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The map label for this gene is hipA [H]

Identifier: 189353047

GI number: 189353047

Start: 1214637

End: 1215971

Strand: Reverse

Name: hipA [H]

Synonym: BMULJ_04281

Alternate gene names: 189353047

Gene position: 1215971-1214637 (Counterclockwise)

Preceding gene: 189353048

Following gene: 189353045

Centisome position: 49.17

GC content: 68.01

Gene sequence:

>1335_bases
ATGGTCGTCCGCACCACCCGCCACGATCGCCTCGATCTATGGATGAACGGCATCCCGGTCGGCTACTGGGAAGTCAGGCG
CGGCGTCGAGCGCCTCGTCTATCTGCCGACATGGATCGACGATCCGCAAGGGCGGCCGCTGTCGCTGTCCCTGCCGTTCA
CGCCGGGCAACCAGCCGCATCACGGCGCGGTCGTCGCCGGCTACTTCGACAACCTGCTGCCGGACAGTCAGCCGATTCGA
CGCCGCATCGCGCAGCGCTACCGGCTCGGTTCGACGTCGCCGTTCGAGCTGCTTGCGTCGATCGGCCGCGACTGCGTCGG
CGCCCTGCAGCTGCTGCCGCCCGACGAAACGCCGGTCGATCTCGACACGATCGAAGGCACCGTGCTCGACGACGCGGCGG
TCGCCGACGTGCTGCGCCAGTCGACCGCCGCGCCGTTGCCCGGTCATGCGGAACACGAGGCAGACCTTCGGCTATCGATC
GCCGGCGCGCAGGAAAAGACGGCGCTGCTGCGTCACGGCAATCGCTGGCTCGTGCCGTCCGGCAGCACGCCGACGACGCA
CATCTTCAAGCTGCCGCTCGGACGCGTCGGCAACATGCAGGCCGACATGCGCACGTCCGTCGAAAACGAGTGGCTGTGCT
CGAAGATCGTCGCCGCTTATGGCCTGCCGGTCGCGCATTGCGACATCGGCCGGTTCGACGATCAGAAGGTGCTGATCGTC
GAGCGCTTCGATCGCCGGCTGTCGCGCGACGGCACGTGGATCCTGCGGCTGCCGCAGGAAGACATGTGCCAGGCGACCGG
CACGCCGCCGGCCGCGAAATACGAATCGGACGGCGGCCCCGGCATCGACACGATCATGGGCATCCTCGCGAATTCGGTCG
ATGCCGCGCGCGACCGGATGAACTTCTTCGTCGCGCAGCTCGTGTTCTGGGTACTCGCGGCAATCGACGGCCACGCGAAG
AATTTCAGCATCGCGCTTCTGCCCGGCAACACGTATCGCAGCACGCCGCTGTACGACGTGCTGTCCGCGCACCCGATCAT
CGGCACGCGCCGCAACCAGCTGGCACCGCGTCGCGCGCGACTCGCGATGGCCGTCAGCGGGAAGAATCGTCACTACGCGA
TCGCCGACATCCAGCCGCGCCATTGGATCGCGCAGGGACGGCGCGTCGGACTGTCCGACGACGACGTACGTACCGCGCTG
ACCGCCGTCGCGGCGCGCACGGAACCGGTGATTGCCGAAGTCGCCGCACACCTGCCGGCCGATTTTCCGGCCGATGTCGC
CGACGCGATCTTCGACGGCATGCGGCGCCAGAGCCGCAAGCTGATCGGCGCGTAG

Upstream 100 bases:

>100_bases
CAACCGCACCCGCAGCGAAAACGCCCGTCGGCGCCGCCGGCAAACGGACGCCCGCCACGCCGCGCAAACGCCGCGTCGCA
AAGCGGGAGGACTGGTAACG

Downstream 100 bases:

>100_bases
CGCGGCGCGGCCGCCTGCCCGCACGCGCGCACACGCATCGGCAAAGCGCGGAAGCCCGGACCGACCGGCCGGGCGCAGCA
GGCGGCGCCCTCGTTCAGCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MVVRTTRHDRLDLWMNGIPVGYWEVRRGVERLVYLPTWIDDPQGRPLSLSLPFTPGNQPHHGAVVAGYFDNLLPDSQPIR
RRIAQRYRLGSTSPFELLASIGRDCVGALQLLPPDETPVDLDTIEGTVLDDAAVADVLRQSTAAPLPGHAEHEADLRLSI
AGAQEKTALLRHGNRWLVPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKIVAAYGLPVAHCDIGRFDDQKVLIV
ERFDRRLSRDGTWILRLPQEDMCQATGTPPAAKYESDGGPGIDTIMGILANSVDAARDRMNFFVAQLVFWVLAAIDGHAK
NFSIALLPGNTYRSTPLYDVLSAHPIIGTRRNQLAPRRARLAMAVSGKNRHYAIADIQPRHWIAQGRRVGLSDDDVRTAL
TAVAARTEPVIAEVAAHLPADFPADVADAIFDGMRRQSRKLIGA

