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The map label for this gene is fdhA [H]

Identifier: 189352682

GI number: 189352682

Start: 776427

End: 778859

Strand: Direct

Name: fdhA [H]

Synonym: BMULJ_03913

Alternate gene names: 189352682

Gene position: 776427-778859 (Clockwise)

Preceding gene: 189352681

Following gene: 189352683

Centisome position: 31.39

GC content: 64.94

Gene sequence:

>2433_bases
ATGACGAACCATTGGGTCGACATCAAGAACGCGGATCTGATTCTCGTGATGGGCGGCAATGCAGCCGAGGCTCATCCGTG
CGGTTTCAAATGGGTGACGGAAGCGAAGGCGCACCGCAAGGCGCGGCTGATCGTCGTCGACCCGCGCTTTACGCGTACGG
CCTCGGTGGCCGACTACTACGCGCCGATCCGTACCGGGACCGACATCGCGTTCCTGGGCGGCGTGATCAACTATTTGCTG
ACGAACGACAAGATCCAGCATGAGTACGTGAAGCACTACACGGACTTCACGTTCATCGTGCGCGAGGATTTCGCGTTCAA
CGACGGTCTCTATTCCGGTTACGACGCGGACAAGCACGCGTATCCGGACAAGTCGAGCTGGGATTACGAGCGCGGCGACG
ACGGGTTCGTGAAGGTCGACCCGACGCTGCAGCATCCGCGCTGCGTCTACAACCTGCTGAAGCAGCACTACGCGCGCTAT
ACGCCGGAAGTGGTCGAACAGGCCTGCGGCACGCCGAAGGAGAAGTTCCTGAAGGTGTGCGAGATGCTGGCGACGACGGC
CGTGCCCGGCCGCGCGGCGACCGTGCTGTATGCGCTCGGCTGGACCCATCACTCGATCGGCGCGCAGATCATCCGCACCG
GCGCGATGGTGCAGCTGCTGCTCGGCAACATCGGCATCGCCGGCGGCGGGATGAACGCGCTGCGCGGGCACTCGAACATC
CAGGGCCTGACCGACCTCGGCCTGATGTCGAACCTGCTGCCCGGCTATATGACGCTGCCGATGCAGGGCGAGCAGGACTT
CAACGCGTATATCGACAAGCGCGCGCAAAAGCCGCTGCGCCCGAACCAGCTCAGCTACTGGAAGAACTACAAGGCGTTCC
ACGTCAGCTTCATGAAGGCGTGGTGGGGCGACGCGGCGACCGCCGAGAACAACTGGGCGTACGACTACCTGCCGAAGCTC
GACAAGCAGTACGACCTGCTGCAGACGATCGAGCTGATGCACGCCGGCAAGATGAACGGCTACATCTGCCAGGGCTTCAA
TCCGCTCGCGGCGGCGCCCGCGAAGGTGAAGACCGCGCAGGCGCTCGCGAAGCTGAAGTGGCTCGTGATCATGGATCCGC
TCGCGACCGAGACGTCGGAGTTCTGGAAGCCGCACGGCGACTACAACGACGTCGATCCGTCGAAGATCCAGACCGAGGTG
TTCCGGCTGCCGACCACCTGCTTCGCGGAGGAAAACGGCTCGCTCGTCAGTTCGAGCCGCGTGCTGCAGTGGCACTGGAA
GGGCGCCGAGCCGCCGGGCGAGGCGCGCAGCGATCTCGAGATCATGGCCGGGCTGTTCGTGCGGCTGCGCCAGATGTACC
GCACCGACGGCGGCAAGTATCCGGATCCGATCGTGAACCTCTCGTGGCCGTACGCGGATCCGGAAAGCCCGACGCCCGAA
GAGCTCGCGAAGGAGTTCAACGGCCGCGCGCTCGCCGATCTGCCTGATCCGAAGGATCCGTCGAAGGTGCTCGTGAAGAA
GGGCGAGCAGCTTGCCGCGTTCGCGCAGCTGAAGGACGACGGCACGACCGCGAGCGGCTGCTGGATTTTCTGCGGCGCGT
GGACGCAGGCCGGCAACCAGATGGCGCGGCGCGACAACTCGGATCCGACCGGCATCGGCCAGACGCTGAACTGGGCGTGG
GCATGGCCCGCGAACCGGCGGATCCTGTACAACCGCGCGTCGGCCGACCTGGCCGGCAAGCCGTTCGATCCGACGCGCAA
GCTCGTCGCGTGGAACGGCGCGGCGTGGACGGGCGCCGACGTGCCCGATTTCAAGGCCGACGAGCCGCCCGAAAACGGGA
TGGGGCCGTTCATCATGAATCCGGAAGGCGTGGCGCGCTTCTTCGCGCGCGCGCAGATGAACGAAGGCCCGTTCCCCGAG
CACTACGAGCCGTTCGAGACGCCGCTTTCCGCGAACCCGCTGCATCCGGACAATCCGCAGGCGCTGAACAACCCGGCCGC
CCGCGTGTTCGCGGACGATCGCGCGTCGTTCGGCAAGGTGGCGGATTTCCCGCACGTCGCGACGACGTACCGGCTGACCG
AGCATTTCCACTACTGGACCAAGCACGCGCGGCTGAATTCGATCATCCAGCCCGAGCAATTCGTCGAGATCGGCGAAGAC
CTCGCGAAGGAAGTCGGCGTCGTGCACGGCGATCGCGTGAAGGTGTCGTCCAAGCGCGGCTACATCGTCGCGGTCGCGCT
CGTCACGAAGCGGATCAAGCCGCTGACCGTCGACGGCAAGAAGGTCCAGACGGTCGGCGTGCCGCTGCACTGGGGCTTCA
AGGGGCTGGCGAAGCCCGGCTATCTCGCCAATACGCTGACTCCGTCCGTGGGTGACGGCAACTCGTACACACCGGAATTC
AAGTCGTTTCTGGTGAAGGTCGAAAAGGCGTAA

