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The map label for this gene is pbpC [H]

Identifier: 189353177

GI number: 189353177

Start: 1399752

End: 1401989

Strand: Direct

Name: pbpC [H]

Synonym: BMULJ_04413

Alternate gene names: 189353177

Gene position: 1399752-1401989 (Clockwise)

Preceding gene: 189353176

Following gene: 189353178

Centisome position: 56.6

GC content: 72.88

Gene sequence:

>2238_bases
ATGCCCGCGCCAACGTCGCCGCGGCCCGCGCGGGCCGCAGGCCGCCTGTTGCTCGCGATCGCGCTCGCGCTCGCCGCGCC
GGCCGTCGCGCACGCGCTGCCGAGCTACGACGACGTACGCGGCGCATGGCGCAGCACCGACTGGGTGCTGCTTGCCCGCG
ACGGCACGCCGCTGCAGCGCACGCGCGTCGACCTGACCGAGCGGCGCGGCGACTGGGTGTCGCTCGCCGACGTCTCGCCC
GCGTTTCGCGAAGCGATCGTCGTGTCCGAGGACAAGCGCTTCTATGCGCATAGCGGCGTCGACTGGCGCGGCATCGCGGG
TGCGGCGTGGGGCAATCTCTGGAACGAGCGCACGCGCGGCGCGTCGACGGTGACGATGCAGCTCGCGGGGCTGCTCGGCG
CTTCGCCGCGTCGTTCGGGGCAGCGCTCGCTGCCGCAGAAGGCCGTGCAGGCGATGGACGCGCTGCGCCTCGAACGCAGC
TGGCGCAAGGACCAGATTCTCGAGGCTTATCTGAACCTCGTTCCGTTTCGCGGCGAGACGGTCGGGCTCGCCGCGCTGTC
GCAGGTGCTGTTCGCGAAGGCGCCGTCCGGCCTCGATACGCGCGAGGCCGCGATCGCCGCCGCGCTCGTGCGCGCGCCGA
ATGCGACGCCGGCGAAGGTCGCCGAACGCGCGTGCCGGATCCTGCGCGACATGCACGCCGCCGACGCTTGCGCGTCGCTC
GACGGCTACGTGCAGCTCGTCACGGCGCGCCCCGCCGCCGCCGTCCGCGACGACGGCGCGGCGCTCGCGCCGCATTTCGC
GCGGCGCATCGCCGCCGAAGTACGGCCGGCCGCCGGCGCGCGCGTGCGCTCGACGCTCGATGCGTCGCTGCAGCGCTTCG
CGCGCGATACGCTGACGCGCGCGCTCACCGAGCTGAACGCGCCCGCGCACCGGCGCAACGTGCAGGACGGCGCGGTCATC
GTGCTCGACAACGCGACGGGCGAGATCCGTGCGTGGGTCGGCTCGTCCGGCGCGCTGTCGAGCGCGCGCGACGTCGACGC
CGTGCTCGCGCCGCGTCAGGCCGGTTCGACGCTGAAGCCGTTCCTGTACGCGCAGGCGATCGACGAGAAGCGGCTGACGG
CGGCGTCGCTGCTCGACGACGCACCGATCAACCTCGCGGCCGGCGGCGGGCTGTACATCCCGCAAAACTACGACAAGGAT
TTCAAGGGCTGGGTCAGCGTGCGCAGCGCGCTCGGCGGCTCGCTGAACGTGCCGGCCGTGCGCACGCTCGTGCTCGTCAC
GCCGCACCGCTTCGCGCGCACGCTGACCGCGCTCGGCCTGCCGCTCGCGCAGGAAGGCGACTACTACGGCTTCAGCCTCG
CGCTCGGCAGCGCGGACGTCACGCTGCTGTCGCTGACGAACGCCTACCGGGCGCTCGCGAACGGCGGCGTCGCGCGCAAG
GTCGTCGACCTGCCGGCGCCGGCGTCCGGTGCCGCGTCGCCCGCGCGCGCAATGGACGGCACGCGCGTGTTCAGCGAAGC
GGCCAGCTTCATCGTCACCGACATCCTCGCCGACAACAACGCGCGCGTGCGCACGTTCGGCTTCGACAACCCGCTCGCGA
CGCGCTTTTTCTCGGCGGTGAAAACCGGCACGAGCAAGGACATGCGCGACAACTGGACGGTCGGCTACACGTCGCGCTAT
ACGGTCGGCGTGTGGGTCGGCAATGCAGACGGCTCGCCGATGTGGGACGTGTCGGGCGTGACGGGCGCGTCGCCGGTCTG
GTCGGCGATCGTCGGCTATCTGCACCGCGACGTGCCGAGCCGCGCGCCCCGCGCGCCGTCCGGTGTCGAAGCGCGCCGCA
TCGCATTCGAGCGCGACGTCGAACCGTCGCGCAACGAATGGTTCGTCGCGGGCACCGCGCTCGACACGATCCGCCTCGCG
GCGCCGGTCACGCCCGACAAGAACGGCACGCGCGCGCCGTTGACGATCGGCGCGCCGACCGACGGGACGATCTTCGCGAT
CGATCCCGACATTCCGCCGCAGCACCAGCGGATCTGGTTCGAGCGCACGGCCGGCCGCGCGGCGCGGTTCGCGTGGCGGC
TCGACGACAAGGTGATCGGGCACGGCGATCGCATCGCATGGATGCCGTGGCCGGGGCGGCACCGGCTCGAACTCGTCGAT
GCGCGCGGCAACGTCGCCGATGCGATCGGCTTCGAGGTGCGCGGCGCGTTCGCCAAACCGAACGCGCGCAAGCCGTAA

