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The map label for this gene is mmr [H]

Identifier: 189352388

GI number: 189352388

Start: 445444

End: 446877

Strand: Reverse

Name: mmr [H]

Synonym: BMULJ_03607

Alternate gene names: 189352388

Gene position: 446877-445444 (Counterclockwise)

Preceding gene: 189352389

Following gene: 189352386

Centisome position: 18.07

GC content: 72.66

Gene sequence:

>1434_bases
ATGGACACCGCCACACCTGCCTTTCCCCGTACACTCGCGCGCATCGTCGCGACCGTCAGCGTCGGCTTCGTCGTCACGCA
GCTCGACGTGACGATCGTCAATATCGCGCTCGCGCACATGGCCGCCGCGCTGCATCTGTCGGTCGCCGGTTTGCAATGGG
TCGTCGATGCGTACACGCTCGCGTTCGCGGTCCTGATGCTGTCGGCCGGCGCGCTCGGCGACCGCTTCGGCGCGCGTCGC
CTCTATGTCGCGGGCCTCGCGCTGTTCGCGCTCGCGTCGCTCGCATGCGGCGCAGCCGTGGCGCCGGCGATGCTGATCGC
GGCGCGTGCCGTGCAAGGCGTCGGCGCGGCGGCCATGCTGCCCAACTCGCTCGCGCTGCTGAACGATGCGTGCCGGCACG
ATCCGGCGCTGCGTGCGCGCGCGGTCGGCGCATGGACGGCGGCCGGTTCGGTGTCGATCGCGGCCGGTCCCGTGCTCGGC
GGCGCGCTGATCGCCGCGTTCGGCTGGCGCAGCATCTTCCTCGTCAATCTGCCGCTCTGTGCGGCCGGGCTCGCGGCCGC
ATTCGCCTGGACACCGGTCGATCGTGCGGCCGCATCGCCTGCGCCGCAGGCGCGTACGCTCGACGTACGCGGCCAGCTCG
TCGCAATCGCGATGCTGACCGCGCTCACCGGCGCGGTGATCGAATGGCGGCCGCTGGGCCTCGCGCATCCGGTCGTCGCC
GGCGGCTTCGTGCTCGCGGTGCTCGCCGCCGCCGCGTTCATCGCGATCGAATCGCGCACCGCGACGCCGATGCTGCCGCT
CGCGCTGTTCCGCCGCCGCACGTTCAGCGCGGCCGTGCTGTTCGGGATCTGCGTCAATCTCACGTATTACGGCACCGTGT
TCGTGATCGCGCTGTATCTGCAGCGCGTGCGCGGCGAATCGGCGCTACAGGCGGGACTCGCGTTCCTGCCGCTGACGGGC
GGCTTCCTGCTCGCGAATCTCGCCAGCGGCCGCGCTGTCGCGCGCTACGGGCCGCGTGCGCCGATGCTCGCCGGCGCGCT
CGTCGCCGCGCTCGGCTACGGGTCGCTGCACTTCGTCGACGGCTCGACGCCGTTGCCCGCGCTGCTCGTGCCGTTCGTGC
TGATTCCGTCGGGGATGGGTTTCGCGGTGCCGGCGATGACGACCGCCGTACTCGCCTCGGTCGAACCGGCGCGCGCCGGT
ATCGCGTCGGCCGTGCTCAATACCGCGCGACAGGCCGGCGGGGCGATCGGCGTTGCGGCGTTCGGCGCGGTGGCCGGCAG
CGGTGGCGCGGTGCCGGTGGTCGATGGGCTGCGCATCGATACCGGCGTGTCGGTCGCGCTGCTGATCGCGGCTGCGCTGC
TCGCCACGCGCGTGCGGCCCGACGCGCATCGCGACGCGCATGGCGGCCGCCGTCCGTTGCAGACGACGGACTGA

Upstream 100 bases:

>100_bases
ATCGGCCCTTCACCCTTCCCGTCCATCGCACAACACGTGTTGCATCGACGCTTCGCCCAGCGCTGAAACGTCCGCGCACG
CAGCCGCTTACGATGGACGC

Downstream 100 bases:

>100_bases
TCGGCGCGGCCGCCGCGACGGGCATACGGATCAGCACGCGCACGAGTGGCCGATCGCTCAGCGCGGCGTCGCGTCGCCGG
CGTCGCCGACCTTTTTCACG

Product: methylenomycin A resistance protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: MMR peptide [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MDTATPAFPRTLARIVATVSVGFVVTQLDVTIVNIALAHMAAALHLSVAGLQWVVDAYTLAFAVLMLSAGALGDRFGARR
LYVAGLALFALASLACGAAVAPAMLIAARAVQGVGAAAMLPNSLALLNDACRHDPALRARAVGAWTAAGSVSIAAGPVLG
GALIAAFGWRSIFLVNLPLCAAGLAAAFAWTPVDRAAASPAPQARTLDVRGQLVAIAMLTALTGAVIEWRPLGLAHPVVA
GGFVLAVLAAAAFIAIESRTATPMLPLALFRRRTFSAAVLFGICVNLTYYGTVFVIALYLQRVRGESALQAGLAFLPLTG
GFLLANLASGRAVARYGPRAPMLAGALVAALGYGSLHFVDGSTPLPALLVPFVLIPSGMGFAVPAMTTAVLASVEPARAG
IASAVLNTARQAGGAIGVAAFGAVAGSGGAVPVVDGLRIDTGVSVALLIAAALLATRVRPDAHRDAHGGRRPLQTTD

Sequences:

>Translated_477_residues
MDTATPAFPRTLARIVATVSVGFVVTQLDVTIVNIALAHMAAALHLSVAGLQWVVDAYTLAFAVLMLSAGALGDRFGARR
LYVAGLALFALASLACGAAVAPAMLIAARAVQGVGAAAMLPNSLALLNDACRHDPALRARAVGAWTAAGSVSIAAGPVLG
GALIAAFGWRSIFLVNLPLCAAGLAAAFAWTPVDRAAASPAPQARTLDVRGQLVAIAMLTALTGAVIEWRPLGLAHPVVA
GGFVLAVLAAAAFIAIESRTATPMLPLALFRRRTFSAAVLFGICVNLTYYGTVFVIALYLQRVRGESALQAGLAFLPLTG
GFLLANLASGRAVARYGPRAPMLAGALVAALGYGSLHFVDGSTPLPALLVPFVLIPSGMGFAVPAMTTAVLASVEPARAG
IASAVLNTARQAGGAIGVAAFGAVAGSGGAVPVVDGLRIDTGVSVALLIAAALLATRVRPDAHRDAHGGRRPLQTTD
>Mature_477_residues
MDTATPAFPRTLARIVATVSVGFVVTQLDVTIVNIALAHMAAALHLSVAGLQWVVDAYTLAFAVLMLSAGALGDRFGARR
LYVAGLALFALASLACGAAVAPAMLIAARAVQGVGAAAMLPNSLALLNDACRHDPALRARAVGAWTAAGSVSIAAGPVLG
GALIAAFGWRSIFLVNLPLCAAGLAAAFAWTPVDRAAASPAPQARTLDVRGQLVAIAMLTALTGAVIEWRPLGLAHPVVA
GGFVLAVLAAAAFIAIESRTATPMLPLALFRRRTFSAAVLFGICVNLTYYGTVFVIALYLQRVRGESALQAGLAFLPLTG
GFLLANLASGRAVARYGPRAPMLAGALVAALGYGSLHFVDGSTPLPALLVPFVLIPSGMGFAVPAMTTAVLASVEPARAG
IASAVLNTARQAGGAIGVAAFGAVAGSGGAVPVVDGLRIDTGVSVALLIAAALLATRVRPDAHRDAHGGRRPLQTTD

Specific function: Resistance to the epoxide antibiotic methylenomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=423, Percent_Identity=30.0236406619385, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081983, Length=406, Percent_Identity=29.8029556650246, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788710, Length=417, Percent_Identity=26.378896882494, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788392, Length=464, Percent_Identity=29.7413793103448, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789042, Length=405, Percent_Identity=27.6543209876543, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324954, Length=418, Percent_Identity=25.8373205741627, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48144; Mature: 48144

Theoretical pI: Translated: 11.21; Mature: 11.21

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTATPAFPRTLARIVATVSVGFVVTQLDVTIVNIALAHMAAALHLSVAGLQWVVDAYTL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFAVLMLSAGALGDRFGARRLYVAGLALFALASLACGAAVAPAMLIAARAVQGVGAAAML
HHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
PNSLALLNDACRHDPALRARAVGAWTAAGSVSIAAGPVLGGALIAAFGWRSIFLVNLPLC
CCHHHHHHHHHHCCHHHHHHHCEEEECCCCCEEECCHHHHHHHHHHHHHHHEEEEECHHH
AAGLAAAFAWTPVDRAAASPAPQARTLDVRGQLVAIAMLTALTGAVIEWRPLGLAHPVVA
HHHHHHHHHCCCHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHH
GGFVLAVLAAAAFIAIESRTATPMLPLALFRRRTFSAAVLFGICVNLTYYGTVFVIALYL
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRVRGESALQAGLAFLPLTGGFLLANLASGRAVARYGPRAPMLAGALVAALGYGSLHFVD
HHHCCHHHHHHCHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEC
GSTPLPALLVPFVLIPSGMGFAVPAMTTAVLASVEPARAGIASAVLNTARQAGGAIGVAA
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHH
FGAVAGSGGAVPVVDGLRIDTGVSVALLIAAALLATRVRPDAHRDAHGGRRPLQTTD
HHHHCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTATPAFPRTLARIVATVSVGFVVTQLDVTIVNIALAHMAAALHLSVAGLQWVVDAYTL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFAVLMLSAGALGDRFGARRLYVAGLALFALASLACGAAVAPAMLIAARAVQGVGAAAML
HHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
PNSLALLNDACRHDPALRARAVGAWTAAGSVSIAAGPVLGGALIAAFGWRSIFLVNLPLC
CCHHHHHHHHHHCCHHHHHHHCEEEECCCCCEEECCHHHHHHHHHHHHHHHEEEEECHHH
AAGLAAAFAWTPVDRAAASPAPQARTLDVRGQLVAIAMLTALTGAVIEWRPLGLAHPVVA
HHHHHHHHHCCCHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHH
GGFVLAVLAAAAFIAIESRTATPMLPLALFRRRTFSAAVLFGICVNLTYYGTVFVIALYL
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRVRGESALQAGLAFLPLTGGFLLANLASGRAVARYGPRAPMLAGALVAALGYGSLHFVD
HHHCCHHHHHHCHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEC
GSTPLPALLVPFVLIPSGMGFAVPAMTTAVLASVEPARAGIASAVLNTARQAGGAIGVAA
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHH
FGAVAGSGGAVPVVDGLRIDTGVSVALLIAAALLATRVRPDAHRDAHGGRRPLQTTD
HHHHCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1379177; 9384377 [H]