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The map label for this gene is gutB [H]

Identifier: 189353137

GI number: 189353137

Start: 1333910

End: 1334971

Strand: Direct

Name: gutB [H]

Synonym: BMULJ_04373

Alternate gene names: 189353137

Gene position: 1333910-1334971 (Clockwise)

Preceding gene: 189353134

Following gene: 189353138

Centisome position: 53.94

GC content: 67.98

Gene sequence:

>1062_bases
ATGAAGGCCGCCGTGTGGCGCGGCCGCCGCGACATCCGCGTCGAAGAGGTTCCCGTACCGGAGCGGCCGCCGGCCGGCTG
GGTGAAGATCCGCGTGCACTGGTGCGGCATCTGCGGCTCGGACCTGCACGAATACGTCGCCGGCCCCGTATTCATTCCGG
TCGACGCGCCGCATCCGCTGACGGGCCTGAAAGGCCAGTGCATCCTCGGTCACGAGTTCAGCGGCGAGATCGCCGAGCTC
GGCGACGGCGTGACGGGCTTCGCGATCGGCGACCGCGTGACGGCCGACGCCTGCCAGCATTGCGGTACCTGCTGGTACTG
CACGCACGGGCTCTACAACATCTGCGAAAACCTCGCGTTCACCGGCTTGATGAACAACGGCGCGTTCGCGGAGTACGTCA
ACGTGCCGGCCGAACTGCTGTACCGGCTGCCCGACGGCTTCCCGACCGAAGCCGGCGCGCTGATCGAGCCGCTCGCGGTC
GGGCTGCACGCGGTGAAGAAGGCCGGCAGCATCGTCGGGCAGACCGTCGTCGTGGTCGGCGCGGGCACGATCGGGCTGTG
CACGATCATGTGCGCGAAGGCCGCCGGCGCGGGCCGCGTGATCGCGCTCGAGATGTCCGACGCGCGCAAGGCGAAGGCGC
TCGAAGTCGGCGCGAGCGTCGTCATCGATCCGAAGACGTCGGACGCGATCGCCGAGGTGAAGGCGCTGACGGGCGGGTAC
GGCGCCGACGTGTCGTTCGAATGCATCGGCCACACGACGACGGCGAAGCTCGCGATCGACGTGATCCGCAAGGCCGGCAA
GTCGGTGATGGTCGGGATCTTCGAAGAGCCGGCGCCGTTCAACTTCTTCGACATCGTGTCGACCGAGAAGGAAGTGATCG
GCTCGCTGGCGTACAACGGCGAGTTCGCGGACGTGATCCGCTTCATCGCGGACGGCCGGATCGACGTGCAGCCGCTGATC
ACCGGCCGCATCGCGCTCGGCGACATCGTCGCGCGCGGCTTCGAGGAGCTCGTCCATCACAAGGACCGCAACGTGAAGAT
CATCGTGCAGCCGGCGACCTAG

Upstream 100 bases:

>100_bases
ATCGCTGAGCGCGGCGCGGTGCCGCGCATCGCGGCACGACGACAGACAAACCCACGGAGACGACAACATGAGTACAGCCG
CATCGAGTTCCGCCCGCAGC

Downstream 100 bases:

>100_bases
CTGGCACTGTGCGCTCGACGCGCTCGGCACCGCCGCGCGATGCCGGCTGCTTCCTGCCGCGCACGGCCACGCACGGCCGC
ACGCGGCATCAGGCGATTCT

Product: L-iditol 2-dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKAAVWRGRRDIRVEEVPVPERPPAGWVKIRVHWCGICGSDLHEYVAGPVFIPVDAPHPLTGLKGQCILGHEFSGEIAEL
GDGVTGFAIGDRVTADACQHCGTCWYCTHGLYNICENLAFTGLMNNGAFAEYVNVPAELLYRLPDGFPTEAGALIEPLAV
GLHAVKKAGSIVGQTVVVVGAGTIGLCTIMCAKAAGAGRVIALEMSDARKAKALEVGASVVIDPKTSDAIAEVKALTGGY
GADVSFECIGHTTTAKLAIDVIRKAGKSVMVGIFEEPAPFNFFDIVSTEKEVIGSLAYNGEFADVIRFIADGRIDVQPLI
TGRIALGDIVARGFEELVHHKDRNVKIIVQPAT

Sequences:

>Translated_353_residues
MKAAVWRGRRDIRVEEVPVPERPPAGWVKIRVHWCGICGSDLHEYVAGPVFIPVDAPHPLTGLKGQCILGHEFSGEIAEL
GDGVTGFAIGDRVTADACQHCGTCWYCTHGLYNICENLAFTGLMNNGAFAEYVNVPAELLYRLPDGFPTEAGALIEPLAV
GLHAVKKAGSIVGQTVVVVGAGTIGLCTIMCAKAAGAGRVIALEMSDARKAKALEVGASVVIDPKTSDAIAEVKALTGGY
GADVSFECIGHTTTAKLAIDVIRKAGKSVMVGIFEEPAPFNFFDIVSTEKEVIGSLAYNGEFADVIRFIADGRIDVQPLI
TGRIALGDIVARGFEELVHHKDRNVKIIVQPAT
>Mature_353_residues
MKAAVWRGRRDIRVEEVPVPERPPAGWVKIRVHWCGICGSDLHEYVAGPVFIPVDAPHPLTGLKGQCILGHEFSGEIAEL
GDGVTGFAIGDRVTADACQHCGTCWYCTHGLYNICENLAFTGLMNNGAFAEYVNVPAELLYRLPDGFPTEAGALIEPLAV
GLHAVKKAGSIVGQTVVVVGAGTIGLCTIMCAKAAGAGRVIALEMSDARKAKALEVGASVVIDPKTSDAIAEVKALTGGY
GADVSFECIGHTTTAKLAIDVIRKAGKSVMVGIFEEPAPFNFFDIVSTEKEVIGSLAYNGEFADVIRFIADGRIDVQPLI
TGRIALGDIVARGFEELVHHKDRNVKIIVQPAT

