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The map label for this gene is iorB [H]

Identifier: 189353055

GI number: 189353055

Start: 1221859

End: 1224078

Strand: Direct

Name: iorB [H]

Synonym: BMULJ_04289

Alternate gene names: 189353055

Gene position: 1221859-1224078 (Clockwise)

Preceding gene: 189353054

Following gene: 189353056

Centisome position: 49.4

GC content: 69.19

Gene sequence:

>2220_bases
ATGTCGCGCGGACTGATCGAAGCAGGCCATGCCGGCGCCGCCATGTCGCGCCGTTCGTTTCTGCGCTTCGGCATGTCGCT
CGGCGCGGCGGCCGGCGGCGGACTGCTGCTCGGCTTCAGCCTGCCGGCCGCGGGCGACGATACGCGGCGCTCGGTGATCG
GCGGCGACGCGGACGAACCCGCGCGGGCGGGCGTGTTCGCGCCCAACGCATTCGTGCAGATCGACCGTAGCGGCCGCGTC
ACGCTCGTGATGCCGAAGGTCGAGATGGGGCAGGGCGTCTACACCGCGCTGCCGATGCTGATCGCGGAAGAGCTCGAGGT
GCCGCTGTCGAGCGTGACGCTCGATCATGCGCCGCCGAACGAAAAGCTGTTCCTCGATCCGCTGCTCGGCGGCCAGTTGA
CCGGCGGCTCGACGTCGGTGCGCTACGCATGGGAGCCGCTGCGTCGCGCCGGTGCGAACGCGCGCGTGCTGCTGGTGTCG
GCGGCCGCGAAGCAATGGAACGTCGACCCGGCTGCCTGTCACGCGGAGAACGGCGAGGTGCGCCATCCACCGAGCGGCCG
CCGCGCATCGTACGGCGAGCTCGCGGATGCGGCCGCAAAGCTGCCGGTGCCGACAGACGTCGCGCTGAAAAAGCCCGAGC
AGTTCAAGCTGATCGGCACGCCTGCGAAGCGCCTCGATTCGCCGGAGAAAGTCGACGGTGTCGCGCAGTTCGGACTCGAC
GTGCGGCTGCCCGGGATGCGCTATGCGGTGATCGTGAACAGCCCGGTGTTCGGCGGCACCGTTGCGAGCGTCGACGATAC
CGCTGCCAAGAAGATTCCCGGCGTGCGTCAGATCGTGCGCGTCGACGATGCCGTCGCGGTGGTCGGCGATCACACGTGGG
CGGCCAAGCGCGGCGCATCGGCGCTGGTCGTCAAATGGAACGAAGGCGCGAACGCCAACGTGTCGACGAAGGATCTGTTC
GCCGATCTTGCGCAGGCGGCCGCGAACGGCAAGGGCGCGGTCGCGCGCAAGGACGGCGACGTCGACCATGCCTTCTCGAA
CGCGAAGACGCGCGTCGACGCGGTGTACGAACAGCCGCTGCTCGCGCACGCGACGATGGAACCCGTGAACTGTACCGTGC
ACGTGCGCAGCGACGCGTGCGAGGTGTGGGTCGGCACGCAGGTGCCGACGCGCGCCCGCGACACCGCGCAGCGGATCACC
GGCCTGCCTGCCGAGCGCATCGTCGTGCACAACCACCTGCTTGGCGGCGGCTTCGGCCGGCGGCTCGAAACCGACATGAT
CGGCCAGGCCGTGAAGATCGCCAAACAGGTCGGCGCGCCGGTGAAGGTCGTGTGGACGCGCGAAGAGGACATCCAGCACG
ACATGTACCGGCCGTGCTACCACGACCGGATCTCGGCCGCGCTCGACGCGAACGGCAAGCCGATCGCATGGCGACACCGG
ATCGTCGGCTCGTCGATCCTCGCGCGCTTCGCGCCGCCGGCTTTCAAGGACGGTGTCGATCCCGACGCGGTCGAGGTAGC
GATCGATCTGCCGTACGACGTCCCGAATCAGCTGATCGACTACGTGCGACAGGAGCCGCGCCATGTGCCGACCGCGTTCT
GGCGCGGCGTCGGGCCGACGCGCAGCACCTTCGTCGTCGAAAGCTTCATCGACGAACTCGCCGCGCAGACCAAAACCGAT
CCCGTCCAGTACCGGCGCGCGCTGCTCGACAAGACGCCGCGTGCGCGCAACGTGCTCGACATCGCGACGAAAGCGGCCGG
GTGGGGCGCGGCGTTGCCGCAAGGGCAGGGCCGCGGCGTCTCGGTGATGCATGCGTTCGGCAGCTTCTTCGCGATCGTCG
CCGACGTCGCGGTCGACGACGGTGAAGTGCGCGTGACGCGCGTCGTCTGCGCGGTCGACTGCGGGATGACCGTGAACCCG
AACACGATCGAGGCGCAGGTGCAGGGCGGCATCATCTTCGGCATCACCGGCGCGCTGTACGGCGAAGTGACGATCGAGAA
CGGGCGCGTGACGCAGCGCAACTTCACCGACTATCGCGTGCTGCGGATCAACGAGACGCCGCCGATCGACGTGCATATCG
TGAAGAGCGGCGAAGCGCCGGGCGGGATCGGCGAGCCCGGCACCGCGGCGACGGCCGCGGCCGTCGCGAACGCGATCTTC
GCGGCGACCGGCAAGCGGCTGCGCAAGCTGCCGATCGGCAACCAGCTGAAAACGGCCTGA

