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The map label for this gene is aptA [C]

Identifier: 189352978

GI number: 189352978

Start: 1137951

End: 1139267

Strand: Direct

Name: aptA [C]

Synonym: BMULJ_04212

Alternate gene names: 189352978

Gene position: 1137951-1139267 (Clockwise)

Preceding gene: 189352976

Following gene: 189352979

Centisome position: 46.01

GC content: 68.26

Gene sequence:

>1317_bases
GTGCGCACCGACGCCGCCTGGCTCGACGCGCACTGGATGCCGTTTACGGCGAACCGCCAGTTCAAGTCCGACCCGCGCAT
GATCGTCTCGGGCAAGGGCGCGTACTACACCGACGCCGAAGGCCGCAAGATCTTCGACGGGCTGTCCGGCCTCTGGTGTA
CGGGCCTCGGTCACGGCCGCACCGAAATCGTCGAAGCGGTGAGCCGCCAGGTCGCACAGCTCGACTACGCGCCGGCATTC
CAGTTCGGCCATCCGAAGTCGTTCGAGCTTGCGAACCGGATCAAGGAACTGACGCCGGCCGGCCTCGACTACGTGTTCTT
CACGGGCTCGGGCTCGGAGGCGGCCGACACGTCGCTGAAGATGGCGCGCGCGTACTGGCGCGCGAAAGGCAAGGGCACGA
AGACGCGGCTGATCGGCCGCGAGAAGGGCTATCACGGCGTGAACTTCGGCGGCATCTCGGTCGGCGGCATCGGGCCGAAC
CGCAAGCTGTTCGGCCAGGGGCTCGACGCCGATTTCCTGCCGCATACGCAGCTGGCCGAAAACAAGTTCTCGCGCGGCAT
GCCCGAGCGCGGCGCCGAACTGGCCGATCGCCTGCTCGACCTGATCGCGCTGCACGACGCGTCGAACATCGCCGCCGTGA
TCGTCGAGCCGTTCGCGGGCTCGGCCGGCGTGATCATCCCGCCGCAAGGCTACCTGCAGCGGCTGCGCGAGATCTGCACC
GCGCACGACATCCTGCTGATCTTCGACGAAGTCATCACGGGCTTCGGCCGCGCCGGCGCGATGACGGGCGCGGAAGCGTT
CGGCGTGACGCCCGACATCATGAACTTCGCGAAGCAGGTGACGAACGGCGTGCAGCCGCTCGGCGGCGTGGTCGCGACCA
AGGAGATCTACGACACGTTCATGGCCGCGGGCGGCCCCGAGTACATGCTCGAATTCCCGCACGGCTACACGTACTCGGCG
CACCCGGTCGCGTGCGCGGCCGGTGTCGCGGCGCTTGACCTGCTCGTGAAGGAAGACGCCGTGGCGCGCGTGCGCGAGCT
CGCGCCGCATTTCGAGGCGGCCGTGCACGGGCTGAAGGGCCAGCGTCATATCGCCGACATCCGCAACTACGGGCTCGCGG
CCGGCCTGACGATCGCCGCGCTGCCGGGCGAACCGGCGCGCCGTCCGTACGAGATCGCGATGCGCTGCTGGGCGAAGGGC
TTCTACGTGCGCTACGGCGGCGACACGATCCAGCTCGCGCCGCCGTTCATCGCCGAAAAGCGCGAGATCGACAATCTGAT
CAACGCGGTGTCCGACGCGCTGAACGAAGTGGACTGA

Upstream 100 bases:

>100_bases
TCGTCCCGACAATGCGCAACATCATCACGAGGAGGAGGGGCGCGCCGCGCCGACCGACATGACCGACACCATCACCGCTC
CGCAACAGGAACAGACGCCC

Downstream 100 bases:

>100_bases
GGCGCGCGCCGCACGATCGCGACCGTTGAATTGAATTCACGAAAGAGTCTGAACGATGAAACACGATAGCAACGTCACTT
CCACGCTGGGCCACCTGATC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRTDAAWLDAHWMPFTANRQFKSDPRMIVSGKGAYYTDAEGRKIFDGLSGLWCTGLGHGRTEIVEAVSRQVAQLDYAPAF
QFGHPKSFELANRIKELTPAGLDYVFFTGSGSEAADTSLKMARAYWRAKGKGTKTRLIGREKGYHGVNFGGISVGGIGPN
RKLFGQGLDADFLPHTQLAENKFSRGMPERGAELADRLLDLIALHDASNIAAVIVEPFAGSAGVIIPPQGYLQRLREICT
AHDILLIFDEVITGFGRAGAMTGAEAFGVTPDIMNFAKQVTNGVQPLGGVVATKEIYDTFMAAGGPEYMLEFPHGYTYSA
HPVACAAGVAALDLLVKEDAVARVRELAPHFEAAVHGLKGQRHIADIRNYGLAAGLTIAALPGEPARRPYEIAMRCWAKG
FYVRYGGDTIQLAPPFIAEKREIDNLINAVSDALNEVD

Sequences:

>Translated_438_residues
MRTDAAWLDAHWMPFTANRQFKSDPRMIVSGKGAYYTDAEGRKIFDGLSGLWCTGLGHGRTEIVEAVSRQVAQLDYAPAF
QFGHPKSFELANRIKELTPAGLDYVFFTGSGSEAADTSLKMARAYWRAKGKGTKTRLIGREKGYHGVNFGGISVGGIGPN
RKLFGQGLDADFLPHTQLAENKFSRGMPERGAELADRLLDLIALHDASNIAAVIVEPFAGSAGVIIPPQGYLQRLREICT
AHDILLIFDEVITGFGRAGAMTGAEAFGVTPDIMNFAKQVTNGVQPLGGVVATKEIYDTFMAAGGPEYMLEFPHGYTYSA
HPVACAAGVAALDLLVKEDAVARVRELAPHFEAAVHGLKGQRHIADIRNYGLAAGLTIAALPGEPARRPYEIAMRCWAKG
FYVRYGGDTIQLAPPFIAEKREIDNLINAVSDALNEVD
>Mature_438_residues
MRTDAAWLDAHWMPFTANRQFKSDPRMIVSGKGAYYTDAEGRKIFDGLSGLWCTGLGHGRTEIVEAVSRQVAQLDYAPAF
QFGHPKSFELANRIKELTPAGLDYVFFTGSGSEAADTSLKMARAYWRAKGKGTKTRLIGREKGYHGVNFGGISVGGIGPN
RKLFGQGLDADFLPHTQLAENKFSRGMPERGAELADRLLDLIALHDASNIAAVIVEPFAGSAGVIIPPQGYLQRLREICT
AHDILLIFDEVITGFGRAGAMTGAEAFGVTPDIMNFAKQVTNGVQPLGGVVATKEIYDTFMAAGGPEYMLEFPHGYTYSA
HPVACAAGVAALDLLVKEDAVARVRELAPHFEAAVHGLKGQRHIADIRNYGLAAGLTIAALPGEPARRPYEIAMRCWAKG
FYVRYGGDTIQLAPPFIAEKREIDNLINAVSDALNEVD

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=27.1634615384615, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI37574042, Length=369, Percent_Identity=30.6233062330623, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI226442705, Length=369, Percent_Identity=30.6233062330623, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=25.5656108597285, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI226442709, Length=334, Percent_Identity=30.8383233532934, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=27.0516717325228, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI24119277, Length=381, Percent_Identity=28.0839895013123, Blast_Score=109, Evalue=6e-24,
Organism=Escherichia coli, GI1786991, Length=441, Percent_Identity=29.7052154195011, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI145693181, Length=310, Percent_Identity=32.258064516129, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789759, Length=437, Percent_Identity=27.9176201372998, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788044, Length=403, Percent_Identity=28.7841191066998, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=26.555023923445, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=27.1428571428571, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786349, Length=328, Percent_Identity=28.6585365853659, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=26.7415730337079, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=25.7075471698113, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=441, Percent_Identity=26.984126984127, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=241, Percent_Identity=28.6307053941909, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=311, Percent_Identity=24.1157556270096, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=434, Percent_Identity=25.1152073732719, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=473, Percent_Identity=24.1014799154334, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=25.0591016548463, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=25.6658595641646, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574759, Length=452, Percent_Identity=28.3185840707965, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=27.4193548387097, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI161085790, Length=441, Percent_Identity=27.437641723356, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47389; Mature: 47389

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTDAAWLDAHWMPFTANRQFKSDPRMIVSGKGAYYTDAEGRKIFDGLSGLWCTGLGHGR
CCCCCCCCCCCCCCEECCCCCCCCCCEEEECCCCEEECCCCCHHHHCCCCCEECCCCCCH
TEIVEAVSRQVAQLDYAPAFQFGHPKSFELANRIKELTPAGLDYVFFTGSGSEAADTSLK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
MARAYWRAKGKGTKTRLIGREKGYHGVNFGGISVGGIGPNRKLFGQGLDADFLPHTQLAE
HHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCCHHHHH
NKFSRGMPERGAELADRLLDLIALHDASNIAAVIVEPFAGSAGVIIPPQGYLQRLREICT
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHH
AHDILLIFDEVITGFGRAGAMTGAEAFGVTPDIMNFAKQVTNGVQPLGGVVATKEIYDTF
HHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MAAGGPEYMLEFPHGYTYSAHPVACAAGVAALDLLVKEDAVARVRELAPHFEAAVHGLKG
HHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QRHIADIRNYGLAAGLTIAALPGEPARRPYEIAMRCWAKGFYVRYGGDTIQLAPPFIAEK
CHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCEEEECCCHHHHH
REIDNLINAVSDALNEVD
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTDAAWLDAHWMPFTANRQFKSDPRMIVSGKGAYYTDAEGRKIFDGLSGLWCTGLGHGR
CCCCCCCCCCCCCCEECCCCCCCCCCEEEECCCCEEECCCCCHHHHCCCCCEECCCCCCH
TEIVEAVSRQVAQLDYAPAFQFGHPKSFELANRIKELTPAGLDYVFFTGSGSEAADTSLK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
MARAYWRAKGKGTKTRLIGREKGYHGVNFGGISVGGIGPNRKLFGQGLDADFLPHTQLAE
HHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCCHHHHH
NKFSRGMPERGAELADRLLDLIALHDASNIAAVIVEPFAGSAGVIIPPQGYLQRLREICT
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHH
AHDILLIFDEVITGFGRAGAMTGAEAFGVTPDIMNFAKQVTNGVQPLGGVVATKEIYDTF
HHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MAAGGPEYMLEFPHGYTYSAHPVACAAGVAALDLLVKEDAVARVRELAPHFEAAVHGLKG
HHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QRHIADIRNYGLAAGLTIAALPGEPARRPYEIAMRCWAKGFYVRYGGDTIQLAPPFIAEK
CHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCEEEECCCHHHHH
REIDNLINAVSDALNEVD
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]