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=327, Percent_Identity=32.4159021406728, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4501929, Length=297, Percent_Identity=32.6599326599327, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4501933, Length=297, Percent_Identity=32.3232323232323, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI34577061, Length=307, Percent_Identity=31.2703583061889, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI71565154, Length=384, Percent_Identity=26.3020833333333, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4501939, Length=356, Percent_Identity=26.685393258427, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=26.685393258427, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI71565152, Length=334, Percent_Identity=26.0479041916168, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788073, Length=345, Percent_Identity=35.6521739130435, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=31.5789473684211, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=31.5315315315315, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=29.7376093294461, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787863, Length=322, Percent_Identity=29.5031055900621, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790718, Length=340, Percent_Identity=28.8235294117647, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=27.299703264095, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87082125, Length=301, Percent_Identity=30.8970099667774, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI87081918, Length=292, Percent_Identity=31.1643835616438, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786825, Length=405, Percent_Identity=25.679012345679, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=25.8152173913043, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786518, Length=314, Percent_Identity=26.1146496815287, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082401, Length=302, Percent_Identity=25.1655629139073, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=328, Percent_Identity=32.3170731707317, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17562878, Length=330, Percent_Identity=31.8181818181818, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25146526, Length=304, Percent_Identity=29.6052631578947, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=305, Percent_Identity=29.5081967213115, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17565904, Length=237, Percent_Identity=31.6455696202532, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=346, Percent_Identity=24.8554913294798, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=27.1386430678466, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=320, Percent_Identity=25.625, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=375, Percent_Identity=35.7333333333333, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319257, Length=377, Percent_Identity=32.6259946949602, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322619, Length=355, Percent_Identity=33.2394366197183, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6319955, Length=355, Percent_Identity=33.2394366197183, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6323099, Length=356, Percent_Identity=31.1797752808989, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=26.9333333333333, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324486, Length=349, Percent_Identity=26.9340974212034, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=28.4883720930233, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=303, Percent_Identity=25.0825082508251, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=27.3809523809524, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=254, Percent_Identity=28.740157480315, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17137530, Length=338, Percent_Identity=32.5443786982249, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17737897, Length=338, Percent_Identity=31.0650887573964, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI45550770, Length=309, Percent_Identity=30.0970873786408, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221457811, Length=309, Percent_Identity=30.0970873786408, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45551930, Length=309, Percent_Identity=30.0970873786408, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737895, Length=303, Percent_Identity=27.7227722772277, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37434; Mature: 37434

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVWRGRRDIRVEEVPVPERPPAGWVKIRVHWCGICGSDLHEYVAGPVFIPVDAPHPL
CCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCEEEECCCCCCC
TGLKGQCILGHEFSGEIAELGDGVTGFAIGDRVTADACQHCGTCWYCTHGLYNICENLAF
CCCCCCEEECCCCCCCHHHHCCCCEEEEECCCCCHHHHHHCCCEEEHHHHHHHHHHHHHE
TGLMNNGAFAEYVNVPAELLYRLPDGFPTEAGALIEPLAVGLHAVKKAGSIVGQTVVVVG
EEECCCCCHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEE
AGTIGLCTIMCAKAAGAGRVIALEMSDARKAKALEVGASVVIDPKTSDAIAEVKALTGGY
CCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHEECCCEEEECCCCCHHHHHHHHHCCCC
GADVSFECIGHTTTAKLAIDVIRKAGKSVMVGIFEEPAPFNFFDIVSTEKEVIGSLAYNG
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEHHCCHHHHHHHHHCCC
EFADVIRFIADGRIDVQPLITGRIALGDIVARGFEELVHHKDRNVKIIVQPAT
CHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MKAAVWRGRRDIRVEEVPVPERPPAGWVKIRVHWCGICGSDLHEYVAGPVFIPVDAPHPL
CCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCEEEECCCCCCC
TGLKGQCILGHEFSGEIAELGDGVTGFAIGDRVTADACQHCGTCWYCTHGLYNICENLAF
CCCCCCEEECCCCCCCHHHHCCCCEEEEECCCCCHHHHHHCCCEEEHHHHHHHHHHHHHE
TGLMNNGAFAEYVNVPAELLYRLPDGFPTEAGALIEPLAVGLHAVKKAGSIVGQTVVVVG
EEECCCCCHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEE
AGTIGLCTIMCAKAAGAGRVIALEMSDARKAKALEVGASVVIDPKTSDAIAEVKALTGGY
CCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHEECCCEEEECCCCCHHHHHHHHHCCCC
GADVSFECIGHTTTAKLAIDVIRKAGKSVMVGIFEEPAPFNFFDIVSTEKEVIGSLAYNG
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEHHCCHHHHHHHHHCCC
EFADVIRFIADGRIDVQPLITGRIALGDIVARGFEELVHHKDRNVKIIVQPAT
CHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]