Sequences:

>Translated_444_residues
MVVRTTRHDRLDLWMNGIPVGYWEVRRGVERLVYLPTWIDDPQGRPLSLSLPFTPGNQPHHGAVVAGYFDNLLPDSQPIR
RRIAQRYRLGSTSPFELLASIGRDCVGALQLLPPDETPVDLDTIEGTVLDDAAVADVLRQSTAAPLPGHAEHEADLRLSI
AGAQEKTALLRHGNRWLVPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKIVAAYGLPVAHCDIGRFDDQKVLIV
ERFDRRLSRDGTWILRLPQEDMCQATGTPPAAKYESDGGPGIDTIMGILANSVDAARDRMNFFVAQLVFWVLAAIDGHAK
NFSIALLPGNTYRSTPLYDVLSAHPIIGTRRNQLAPRRARLAMAVSGKNRHYAIADIQPRHWIAQGRRVGLSDDDVRTAL
TAVAARTEPVIAEVAAHLPADFPADVADAIFDGMRRQSRKLIGA
>Mature_444_residues
MVVRTTRHDRLDLWMNGIPVGYWEVRRGVERLVYLPTWIDDPQGRPLSLSLPFTPGNQPHHGAVVAGYFDNLLPDSQPIR
RRIAQRYRLGSTSPFELLASIGRDCVGALQLLPPDETPVDLDTIEGTVLDDAAVADVLRQSTAAPLPGHAEHEADLRLSI
AGAQEKTALLRHGNRWLVPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKIVAAYGLPVAHCDIGRFDDQKVLIV
ERFDRRLSRDGTWILRLPQEDMCQATGTPPAAKYESDGGPGIDTIMGILANSVDAARDRMNFFVAQLVFWVLAAIDGHAK
NFSIALLPGNTYRSTPLYDVLSAHPIIGTRRNQLAPRRARLAMAVSGKNRHYAIADIQPRHWIAQGRRVGLSDDDVRTAL
TAVAARTEPVIAEVAAHLPADFPADVADAIFDGMRRQSRKLIGA

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=436, Percent_Identity=41.9724770642202, Blast_Score=321, Evalue=7e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 48884; Mature: 48884

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVRTTRHDRLDLWMNGIPVGYWEVRRGVERLVYLPTWIDDPQGRPLSLSLPFTPGNQPH
CEEECCCCCCHHHEECCCCCCHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCCCCCCCC
HGAVVAGYFDNLLPDSQPIRRRIAQRYRLGSTSPFELLASIGRDCVGALQLLPPDETPVD
CCCEEEEHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCC
LDTIEGTVLDDAAVADVLRQSTAAPLPGHAEHEADLRLSIAGAQEKTALLRHGNRWLVPS
HHHCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCEEEECC
GSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKIVAAYGLPVAHCDIGRFDDQKVLIV
CCCCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEH
ERFDRRLSRDGTWILRLPQEDMCQATGTPPAAKYESDGGPGIDTIMGILANSVDAARDRM
HHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
NFFVAQLVFWVLAAIDGHAKNFSIALLPGNTYRSTPLYDVLSAHPIIGTRRNQLAPRRAR
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHE
LAMAVSGKNRHYAIADIQPRHWIAQGRRVGLSDDDVRTALTAVAARTEPVIAEVAAHLPA
EEEEEECCCCEEEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCC
DFPADVADAIFDGMRRQSRKLIGA
CCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVVRTTRHDRLDLWMNGIPVGYWEVRRGVERLVYLPTWIDDPQGRPLSLSLPFTPGNQPH
CEEECCCCCCHHHEECCCCCCHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCCCCCCCC
HGAVVAGYFDNLLPDSQPIRRRIAQRYRLGSTSPFELLASIGRDCVGALQLLPPDETPVD
CCCEEEEHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCC
LDTIEGTVLDDAAVADVLRQSTAAPLPGHAEHEADLRLSIAGAQEKTALLRHGNRWLVPS
HHHCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCEEEECC
GSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKIVAAYGLPVAHCDIGRFDDQKVLIV
CCCCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEH
ERFDRRLSRDGTWILRLPQEDMCQATGTPPAAKYESDGGPGIDTIMGILANSVDAARDRM
HHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
NFFVAQLVFWVLAAIDGHAKNFSIALLPGNTYRSTPLYDVLSAHPIIGTRRNQLAPRRAR
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHE
LAMAVSGKNRHYAIADIQPRHWIAQGRRVGLSDDDVRTALTAVAARTEPVIAEVAAHLPA
EEEEEECCCCEEEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCC
DFPADVADAIFDGMRRQSRKLIGA
CCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]