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The map label for this gene is ptxR [H]

Identifier: 189352738

GI number: 189352738

Start: 844308

End: 845270

Strand: Direct

Name: ptxR [H]

Synonym: BMULJ_03970

Alternate gene names: 189352738

Gene position: 844308-845270 (Clockwise)

Preceding gene: 189352734

Following gene: 189352741

Centisome position: 34.14

GC content: 69.57

Gene sequence:

>963_bases
ATGCGACATCCGACCGAGCCGGTTGCCGGCAAGCTGAACTGGGACGACCTGCGCTTCTTCCTCGAAGTCGCGCGCACGCA
GCGGGCGAGCGGTGCCGCAAAGCGGCTCGGCGTCGACTACACGACCGTCGCACGGCGCATCCGCGCGCTGGAGGCGTCGC
TCGGCACGCTGCTGTTCGACAAGTCGCGCGCGGAAGGCTTCACGCTGACGGCCGAAGGGCAGCGGCTCGTCGCCTACGCG
GACGCGATGGAGACGACCGTGCAGTCCGCCTGCGACCAGGTCGCGCATACGGGCGAGGCGTTGTCCGGCCACGTGCGGAT
CGGGTCGACCGAAGGGTTCGGCTGCTTCTTTCTCGCGCCGCAGCTCGCGCGGTTTCGCGCCGCGCATCCGCGCGTGACGG
TCGATCTGCTGCCGGTGCCGCATTTCGTCAGCCTCACGAAGCGCGAGGCCGATCTCGCCGTCACGCTCGAGCGGCCGGAG
CGCGGCCCTTACGTCTGCACGAAGCTTTGCGACTATCAGTTGCGGCTTTATGCGACGCGCGACTATCTCGCGAGCCATCC
GCCGATCGCGGGCACCGACGATCTCGCGCGGCATACCTTCATCAGCTATGTCGACGATCTCGCGTTCAGCAGCGAGCTGC
TCTATCTCGAGCGCGCGGTGCCGGGCGCGACGGCCGGACTCAGAACGACGAGCGTGATCGCGCAGTCCTTCGCGGCGCTG
CACGGCGGCGGGCTCGCGATCCTGCCGTGCTTCATCGCGGCCGCGCAGCCGGCGCTCGTGCCGGTGCTGCCGGATCAGGT
CGTCGTCACACGCTGCTTCTGGCTGACCTGCCGTGAGGACTTGCGCAAGCTGCGGCGCGTGACCGCGCTGTGGGACTATC
TGCGCGCGGCGGCGGACGCGAACCGCGCGCTGCTGTCGGGTGAGTCGAGCGAGTTGCGGTTCGTCGGGGAGCCGGGCGGT
TGA

Upstream 100 bases:

>100_bases
GTTATGCGCAGATTCGCGATGTACCGACAAAGAAACCGGTTGGATGTGCATGAATGCATATCGCGGCCGGCACGGAGACA
CTTCTCATACGATCCCGCCG

Downstream 100 bases:

>100_bases
GGGCGGGCGCGTAGCGTGTCGTGGCCCGCGCGGGCGGCGACGGGCCTCGCACATCGAGTACCACGCGTCCGCGCGCCGCT
CAGTCGCCGCAGCCCAACTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRHPTEPVAGKLNWDDLRFFLEVARTQRASGAAKRLGVDYTTVARRIRALEASLGTLLFDKSRAEGFTLTAEGQRLVAYA
DAMETTVQSACDQVAHTGEALSGHVRIGSTEGFGCFFLAPQLARFRAAHPRVTVDLLPVPHFVSLTKREADLAVTLERPE
RGPYVCTKLCDYQLRLYATRDYLASHPPIAGTDDLARHTFISYVDDLAFSSELLYLERAVPGATAGLRTTSVIAQSFAAL
HGGGLAILPCFIAAAQPALVPVLPDQVVVTRCFWLTCREDLRKLRRVTALWDYLRAAADANRALLSGESSELRFVGEPGG

Sequences:

>Translated_320_residues
MRHPTEPVAGKLNWDDLRFFLEVARTQRASGAAKRLGVDYTTVARRIRALEASLGTLLFDKSRAEGFTLTAEGQRLVAYA
DAMETTVQSACDQVAHTGEALSGHVRIGSTEGFGCFFLAPQLARFRAAHPRVTVDLLPVPHFVSLTKREADLAVTLERPE
RGPYVCTKLCDYQLRLYATRDYLASHPPIAGTDDLARHTFISYVDDLAFSSELLYLERAVPGATAGLRTTSVIAQSFAAL
HGGGLAILPCFIAAAQPALVPVLPDQVVVTRCFWLTCREDLRKLRRVTALWDYLRAAADANRALLSGESSELRFVGEPGG
>Mature_320_residues
MRHPTEPVAGKLNWDDLRFFLEVARTQRASGAAKRLGVDYTTVARRIRALEASLGTLLFDKSRAEGFTLTAEGQRLVAYA
DAMETTVQSACDQVAHTGEALSGHVRIGSTEGFGCFFLAPQLARFRAAHPRVTVDLLPVPHFVSLTKREADLAVTLERPE
RGPYVCTKLCDYQLRLYATRDYLASHPPIAGTDDLARHTFISYVDDLAFSSELLYLERAVPGATAGLRTTSVIAQSFAAL
HGGGLAILPCFIAAAQPALVPVLPDQVVVTRCFWLTCREDLRKLRRVTALWDYLRAAADANRALLSGESSELRFVGEPGG

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=183, Percent_Identity=28.9617486338798, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786401, Length=289, Percent_Identity=23.1833910034602, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994962, Length=170, Percent_Identity=32.3529411764706, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=271, Percent_Identity=25.4612546125461, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=294, Percent_Identity=25.1700680272109, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35004; Mature: 35004

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHPTEPVAGKLNWDDLRFFLEVARTQRASGAAKRLGVDYTTVARRIRALEASLGTLLFD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHEE
KSRAEGFTLTAEGQRLVAYADAMETTVQSACDQVAHTGEALSGHVRIGSTEGFGCFFLAP
CCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECH
QLARFRAAHPRVTVDLLPVPHFVSLTKREADLAVTLERPERGPYVCTKLCDYQLRLYATR
HHHHHHCCCCCEEEEEECCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCEEEEEEEH
DYLASHPPIAGTDDLARHTFISYVDDLAFSSELLYLERAVPGATAGLRTTSVIAQSFAAL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
HGGGLAILPCFIAAAQPALVPVLPDQVVVTRCFWLTCREDLRKLRRVTALWDYLRAAADA
CCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NRALLSGESSELRFVGEPGG
CHHEECCCCCCEEEEECCCC
>Mature Secondary Structure
MRHPTEPVAGKLNWDDLRFFLEVARTQRASGAAKRLGVDYTTVARRIRALEASLGTLLFD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHEE
KSRAEGFTLTAEGQRLVAYADAMETTVQSACDQVAHTGEALSGHVRIGSTEGFGCFFLAP
CCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECH
QLARFRAAHPRVTVDLLPVPHFVSLTKREADLAVTLERPERGPYVCTKLCDYQLRLYATR
HHHHHHCCCCCEEEEEECCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCEEEEEEEH
DYLASHPPIAGTDDLARHTFISYVDDLAFSSELLYLERAVPGATAGLRTTSVIAQSFAAL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
HGGGLAILPCFIAAAQPALVPVLPDQVVVTRCFWLTCREDLRKLRRVTALWDYLRAAADA
CCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NRALLSGESSELRFVGEPGG
CHHEECCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]