Upstream 100 bases:

>100_bases
GGCTGTCCGCAGCCTCGGGATGCTCGCATTCGACAATCAGGCGCGTGTCTGACATGGCCCGACGGTGGCAGGTCTTGCCC
CGACATTTGGCCGTGGAGCG

Downstream 100 bases:

>100_bases
GGGGGACGAGATGGCATTGCAATCGCTGGACATCAAGCGCGTATCGGCCACCACGACGCCGCCGCCCACGGCGCGCGAAC
CGGTGACCGGCAGCGTCGCG

Product: formate dehydrogenase alpha subunit

Products: NA

Alternate protein names: Aerobic formate dehydrogenase major subunit; FDH-Z subunit alpha; Formate dehydrogenase-O subunit alpha [H]

Number of amino acids: Translated: 810; Mature: 809

Protein sequence:

>810_residues
MTNHWVDIKNADLILVMGGNAAEAHPCGFKWVTEAKAHRKARLIVVDPRFTRTASVADYYAPIRTGTDIAFLGGVINYLL
TNDKIQHEYVKHYTDFTFIVREDFAFNDGLYSGYDADKHAYPDKSSWDYERGDDGFVKVDPTLQHPRCVYNLLKQHYARY
TPEVVEQACGTPKEKFLKVCEMLATTAVPGRAATVLYALGWTHHSIGAQIIRTGAMVQLLLGNIGIAGGGMNALRGHSNI
QGLTDLGLMSNLLPGYMTLPMQGEQDFNAYIDKRAQKPLRPNQLSYWKNYKAFHVSFMKAWWGDAATAENNWAYDYLPKL
DKQYDLLQTIELMHAGKMNGYICQGFNPLAAAPAKVKTAQALAKLKWLVIMDPLATETSEFWKPHGDYNDVDPSKIQTEV
FRLPTTCFAEENGSLVSSSRVLQWHWKGAEPPGEARSDLEIMAGLFVRLRQMYRTDGGKYPDPIVNLSWPYADPESPTPE
ELAKEFNGRALADLPDPKDPSKVLVKKGEQLAAFAQLKDDGTTASGCWIFCGAWTQAGNQMARRDNSDPTGIGQTLNWAW
AWPANRRILYNRASADLAGKPFDPTRKLVAWNGAAWTGADVPDFKADEPPENGMGPFIMNPEGVARFFARAQMNEGPFPE
HYEPFETPLSANPLHPDNPQALNNPAARVFADDRASFGKVADFPHVATTYRLTEHFHYWTKHARLNSIIQPEQFVEIGED
LAKEVGVVHGDRVKVSSKRGYIVAVALVTKRIKPLTVDGKKVQTVGVPLHWGFKGLAKPGYLANTLTPSVGDGNSYTPEF
KSFLVKVEKA

Sequences:

>Translated_810_residues
MTNHWVDIKNADLILVMGGNAAEAHPCGFKWVTEAKAHRKARLIVVDPRFTRTASVADYYAPIRTGTDIAFLGGVINYLL
TNDKIQHEYVKHYTDFTFIVREDFAFNDGLYSGYDADKHAYPDKSSWDYERGDDGFVKVDPTLQHPRCVYNLLKQHYARY
TPEVVEQACGTPKEKFLKVCEMLATTAVPGRAATVLYALGWTHHSIGAQIIRTGAMVQLLLGNIGIAGGGMNALRGHSNI
QGLTDLGLMSNLLPGYMTLPMQGEQDFNAYIDKRAQKPLRPNQLSYWKNYKAFHVSFMKAWWGDAATAENNWAYDYLPKL
DKQYDLLQTIELMHAGKMNGYICQGFNPLAAAPAKVKTAQALAKLKWLVIMDPLATETSEFWKPHGDYNDVDPSKIQTEV
FRLPTTCFAEENGSLVSSSRVLQWHWKGAEPPGEARSDLEIMAGLFVRLRQMYRTDGGKYPDPIVNLSWPYADPESPTPE
ELAKEFNGRALADLPDPKDPSKVLVKKGEQLAAFAQLKDDGTTASGCWIFCGAWTQAGNQMARRDNSDPTGIGQTLNWAW
AWPANRRILYNRASADLAGKPFDPTRKLVAWNGAAWTGADVPDFKADEPPENGMGPFIMNPEGVARFFARAQMNEGPFPE
HYEPFETPLSANPLHPDNPQALNNPAARVFADDRASFGKVADFPHVATTYRLTEHFHYWTKHARLNSIIQPEQFVEIGED
LAKEVGVVHGDRVKVSSKRGYIVAVALVTKRIKPLTVDGKKVQTVGVPLHWGFKGLAKPGYLANTLTPSVGDGNSYTPEF
KSFLVKVEKA
>Mature_809_residues
TNHWVDIKNADLILVMGGNAAEAHPCGFKWVTEAKAHRKARLIVVDPRFTRTASVADYYAPIRTGTDIAFLGGVINYLLT
NDKIQHEYVKHYTDFTFIVREDFAFNDGLYSGYDADKHAYPDKSSWDYERGDDGFVKVDPTLQHPRCVYNLLKQHYARYT
PEVVEQACGTPKEKFLKVCEMLATTAVPGRAATVLYALGWTHHSIGAQIIRTGAMVQLLLGNIGIAGGGMNALRGHSNIQ
GLTDLGLMSNLLPGYMTLPMQGEQDFNAYIDKRAQKPLRPNQLSYWKNYKAFHVSFMKAWWGDAATAENNWAYDYLPKLD
KQYDLLQTIELMHAGKMNGYICQGFNPLAAAPAKVKTAQALAKLKWLVIMDPLATETSEFWKPHGDYNDVDPSKIQTEVF
RLPTTCFAEENGSLVSSSRVLQWHWKGAEPPGEARSDLEIMAGLFVRLRQMYRTDGGKYPDPIVNLSWPYADPESPTPEE
LAKEFNGRALADLPDPKDPSKVLVKKGEQLAAFAQLKDDGTTASGCWIFCGAWTQAGNQMARRDNSDPTGIGQTLNWAWA
WPANRRILYNRASADLAGKPFDPTRKLVAWNGAAWTGADVPDFKADEPPENGMGPFIMNPEGVARFFARAQMNEGPFPEH
YEPFETPLSANPLHPDNPQALNNPAARVFADDRASFGKVADFPHVATTYRLTEHFHYWTKHARLNSIIQPEQFVEIGEDL
AKEVGVVHGDRVKVSSKRGYIVAVALVTKRIKPLTVDGKKVQTVGVPLHWGFKGLAKPGYLANTLTPSVGDGNSYTPEFK
SFLVKVEKA

Specific function: Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868720, Length=809, Percent_Identity=65.0185414091471, Blast_Score=1131, Evalue=0.0,
Organism=Escherichia coli, GI3868719, Length=810, Percent_Identity=62.0987654320988, Blast_Score=1095, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=449, Percent_Identity=22.0489977728285, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI87081797, Length=239, Percent_Identity=26.7782426778243, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 90277; Mature: 90146

