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The map label for this gene is ilvD [H]

Identifier: 189352695

GI number: 189352695

Start: 794175

End: 795956

Strand: Direct

Name: ilvD [H]

Synonym: BMULJ_03927

Alternate gene names: 189352695

Gene position: 794175-795956 (Clockwise)

Preceding gene: 189352694

Following gene: 189352696

Centisome position: 32.11

GC content: 68.63

Gene sequence:

>1782_bases
ATGACGCAATCCCCGCGCAGGCTGCGCAGCCAGGAGTGGTTCGACGATCCGTCGCATGCCGACATGACGGCGCTCTATGT
CGAGCGATTCATGAACTACGGTCTCACGCGCGAAGAGCTGCAATCGGGCCGGCCGATCGTCGGCATCGCGCAGACGGGCA
GCGACCTCGCGCCGTGCAACCGTCATCACATCGCGCTCGCCGAGCGCGTCAAGGCCGGCATTCGCGATGCGGGCGGCATT
CCGATGGAATTCCCGGTGCATCCGCTCGCCGAGCAAAGCCGGCGTCCGACCGCCGCGCTCGACCGCAATCTCGCCTATCT
CGGCCTCGTCGAAATCCTGCACGGCTTTCCGCTCGACGGTGTCGTGCTGACGACCGGTTGCGACAAGACGACGCCCGCCT
GCCTGATGGCGGCCGCGACGGTCGATCTGCCCGCGATCGTGCTGTCCGGCGGCCCGATGCTCGACGGCTGGCACGAAGGC
AAGCGCGTCGGCTCGGGCACCGTGATCTGGCATGCGCGCAATCTGCTCGCGGCCGGCGAAATCGATTACGAAGGGTTCAT
GCGGCTGACGACCGCATCGTCGCCGTCGATCGGACACTGCAACACGATGGGCACGGCGCTCTCGATGAACTGTCTGGCCG
AGGCGCTCGGCATGTCGCTGCCGGGCTGCGCGAGCATACCGGCCGCGTATCGCGAGCGCGGGCAGATGGCGTATGCGACC
GGCAAGCGCATCGTCGATCTCGTGCGCGACGACGTGCGCCCGTCGCAGATCATGACGCGCGACGCGTTCGAGAATGCGAT
CGTCGTCGCGTCGGCGCTCGGTGCGTCGACGAACTGTCCGCCGCACCTGATCGCGATTGCGCGGCACATGGGCGTCGAGC
TGAGCCTCGCGGACTGGCAGCGCGTCGGCGAACAGGTGCCGCTGCTCGCGAACTGCATGCCGGCCGGCGAATATCTCGGC
GAGAGCTTCCATCGCGCGGGCGGCGTGCCCGCGATCCTGCGGCAGCTCGACGCCGCCGGACTGATTCATCGCGACTGCAT
GACCGTGTCGGGCCGCACGATCGCCGACATCGTGGCCGCGGCACCGGCCGCGGACGGCGACGTGATCCGGCCGCACGATG
CGCCGCTGAAGCACGGCGCGGGCTTCATCGTGCTGTCGGGCAACTTCTTCGACAGCGCGATCATGAAGATGTCGGTCGTC
GGCGACGCGTTCCGCCGCACGTATCTGAGCGAACCGGGCGCGGAAAACGTCTTCGAGGCGCGTGCGATCGTGTTCGACGG
CCCCGAGGACTATCGCGCGCGAATCAACGATCCGGCGCTCGCGATCGACGAGCGATGCATCCTCGTGATCCGCGGCTGCG
GGACGGTCGGCTATCCGGGCAGTGCGGAGGTCGTCAACATGGCGCCGCCGGCGGCGCTCGTCAAGCGCGGTGTCGAATCG
CTGCCGTGCATGGGCGACGGCCGCCAGAGCGGCACGTCGGCGAGCCCGTCGATCCTCAACATGTCGCCGGAAGCGGCGGC
GGGCGGCGGTCTCGCGCTGCTGCGCACGAACGACCGGATTCGCGTCGATCTGAACGCGCGGCGCGTCGACGTGCTGGTGC
CCGACGACGAACTGGCGCGTCGCCGCGAATCCGCCGAATTCCAGGTGCCGCCGTCGCAGACGCCGTGGCAGGAACTGTAT
CGGCAGTTCGTCGGGCAACTGTCGACCGGCGGCTGCCTCGAGCCCGCGACGCTGTATCTGAAGGTGATCGCCGAGCGCGG
CGAGCCGCGTCATTCCCATTGA

