Click here to switch to the map view.

The map label for this gene is bioA [C]

Identifier: 189353455

GI number: 189353455

Start: 1671695

End: 1673035

Strand: Reverse

Name: bioA [C]

Synonym: BMULJ_04698

Alternate gene names: 189353455

Gene position: 1673035-1671695 (Counterclockwise)

Preceding gene: 189353456

Following gene: 189353454

Centisome position: 67.65

GC content: 67.79

Gene sequence:

>1341_bases
ATGAGCTACAACGAAGCGAAATTCTGGCACCCGATGCTGCATCCGAACGAAATGAAGCGGCGCAAGCCGATCCGCATCGT
ACGCGGCGACGGCTGCTACGTGTTCGACGAGGACGGCAAGGCGCTCGTCGACGGCGTCGCGGGCCTGTGGAACGTGAACG
TCGGGCACAACCGCCGCGAAGTGAAGGACGCGATCGTGCGCCAGCTCGACGAGCTCGAATACTTCCAGCTGTTCGACGGG
ATCACGCATCCGCGCGCGGAGGAACTGTCGAAGCGGCTGATCGATCTGCTCGAGCCCGAAGGCATGCGCCGCGTGCTGTA
CAGCTCGGGCGGCTCAGATTCGGTCGAGACCGCGCTGAAGATCGCGCGCCAGTACTGGAAGGTGCGCGGCCAGGCCGATC
GCACGAAGTTCATCTCGCTGAAGCAGGGCTATCACGGCACGCACTTCGGCGGCGCGTCGGTGAACGGCAACACGGTGTTT
CGCCGCAACTACGAGCCGAATCTGCCGGGGTGCTTCCACGTCGAGACGCCGTGGCTGTACCGCAACCCGTTCACGCAGGA
TCCGGAAGAACTCGGCCGCATTTGCGCGGCGCTGCTGGAACGCGAGATCCAGTTCCAGAGCCCCGATACGGTCGCGGCGT
TCATCGCGGAGCCGATCCAGGGCGCGGGCGGTGTGATCGTGCCGCCGGCGAACTACTGGCCGCTCGTGCGCGAGGTCTGC
GACCGCTACGGCGTGCTGCTGATCGCCGACGAAGTCGTCACGGGCTTCGGCCGCAGCGGCAGCCTGTTCGGCAGCCGCGG
CTGGGGCGTGCGTCCGGACATCATGTGTCTCGCGAAGGGCATTTCCTCAGGCTACGTGCCGCTCGGCGCGACGGCCGTGA
ACGCGCGAATCGAGGACGCGTTCGCGCAGAACGCCGACTTCGGCGGCGCGATCATGCACGGCTACACGTACGCGGGCCAT
CCGGTCGCCTGCGCGGCGGCGCTCGCGAGCCTCGACATCGTCGTGAACGAAGACCTGCCGGCGAACGCCGCGAAGCAGGG
CGCCTATCTGCTCGAAGCGCTGCAGCCGTTCGTGGAGCGTTTCGCGGCGGTCGGCGAGGTGCGCGGCAAGGGGCTGATGC
TCGCGCTCGATCTGGTCGCGGACAAGACGACGCGCGAGCCGATCGACCCGCTGTCGGGCTATGCGAACGCGGTGGCCGAA
GTCGCGCGCGAGCACGGCGTGCTGGTGCGGCCGGTCGGCACGAAGATCATCCTGTCGCCGCCGCTCGTGATCGAGCGGCC
CGAACTCGACCGGATCGTCGACGCGCTCGCCGCGGGCTTCGAGGCCGTACCGGTCGCATGA

Upstream 100 bases:

>100_bases
CGGCCAGTACGCGATCGAGGGCTTCACCGAAACCAAATCCGTGTGCATCGCGCACTGATCGCGCGATACCGGCACCCAAC
CATCCGAACTGGAGATTGCA

Downstream 100 bases:

>100_bases
CGGCGCCGGCACGGGCGTCGCGGATTGCGCAGGCGCCGCGGCCCGCGCCCGCCCACCGGTTTGCCGATTTGCGCTATCCC
GCCGCATTTTTGCCTGCGTA

Product: hypothetical protein

Products: L-Glutamate; L-Glutamate 5-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSYNEAKFWHPMLHPNEMKRRKPIRIVRGDGCYVFDEDGKALVDGVAGLWNVNVGHNRREVKDAIVRQLDELEYFQLFDG
ITHPRAEELSKRLIDLLEPEGMRRVLYSSGGSDSVETALKIARQYWKVRGQADRTKFISLKQGYHGTHFGGASVNGNTVF
RRNYEPNLPGCFHVETPWLYRNPFTQDPEELGRICAALLEREIQFQSPDTVAAFIAEPIQGAGGVIVPPANYWPLVREVC
DRYGVLLIADEVVTGFGRSGSLFGSRGWGVRPDIMCLAKGISSGYVPLGATAVNARIEDAFAQNADFGGAIMHGYTYAGH
PVACAAALASLDIVVNEDLPANAAKQGAYLLEALQPFVERFAAVGEVRGKGLMLALDLVADKTTREPIDPLSGYANAVAE
VAREHGVLVRPVGTKIILSPPLVIERPELDRIVDALAAGFEAVPVA

Sequences:

>Translated_446_residues
MSYNEAKFWHPMLHPNEMKRRKPIRIVRGDGCYVFDEDGKALVDGVAGLWNVNVGHNRREVKDAIVRQLDELEYFQLFDG
ITHPRAEELSKRLIDLLEPEGMRRVLYSSGGSDSVETALKIARQYWKVRGQADRTKFISLKQGYHGTHFGGASVNGNTVF
RRNYEPNLPGCFHVETPWLYRNPFTQDPEELGRICAALLEREIQFQSPDTVAAFIAEPIQGAGGVIVPPANYWPLVREVC
DRYGVLLIADEVVTGFGRSGSLFGSRGWGVRPDIMCLAKGISSGYVPLGATAVNARIEDAFAQNADFGGAIMHGYTYAGH
PVACAAALASLDIVVNEDLPANAAKQGAYLLEALQPFVERFAAVGEVRGKGLMLALDLVADKTTREPIDPLSGYANAVAE
VAREHGVLVRPVGTKIILSPPLVIERPELDRIVDALAAGFEAVPVA
>Mature_445_residues
SYNEAKFWHPMLHPNEMKRRKPIRIVRGDGCYVFDEDGKALVDGVAGLWNVNVGHNRREVKDAIVRQLDELEYFQLFDGI
THPRAEELSKRLIDLLEPEGMRRVLYSSGGSDSVETALKIARQYWKVRGQADRTKFISLKQGYHGTHFGGASVNGNTVFR
RNYEPNLPGCFHVETPWLYRNPFTQDPEELGRICAALLEREIQFQSPDTVAAFIAEPIQGAGGVIVPPANYWPLVREVCD
RYGVLLIADEVVTGFGRSGSLFGSRGWGVRPDIMCLAKGISSGYVPLGATAVNARIEDAFAQNADFGGAIMHGYTYAGHP
VACAAALASLDIVVNEDLPANAAKQGAYLLEALQPFVERFAAVGEVRGKGLMLALDLVADKTTREPIDPLSGYANAVAEV
AREHGVLVRPVGTKIILSPPLVIERPELDRIVDALAAGFEAVPVA

Specific function: Unknown

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=31.9905213270142, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=31.9905213270142, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=28.9592760180996, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=31.4578005115089, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=30.3102625298329, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI24119277, Length=430, Percent_Identity=27.906976744186, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=32.8267477203647, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI145693181, Length=418, Percent_Identity=32.5358851674641, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786991, Length=448, Percent_Identity=32.3660714285714, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=30.0492610837438, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789016, Length=443, Percent_Identity=29.3453724604966, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=27.6190476190476, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1787560, Length=438, Percent_Identity=29.2237442922374, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786349, Length=339, Percent_Identity=29.2035398230088, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=451, Percent_Identity=29.490022172949, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=28.9473684210526, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=28.3752860411899, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI25144274, Length=228, Percent_Identity=36.4035087719298, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324386, Length=464, Percent_Identity=27.3706896551724, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=28.3018867924528, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6324432, Length=440, Percent_Identity=25.9090909090909, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574759, Length=452, Percent_Identity=29.646017699115, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161085790, Length=456, Percent_Identity=28.9473684210526, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=31.7972350230415, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21357415, Length=418, Percent_Identity=30.3827751196172, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI281366494, Length=393, Percent_Identity=22.9007633587786, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667139, Length=393, Percent_Identity=22.9007633587786, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667143, Length=393, Percent_Identity=22.9007633587786, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.13 [C]

Molecular weight: Translated: 48837; Mature: 48706

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNEAKFWHPMLHPNEMKRRKPIRIVRGDGCYVFDEDGKALVDGVAGLWNVNVGHNRRE
CCCCCCCCCCCCCCCHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHEECCCCCCHHH
VKDAIVRQLDELEYFQLFDGITHPRAEELSKRLIDLLEPEGMRRVLYSSGGSDSVETALK
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHH
IARQYWKVRGQADRTKFISLKQGYHGTHFGGASVNGNTVFRRNYEPNLPGCFHVETPWLY
HHHHHHHHCCCCCCHHEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCEEE
RNPFTQDPEELGRICAALLEREIQFQSPDTVAAFIAEPIQGAGGVIVPPANYWPLVREVC
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
DRYGVLLIADEVVTGFGRSGSLFGSRGWGVRPDIMCLAKGISSGYVPLGATAVNARIEDA
HHCCEEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
FAQNADFGGAIMHGYTYAGHPVACAAALASLDIVVNEDLPANAAKQGAYLLEALQPFVER
HHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FAAVGEVRGKGLMLALDLVADKTTREPIDPLSGYANAVAEVAREHGVLVRPVGTKIILSP
HHHHHHHCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEECC
PLVIERPELDRIVDALAAGFEAVPVA
CCEEECCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SYNEAKFWHPMLHPNEMKRRKPIRIVRGDGCYVFDEDGKALVDGVAGLWNVNVGHNRRE
CCCCCCCCCCCCCCHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHEECCCCCCHHH
VKDAIVRQLDELEYFQLFDGITHPRAEELSKRLIDLLEPEGMRRVLYSSGGSDSVETALK
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHH
IARQYWKVRGQADRTKFISLKQGYHGTHFGGASVNGNTVFRRNYEPNLPGCFHVETPWLY
HHHHHHHHCCCCCCHHEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCEEE
RNPFTQDPEELGRICAALLEREIQFQSPDTVAAFIAEPIQGAGGVIVPPANYWPLVREVC
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
DRYGVLLIADEVVTGFGRSGSLFGSRGWGVRPDIMCLAKGISSGYVPLGATAVNARIEDA
HHCCEEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
FAQNADFGGAIMHGYTYAGHPVACAAALASLDIVVNEDLPANAAKQGAYLLEALQPFVER
HHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FAAVGEVRGKGLMLALDLVADKTTREPIDPLSGYANAVAEVAREHGVLVRPVGTKIILSP
HHHHHHHCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEECC
PLVIERPELDRIVDALAAGFEAVPVA
CCEEECCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; Ornithine [C]

Specific reaction: 2-Oxoglutarate + Ornithine --> L-Glutamate + L-Glutamate 5-semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]