Upstream 100 bases:

>100_bases
GACGCCGACATCGACGCCGCCATGGCCGGCAACATCTGCCGCTGCGGCACGTACCACCGGATTCGTGCGGCGATCAAGCA
AGCCGCGCAGGAGGCCTGAC

Downstream 100 bases:

>100_bases
GGGGAGCGGCGACCATGCGAAACCTGAACCTGAGTGCGCGTGCGCTTTGCGCGTCGTTGTTCGCGCTGTCGGCACTGGTG
ACCGCGACGACCGCACACGC

Product: isoquinoline 1-oxidoreductase, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MSRGLIEAGHAGAAMSRRSFLRFGMSLGAAAGGGLLLGFSLPAAGDDTRRSVIGGDADEPARAGVFAPNAFVQIDRSGRV
TLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPNEKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGANARVLLVS
AAAKQWNVDPAACHAENGEVRHPPSGRRASYGELADAAAKLPVPTDVALKKPEQFKLIGTPAKRLDSPEKVDGVAQFGLD
VRLPGMRYAVIVNSPVFGGTVASVDDTAAKKIPGVRQIVRVDDAVAVVGDHTWAAKRGASALVVKWNEGANANVSTKDLF
ADLAQAAANGKGAVARKDGDVDHAFSNAKTRVDAVYEQPLLAHATMEPVNCTVHVRSDACEVWVGTQVPTRARDTAQRIT
GLPAERIVVHNHLLGGGFGRRLETDMIGQAVKIAKQVGAPVKVVWTREEDIQHDMYRPCYHDRISAALDANGKPIAWRHR
IVGSSILARFAPPAFKDGVDPDAVEVAIDLPYDVPNQLIDYVRQEPRHVPTAFWRGVGPTRSTFVVESFIDELAAQTKTD
PVQYRRALLDKTPRARNVLDIATKAAGWGAALPQGQGRGVSVMHAFGSFFAIVADVAVDDGEVRVTRVVCAVDCGMTVNP
NTIEAQVQGGIIFGITGALYGEVTIENGRVTQRNFTDYRVLRINETPPIDVHIVKSGEAPGGIGEPGTAATAAAVANAIF
AATGKRLRKLPIGNQLKTA

Sequences:

