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The map label for this gene is sdhA [H]

Identifier: 189352635

GI number: 189352635

Start: 722465

End: 724240

Strand: Direct

Name: sdhA [H]

Synonym: BMULJ_03866

Alternate gene names: 189352635

Gene position: 722465-724240 (Clockwise)

Preceding gene: 189352634

Following gene: 189352636

Centisome position: 29.21

GC content: 65.71

Gene sequence:

>1776_bases
ATGGCTGCAATCAAAACTTCCCTCCCGCGTCGCAAGTTCGACGTCGTGATCGTCGGCGCGGGCGGCTCCGGCTTGCGCGC
GGCGCTGCAACTGTCGCGCGCGGGCCTGTCGGTCGGCGTGCTGTCGAAGGTGTTCCCGACCCGTTCGCACACGGTGGCCG
CGCAGGGCGGCATCGGCGCGTCGCTCGGCAACATGAGCGAAGACAACTGGCACTTCCACTTCTACGACACGATCAAGGGC
TCCGACTGGCTCGGCGACCAGGACGCGATCGAATTCATGTGCCGTGAGGCGCCGAACGTCGTGTACGAGCTCGAGCACTT
CGGCATGCCGTTCGACCGTAACGCCGACGGCACGATCTATCAGCGTCCGTTCGGCGGCCACACCGCGAACTACGGCGAGA
AGCCGGTCCAGCGCGCCTGCGCGGCCGCCGACCGTACCGGTCACGCGCTGCTGCACACGCTGTACCAGCAAAACGTCGAA
GCGAAGACGCAGTTCTTCGTCGAATGGATGGCGCTCGACCTGATCCGCGACGCGGACGGCGACGTGCTCGGCGTGACGGC
GCTCGAAATGGAAACGGGCGACGTCTACATCATGGAAGGCAAGACGACGCTGTTCGCGACGGGCGGCGCAGGCCGGATCT
TCGCGGCGTCGACCAACGCGTTCATCAACACCGGCGACGGCCTCGGCATGGCGGCGCGCGCAGGCGTGGCGCTGCAGGAC
ATGGAGTTCTGGCAGTTCCACCCGACCGGCGTGGCCGGCGCGGGCGTGCTGATCACCGAAGGCGTGCGCGGCGAAGGCGG
CATTCTGCGCAACGCGAACGGCGAGCGCTTCATGGAGCGCTACGCGCCGACGCTGAAGGATCTGGCGCCGCGCGATTTCG
TGTCGCGTTCGATGGACCAGGAAATCAAGGAAGGCCGCGGCGTCGGTCCGAACAAGGATCACGTGCTGCTCGACCTGTCG
CACATCGGCGCCGAGACGATCATGAAGCGTCTGCCGTCGATCCGCGAGATCGCGCTGAAGTTCGCGAACGTCGACTGCAT
CAAGGAGCCGATCCCGGTCGTCCCGACGATCCACTATCAGATGGGCGGCATCCCGACCAACATCCACGGTCAGGTCGTCG
GCACGTCGCGCGATCACAAGGAGCCGATCAACGGCTTCTACGCCGTGGGCGAATGCTCGTGCGTGTCGGTGCACGGCGCG
AACCGCCTCGGCACGAACTCGCTGCTGGACCTCGTGGTGTTCGGCCGTGCGGCCGGCAACCACATCGTCGAGCAGGTCAA
GAAGCAGAAGGAACACAAGCCGCTGCCGGCCGACGCGGGCGAATTCTCGCTGGCGCGCCTGAACAAGCTCGACAAGTCGA
GCTCAGGCGAGTACACGCAGGACGTCGCGAACGACATCCGCGCGACGATGCAGAAGCATGCAGGCGTGTTCCGCACCTCG
GCGCTGCTGAAGGAAGGCGTCGAACTGATGGACGGCCTCAAGCAGCGTGTCGAGCACATCCATCTGAAGGACAAGTCGAA
GGTGTTCAACACCGCGCGCGTCGAAGCGCTCGAGCTGGAGAACCTGATCGAAGTCGCCCGCGCGACGATGGTCTCGGCCG
AGGCGCGCAAGGAAAGCCGTGGCGCGCACGCGCACAGCGACTACGAGCACCGCGACGACGAGAACTGGCTGCGTCACACG
CTGTGGTACAGCGAAGGTGACCGCCTCGACTACAAGCCGGTTCAAATGCAGCCGCTGACGGTCGAGTCCGTGCCGCCGAA
GGCGCGTACGTTCTAA

Upstream 100 bases:

>100_bases
GAAGCCCGTCGGTGTGCGCCTGCTGCTGCAATCGCTGACCATCGTCTGGCTGCTCGCATGTGCGGGCTACGCCGCGCAGA
TTCTCTGGAGAGTGTAAAGA

Downstream 100 bases:

>100_bases
GCCGAATCAAAGGAATCTGAAATGGCAAAACGCATTTTTGAAGTCTACCGCTACGATCCGGACAAGGACGCGGCGCCGCG
CATGCAGACGTACGAGCTCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MAAIKTSLPRRKFDVVIVGAGGSGLRAALQLSRAGLSVGVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHFHFYDTIKG
SDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVE
AKTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYIMEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGVALQD
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLS
HIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGA
NRLGTNSLLDLVVFGRAAGNHIVEQVKKQKEHKPLPADAGEFSLARLNKLDKSSSGEYTQDVANDIRATMQKHAGVFRTS
ALLKEGVELMDGLKQRVEHIHLKDKSKVFNTARVEALELENLIEVARATMVSAEARKESRGAHAHSDYEHRDDENWLRHT
LWYSEGDRLDYKPVQMQPLTVESVPPKARTF

Sequences:

>Translated_591_residues
MAAIKTSLPRRKFDVVIVGAGGSGLRAALQLSRAGLSVGVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHFHFYDTIKG
SDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVE
AKTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYIMEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGVALQD
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLS
HIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGA
NRLGTNSLLDLVVFGRAAGNHIVEQVKKQKEHKPLPADAGEFSLARLNKLDKSSSGEYTQDVANDIRATMQKHAGVFRTS
ALLKEGVELMDGLKQRVEHIHLKDKSKVFNTARVEALELENLIEVARATMVSAEARKESRGAHAHSDYEHRDDENWLRHT
LWYSEGDRLDYKPVQMQPLTVESVPPKARTF
>Mature_590_residues
AAIKTSLPRRKFDVVIVGAGGSGLRAALQLSRAGLSVGVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHFHFYDTIKGS
DWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVEA
KTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYIMEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGVALQDM
EFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLSH
IGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGAN
RLGTNSLLDLVVFGRAAGNHIVEQVKKQKEHKPLPADAGEFSLARLNKLDKSSSGEYTQDVANDIRATMQKHAGVFRTSA
LLKEGVELMDGLKQRVEHIHLKDKSKVFNTARVEALELENLIEVARATMVSAEARKESRGAHAHSDYEHRDDENWLRHTL
WYSEGDRLDYKPVQMQPLTVESVPPKARTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=586, Percent_Identity=51.3651877133106, Blast_Score=588, Evalue=1e-168,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=55.6313993174061, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=39.7905759162304, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=32.258064516129, Blast_Score=236, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17550100, Length=587, Percent_Identity=50.9369676320273, Blast_Score=584, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17505833, Length=588, Percent_Identity=50.6802721088435, Blast_Score=574, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=52.3728813559322, Blast_Score=601, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=52.7118644067797, Blast_Score=597, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6320788, Length=487, Percent_Identity=26.2833675564682, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=52.6490066225166, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=52.6490066225166, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=52.6490066225166, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=47.2222222222222, Blast_Score=538, Evalue=1e-153,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64799; Mature: 64668

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIKTSLPRRKFDVVIVGAGGSGLRAALQLSRAGLSVGVLSKVFPTRSHTVAAQGGIGA
CCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHFHFYDTIKGSDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIY
CCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVEAKTQFFVEWMALDLIRDADG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGDVYIMEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGVALQD
CEEEEEEEEEECCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCHHHHCCCEEEC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGVGPNKDHVLLDLSHIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCEEEEE
MGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGANRLGTNSLLDLVVFGRAAGN
CCCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCH
HIVEQVKKQKEHKPLPADAGEFSLARLNKLDKSSSGEYTQDVANDIRATMQKHAGVFRTS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
ALLKEGVELMDGLKQRVEHIHLKDKSKVFNTARVEALELENLIEVARATMVSAEARKESR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAHSDYEHRDDENWLRHTLWYSEGDRLDYKPVQMQPLTVESVPPKARTF
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCCCCCCC
>Mature Secondary Structure 
AAIKTSLPRRKFDVVIVGAGGSGLRAALQLSRAGLSVGVLSKVFPTRSHTVAAQGGIGA
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHFHFYDTIKGSDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIY
CCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVEAKTQFFVEWMALDLIRDADG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGDVYIMEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGVALQD
CEEEEEEEEEECCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCHHHHCCCEEEC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGVGPNKDHVLLDLSHIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCEEEEE
MGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGANRLGTNSLLDLVVFGRAAGN
CCCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCH
HIVEQVKKQKEHKPLPADAGEFSLARLNKLDKSSSGEYTQDVANDIRATMQKHAGVFRTS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
ALLKEGVELMDGLKQRVEHIHLKDKSKVFNTARVEALELENLIEVARATMVSAEARKESR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAHSDYEHRDDENWLRHTLWYSEGDRLDYKPVQMQPLTVESVPPKARTF
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]