149, Percent_Identity=38.255033557047, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI71773480, Length=107, Percent_Identity=34.5794392523364, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786480, Length=167, Percent_Identity=38.9221556886228, Blast_Score=108, Evalue=1e-25,
Organism=Escherichia coli, GI1789232, Length=147, Percent_Identity=36.734693877551, Blast_Score=85, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=156, Percent_Identity=41.025641025641, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17539860, Length=153, Percent_Identity=35.2941176470588, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32566215, Length=161, Percent_Identity=34.1614906832298, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17737937, Length=149, Percent_Identity=36.9127516778523, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24647201, Length=158, Percent_Identity=34.8101265822785, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24647199, Length=158, Percent_Identity=36.7088607594937, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647193, Length=164, Percent_Identity=37.1951219512195, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24647197, Length=164, Percent_Identity=30.4878048780488, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24647195, Length=164, Percent_Identity=30.4878048780488, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15951; Mature: 15819

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTFVLNGKSVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTIHLEGQPVRSCV
CCEEEEECCCEEEEECCCCCCEEEEEHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHH
LPLAGIADKHVTTIEGLQSKPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
HHHCCCCCCCHHHHHCCCCCHHHHHHEEEEEEECCCCCCCCCCCEEEEHHHHHCCCCCCC
ADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATTFVLNGKSVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTIHLEGQPVRSCV
CEEEEECCCEEEEECCCCCCEEEEEHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHH
LPLAGIADKHVTTIEGLQSKPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
HHHCCCCCCCHHHHHCCCCCHHHHHHEEEEEEECCCCCCCCCCCEEEEHHHHHCCCCCCC
ADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]