Upstream 100 bases:

>100_bases
CGACGCGCGTCGAGGCGCTGTACGCGCCGTCGGTGTATGGGCTGTGGCCGAATCCGCCGGTCACCGTGAAGCCGGCCGCC
GCGAGCCGGCCGTGAGCGCG

Downstream 100 bases:

>100_bases
CGGCGGGCGCGCGTCGGTTCGCGGGCCGTGCGCGGAAGCCGCGGGCCGGCGTGGGCGACAGTCCCGCTTGTTTCAGTTAC
CCGACGCCGCGTCGCGCGTC

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MPAPTSPRPARAAGRLLLAIALALAAPAVAHALPSYDDVRGAWRSTDWVLLARDGTPLQRTRVDLTERRGDWVSLADVSP
AFREAIVVSEDKRFYAHSGVDWRGIAGAAWGNLWNERTRGASTVTMQLAGLLGASPRRSGQRSLPQKAVQAMDALRLERS
WRKDQILEAYLNLVPFRGETVGLAALSQVLFAKAPSGLDTREAAIAAALVRAPNATPAKVAERACRILRDMHAADACASL
DGYVQLVTARPAAAVRDDGAALAPHFARRIAAEVRPAAGARVRSTLDASLQRFARDTLTRALTELNAPAHRRNVQDGAVI
VLDNATGEIRAWVGSSGALSSARDVDAVLAPRQAGSTLKPFLYAQAIDEKRLTAASLLDDAPINLAAGGGLYIPQNYDKD
FKGWVSVRSALGGSLNVPAVRTLVLVTPHRFARTLTALGLPLAQEGDYYGFSLALGSADVTLLSLTNAYRALANGGVARK
VVDLPAPASGAASPARAMDGTRVFSEAASFIVTDILADNNARVRTFGFDNPLATRFFSAVKTGTSKDMRDNWTVGYTSRY
TVGVWVGNADGSPMWDVSGVTGASPVWSAIVGYLHRDVPSRAPRAPSGVEARRIAFERDVEPSRNEWFVAGTALDTIRLA
APVTPDKNGTRAPLTIGAPTDGTIFAIDPDIPPQHQRIWFERTAGRAARFAWRLDDKVIGHGDRIAWMPWPGRHRLELVD
ARGNVADAIGFEVRGAFAKPNARKP

Sequences:

>Translated_745_residues
MPAPTSPRPARAAGRLLLAIALALAAPAVAHALPSYDDVRGAWRSTDWVLLARDGTPLQRTRVDLTERRGDWVSLADVSP
AFREAIVVSEDKRFYAHSGVDWRGIAGAAWGNLWNERTRGASTVTMQLAGLLGASPRRSGQRSLPQKAVQAMDALRLERS
WRKDQILEAYLNLVPFRGETVGLAALSQVLFAKAPSGLDTREAAIAAALVRAPNATPAKVAERACRILRDMHAADACASL
DGYVQLVTARPAAAVRDDGAALAPHFARRIAAEVRPAAGARVRSTLDASLQRFARDTLTRALTELNAPAHRRNVQDGAVI
VLDNATGEIRAWVGSSGALSSARDVDAVLAPRQAGSTLKPFLYAQAIDEKRLTAASLLDDAPINLAAGGGLYIPQNYDKD
FKGWVSVRSALGGSLNVPAVRTLVLVTPHRFARTLTALGLPLAQEGDYYGFSLALGSADVTLLSLTNAYRALANGGVARK
VVDLPAPASGAASPARAMDGTRVFSEAASFIVTDILADNNARVRTFGFDNPLATRFFSAVKTGTSKDMRDNWTVGYTSRY
TVGVWVGNADGSPMWDVSGVTGASPVWSAIVGYLHRDVPSRAPRAPSGVEARRIAFERDVEPSRNEWFVAGTALDTIRLA
APVTPDKNGTRAPLTIGAPTDGTIFAIDPDIPPQHQRIWFERTAGRAARFAWRLDDKVIGHGDRIAWMPWPGRHRLELVD
ARGNVADAIGFEVRGAFAKPNARKP
>Mature_744_residues
PAPTSPRPARAAGRLLLAIALALAAPAVAHALPSYDDVRGAWRSTDWVLLARDGTPLQRTRVDLTERRGDWVSLADVSPA
FREAIVVSEDKRFYAHSGVDWRGIAGAAWGNLWNERTRGASTVTMQLAGLLGASPRRSGQRSLPQKAVQAMDALRLERSW
RKDQILEAYLNLVPFRGETVGLAALSQVLFAKAPSGLDTREAAIAAALVRAPNATPAKVAERACRILRDMHAADACASLD
GYVQLVTARPAAAVRDDGAALAPHFARRIAAEVRPAAGARVRSTLDASLQRFARDTLTRALTELNAPAHRRNVQDGAVIV
LDNATGEIRAWVGSSGALSSARDVDAVLAPRQAGSTLKPFLYAQAIDEKRLTAASLLDDAPINLAAGGGLYIPQNYDKDF
KGWVSVRSALGGSLNVPAVRTLVLVTPHRFARTLTALGLPLAQEGDYYGFSLALGSADVTLLSLTNAYRALANGGVARKV
VDLPAPASGAASPARAMDGTRVFSEAASFIVTDILADNNARVRTFGFDNPLATRFFSAVKTGTSKDMRDNWTVGYTSRYT
VGVWVGNADGSPMWDVSGVTGASPVWSAIVGYLHRDVPSRAPRAPSGVEARRIAFERDVEPSRNEWFVAGTALDTIRLAA
PVTPDKNGTRAPLTIGAPTDGTIFAIDPDIPPQHQRIWFERTAGRAARFAWRLDDKVIGHGDRIAWMPWPGRHRLELVDA
RGNVADAIGFEVRGAFAKPNARKP

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=560, Percent_Identity=34.8214285714286, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786343, Length=553, Percent_Identity=26.4014466546112, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87082258, Length=161, Percent_Identity=37.2670807453416, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789601, Length=170, Percent_Identity=37.0588235294118, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 79863; Mature: 79732