>Translated_739_residues
MSRGLIEAGHAGAAMSRRSFLRFGMSLGAAAGGGLLLGFSLPAAGDDTRRSVIGGDADEPARAGVFAPNAFVQIDRSGRV
TLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPNEKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGANARVLLVS
AAAKQWNVDPAACHAENGEVRHPPSGRRASYGELADAAAKLPVPTDVALKKPEQFKLIGTPAKRLDSPEKVDGVAQFGLD
VRLPGMRYAVIVNSPVFGGTVASVDDTAAKKIPGVRQIVRVDDAVAVVGDHTWAAKRGASALVVKWNEGANANVSTKDLF
ADLAQAAANGKGAVARKDGDVDHAFSNAKTRVDAVYEQPLLAHATMEPVNCTVHVRSDACEVWVGTQVPTRARDTAQRIT
GLPAERIVVHNHLLGGGFGRRLETDMIGQAVKIAKQVGAPVKVVWTREEDIQHDMYRPCYHDRISAALDANGKPIAWRHR
IVGSSILARFAPPAFKDGVDPDAVEVAIDLPYDVPNQLIDYVRQEPRHVPTAFWRGVGPTRSTFVVESFIDELAAQTKTD
PVQYRRALLDKTPRARNVLDIATKAAGWGAALPQGQGRGVSVMHAFGSFFAIVADVAVDDGEVRVTRVVCAVDCGMTVNP
NTIEAQVQGGIIFGITGALYGEVTIENGRVTQRNFTDYRVLRINETPPIDVHIVKSGEAPGGIGEPGTAATAAAVANAIF
AATGKRLRKLPIGNQLKTA
>Mature_738_residues
SRGLIEAGHAGAAMSRRSFLRFGMSLGAAAGGGLLLGFSLPAAGDDTRRSVIGGDADEPARAGVFAPNAFVQIDRSGRVT
LVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPNEKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGANARVLLVSA
AAKQWNVDPAACHAENGEVRHPPSGRRASYGELADAAAKLPVPTDVALKKPEQFKLIGTPAKRLDSPEKVDGVAQFGLDV
RLPGMRYAVIVNSPVFGGTVASVDDTAAKKIPGVRQIVRVDDAVAVVGDHTWAAKRGASALVVKWNEGANANVSTKDLFA
DLAQAAANGKGAVARKDGDVDHAFSNAKTRVDAVYEQPLLAHATMEPVNCTVHVRSDACEVWVGTQVPTRARDTAQRITG
LPAERIVVHNHLLGGGFGRRLETDMIGQAVKIAKQVGAPVKVVWTREEDIQHDMYRPCYHDRISAALDANGKPIAWRHRI
VGSSILARFAPPAFKDGVDPDAVEVAIDLPYDVPNQLIDYVRQEPRHVPTAFWRGVGPTRSTFVVESFIDELAAQTKTDP
VQYRRALLDKTPRARNVLDIATKAAGWGAALPQGQGRGVSVMHAFGSFFAIVADVAVDDGEVRVTRVVCAVDCGMTVNPN
TIEAQVQGGIIFGITGALYGEVTIENGRVTQRNFTDYRVLRINETPPIDVHIVKSGEAPGGIGEPGTAATAAAVANAIFA
ATGKRLRKLPIGNQLKTA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786478, Length=386, Percent_Identity=24.6113989637306, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789230, Length=136, Percent_Identity=32.3529411764706, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 78564; Mature: 78433