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHWVDIKNADLILVMGGNAAEAHPCGFKWVTEAKAHRKARLIVVDPRFTRTASVADYY
CCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
APIRTGTDIAFLGGVINYLLTNDKIQHEYVKHYTDFTFIVREDFAFNDGLYSGYDADKHA
HHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCC
YPDKSSWDYERGDDGFVKVDPTLQHPRCVYNLLKQHYARYTPEVVEQACGTPKEKFLKVC
CCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHH
EMLATTAVPGRAATVLYALGWTHHSIGAQIIRTGAMVQLLLGNIGIAGGGMNALRGHSNI
HHHHHHCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
QGLTDLGLMSNLLPGYMTLPMQGEQDFNAYIDKRAQKPLRPNQLSYWKNYKAFHVSFMKA
CCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHH
WWGDAATAENNWAYDYLPKLDKQYDLLQTIELMHAGKMNGYICQGFNPLAAAPAKVKTAQ
HCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHCCCCHHHHHH
ALAKLKWLVIMDPLATETSEFWKPHGDYNDVDPSKIQTEVFRLPTTCFAEENGSLVSSSR
HHHHHEEEEEECCHHHCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEECCC
VLQWHWKGAEPPGEARSDLEIMAGLFVRLRQMYRTDGGKYPDPIVNLSWPYADPESPTPE
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHH
ELAKEFNGRALADLPDPKDPSKVLVKKGEQLAAFAQLKDDGTTASGCWIFCGAWTQAGNQ
HHHHHHCCCEEECCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECHHHHHHH
MARRDNSDPTGIGQTLNWAWAWPANRRILYNRASADLAGKPFDPTRKLVAWNGAAWTGAD
HHHCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCC
VPDFKADEPPENGMGPFIMNPEGVARFFARAQMNEGPFPEHYEPFETPLSANPLHPDNPQ
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
ALNNPAARVFADDRASFGKVADFPHVATTYRLTEHFHYWTKHARLNSIIQPEQFVEIGED
HCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LAKEVGVVHGDRVKVSSKRGYIVAVALVTKRIKPLTVDGKKVQTVGVPLHWGFKGLAKPG
HHHHHCCCCCCEEEEECCCCEEEEEEEHHHCCCCEEECCCEEEEEECCCCCCCHHCCCCC
YLANTLTPSVGDGNSYTPEFKSFLVKVEKA
CCHHCCCCCCCCCCCCCHHHHHHHEEEECC
>Mature Secondary Structure 
TNHWVDIKNADLILVMGGNAAEAHPCGFKWVTEAKAHRKARLIVVDPRFTRTASVADYY
CCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
APIRTGTDIAFLGGVINYLLTNDKIQHEYVKHYTDFTFIVREDFAFNDGLYSGYDADKHA
HHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCC
YPDKSSWDYERGDDGFVKVDPTLQHPRCVYNLLKQHYARYTPEVVEQACGTPKEKFLKVC
CCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHH
EMLATTAVPGRAATVLYALGWTHHSIGAQIIRTGAMVQLLLGNIGIAGGGMNALRGHSNI
HHHHHHCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
QGLTDLGLMSNLLPGYMTLPMQGEQDFNAYIDKRAQKPLRPNQLSYWKNYKAFHVSFMKA
CCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHH
WWGDAATAENNWAYDYLPKLDKQYDLLQTIELMHAGKMNGYICQGFNPLAAAPAKVKTAQ
HCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHCCCCHHHHHH
ALAKLKWLVIMDPLATETSEFWKPHGDYNDVDPSKIQTEVFRLPTTCFAEENGSLVSSSR
HHHHHEEEEEECCHHHCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEECCC
VLQWHWKGAEPPGEARSDLEIMAGLFVRLRQMYRTDGGKYPDPIVNLSWPYADPESPTPE
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHH
ELAKEFNGRALADLPDPKDPSKVLVKKGEQLAAFAQLKDDGTTASGCWIFCGAWTQAGNQ
HHHHHHCCCEEECCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECHHHHHHH
MARRDNSDPTGIGQTLNWAWAWPANRRILYNRASADLAGKPFDPTRKLVAWNGAAWTGAD
HHHCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCC
VPDFKADEPPENGMGPFIMNPEGVARFFARAQMNEGPFPEHYEPFETPLSANPLHPDNPQ
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
ALNNPAARVFADDRASFGKVADFPHVATTYRLTEHFHYWTKHARLNSIIQPEQFVEIGED
HCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LAKEVGVVHGDRVKVSSKRGYIVAVALVTKRIKPLTVDGKKVQTVGVPLHWGFKGLAKPG
HHHHHCCCCCCEEEEECCCCEEEEEEEHHHCCCCEEECCCEEEEEECCCCCCCHHCCCCC
YLANTLTPSVGDGNSYTPEFKSFLVKVEKA
CCHHCCCCCCCCCCCCCHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8346018; 9278503; 8522521 [H]