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The map label for this gene is galM [H]

Identifier: 189353066

GI number: 189353066

Start: 1238168

End: 1239256

Strand: Direct

Name: galM [H]

Synonym: BMULJ_04300

Alternate gene names: 189353066

Gene position: 1238168-1239256 (Clockwise)

Preceding gene: 189353065

Following gene: 189353067

Centisome position: 50.06

GC content: 68.96

Gene sequence:

>1089_bases
ATGACCTTCGATACCGATTCTTCCCGCACCGCGTCCGACGTCGCCCGCACTCCGTCCGAGCCGTGGGGTCCGCTGCCCGG
CGGCGATCCGGTGCGGCGCTATACGCTGCGCAACGCGCACGGGATGCGCGTCGTCGTCAGCGACCTCGGCGCGACCGTGG
TGTCGTGGCTCGCGCCCGACCGCACCGGCCGCTTCGCCGACATCGTGCTCGCGCACGACACGCCGGCCGACTATCTCGCG
TCCGGCGCGTATCTCGGCGCGACGGTCGGCCGCTGGGCGAACCGGATCGCCGGCGCGCGCTTCACGCTCGACGGCATCGA
CTATCCGCTCGATCGCAACGAGAACGGCAATCTGCTGCACGGCGGCGCAAGCGGCTTTCATCGCGAACGCTGGGACGTGA
TCGACGATCGCGGCGGCCTCACGCTGCGGCTCGATTCGCCCGAAGGCGACGCGGGGTTTCCCGGCAACGTCAGCGTACAA
GTGCGCTATACGCTCGACGACGACGGCACGCTGACGATCGACTACACGGGCACGAGCGATGCACCGACGCCGCTGAACCT
GACGAATCACAGCTACTTCAATCTGAGCGGCCGCGCGGGCAGCGACGTGCGCGGCCACGTGCTGAGGATCGATGCGGACG
CGTTTCTCGAAGTCGACGACGCGCTGATTCCGACCGGCCGCGCCGACGTGACGGGCACCGCGTTCGATTTCCGGCAAAGC
GCGCCGCTCGGTGCGCGCCTCGATTGGCCGCACGCGCAGCTCGCGCGTGGCCGCGGCTTCGATCACTGCTACGTGCTGCG
CGACGACGTGCACGGCGTGCGGCCGGTCGCGAGCATCTACGATCCGGAAAGCGGCCGCGAGCTGACCGTGTCGACCGATC
AATGCGGGCTGCAGCTCTATACCGGCAACTATCTCGACGGCCTGCGCGTCAGCGGCGGCACGACCTGCGTGCGGCATGCG
GCGCTGTGCGTCGAGGCCGGCTGCTTTCCGAATCAGATCAACATGGCGGAGCTCGCTGATGCCACGATCGTACGGCCCGG
CGATACGTATCGGCAGACGACGCGCTATCGCGTCGCCGTGCGCGCGTAA

Upstream 100 bases:

>100_bases
TATGCGGTGTTCCGGCGCGAACTCGGCTGCACGCCGCGCGAATACCAGGAACGCGCGGTGTCCGCGCACTGACGCTCATC
GTCTCGACGACCGATTACTC

Downstream 100 bases:

>100_bases
TCGCCGCGCGCGGTACGGCCGCGTGATGCGCGCGCCGTCGCAGGCCGCGATCGTTCGTGCCGCGCGCTGCGTCCTGCCAT
CGAGCTGAGGGCAGCGCGCG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTFDTDSSRTASDVARTPSEPWGPLPGGDPVRRYTLRNAHGMRVVVSDLGATVVSWLAPDRTGRFADIVLAHDTPADYLA
SGAYLGATVGRWANRIAGARFTLDGIDYPLDRNENGNLLHGGASGFHRERWDVIDDRGGLTLRLDSPEGDAGFPGNVSVQ
VRYTLDDDGTLTIDYTGTSDAPTPLNLTNHSYFNLSGRAGSDVRGHVLRIDADAFLEVDDALIPTGRADVTGTAFDFRQS
APLGARLDWPHAQLARGRGFDHCYVLRDDVHGVRPVASIYDPESGRELTVSTDQCGLQLYTGNYLDGLRVSGGTTCVRHA
ALCVEAGCFPNQINMAELADATIVRPGDTYRQTTRYRVAVRA

Sequences:

>Translated_362_residues
MTFDTDSSRTASDVARTPSEPWGPLPGGDPVRRYTLRNAHGMRVVVSDLGATVVSWLAPDRTGRFADIVLAHDTPADYLA
SGAYLGATVGRWANRIAGARFTLDGIDYPLDRNENGNLLHGGASGFHRERWDVIDDRGGLTLRLDSPEGDAGFPGNVSVQ
VRYTLDDDGTLTIDYTGTSDAPTPLNLTNHSYFNLSGRAGSDVRGHVLRIDADAFLEVDDALIPTGRADVTGTAFDFRQS
APLGARLDWPHAQLARGRGFDHCYVLRDDVHGVRPVASIYDPESGRELTVSTDQCGLQLYTGNYLDGLRVSGGTTCVRHA
ALCVEAGCFPNQINMAELADATIVRPGDTYRQTTRYRVAVRA
>Mature_361_residues
TFDTDSSRTASDVARTPSEPWGPLPGGDPVRRYTLRNAHGMRVVVSDLGATVVSWLAPDRTGRFADIVLAHDTPADYLAS
GAYLGATVGRWANRIAGARFTLDGIDYPLDRNENGNLLHGGASGFHRERWDVIDDRGGLTLRLDSPEGDAGFPGNVSVQV
RYTLDDDGTLTIDYTGTSDAPTPLNLTNHSYFNLSGRAGSDVRGHVLRIDADAFLEVDDALIPTGRADVTGTAFDFRQSA
PLGARLDWPHAQLARGRGFDHCYVLRDDVHGVRPVASIYDPESGRELTVSTDQCGLQLYTGNYLDGLRVSGGTTCVRHAA
LCVEAGCFPNQINMAELADATIVRPGDTYRQTTRYRVAVRA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=342, Percent_Identity=39.1812865497076, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI1786971, Length=337, Percent_Identity=38.2789317507418, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17557428, Length=328, Percent_Identity=31.7073170731707, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI115533334, Length=328, Percent_Identity=31.7073170731707, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322004, Length=350, Percent_Identity=30.8571428571429, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319493, Length=338, Percent_Identity=28.1065088757396, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324399, Length=351, Percent_Identity=29.3447293447293, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24659048, Length=346, Percent_Identity=37.5722543352601, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24583720, Length=339, Percent_Identity=37.7581120943953, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24668278, Length=343, Percent_Identity=36.4431486880466, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24668282, Length=342, Percent_Identity=34.7953216374269, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24641876, Length=348, Percent_Identity=28.735632183908, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39197; Mature: 39066

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDTDSSRTASDVARTPSEPWGPLPGGDPVRRYTLRNAHGMRVVVSDLGATVVSWLAPD
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHEEEECCCCCCEEEEHHHHHHHHHHHCCC
RTGRFADIVLAHDTPADYLASGAYLGATVGRWANRIAGARFTLDGIDYPLDRNENGNLLH
CCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEE
GGASGFHRERWDVIDDRGGLTLRLDSPEGDAGFPGNVSVQVRYTLDDDGTLTIDYTGTSD
CCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCC
APTPLNLTNHSYFNLSGRAGSDVRGHVLRIDADAFLEVDDALIPTGRADVTGTAFDFRQS
CCCCEEECCCEEEEECCCCCCCCCCEEEEECCHHEEEECCCCCCCCCCCCCCCEEHHCCC
APLGARLDWPHAQLARGRGFDHCYVLRDDVHGVRPVASIYDPESGRELTVSTDQCGLQLY
CCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCCCCCEEEEECCCCCEEEE
TGNYLDGLRVSGGTTCVRHAALCVEAGCFPNQINMAELADATIVRPGDTYRQTTRYRVAV
ECCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHCCEEEECCCCHHHHCEEEEEEE
RA
EC
>Mature Secondary Structure 
TFDTDSSRTASDVARTPSEPWGPLPGGDPVRRYTLRNAHGMRVVVSDLGATVVSWLAPD
CCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHEEEECCCCCCEEEEHHHHHHHHHHHCCC
RTGRFADIVLAHDTPADYLASGAYLGATVGRWANRIAGARFTLDGIDYPLDRNENGNLLH
CCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEE
GGASGFHRERWDVIDDRGGLTLRLDSPEGDAGFPGNVSVQVRYTLDDDGTLTIDYTGTSD
CCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCC
APTPLNLTNHSYFNLSGRAGSDVRGHVLRIDADAFLEVDDALIPTGRADVTGTAFDFRQS
CCCCEEECCCEEEEECCCCCCCCCCEEEEECCHHEEEECCCCCCCCCCCCCCCEEHHCCC
APLGARLDWPHAQLARGRGFDHCYVLRDDVHGVRPVASIYDPESGRELTVSTDQCGLQLY
CCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCCCCCEEEEECCCCCEEEE
TGNYLDGLRVSGGTTCVRHAALCVEAGCFPNQINMAELADATIVRPGDTYRQTTRYRVAV
ECCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHCCEEEECCCCHHHHCEEEEEEE
RA
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]