Upstream 100 bases:

>100_bases
ATCGGCGCTGATGTTACCGGTAACTATTCGGCGCGTGCGGCGACGAAGCGGCCGGTACGGAGTCCGGCGCGGCCGGAGCA
GAAAAGCAGGAGAAGGAGAC

Downstream 100 bases:

>100_bases
TCCGCTAACCGACGGAATACCGCCATGAATACGCTTCCTGTTTCCGCTTGTCTGCCGACCGATCTCGACGACGCGCTGCT
CGTCGGACGCGTGTGGCGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTQSPRRLRSQEWFDDPSHADMTALYVERFMNYGLTREELQSGRPIVGIAQTGSDLAPCNRHHIALAERVKAGIRDAGGI
PMEFPVHPLAEQSRRPTAALDRNLAYLGLVEILHGFPLDGVVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGWHEG
KRVGSGTVIWHARNLLAAGEIDYEGFMRLTTASSPSIGHCNTMGTALSMNCLAEALGMSLPGCASIPAAYRERGQMAYAT
GKRIVDLVRDDVRPSQIMTRDAFENAIVVASALGASTNCPPHLIAIARHMGVELSLADWQRVGEQVPLLANCMPAGEYLG
ESFHRAGGVPAILRQLDAAGLIHRDCMTVSGRTIADIVAAAPAADGDVIRPHDAPLKHGAGFIVLSGNFFDSAIMKMSVV
GDAFRRTYLSEPGAENVFEARAIVFDGPEDYRARINDPALAIDERCILVIRGCGTVGYPGSAEVVNMAPPAALVKRGVES
LPCMGDGRQSGTSASPSILNMSPEAAAGGGLALLRTNDRIRVDLNARRVDVLVPDDELARRRESAEFQVPPSQTPWQELY
RQFVGQLSTGGCLEPATLYLKVIAERGEPRHSH

Sequences:

>Translated_593_residues
MTQSPRRLRSQEWFDDPSHADMTALYVERFMNYGLTREELQSGRPIVGIAQTGSDLAPCNRHHIALAERVKAGIRDAGGI
PMEFPVHPLAEQSRRPTAALDRNLAYLGLVEILHGFPLDGVVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGWHEG
KRVGSGTVIWHARNLLAAGEIDYEGFMRLTTASSPSIGHCNTMGTALSMNCLAEALGMSLPGCASIPAAYRERGQMAYAT
GKRIVDLVRDDVRPSQIMTRDAFENAIVVASALGASTNCPPHLIAIARHMGVELSLADWQRVGEQVPLLANCMPAGEYLG
ESFHRAGGVPAILRQLDAAGLIHRDCMTVSGRTIADIVAAAPAADGDVIRPHDAPLKHGAGFIVLSGNFFDSAIMKMSVV
GDAFRRTYLSEPGAENVFEARAIVFDGPEDYRARINDPALAIDERCILVIRGCGTVGYPGSAEVVNMAPPAALVKRGVES
LPCMGDGRQSGTSASPSILNMSPEAAAGGGLALLRTNDRIRVDLNARRVDVLVPDDELARRRESAEFQVPPSQTPWQELY
RQFVGQLSTGGCLEPATLYLKVIAERGEPRHSH
>Mature_592_residues
TQSPRRLRSQEWFDDPSHADMTALYVERFMNYGLTREELQSGRPIVGIAQTGSDLAPCNRHHIALAERVKAGIRDAGGIP
MEFPVHPLAEQSRRPTAALDRNLAYLGLVEILHGFPLDGVVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGWHEGK
RVGSGTVIWHARNLLAAGEIDYEGFMRLTTASSPSIGHCNTMGTALSMNCLAEALGMSLPGCASIPAAYRERGQMAYATG
KRIVDLVRDDVRPSQIMTRDAFENAIVVASALGASTNCPPHLIAIARHMGVELSLADWQRVGEQVPLLANCMPAGEYLGE
SFHRAGGVPAILRQLDAAGLIHRDCMTVSGRTIADIVAAAPAADGDVIRPHDAPLKHGAGFIVLSGNFFDSAIMKMSVVG
DAFRRTYLSEPGAENVFEARAIVFDGPEDYRARINDPALAIDERCILVIRGCGTVGYPGSAEVVNMAPPAALVKRGVESL
PCMGDGRQSGTSASPSILNMSPEAAAGGGLALLRTNDRIRVDLNARRVDVLVPDDELARRRESAEFQVPPSQTPWQELYR
QFVGQLSTGGCLEPATLYLKVIAERGEPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=582, Percent_Identity=30.2405498281787, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1788157, Length=444, Percent_Identity=30.6306306306306, Blast_Score=171, Evalue=2e-43,
Organism=Escherichia coli, GI2367371, Length=462, Percent_Identity=27.4891774891775, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786464, Length=603, Percent_Identity=27.363184079602, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322476, Length=557, Percent_Identity=28.3662477558348, Blast_Score=205, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 63591; Mature: 63460