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPTSPRPARAAGRLLLAIALALAAPAVAHALPSYDDVRGAWRSTDWVLLARDGTPLQR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEECCCCCHHH
TRVDLTERRGDWVSLADVSPAFREAIVVSEDKRFYAHSGVDWRGIAGAAWGNLWNERTRG
HHHHHHHCCCCEEEECCCCHHHHHEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCC
ASTVTMQLAGLLGASPRRSGQRSLPQKAVQAMDALRLERSWRKDQILEAYLNLVPFRGET
CHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
VGLAALSQVLFAKAPSGLDTREAAIAAALVRAPNATPAKVAERACRILRDMHAADACASL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DGYVQLVTARPAAAVRDDGAALAPHFARRIAAEVRPAAGARVRSTLDASLQRFARDTLTR
CCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALTELNAPAHRRNVQDGAVIVLDNATGEIRAWVGSSGALSSARDVDAVLAPRQAGSTLKP
HHHHCCCCHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCH
FLYAQAIDEKRLTAASLLDDAPINLAAGGGLYIPQNYDKDFKGWVSVRSALGGSLNVPAV
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCE
RTLVLVTPHRFARTLTALGLPLAQEGDYYGFSLALGSADVTLLSLTNAYRALANGGVARK
EEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHCCCHHEE
VVDLPAPASGAASPARAMDGTRVFSEAASFIVTDILADNNARVRTFGFDNPLATRFFSAV
EEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHH
KTGTSKDMRDNWTVGYTSRYTVGVWVGNADGSPMWDVSGVTGASPVWSAIVGYLHRDVPS
HCCCCCCCCCCCEEEECCEEEEEEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCC
RAPRAPSGVEARRIAFERDVEPSRNEWFVAGTALDTIRLAAPVTPDKNGTRAPLTIGAPT
CCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCCCEEECCCC
DGTIFAIDPDIPPQHQRIWFERTAGRAARFAWRLDDKVIGHGDRIAWMPWPGRHRLELVD
CCEEEEECCCCCCCHHHEEEEHHCCCHHEEEEECCCCEECCCCEEEECCCCCCCCEEEEE
ARGNVADAIGFEVRGAFAKPNARKP
CCCCCHHHHCCEEECCCCCCCCCCC
>Mature Secondary Structure 
PAPTSPRPARAAGRLLLAIALALAAPAVAHALPSYDDVRGAWRSTDWVLLARDGTPLQR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEECCCCCHHH
TRVDLTERRGDWVSLADVSPAFREAIVVSEDKRFYAHSGVDWRGIAGAAWGNLWNERTRG
HHHHHHHCCCCEEEECCCCHHHHHEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCC
ASTVTMQLAGLLGASPRRSGQRSLPQKAVQAMDALRLERSWRKDQILEAYLNLVPFRGET
CHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
VGLAALSQVLFAKAPSGLDTREAAIAAALVRAPNATPAKVAERACRILRDMHAADACASL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DGYVQLVTARPAAAVRDDGAALAPHFARRIAAEVRPAAGARVRSTLDASLQRFARDTLTR
CCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALTELNAPAHRRNVQDGAVIVLDNATGEIRAWVGSSGALSSARDVDAVLAPRQAGSTLKP
HHHHCCCCHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCH
FLYAQAIDEKRLTAASLLDDAPINLAAGGGLYIPQNYDKDFKGWVSVRSALGGSLNVPAV
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCE
RTLVLVTPHRFARTLTALGLPLAQEGDYYGFSLALGSADVTLLSLTNAYRALANGGVARK
EEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHCCCHHEE
VVDLPAPASGAASPARAMDGTRVFSEAASFIVTDILADNNARVRTFGFDNPLATRFFSAV
EEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHH
KTGTSKDMRDNWTVGYTSRYTVGVWVGNADGSPMWDVSGVTGASPVWSAIVGYLHRDVPS
HCCCCCCCCCCCEEEECCEEEEEEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCC
RAPRAPSGVEARRIAFERDVEPSRNEWFVAGTALDTIRLAAPVTPDKNGTRAPLTIGAPT
CCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCCCEEECCCC
DGTIFAIDPDIPPQHQRIWFERTAGRAARFAWRLDDKVIGHGDRIAWMPWPGRHRLELVD
CCEEEEECCCCCCCHHHEEEEHHCCCHHEEEEECCCCEECCCCEEEECCCCCCCCEEEEE
ARGNVADAIGFEVRGAFAKPNARKP
CCCCCHHHHCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]