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The map label for this gene is selB [H]

Identifier: 189352687

GI number: 189352687

Start: 783031

End: 784956

Strand: Direct

Name: selB [H]

Synonym: BMULJ_03918

Alternate gene names: 189352687

Gene position: 783031-784956 (Clockwise)

Preceding gene: 189352686

Following gene: 189352690

Centisome position: 31.66

GC content: 70.25

Gene sequence:

>1926_bases
ATGATCGTCGGCACCGCAGGACACATCGACCACGGCAAGACGACGCTCGTGCGCGCGCTGACCGGCGTCGACACCGATCG
TCTGAAGGAAGAGAAGGCGCGCGGCATTTCGATCGAGCTCGGCTATGCGTATACGCCGCTCGAGAACGGCGACGTGCTCG
GCCTGATCGACGTGCCGGGTCACGAGAAGCTGATTCATACGATGGCCGCCGGCGCGTGCGGAATCGATTTCGCGCTGCTC
GTGATCGCCGCCGACGACGGCGTGATGCCGCAGACGCGCGAACACGTCGCGATTCTGCAGTTGCTCGGCGTCGCGCATGG
CGCGGTCGCGCTGACGAAGTGCGATCGCGTCGAAGCCGCACGCATCGCGCAGGTGCGCGACGAGATCGACGGCTGGCTGC
GCGATTCGACGCTGGCCGGTGCGCCGATCTTCGAGACGCGTGCGACCGCCGCCGACGATCCGGGCGTCGCCGCGCTGAAG
CAGCACCTCGCGGACGCCGCGCTTGCCTGGCGCGCACGCCGCGACGACGGGCTGTTCCGGCTTGCCGTCGACCGCGTGTT
TACGCTGGCCGGGCAGGGCACCGTCGTGACGGGCACGGCCTTCGCGGGCCGCGTGAAGAATGGCGACACGCTCGCGATCG
CGCGCACTGCGCGCGATGTGCGCGTGCGCAGCATCCATGCGCAGAATCGGCCGGTCGACGCCGGTTGCGCGGGCGAGCGT
TGCGCGCTGAATCTCGCCGGCATCGACAAGGCCGACATCGAACGCGGCGATACCGTCGCGGACGCGCGGCTGGCTGCGAC
GTCGCCGCGCGTCGACGTCGAACTGACGCTCGTCGACGATGCCGGCCTGACGCTCACGCACTGGTCGCCGCTGCACGTGC
ATCTCGGCACGCTGCATCGTGTGGCGCACGTCGCGCTGCTCGACGGCGACACGCTGGCCGCCGGCCAGCGCATGCGCGTG
CAGCTCGTGTTCGACGAGCCGGTGTTCGCGCTGCCGGGCGACCGCTTCATCGTGCGCAATGCGCAGGCGACGCGTACCGT
CGGCGGCGGCCGTGTGCTCGATCCGTTCGGGCCCGCGCGCAAGCGTCGCACGCCGGCGCGCCTTGCGTGGCTCGATGCGC
TTGCCGTGTGGCTCGACGCGCGCCGGCTCGAGCCGCTGCTCGCGCAGGCGCCGCTCGGCATCGCACGCGCGACGCTCACG
CATCTGACCGGTTTCGCGCCGGACGTGCTGCCGCTGCCCGACGACGCGCTGTCGGTCGGCCAGCGCGACCGCGCGTCGAA
CGACGGCACGGTGATTTCGCGCGCGCACTGGCGTGCGCTGCAGTCGCGTGCGATCGACACGCTGCGCGCGTATCACGAAC
GCATGCCGGACGAGCAGGGCCTCGATGCGGGGCGGCTGCGACGGATGGCCGTGCCGCTTGCCGGCGATACGCTGTGGCGC
GCGCTCGTCGATGCGCTCGTCGACGGCGGCGAGCTCGCGCGTAGCGGGCCGTGGCTGCATCTGCCGTCGCATACGGTCAA
TCTCGACGCGCGCGACGAAGTGCTGGCGCAGCAGCTGTTGCCGCTGCTGCATGCGGGCCGTTTCGATCCGCCGTGGGTGC
GCGACATGGCGCGCGATACCGGTGTGGCGGAGGACAACGTGCGCACGCTGTTGCGCAAGCTCGCGCGGCGCGGCGACGTG
CATCAGGTCGTGCGCGATCTGTTCTATCACGCGGACGTATTGCGCGAACTTGCGCGGCTCGTCGCGCATCTCGTGGATTC
GTGCGGCGGGGCCGTCGATGCGGCGACGTTTCGCGACGCGACGGGGCTCGGCCGCAAGCGTGCGATCCAGATTCTCGAGT
TCTTCGATCGCGTTGGGTATACTCGCTTCCACCGCGATCTTCACTTCCTGCGTACGGATAGTGGGTGGGCCGGTAGTCAC
GCATAG

Upstream 100 bases:

>100_bases
GCGTCGCCGACAACGCGCTGCGGCTCGATCTGCGCTGTCTCGAAGCCGCGGACGAAGCGGCGTTCGTCGCGCAATGCGCG
CGGATTGCGGAGCCCGCTGC

Downstream 100 bases:

>100_bases
GTGATGGTCGGGCGGTTGTCGGTCGGCGCGTCGCGTCGTTTCTTTTCTCCGCGGAAGGCATTCGTATCCGGTGGTACGGC
TGGACTTCAAATCCAGTTGG

Product: selenocysteine-specific elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLENGDVLGLIDVPGHEKLIHTMAAGACGIDFALL
VIAADDGVMPQTREHVAILQLLGVAHGAVALTKCDRVEAARIAQVRDEIDGWLRDSTLAGAPIFETRATAADDPGVAALK
QHLADAALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAFAGRVKNGDTLAIARTARDVRVRSIHAQNRPVDAGCAGER
CALNLAGIDKADIERGDTVADARLAATSPRVDVELTLVDDAGLTLTHWSPLHVHLGTLHRVAHVALLDGDTLAAGQRMRV
QLVFDEPVFALPGDRFIVRNAQATRTVGGGRVLDPFGPARKRRTPARLAWLDALAVWLDARRLEPLLAQAPLGIARATLT
HLTGFAPDVLPLPDDALSVGQRDRASNDGTVISRAHWRALQSRAIDTLRAYHERMPDEQGLDAGRLRRMAVPLAGDTLWR
ALVDALVDGGELARSGPWLHLPSHTVNLDARDEVLAQQLLPLLHAGRFDPPWVRDMARDTGVAEDNVRTLLRKLARRGDV
HQVVRDLFYHADVLRELARLVAHLVDSCGGAVDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHFLRTDSGWAGSH
A

Sequences:

>Translated_641_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLENGDVLGLIDVPGHEKLIHTMAAGACGIDFALL
VIAADDGVMPQTREHVAILQLLGVAHGAVALTKCDRVEAARIAQVRDEIDGWLRDSTLAGAPIFETRATAADDPGVAALK
QHLADAALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAFAGRVKNGDTLAIARTARDVRVRSIHAQNRPVDAGCAGER
CALNLAGIDKADIERGDTVADARLAATSPRVDVELTLVDDAGLTLTHWSPLHVHLGTLHRVAHVALLDGDTLAAGQRMRV
QLVFDEPVFALPGDRFIVRNAQATRTVGGGRVLDPFGPARKRRTPARLAWLDALAVWLDARRLEPLLAQAPLGIARATLT
HLTGFAPDVLPLPDDALSVGQRDRASNDGTVISRAHWRALQSRAIDTLRAYHERMPDEQGLDAGRLRRMAVPLAGDTLWR
ALVDALVDGGELARSGPWLHLPSHTVNLDARDEVLAQQLLPLLHAGRFDPPWVRDMARDTGVAEDNVRTLLRKLARRGDV
HQVVRDLFYHADVLRELARLVAHLVDSCGGAVDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHFLRTDSGWAGSH
A
>Mature_641_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLENGDVLGLIDVPGHEKLIHTMAAGACGIDFALL
VIAADDGVMPQTREHVAILQLLGVAHGAVALTKCDRVEAARIAQVRDEIDGWLRDSTLAGAPIFETRATAADDPGVAALK
QHLADAALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAFAGRVKNGDTLAIARTARDVRVRSIHAQNRPVDAGCAGER
CALNLAGIDKADIERGDTVADARLAATSPRVDVELTLVDDAGLTLTHWSPLHVHLGTLHRVAHVALLDGDTLAAGQRMRV
QLVFDEPVFALPGDRFIVRNAQATRTVGGGRVLDPFGPARKRRTPARLAWLDALAVWLDARRLEPLLAQAPLGIARATLT
HLTGFAPDVLPLPDDALSVGQRDRASNDGTVISRAHWRALQSRAIDTLRAYHERMPDEQGLDAGRLRRMAVPLAGDTLWR
ALVDALVDGGELARSGPWLHLPSHTVNLDARDEVLAQQLLPLLHAGRFDPPWVRDMARDTGVAEDNVRTLLRKLARRGDV
HQVVRDLFYHADVLRELARLVAHLVDSCGGAVDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHFLRTDSGWAGSH
A

