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The map label for this gene is fdh [H]

Identifier: 189352681

GI number: 189352681

Start: 775788

End: 776378

Strand: Direct

Name: fdh [H]

Synonym: BMULJ_03912

Alternate gene names: 189352681

Gene position: 775788-776378 (Clockwise)

Preceding gene: 189352677

Following gene: 189352682

Centisome position: 31.37

GC content: 64.81

Gene sequence:

>591_bases
ATGCTACACATGTCCCGGCGCCAGTTCCTGAAGGTGACGGCAACGTCGCTTGCCGGATCGAGCCTGGCCCTGATGGGCTT
TTCTCCGTCCGAAGCGCTTGCCGAAGTCCGACAGTACAAGCTGGCGCGCACAGTCGAAACGCGCAACACCTGTCCTTACT
GTTCAGTCGGTTGCGGCATCCTGATGTACGGCCTGGGCGACGGCGCGAAAAACGCGCAGTCGAGCATCATCCACATCGAG
GGCGACCCCGATCACCCGGTCAACCGCGGCACGCTGTGCCCGAAGGGCGCGAGCCTGATCGACTTCATCCACAGCCCGAA
CCGCCTGACGCACCCGGAATACCGCGCGCCCGGCTCGGACAAGTGGGAGCGCATCTCGTGGAGCGACGCGCTCGACCGGA
TCGCGAAGCTGATGAAGGCCGACCGCGACGCGAACTTCGTCGAGACGACCGAAGACGGCGCCAAGGTCAACCGCTGGCTC
ACGACCGGCATGCTGGCCGCGTCGGCGGGCAGCAACGAAGTCGGCTATCTGACGCACAAGGCTGTCCGCAGCCTCGGGAT
GCTCGCATTCGACAATCAGGCGCGTGTCTGA

Upstream 100 bases:

>100_bases
GATTCAAGTATTGATCCGAAGAGCCGTACATAGTTGCGAAGTTTGCGAAGTGTCTATAATTGCTTTCAGCTTCCTACCCC
ACAATAACGCCGAGACCACC

Downstream 100 bases:

>100_bases
CATGGCCCGACGGTGGCAGGTCTTGCCCCGACATTTGGCCGTGGAGCGATGACGAACCATTGGGTCGACATCAAGAACGC
GGATCTGATTCTCGTGATGG

Product: formate dehydrogenase

Products: NA

Alternate protein names: Aerobic formate dehydrogenase major subunit; FDH-Z subunit alpha; Formate dehydrogenase-O subunit alpha [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MLHMSRRQFLKVTATSLAGSSLALMGFSPSEALAEVRQYKLARTVETRNTCPYCSVGCGILMYGLGDGAKNAQSSIIHIE
GDPDHPVNRGTLCPKGASLIDFIHSPNRLTHPEYRAPGSDKWERISWSDALDRIAKLMKADRDANFVETTEDGAKVNRWL
TTGMLAASAGSNEVGYLTHKAVRSLGMLAFDNQARV

Sequences:

>Translated_196_residues
MLHMSRRQFLKVTATSLAGSSLALMGFSPSEALAEVRQYKLARTVETRNTCPYCSVGCGILMYGLGDGAKNAQSSIIHIE
GDPDHPVNRGTLCPKGASLIDFIHSPNRLTHPEYRAPGSDKWERISWSDALDRIAKLMKADRDANFVETTEDGAKVNRWL
TTGMLAASAGSNEVGYLTHKAVRSLGMLAFDNQARV
>Mature_196_residues
MLHMSRRQFLKVTATSLAGSSLALMGFSPSEALAEVRQYKLARTVETRNTCPYCSVGCGILMYGLGDGAKNAQSSIIHIE
GDPDHPVNRGTLCPKGASLIDFIHSPNRLTHPEYRAPGSDKWERISWSDALDRIAKLMKADRDANFVETTEDGAKVNRWL
TTGMLAASAGSNEVGYLTHKAVRSLGMLAFDNQARV

Specific function: Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868720, Length=195, Percent_Identity=71.2820512820513, Blast_Score=304, Evalue=2e-84,
Organism=Escherichia coli, GI3868719, Length=195, Percent_Identity=68.2051282051282, Blast_Score=295, Evalue=1e-81,
Organism=Escherichia coli, GI1788534, Length=143, Percent_Identity=30.0699300699301, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 21399; Mature: 21399

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHMSRRQFLKVTATSLAGSSLALMGFSPSEALAEVRQYKLARTVETRNTCPYCSVGCGI
CCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCE
LMYGLGDGAKNAQSSIIHIEGDPDHPVNRGTLCPKGASLIDFIHSPNRLTHPEYRAPGSD
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
KWERISWSDALDRIAKLMKADRDANFVETTEDGAKVNRWLTTGMLAASAGSNEVGYLTHK
CCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AVRSLGMLAFDNQARV
HHHHHCCEECCCCCCC
>Mature Secondary Structure
MLHMSRRQFLKVTATSLAGSSLALMGFSPSEALAEVRQYKLARTVETRNTCPYCSVGCGI
CCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCE
LMYGLGDGAKNAQSSIIHIEGDPDHPVNRGTLCPKGASLIDFIHSPNRLTHPEYRAPGSD
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
KWERISWSDALDRIAKLMKADRDANFVETTEDGAKVNRWLTTGMLAASAGSNEVGYLTHK
CCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AVRSLGMLAFDNQARV
HHHHHCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8346018; 9278503; 8522521 [H]