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The map label for this gene is yveA [H]

Identifier: 189352827

GI number: 189352827

Start: 949437

End: 951062

Strand: Reverse

Name: yveA [H]

Synonym: BMULJ_04061

Alternate gene names: 189352827

Gene position: 951062-949437 (Counterclockwise)

Preceding gene: 189352832

Following gene: 189352826

Centisome position: 38.46

GC content: 66.61

Gene sequence:

>1626_bases
ATGCCAGGCCAAGGCAACGCTCAATCGTCCGTCCCGCTTTCCGGTTCCGCGCACCCCGACGCGGGCCACGGCAAGTTCAA
GAAACAGCTGTCGCTCACCGACCTGACCTTCATCGGTCTCGGCGCCATCTTCGGTTCCGGCTGGCTGTTCGCCGCGAGCC
ACGTGTCGACGATCGCCGGCCCGGCCGGCATCTTCTCGTGGCTGCTCGGCGGCTTCGCGGTGCTGCTGCTCGGCATCGTC
TACTGCGAGCTCGGCGCCGCGCTGCCGCGCGCGGGCGGCGTCGTGCGCTATCCGGTGTTCTCGCACGGCCCGCTGCTCGG
CTATCTGATGGGCTTCATCACGCTGATCGCGTTCTCGAGCCTGATCGCGATCGAAGTCGTGGCCGCGCGGCAATATGCGG
CCGCATGGTTTCCGGGGCTCACCGTCGAAGGGTCGAGCGACCCGACGACGCTCGGCTGGCTCGTGCAGGCGGCCCTGCTC
TGCTTCTTCTTTTATCTGAACTACTCGAGCGTGAAGACGTTCGCGAAGGCGAACAACATCATCAGCATCTTCAAGTTCAT
CGTGCCGCTGTCGGTGATCGCGGTGCTGTTCACGTTCTTCAAGCCCGCCAACCTCACCGTGCACGGCTTCGCGCCGTTCG
GCATGCCGGGCATCGAAATGGCCGTGTCCGCCGGCGGCATCATCTTCGCGTATCTCGGCCTCACGCCGATCGTGTCGGTC
GCGAGCGAAGTGCGCAATCCGCAGCGCACGATTCCGATCGCGCTGATCTTGTCGATCCTGCTGTCGACGCTGATCTACGT
GCTGCTGCAGCTCGCGTTCATCGGCAGCATCCCGACCGACATGCTCGCCGCCGGCTGGCACGACGTCAGCAAGGCCTTCT
CGCTGCCGTACCGCGACATCGCGCTCGCGCTCGGCGTCGGCTGGCTCGCCGTGATGGTCGTCGCGGACGCGATGATCTCG
CCGAGCGGCTGCGGCAACATCTACATGAATGCGACGCCGCGCGTCGTGTACGGCTGGGCGAAGACGGGTACGTTCTTCAA
GGTCTTCACGCGCGTCGACGAGGCGTCGGGCATTCCGCGCGCGGGCCTCTGGCTCACGTTCGGCCTCTCGATCTTCTGGA
CGATGCCGTTCCCGTCGTGGGAAGCGTTGATCAACATCGTGTCGGCGGCGCTCGTGCTCAGCTACGCGGTCGCGCCGGTA
TCGGTCGCCGCGCTGCGCCGCACGGCGCCCGATCTGCCGCGTCCGTTCCGCGCGAGCGCGTTCGCAATCACCGGCCCGGC
GTCGTTCGTGATCGCCGCGCTGATCGTCTACTGGTCGGGCTGGCACACGGTGTCCTGGCTGCTCGGCCTGCAGATCGCGA
TGTTCGCGATCTATCTCGCGTGCCGCCGCTGGGTGCCCACCGCGCATCTGAGCCTCGCCGAACAGGTGCGCTCGTCCGCG
TGGCTGATCGCGTTCTACGCGGCCATGATCGTGCTGTCGTACTTCGGCGGCTTCGGCGGTACCGGCCAGCTTGCGCATCC
GTACGACACGGTCGTCGTCGCCGCGGTCGCGCTCGCCATCTACTACTGGGGCGCGAATACGGGCGTGCGTTCCGACAAGC
TGCAGCTCGAGGACGACGAAGGCTGA

Upstream 100 bases:

>100_bases
GCTCGAACCGGATTACGCCGACCGGCAGGCGTGCGCCGCTGCTCCGTCGGAGCGCGGCGCACATGAAGCCTGTGCCGACA
TTCCCATAGGAGACACGCCC

Downstream 100 bases:

>100_bases
CGCGCGCGCTTTCCCCATCATCCGTCGGCCGGGCGATCGCGCCCGGCCCTGCTTTTTTCCGAGGAGAACCATGCAACTCA
CAGGTCAGCTGTTGATCGGC

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MPGQGNAQSSVPLSGSAHPDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSTIAGPAGIFSWLLGGFAVLLLGIV
YCELGAALPRAGGVVRYPVFSHGPLLGYLMGFITLIAFSSLIAIEVVAARQYAAAWFPGLTVEGSSDPTTLGWLVQAALL
CFFFYLNYSSVKTFAKANNIISIFKFIVPLSVIAVLFTFFKPANLTVHGFAPFGMPGIEMAVSAGGIIFAYLGLTPIVSV
ASEVRNPQRTIPIALILSILLSTLIYVLLQLAFIGSIPTDMLAAGWHDVSKAFSLPYRDIALALGVGWLAVMVVADAMIS
PSGCGNIYMNATPRVVYGWAKTGTFFKVFTRVDEASGIPRAGLWLTFGLSIFWTMPFPSWEALINIVSAALVLSYAVAPV
SVAALRRTAPDLPRPFRASAFAITGPASFVIAALIVYWSGWHTVSWLLGLQIAMFAIYLACRRWVPTAHLSLAEQVRSSA
WLIAFYAAMIVLSYFGGFGGTGQLAHPYDTVVVAAVALAIYYWGANTGVRSDKLQLEDDEG

Sequences:

>Translated_541_residues
MPGQGNAQSSVPLSGSAHPDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSTIAGPAGIFSWLLGGFAVLLLGIV
YCELGAALPRAGGVVRYPVFSHGPLLGYLMGFITLIAFSSLIAIEVVAARQYAAAWFPGLTVEGSSDPTTLGWLVQAALL
CFFFYLNYSSVKTFAKANNIISIFKFIVPLSVIAVLFTFFKPANLTVHGFAPFGMPGIEMAVSAGGIIFAYLGLTPIVSV
ASEVRNPQRTIPIALILSILLSTLIYVLLQLAFIGSIPTDMLAAGWHDVSKAFSLPYRDIALALGVGWLAVMVVADAMIS
PSGCGNIYMNATPRVVYGWAKTGTFFKVFTRVDEASGIPRAGLWLTFGLSIFWTMPFPSWEALINIVSAALVLSYAVAPV
SVAALRRTAPDLPRPFRASAFAITGPASFVIAALIVYWSGWHTVSWLLGLQIAMFAIYLACRRWVPTAHLSLAEQVRSSA
WLIAFYAAMIVLSYFGGFGGTGQLAHPYDTVVVAAVALAIYYWGANTGVRSDKLQLEDDEG
>Mature_540_residues
PGQGNAQSSVPLSGSAHPDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSTIAGPAGIFSWLLGGFAVLLLGIVY
CELGAALPRAGGVVRYPVFSHGPLLGYLMGFITLIAFSSLIAIEVVAARQYAAAWFPGLTVEGSSDPTTLGWLVQAALLC
FFFYLNYSSVKTFAKANNIISIFKFIVPLSVIAVLFTFFKPANLTVHGFAPFGMPGIEMAVSAGGIIFAYLGLTPIVSVA
SEVRNPQRTIPIALILSILLSTLIYVLLQLAFIGSIPTDMLAAGWHDVSKAFSLPYRDIALALGVGWLAVMVVADAMISP
SGCGNIYMNATPRVVYGWAKTGTFFKVFTRVDEASGIPRAGLWLTFGLSIFWTMPFPSWEALINIVSAALVLSYAVAPVS
VAALRRTAPDLPRPFRASAFAITGPASFVIAALIVYWSGWHTVSWLLGLQIAMFAIYLACRRWVPTAHLSLAEQVRSSAW
LIAFYAAMIVLSYFGGFGGTGQLAHPYDTVVVAAVALAIYYWGANTGVRSDKLQLEDDEG