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=393, Percent_Identity=28.7531806615776, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI54607086, Length=302, Percent_Identity=28.476821192053, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI5729864, Length=373, Percent_Identity=27.3458445040214, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI223555963, Length=373, Percent_Identity=27.3458445040214, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI4503475, Length=430, Percent_Identity=23.2558139534884, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI4503471, Length=399, Percent_Identity=23.0576441102757, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI53729339, Length=222, Percent_Identity=28.3783783783784, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI53729337, Length=222, Percent_Identity=28.3783783783784, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367247, Length=634, Percent_Identity=42.4290220820189, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1789737, Length=386, Percent_Identity=29.0155440414508, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1790412, Length=381, Percent_Identity=29.1338582677165, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1789108, Length=262, Percent_Identity=30.1526717557252, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789559, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556456, Length=442, Percent_Identity=27.8280542986425, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25141371, Length=305, Percent_Identity=32.1311475409836, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17506081, Length=261, Percent_Identity=28.3524904214559, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17565438, Length=322, Percent_Identity=23.6024844720497, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32566629, Length=374, Percent_Identity=24.8663101604278, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI115532065, Length=319, Percent_Identity=24.4514106583072, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532067, Length=319, Percent_Identity=24.4514106583072, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=285, Percent_Identity=32.280701754386, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6325337, Length=401, Percent_Identity=25.4364089775561, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319594, Length=401, Percent_Identity=25.4364089775561, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281363316, Length=385, Percent_Identity=27.7922077922078, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17864358, Length=385, Percent_Identity=27.7922077922078, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI19921738, Length=282, Percent_Identity=33.6879432624113, Blast_Score=120, Evalue=4e-27,
Organism=Drosophila melanogaster, GI19922690, Length=271, Percent_Identity=30.2583025830258, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI17137380, Length=345, Percent_Identity=23.4782608695652, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550900, Length=364, Percent_Identity=24.1758241758242, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28572034, Length=120, Percent_Identity=42.5, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 69521; Mature: 69521

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLENGDVLGLIDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKLIHTMAAGACGIDFALLVIAADDGVMPQTREHVAILQLLGVAHGAVALTKCDRVEAA
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
RIAQVRDEIDGWLRDSTLAGAPIFETRATAADDPGVAALKQHLADAALAWRARRDDGLFR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LAVDRVFTLAGQGTVVTGTAFAGRVKNGDTLAIARTARDVRVRSIHAQNRPVDAGCAGER
HHHHHHHHHCCCCEEEEECCEECCCCCCCEEEEEECCHHHEEEEEECCCCCCCCCCCCCC
CALNLAGIDKADIERGDTVADARLAATSPRVDVELTLVDDAGLTLTHWSPLHVHLGTLHR
EEEEECCCCHHHCCCCCCHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCEEHHHHHHH
VAHVALLDGDTLAAGQRMRVQLVFDEPVFALPGDRFIVRNAQATRTVGGGRVLDPFGPAR
HHEEEEECCCCCCCCCCEEEEEEECCCEEECCCCEEEEECCCHHEECCCCEEECCCCCHH
KRRTPARLAWLDALAVWLDARRLEPLLAQAPLGIARATLTHLTGFAPDVLPLPDDALSVG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCC
QRDRASNDGTVISRAHWRALQSRAIDTLRAYHERMPDEQGLDAGRLRRMAVPLAGDTLWR
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHH
ALVDALVDGGELARSGPWLHLPSHTVNLDARDEVLAQQLLPLLHAGRFDPPWVRDMARDT
HHHHHHHCCCHHHCCCCEEECCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GVAEDNVRTLLRKLARRGDVHQVVRDLFYHADVLRELARLVAHLVDSCGGAVDAATFRDA
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TGLGRKRAIQILEFFDRVGYTRFHRDLHFLRTDSGWAGSHA
CCCCHHHHHHHHHHHHHHCHHHHHHHHHEEECCCCCCCCCC
>Mature Secondary Structure
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLENGDVLGLIDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKLIHTMAAGACGIDFALLVIAADDGVMPQTREHVAILQLLGVAHGAVALTKCDRVEAA
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
RIAQVRDEIDGWLRDSTLAGAPIFETRATAADDPGVAALKQHLADAALAWRARRDDGLFR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LAVDRVFTLAGQGTVVTGTAFAGRVKNGDTLAIARTARDVRVRSIHAQNRPVDAGCAGER
HHHHHHHHHCCCCEEEEECCEECCCCCCCEEEEEECCHHHEEEEEECCCCCCCCCCCCCC
CALNLAGIDKADIERGDTVADARLAATSPRVDVELTLVDDAGLTLTHWSPLHVHLGTLHR
EEEEECCCCHHHCCCCCCHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCEEHHHHHHH
VAHVALLDGDTLAAGQRMRVQLVFDEPVFALPGDRFIVRNAQATRTVGGGRVLDPFGPAR
HHEEEEECCCCCCCCCCEEEEEEECCCEEECCCCEEEEECCCHHEECCCCEEECCCCCHH
KRRTPARLAWLDALAVWLDARRLEPLLAQAPLGIARATLTHLTGFAPDVLPLPDDALSVG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCC
QRDRASNDGTVISRAHWRALQSRAIDTLRAYHERMPDEQGLDAGRLRRMAVPLAGDTLWR
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHH
ALVDALVDGGELARSGPWLHLPSHTVNLDARDEVLAQQLLPLLHAGRFDPPWVRDMARDT
HHHHHHHCCCHHHCCCCEEECCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GVAEDNVRTLLRKLARRGDVHQVVRDLFYHADVLRELARLVAHLVDSCGGAVDAATFRDA
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TGLGRKRAIQILEFFDRVGYTRFHRDLHFLRTDSGWAGSHA
CCCCHHHHHHHHHHHHHHCHHHHHHHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]