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The map label for this gene is cobB [H]

Identifier: 189352605

GI number: 189352605

Start: 689868

End: 690761

Strand: Direct

Name: cobB [H]

Synonym: BMULJ_03836

Alternate gene names: 189352605

Gene position: 689868-690761 (Clockwise)

Preceding gene: 189352602

Following gene: 189352606

Centisome position: 27.89

GC content: 72.26

Gene sequence:

>894_bases
ATGAACGATACCGACTTCCCCGATCCCTCCGTCGCCGCCGAGCCGGCCGCGCTCGATGCGCTGCATGCGTTCGTCGAACG
TCATCCGCGCCTGCTCGTGCTGACCGGCGCGGGCATCAGCACCGATTCCGGCATTCCCGGCTATCGCGACCGCAACGGCC
AGTGGACGCGCTCGCCGCCGATCCAGCTGCACGAATTCCTCGGCTCGGACGCCGCGCGGCGCCGCTACTGGGCGCGCAGC
ATGATCGGCTGGCCGGTCGTCGGCCGCGCGCAGCCGAACCGCTCGCACACGGCGCTCGCCCGGCTCGGCCGCGCGGGGCG
GATCGAGCGCCTCGTCACGCAGAACGTCGACGGCTTGCATCAGCGCGCGGGCAGCGTCGACGTGATCGAGCTGCACGGCG
GCATTCGCGGCGTCACGTGCATCGACTGCGGCGCGCATCACGCGCGCGCGACGATCCAGGCGCAGCTCGAAGCGGACAAT
CCGGCGCTGCTCGGCGTGCAGGCCGACGCGGCCGCGGACGGCGACGCGCACCTCGAATGGTCGGCGCTCGACACGTTTCG
CGTCCCCGCGTGCCCGACGTGCGGCGGGCTGCTGAAACCGGCCGTCGTGTTCTTCGGCGAAAACGTGCCGCGCGAGCGCG
TCGCGCTTGCTTCGCAGGCGCTCGATGCGGCCGATGCGCTGCTCGTCGTCGGCTCGTCGCTGATGGTGTATTCCGGCTAT
CGCTTCTGCCGGTGGGCGCAGGCGCAGCACAAGCCGATCGCGGCGTTGAACCTCGGCCGCACGCGCGCCGATCCGATGCT
CGCGCTGAAGGTCGAAGCGCGCTGCGCGCCGGCGCTCGAGGCGCTGACCGCGCGGCTCGGGCTCGCGCACGACGACGCGG
AGCATGCATCGTGA

Upstream 100 bases:

>100_bases
CGACGACCTGCCCGATCGCGCGGCGTTCGGTATCATGTGCTGGCGCGCCGGCCGATCGCGCCGGTCCACGGCCTGCCGGC
GCGCGCTCCGCCGCCCCGTC

Downstream 100 bases:

>100_bases
GCGCGCCGAACCCTGCGACGAATCCGTCCGCCCGACGGTCCGCGCCGGCGGCCGAGCGCAATCGCGGTCCGATCCTCGAC
GTGCTGCGCCGCGTGCTGCC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNDTDFPDPSVAAEPAALDALHAFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWTRSPPIQLHEFLGSDAARRRYWARS
MIGWPVVGRAQPNRSHTALARLGRAGRIERLVTQNVDGLHQRAGSVDVIELHGGIRGVTCIDCGAHHARATIQAQLEADN
PALLGVQADAAADGDAHLEWSALDTFRVPACPTCGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGY
RFCRWAQAQHKPIAALNLGRTRADPMLALKVEARCAPALEALTARLGLAHDDAEHAS

Sequences:

>Translated_297_residues
MNDTDFPDPSVAAEPAALDALHAFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWTRSPPIQLHEFLGSDAARRRYWARS
MIGWPVVGRAQPNRSHTALARLGRAGRIERLVTQNVDGLHQRAGSVDVIELHGGIRGVTCIDCGAHHARATIQAQLEADN
PALLGVQADAAADGDAHLEWSALDTFRVPACPTCGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGY
RFCRWAQAQHKPIAALNLGRTRADPMLALKVEARCAPALEALTARLGLAHDDAEHAS
>Mature_297_residues
MNDTDFPDPSVAAEPAALDALHAFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWTRSPPIQLHEFLGSDAARRRYWARS
MIGWPVVGRAQPNRSHTALARLGRAGRIERLVTQNVDGLHQRAGSVDVIELHGGIRGVTCIDCGAHHARATIQAQLEADN
PALLGVQADAAADGDAHLEWSALDTFRVPACPTCGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGY
RFCRWAQAQHKPIAALNLGRTRADPMLALKVEARCAPALEALTARLGLAHDDAEHAS

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=269, Percent_Identity=45.3531598513011, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI6912664, Length=276, Percent_Identity=30.7971014492754, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI13787215, Length=256, Percent_Identity=31.25, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI300795542, Length=274, Percent_Identity=29.5620437956204, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI6912660, Length=246, Percent_Identity=30.0813008130081, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI7657575, Length=224, Percent_Identity=29.9107142857143, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI63054862, Length=242, Percent_Identity=29.7520661157025, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI300797577, Length=256, Percent_Identity=26.5625, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI300797597, Length=120, Percent_Identity=35.8333333333333, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI308199517, Length=270, Percent_Identity=29.6296296296296, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71990482, Length=259, Percent_Identity=40.9266409266409, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71990487, Length=261, Percent_Identity=40.6130268199234, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17567771, Length=272, Percent_Identity=37.5, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17541892, Length=228, Percent_Identity=29.3859649122807, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17505510, Length=124, Percent_Identity=32.258064516129, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571445, Length=268, Percent_Identity=43.6567164179104, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28571443, Length=218, Percent_Identity=42.6605504587156, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28571441, Length=218, Percent_Identity=42.6605504587156, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17137536, Length=232, Percent_Identity=29.7413793103448, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648389, Length=216, Percent_Identity=25.462962962963, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31810; Mature: 31810

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTDFPDPSVAAEPAALDALHAFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWTRSPP
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
IQLHEFLGSDAARRRYWARSMIGWPVVGRAQPNRSHTALARLGRAGRIERLVTQNVDGLH
HHHHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCHHHHHHHCCHHHHH
QRAGSVDVIELHGGIRGVTCIDCGAHHARATIQAQLEADNPALLGVQADAAADGDAHLEW
HHCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEE
SALDTFRVPACPTCGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGY
ECCCEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEECCCC
RFCRWAQAQHKPIAALNLGRTRADPMLALKVEARCAPALEALTARLGLAHDDAEHAS
HHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNDTDFPDPSVAAEPAALDALHAFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWTRSPP
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
IQLHEFLGSDAARRRYWARSMIGWPVVGRAQPNRSHTALARLGRAGRIERLVTQNVDGLH
HHHHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCHHHHHHHCCHHHHH
QRAGSVDVIELHGGIRGVTCIDCGAHHARATIQAQLEADNPALLGVQADAAADGDAHLEW
HHCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEE
SALDTFRVPACPTCGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGY
ECCCEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEECCCC
RFCRWAQAQHKPIAALNLGRTRADPMLALKVEARCAPALEALTARLGLAHDDAEHAS
HHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA