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The map label for this gene is hppD [H]

Identifier: 189353046

GI number: 189353046

Start: 1213487

End: 1214542

Strand: Direct

Name: hppD [H]

Synonym: BMULJ_04280

Alternate gene names: 189353046

Gene position: 1213487-1214542 (Clockwise)

Preceding gene: 189353044

Following gene: 189353050

Centisome position: 49.07

GC content: 67.14

Gene sequence:

>1056_bases
ATGGCGGGGATCGAGTTCGTCGAGTTCGCGGCGCCGGTGCCGGACGTGCTCGCGCAGCGTTTCGAACAGCTCGGCTTCAA
GGCGATCGCGCGGCACGTCAGCAAGGCCGTGACGCTGTATCGGCAGGGGCAGATGCATTTCCTGATCAACGCTGAACCGG
ACTCGTTCGCCGCGCGCTATGCGGAGGAATACGGGATGGGAGTCTGCGCGATCGGCATCCGCGTCGCGAACGCGCGGCGC
TCGTTCGAACGCGCGATCGAACTGGGCGCGTGGGCGTTCGAGGGCGAGCGCGTCGGCGTCGGTGAGCTGAAGATTCCGGC
GATCCAGGGCATCGGCGATTCGCATCTGTACTTCGTCGATCGCTGGCGCGGGCGCAACGGCCAGCGCGGCGGCGTGGGCG
ACATCTCGATCTTCGACATCGATTTCCGGCCGATCGACATCGCCACCGCGCACACCGATCTCGATTTCGCGGGCACCGGG
CTGCAGCAGGTCGACCATTTCACGCAGACGGTCGGCGCCGGGCGCATGCAGGAGTGGCTCGACTTCTACCACGATCTGCT
GCACTTCCGCGAGATTCACGAAATCGATGCGCACTGGCACGTGTCGGAGGAGTCGCGCGTGATGGTGTCGCCGTGCGGCG
CGCTGCGGATTCCGGTGTACGAGGAAGGCACGCGCCGCACCGAGCTGATGCACGCGTATCTGCCCGACCATCCGGGCGAG
GGCGTCCAGCACATCGCGCTCGCGACGGACGACATCCTCGCGTCGGTCGACGCGTTGCGGGCGAACGGCGTCGAGTTCAT
CGAGCCGCCCGCGCGCTACTACGACGAGGTGGACCAGCGGTTGCCGGGGCACGGCGTCGATCTGGACGCGCTGCGCCGTC
GTGCGGTATTGATCGACGGCGAGATCGGCGAAGACGGCGTGCCGCGCCTGTTCTTCCAGACGTTCGTCAAGCGCCGGCCC
GGCGAAATCTTCTTCGAGATCGTGCAGCGCAAGGGGCATCACGGTTTCGGCGAAGGCAATCTCGCGGCGCTCGCGCGCGC
TCGCGACGCAAGCTGA

Upstream 100 bases:

>100_bases
CCATAGAATGCATCCCTCGGAGACTGGAATGTCCGGCAATCCCCATCCACTGTCCAGCGATACGCCGCCCGTCGACGATC
CGGCCGCCAATCCGCTCGGG

Downstream 100 bases:

>100_bases
ACGAGGGCGCCGCCTGCTGCGCCCGGCCGGTCGGTCCGGGCTTCCGCGCTTTGCCGATGCGTGTGCGCGCGTGCGGGCAG
GCGGCCGCGCCGCGCTACGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MAGIEFVEFAAPVPDVLAQRFEQLGFKAIARHVSKAVTLYRQGQMHFLINAEPDSFAARYAEEYGMGVCAIGIRVANARR
SFERAIELGAWAFEGERVGVGELKIPAIQGIGDSHLYFVDRWRGRNGQRGGVGDISIFDIDFRPIDIATAHTDLDFAGTG
LQQVDHFTQTVGAGRMQEWLDFYHDLLHFREIHEIDAHWHVSEESRVMVSPCGALRIPVYEEGTRRTELMHAYLPDHPGE
GVQHIALATDDILASVDALRANGVEFIEPPARYYDEVDQRLPGHGVDLDALRRRAVLIDGEIGEDGVPRLFFQTFVKRRP
GEIFFEIVQRKGHHGFGEGNLAALARARDAS

Sequences:

>Translated_351_residues
MAGIEFVEFAAPVPDVLAQRFEQLGFKAIARHVSKAVTLYRQGQMHFLINAEPDSFAARYAEEYGMGVCAIGIRVANARR
SFERAIELGAWAFEGERVGVGELKIPAIQGIGDSHLYFVDRWRGRNGQRGGVGDISIFDIDFRPIDIATAHTDLDFAGTG
LQQVDHFTQTVGAGRMQEWLDFYHDLLHFREIHEIDAHWHVSEESRVMVSPCGALRIPVYEEGTRRTELMHAYLPDHPGE
GVQHIALATDDILASVDALRANGVEFIEPPARYYDEVDQRLPGHGVDLDALRRRAVLIDGEIGEDGVPRLFFQTFVKRRP
GEIFFEIVQRKGHHGFGEGNLAALARARDAS
>Mature_350_residues
AGIEFVEFAAPVPDVLAQRFEQLGFKAIARHVSKAVTLYRQGQMHFLINAEPDSFAARYAEEYGMGVCAIGIRVANARRS
FERAIELGAWAFEGERVGVGELKIPAIQGIGDSHLYFVDRWRGRNGQRGGVGDISIFDIDFRPIDIATAHTDLDFAGTGL
QQVDHFTQTVGAGRMQEWLDFYHDLLHFREIHEIDAHWHVSEESRVMVSPCGALRIPVYEEGTRRTELMHAYLPDHPGEG
VQHIALATDDILASVDALRANGVEFIEPPARYYDEVDQRLPGHGVDLDALRRRAVLIDGEIGEDGVPRLFFQTFVKRRPG
EIFFEIVQRKGHHGFGEGNLAALARARDAS

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=349, Percent_Identity=24.6418338108883, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI4504477, Length=349, Percent_Identity=24.6418338108883, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI14249394, Length=231, Percent_Identity=28.1385281385281, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555220, Length=196, Percent_Identity=32.1428571428571, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550752, Length=194, Percent_Identity=29.3814432989691, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667510, Length=356, Percent_Identity=27.5280898876405, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356105, Length=299, Percent_Identity=28.0936454849498, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 39272; Mature: 39141

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIEFVEFAAPVPDVLAQRFEQLGFKAIARHVSKAVTLYRQGQMHFLINAEPDSFAARY
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
AEEYGMGVCAIGIRVANARRSFERAIELGAWAFEGERVGVGELKIPAIQGIGDSHLYFVD
HHHHCCEEEEEHEEEHHHHHHHHHHHHHCCEEECCCEECCCCEECCCCCCCCCCCEEEEE
RWRGRNGQRGGVGDISIFDIDFRPIDIATAHTDLDFAGTGLQQVDHFTQTVGAGRMQEWL
EECCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
DFYHDLLHFREIHEIDAHWHVSEESRVMVSPCGALRIPVYEEGTRRTELMHAYLPDHPGE
HHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCEEECCCCCCCCHHHHHHHHHCCCCCCC
GVQHIALATDDILASVDALRANGVEFIEPPARYYDEVDQRLPGHGVDLDALRRRAVLIDG
CCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCEEEEEEC
EIGEDGVPRLFFQTFVKRRPGEIFFEIVQRKGHHGFGEGNLAALARARDAS
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
AGIEFVEFAAPVPDVLAQRFEQLGFKAIARHVSKAVTLYRQGQMHFLINAEPDSFAARY
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
AEEYGMGVCAIGIRVANARRSFERAIELGAWAFEGERVGVGELKIPAIQGIGDSHLYFVD
HHHHCCEEEEEHEEEHHHHHHHHHHHHHCCEEECCCEECCCCEECCCCCCCCCCCEEEEE
RWRGRNGQRGGVGDISIFDIDFRPIDIATAHTDLDFAGTGLQQVDHFTQTVGAGRMQEWL
EECCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
DFYHDLLHFREIHEIDAHWHVSEESRVMVSPCGALRIPVYEEGTRRTELMHAYLPDHPGE
HHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCEEECCCCCCCCHHHHHHHHHCCCCCCC
GVQHIALATDDILASVDALRANGVEFIEPPARYYDEVDQRLPGHGVDLDALRRRAVLIDG
CCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCEEEEEEC
EIGEDGVPRLFFQTFVKRRPGEIFFEIVQRKGHHGFGEGNLAALARARDAS
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]