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The map label for this gene is mmsB [H]

Identifier: 189352735

GI number: 189352735

Start: 840290

End: 841180

Strand: Reverse

Name: mmsB [H]

Synonym: BMULJ_03967

Alternate gene names: 189352735

Gene position: 841180-840290 (Counterclockwise)

Preceding gene: 189352736

Following gene: 189352730

Centisome position: 34.01

GC content: 70.71

Gene sequence:

>891_bases
ATGGACATCGCATTCATCGGACTCGGCAACATGGGCGGCACGATGGCCGCCAATCTGCTGCGCGCCGGGCACGCACTGAC
GGTATTCGACCTCGATACGCACGCGGTCAACGCCGCGGTGCGCGCGGGCGCGACGGCGGCACGCTCGCCGCGCGAGGCCG
CCGCGCGCGCGACGGTCGTGATCACGATGCTGCCGGCCGCCGCGCACGTACGCGGCGTCTACGAGGGCGACGACGGCGTG
CTGGCCGGTGCGCGCGGCGGCGCGTGGCTGATCGACTGCAGCACGATCGACCCCGATACCGTGCGCACGCTCGCCGACGC
GGCCGCGCAGCGCGACTGCCGGCTCGCCGATGCGCCGGTGTCGGGCGGCACCGGCGGCGCGCAGGCCGGCACGCTGACGT
TCATGGTCGGCGCGGAGCCGGCGCTGTTCGAGCGGATCCGTCCAGTGCTGCTCGCGATGGGCAAGCATGTCGTCCATTGC
GGCGGCACCGGCACCGGCCAGATCGCGAAGCTCTGCAACAACCTGCTGCTCGGGATTTCGATGATGGGCGTATCGGAGGC
GATGGCGCTCGGCGTTGCACTCGGCATCGATCCGTCCGTGCTCGCGGGCATCATCAACACGTCGACCGGACGCTGCTGGA
GCTCGGACACGTATAACCCGTATCCGGGCGTCAGCGATGCCGCGCCGTCGTCGCGCGGCTACACGGGCGGTTTCGCGACG
AATCTGATGCTGAAGGATCTCGGGCTCGCGACCGACGCCGCGCGGCACGCACGGCAGCCGGTATGGATGGGCGCGCTCGC
GCAACAGCTCTATCAGTCGATGAGCCAGCAAGGGCTCGGGGCGCTCGACTTCTCGGCGTGCGTGAAGCTGTACGCGCCGC
CGGGCAGTTGA

Upstream 100 bases:

>100_bases
TCTACACGCAGACGAAGACCGTCACCGCGCGCTGGTTCGACGACGAGGCGACGGCCGGCGGCGTCAATACGACGATCGCG
CTGCGCTGACCGGAGGCCGC

Downstream 100 bases:

>100_bases
CCGACGACCGGCGTGCGTCGACCCGCGATGCGCATGCGCGGCATCGCGGGTCGGTCGGAATCGGGGGAAAGCTCTTCGTG
TGCGGCGCGCCGCCTCATGC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDIAFIGLGNMGGTMAANLLRAGHALTVFDLDTHAVNAAVRAGATAARSPREAAARATVVITMLPAAAHVRGVYEGDDGV
LAGARGGAWLIDCSTIDPDTVRTLADAAAQRDCRLADAPVSGGTGGAQAGTLTFMVGAEPALFERIRPVLLAMGKHVVHC
GGTGTGQIAKLCNNLLLGISMMGVSEAMALGVALGIDPSVLAGIINTSTGRCWSSDTYNPYPGVSDAAPSSRGYTGGFAT
NLMLKDLGLATDAARHARQPVWMGALAQQLYQSMSQQGLGALDFSACVKLYAPPGS

Sequences:

>Translated_296_residues
MDIAFIGLGNMGGTMAANLLRAGHALTVFDLDTHAVNAAVRAGATAARSPREAAARATVVITMLPAAAHVRGVYEGDDGV
LAGARGGAWLIDCSTIDPDTVRTLADAAAQRDCRLADAPVSGGTGGAQAGTLTFMVGAEPALFERIRPVLLAMGKHVVHC
GGTGTGQIAKLCNNLLLGISMMGVSEAMALGVALGIDPSVLAGIINTSTGRCWSSDTYNPYPGVSDAAPSSRGYTGGFAT
NLMLKDLGLATDAARHARQPVWMGALAQQLYQSMSQQGLGALDFSACVKLYAPPGS
>Mature_296_residues
MDIAFIGLGNMGGTMAANLLRAGHALTVFDLDTHAVNAAVRAGATAARSPREAAARATVVITMLPAAAHVRGVYEGDDGV
LAGARGGAWLIDCSTIDPDTVRTLADAAAQRDCRLADAPVSGGTGGAQAGTLTFMVGAEPALFERIRPVLLAMGKHVVHC
GGTGTGQIAKLCNNLLLGISMMGVSEAMALGVALGIDPSVLAGIINTSTGRCWSSDTYNPYPGVSDAAPSSRGYTGGFAT
NLMLKDLGLATDAARHARQPVWMGALAQQLYQSMSQQGLGALDFSACVKLYAPPGS

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=47.9166666666667, Blast_Score=282, Evalue=2e-76,
Organism=Homo sapiens, GI40556376, Length=296, Percent_Identity=28.3783783783784, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=35.0515463917526, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=36.8965517241379, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=31.2080536912752, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789092, Length=292, Percent_Identity=30.1369863013699, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=273, Percent_Identity=49.0842490842491, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=48.7889273356401, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=48.7889273356401, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI28574115, Length=292, Percent_Identity=22.6027397260274, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30157; Mature: 30157

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIAFIGLGNMGGTMAANLLRAGHALTVFDLDTHAVNAAVRAGATAARSPREAAARATVV
CCEEEEEECCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCHHCCCCHHHHHHEEEE
ITMLPAAAHVRGVYEGDDGVLAGARGGAWLIDCSTIDPDTVRTLADAAAQRDCRLADAPV
EEECCHHHHHCEEEECCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCCC
SGGTGGAQAGTLTFMVGAEPALFERIRPVLLAMGKHVVHCGGTGTGQIAKLCNNLLLGIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHH
MMGVSEAMALGVALGIDPSVLAGIINTSTGRCWSSDTYNPYPGVSDAAPSSRGYTGGFAT
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
NLMLKDLGLATDAARHARQPVWMGALAQQLYQSMSQQGLGALDFSACVKLYAPPGS
HHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCC
>Mature Secondary Structure
MDIAFIGLGNMGGTMAANLLRAGHALTVFDLDTHAVNAAVRAGATAARSPREAAARATVV
CCEEEEEECCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCHHCCCCHHHHHHEEEE
ITMLPAAAHVRGVYEGDDGVLAGARGGAWLIDCSTIDPDTVRTLADAAAQRDCRLADAPV
EEECCHHHHHCEEEECCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCCC
SGGTGGAQAGTLTFMVGAEPALFERIRPVLLAMGKHVVHCGGTGTGQIAKLCNNLLLGIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHH
MMGVSEAMALGVALGIDPSVLAGIINTSTGRCWSSDTYNPYPGVSDAAPSSRGYTGGFAT
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
NLMLKDLGLATDAARHARQPVWMGALAQQLYQSMSQQGLGALDFSACVKLYAPPGS
HHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]