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGLIEAGHAGAAMSRRSFLRFGMSLGAAAGGGLLLGFSLPAAGDDTRRSVIGGDADEP
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCC
ARAGVFAPNAFVQIDRSGRVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
CCCCEECCCCEEEECCCCCEEEEECCHHHCCCHHHHHHHHHHHHHCCCHHHEEECCCCCC
EKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGANARVLLVSAAAKQWNVDPAACHAENGEV
CCEEECCCCCCEECCCCCEEEEEHHHHHHCCCCCEEEEEEECCHHCCCCHHHEECCCCCC
RHPPSGRRASYGELADAAAKLPVPTDVALKKPEQFKLIGTPAKRLDSPEKVDGVAQFGLD
CCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCEEEECCCHHHCCCCHHHHHHHHCCCE
VRLPGMRYAVIVNSPVFGGTVASVDDTAAKKIPGVRQIVRVDDAVAVVGDHTWAAKRGAS
EECCCEEEEEEECCCCCCCEEECCCHHHHHHCCCHHHHHHHCCEEEEEECCCHHHHCCCC
ALVVKWNEGANANVSTKDLFADLAQAAANGKGAVARKDGDVDHAFSNAKTRVDAVYEQPL
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCHHHHHHHHHCCH
LAHATMEPVNCTVHVRSDACEVWVGTQVPTRARDTAQRITGLPAERIVVHNHLLGGGFGR
HHCCCCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCHHHEEEECCEECCCCCC
RLETDMIGQAVKIAKQVGAPVKVVWTREEDIQHDMYRPCYHDRISAALDANGKPIAWRHR
CCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHH
IVGSSILARFAPPAFKDGVDPDAVEVAIDLPYDVPNQLIDYVRQEPRHVPTAFWRGVGPT
HHHHHHHHHHCCCHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHCCCCCC
RSTFVVESFIDELAAQTKTDPVQYRRALLDKTPRARNVLDIATKAAGWGAALPQGQGRGV
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
SVMHAFGSFFAIVADVAVDDGEVRVTRVVCAVDCGMTVNPNTIEAQVQGGIIFGITGALY
HHHHHHHHHHHHHHHHEECCCCEEEEEEEEEEECCCEECCCEEEEEECCCEEEEECCEEE
GEVTIENGRVTQRNFTDYRVLRINETPPIDVHIVKSGEAPGGIGEPGTAATAAAVANAIF
EEEEEECCEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
AATGKRLRKLPIGNQLKTA
HHHCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SRGLIEAGHAGAAMSRRSFLRFGMSLGAAAGGGLLLGFSLPAAGDDTRRSVIGGDADEP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCC
ARAGVFAPNAFVQIDRSGRVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
CCCCEECCCCEEEECCCCCEEEEECCHHHCCCHHHHHHHHHHHHHCCCHHHEEECCCCCC
EKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGANARVLLVSAAAKQWNVDPAACHAENGEV
CCEEECCCCCCEECCCCCEEEEEHHHHHHCCCCCEEEEEEECCHHCCCCHHHEECCCCCC
RHPPSGRRASYGELADAAAKLPVPTDVALKKPEQFKLIGTPAKRLDSPEKVDGVAQFGLD
CCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCEEEECCCHHHCCCCHHHHHHHHCCCE
VRLPGMRYAVIVNSPVFGGTVASVDDTAAKKIPGVRQIVRVDDAVAVVGDHTWAAKRGAS
EECCCEEEEEEECCCCCCCEEECCCHHHHHHCCCHHHHHHHCCEEEEEECCCHHHHCCCC
ALVVKWNEGANANVSTKDLFADLAQAAANGKGAVARKDGDVDHAFSNAKTRVDAVYEQPL
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCHHHHHHHHHCCH
LAHATMEPVNCTVHVRSDACEVWVGTQVPTRARDTAQRITGLPAERIVVHNHLLGGGFGR
HHCCCCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCHHHEEEECCEECCCCCC
RLETDMIGQAVKIAKQVGAPVKVVWTREEDIQHDMYRPCYHDRISAALDANGKPIAWRHR
CCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHH
IVGSSILARFAPPAFKDGVDPDAVEVAIDLPYDVPNQLIDYVRQEPRHVPTAFWRGVGPT
HHHHHHHHHHCCCHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHCCCCCC
RSTFVVESFIDELAAQTKTDPVQYRRALLDKTPRARNVLDIATKAAGWGAALPQGQGRGV
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
SVMHAFGSFFAIVADVAVDDGEVRVTRVVCAVDCGMTVNPNTIEAQVQGGIIFGITGALY
HHHHHHHHHHHHHHHHEECCCCEEEEEEEEEEECCCEECCCEEEEEECCCEEEEECCEEE
GEVTIENGRVTQRNFTDYRVLRINETPPIDVHIVKSGEAPGGIGEPGTAATAAAVANAIF
EEEEEECCEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
AATGKRLRKLPIGNQLKTA
HHHCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]