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSPRRLRSQEWFDDPSHADMTALYVERFMNYGLTREELQSGRPIVGIAQTGSDLAPCN
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCCC
RHHIALAERVKAGIRDAGGIPMEFPVHPLAEQSRRPTAALDRNLAYLGLVEILHGFPLDG
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCCC
VVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGWHEGKRVGSGTVIWHARNLLAAGE
EEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHCCCCCCCCEEEEEECCCCCCCC
IDYEGFMRLTTASSPSIGHCNTMGTALSMNCLAEALGMSLPGCASIPAAYRERGQMAYAT
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEHH
GKRIVDLVRDDVRPSQIMTRDAFENAIVVASALGASTNCPPHLIAIARHMGVELSLADWQ
HHHHHHHHHCCCCHHHHHHHHHHCCCEEEEHHHCCCCCCCHHHHHHHHHCCCEEEHHHHH
RVGEQVPLLANCMPAGEYLGESFHRAGGVPAILRQLDAAGLIHRDCMTVSGRTIADIVAA
HHHCCCCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHEECCCHHHHHHHH
APAADGDVIRPHDAPLKHGAGFIVLSGNFFDSAIMKMSVVGDAFRRTYLSEPGAENVFEA
CCCCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHC
RAIVFDGPEDYRARINDPALAIDERCILVIRGCGTVGYPGSAEVVNMAPPAALVKRGVES
EEEEECCCHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHCCHHH
LPCMGDGRQSGTSASPSILNMSPEAAAGGGLALLRTNDRIRVDLNARRVDVLVPDDELAR
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCEEEEEECCEEEEEEECCHHHHH
RRESAEFQVPPSQTPWQELYRQFVGQLSTGGCLEPATLYLKVIAERGEPRHSH
HHCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQSPRRLRSQEWFDDPSHADMTALYVERFMNYGLTREELQSGRPIVGIAQTGSDLAPCN
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCCC
RHHIALAERVKAGIRDAGGIPMEFPVHPLAEQSRRPTAALDRNLAYLGLVEILHGFPLDG
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCCC
VVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGWHEGKRVGSGTVIWHARNLLAAGE
EEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHCCCCCCCCEEEEEECCCCCCCC
IDYEGFMRLTTASSPSIGHCNTMGTALSMNCLAEALGMSLPGCASIPAAYRERGQMAYAT
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEHH
GKRIVDLVRDDVRPSQIMTRDAFENAIVVASALGASTNCPPHLIAIARHMGVELSLADWQ
HHHHHHHHHCCCCHHHHHHHHHHCCCEEEEHHHCCCCCCCHHHHHHHHHCCCEEEHHHHH
RVGEQVPLLANCMPAGEYLGESFHRAGGVPAILRQLDAAGLIHRDCMTVSGRTIADIVAA
HHHCCCCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHEECCCHHHHHHHH
APAADGDVIRPHDAPLKHGAGFIVLSGNFFDSAIMKMSVVGDAFRRTYLSEPGAENVFEA
CCCCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHC
RAIVFDGPEDYRARINDPALAIDERCILVIRGCGTVGYPGSAEVVNMAPPAALVKRGVES
EEEEECCCHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHCCHHH
LPCMGDGRQSGTSASPSILNMSPEAAAGGGLALLRTNDRIRVDLNARRVDVLVPDDELAR
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCEEEEEECCEEEEEEECCHHHHH
RRESAEFQVPPSQTPWQELYRQFVGQLSTGGCLEPATLYLKVIAERGEPRHSH
HHCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]