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=403, Percent_Identity=26.0545905707196, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI258614005, Length=436, Percent_Identity=23.1651376146789, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI258614003, Length=436, Percent_Identity=22.7064220183486, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33286428, Length=436, Percent_Identity=25.4587155963303, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI114326544, Length=422, Percent_Identity=22.5118483412322, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI114326550, Length=422, Percent_Identity=22.5118483412322, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI258645169, Length=436, Percent_Identity=23.1651376146789, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI187423910, Length=402, Percent_Identity=24.1293532338308, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI7657591, Length=402, Percent_Identity=24.1293532338308, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI186910308, Length=460, Percent_Identity=22.6086956521739, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI186910306, Length=460, Percent_Identity=22.6086956521739, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI186910304, Length=460, Percent_Identity=22.6086956521739, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI115648063, Length=469, Percent_Identity=21.7484008528785, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI115648022, Length=469, Percent_Identity=21.7484008528785, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI181337167, Length=399, Percent_Identity=21.8045112781955, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788480, Length=362, Percent_Identity=29.0055248618785, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI87082250, Length=358, Percent_Identity=29.3296089385475, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786302, Length=417, Percent_Identity=23.5011990407674, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786602, Length=437, Percent_Identity=23.5697940503432, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081708, Length=358, Percent_Identity=24.0223463687151, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790653, Length=361, Percent_Identity=22.9916897506925, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI2367353, Length=344, Percent_Identity=27.3255813953488, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786789, Length=428, Percent_Identity=24.0654205607477, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=422, Percent_Identity=26.5402843601896, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532491, Length=413, Percent_Identity=27.8450363196126, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533459, Length=422, Percent_Identity=25.5924170616114, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540018, Length=413, Percent_Identity=24.2130750605327, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17568033, Length=434, Percent_Identity=24.8847926267281, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667468, Length=445, Percent_Identity=24.0449438202247, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357367, Length=444, Percent_Identity=27.4774774774775, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221512776, Length=414, Percent_Identity=24.8792270531401, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24666159, Length=418, Percent_Identity=25.1196172248804, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550968, Length=480, Percent_Identity=26.0416666666667, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921172, Length=480, Percent_Identity=26.0416666666667, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668806, Length=421, Percent_Identity=22.5653206650831, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356285, Length=421, Percent_Identity=22.5653206650831, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24668802, Length=421, Percent_Identity=22.5653206650831, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221331183, Length=271, Percent_Identity=26.1992619926199, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17647653, Length=271, Percent_Identity=26.1992619926199, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664379, Length=271, Percent_Identity=26.1992619926199, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641993, Length=424, Percent_Identity=23.8207547169811, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641995, Length=422, Percent_Identity=23.696682464455, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24651635, Length=441, Percent_Identity=22.9024943310658, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651633, Length=441, Percent_Identity=22.9024943310658, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 57738; Mature: 57607

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGQGNAQSSVPLSGSAHPDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSTIAG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
PAGIFSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGFITLIAFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
LIAIEVVAARQYAAAWFPGLTVEGSSDPTTLGWLVQAALLCFFFYLNYSSVKTFAKANNI
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISIFKFIVPLSVIAVLFTFFKPANLTVHGFAPFGMPGIEMAVSAGGIIFAYLGLTPIVSV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHH
ASEVRNPQRTIPIALILSILLSTLIYVLLQLAFIGSIPTDMLAAGWHDVSKAFSLPYRDI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHCCCHHHH
ALALGVGWLAVMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFTRVDEASGIPR
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
AGLWLTFGLSIFWTMPFPSWEALINIVSAALVLSYAVAPVSVAALRRTAPDLPRPFRASA
CCHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
FAITGPASFVIAALIVYWSGWHTVSWLLGLQIAMFAIYLACRRWVPTAHLSLAEQVRSSA
EEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WLIAFYAAMIVLSYFGGFGGTGQLAHPYDTVVVAAVALAIYYWGANTGVRSDKLQLEDDE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure 
PGQGNAQSSVPLSGSAHPDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSTIAG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
PAGIFSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGFITLIAFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
LIAIEVVAARQYAAAWFPGLTVEGSSDPTTLGWLVQAALLCFFFYLNYSSVKTFAKANNI
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISIFKFIVPLSVIAVLFTFFKPANLTVHGFAPFGMPGIEMAVSAGGIIFAYLGLTPIVSV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHH
ASEVRNPQRTIPIALILSILLSTLIYVLLQLAFIGSIPTDMLAAGWHDVSKAFSLPYRDI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHCCCHHHH
ALALGVGWLAVMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFTRVDEASGIPR
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
AGLWLTFGLSIFWTMPFPSWEALINIVSAALVLSYAVAPVSVAALRRTAPDLPRPFRASA
CCHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
FAITGPASFVIAALIVYWSGWHTVSWLLGLQIAMFAIYLACRRWVPTAHLSLAEQVRSSA
EEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WLIAFYAAMIVLSYFGGFGGTGQLAHPYDTVVVAAVALAIYYWGANTGVRSDKLQLEDDE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]